Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

(2018) Hanwei Fang et al.   Nature Communications

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II

(2016) James C. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Invasion of hepatocytes byPlasmodiumsporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4

(2016) K. Govindasamy et al.   MOLECULAR MICROBIOLOGY

Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation

(2016) Jeong Joo Kim et al.   STRUCTURE

Understanding artemisinin-resistant malaria

(2015) Rick M. Fairhurst   CURRENT OPINION IN INFECTIOUS DISEASES

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress

(2015) Jeong Joo Kim et al.   PLoS Pathogens

Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design

(2014) Gilbert Y. Huang et al.   BIOCHEMISTRY

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

The switch helix: A putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase

(2013) Thomas M. Moon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

(2013) Dante Neculai et al.   NATURE

Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I

(2013) Gilbert Y. Huang et al.   STRUCTURE

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

The role of cGMP signalling in regulating life cycle progression of Plasmodium

(2012) Christine S. Hopp et al.   MICROBES AND INFECTION

Structure and Allostery of the PKA RII  Tetrameric Holoenzyme

(2012) P. Zhang et al.   SCIENCE

Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding

(2011) Jeong Joo Kim et al.   PLoS One

Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication

(2011) Brent W. Osborne et al.   STRUCTURE

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

(2011) Lev Solyakov et al.   Nature Communications

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

(2009) Helen M. Taylor et al.   EUKARYOTIC CELL

A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite

(2009) Robert W. Moon et al.   PLoS Pathogens

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase

(2008) Louisa McRobert et al.   PLOS BIOLOGY

A Generalized Allosteric Mechanism for cis-Regulated Cyclic Nucleotide Binding Domains

(2008) Alexandr P. Kornev et al.   PLoS Computational Biology

cGMP-binding Prepares PKG for Substrate Binding by Disclosing the C-terminal Domain

(2007) Vera Alverdi et al.   JOURNAL OF MOLECULAR BIOLOGY