Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b

Structure of the C1r–C1s interaction of the C1 complex of complement activation

(2018) Jamal O. M. Almitairi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

(2018) Deniz Ugurlar et al.   SCIENCE

The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein

(2018) Emiri Hiramoto et al.   Science Advances

Persistence length of collagen molecules based on nonlocal viscoelastic model

(2017) Esmaeal Ghavanloo   JOURNAL OF BIOLOGICAL PHYSICS

Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms

(2017) Kirstie L. S. Cleary et al.   JOURNAL OF IMMUNOLOGY

Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation

(2017) Thomas H. Sharp et al.   JOURNAL OF STRUCTURAL BIOLOGY

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

(2016) Federico Forneris et al.   EMBO JOURNAL

The paradoxical roles of C1q and C3 in autoimmunity

(2016) Diane Scott et al.   IMMUNOBIOLOGY

Guillain-Barré syndrome

(2016) Hugh J Willison et al.   LANCET

Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2

(2016) Ioannis Grammatikakis et al.   Cell Reports

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

(2016) Rob N. de Jong et al.   PLOS BIOLOGY

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

(2016) Katherine E. Lintner et al.   Frontiers in Immunology

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

(2015) Sofia Mortensen et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component

(2015) Duncan B. Richards et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

(2013) Andrew J. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites

(2013) I. Bally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

(2013) R. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

(2013) Umakhanth Venkatraman Girija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyreactive Antibodies Plus Complement Enhance the Phagocytosis of Cells Made Apoptotic by UV-Light or HIV

(2013) Zhao-hua Zhou et al.   Scientific Reports

Structural basis for activation of the complement system by component C4 cleavage

(2012) R. T. Kidmose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

Identification of the C1q-binding Sites of Human C1r and C1s

(2009) Isabelle Bally et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analogous Interactions in Initiating Complexes of the Classical and Lectin Pathways of Complement

(2009) A. E. Phillips et al.   JOURNAL OF IMMUNOLOGY

Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX

(2009) A. W. Pawluczkowycz et al.   JOURNAL OF IMMUNOLOGY

The human IgM pentamer is a mushroom-shaped molecule with a flexural bias

(2009) D. M. Czajkowsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of Human C1q with IgG and IgM: Revisited†

(2008) Mihaela G. Gadjeva et al.   BIOCHEMISTRY