Article
Oncology
Sosse E. Klarenbeek, Mieke J. Aarts, Michel M. Heuvel, Mathias Prokop, Marcia Tummers, Olga C. J. Schuurbiers-Siebers
Summary: The relation between time-to-treatment and survival in early-stage NSCLC patients was examined. Extended time-to-treatment was associated with increased risk of death in clinical stage II patients who underwent surgical treatment. Diagnostic tests were among the factors that contributed to prolonged time-to-treatment.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Jingsheng Cai, Fan Yang, Xun Wang
Summary: This study aims to investigate occult non-small cell lung cancer (NSCLC), an underappreciated tumor, and found that it is an aggressive tumor with poor prognosis. Surgery is the preferred treatment. More attention should be paid to this overlooked disease due to no evidence of tumor imaging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shawn J. Rice, Chandra P. Belani
Summary: Blood-based biomarkers, including systemic inflammation indicators and circulating factors, are associated with poor prognosis in lung cancer patients. Elevated levels of inflammation markers were found in non-small cell lung cancer (NSCLC) patients compared to small cell lung cancer (SCLC) and disease-free (DF) patients. Specific markers were identified as predictors of progression and overall survival in NSCLC patients, highlighting the potential for personalized treatment strategies.
Article
Multidisciplinary Sciences
Qing Li, Zhen Lin, Ye Hong, Yang Fu, Yueyun Chen, Ting Liu, Yue Zheng, Jiangfang Tian, Chunhua Liu, Wei Pu, Zhenyu Ding, Chun Wang
Summary: Patients with advanced non-small cell lung cancer are susceptible to brain metastases, including brain parenchymal metastases and leptomeningeal metastases. Patients with leptomeningeal metastases have a higher proportion of EGFR exon 21 point mutations and shorter survival compared to patients without brain metastases or with brain parenchymal metastases. Two prediction models were developed to predict the development of brain parenchymal metastases and leptomeningeal metastases in advanced non-small cell lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Kenji Sawa, Izumi Sato, Masato Takeuchi, Koji Kawakami
Summary: The risk of developing pneumonitis with ICIs for NSCLC patients with preexisting ILD was similar to that with conventional chemotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Medicine, General & Internal
Xiang Zhang, Nan Feng, Bo Wu, Yiping Wei, Wenxiong Zhang
Summary: Lymph node ratio (LNR) is an important prognostic indicator in non-small-cell lung cancer (NSCLC), with higher LNR indicating worse prognosis. This study found that LNR and positive node category have predictive value for prognosis in stage III NSCLC patients.
Article
Medicine, General & Internal
Nasser Altorki, Xiaofei Wang, David Kozono, Colleen Watt, Rodney Landrenau, Dennis Wigle, Jeffrey Port, David R. Jones, Massimo Conti, Ahmad S. Ashrafi, Moishe Liberman, Kazuhiro Yasufuku, Stephen Yang, John D. Mitchell, Harvey Pass, Robert Keenan, Thomas Bauer, Daniel Miller, Leslie J. Kohman, Thomas E. Stinchcombe, Everett Vokes
Summary: This study compared lobectomy and sublobar resection in lung cancer patients. The results showed that in patients with tumors sized 2 cm or less and negative lymph nodes, sublobar resection was not inferior to lobectomy in terms of disease-free survival, and overall survival was similar between the two procedures.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Erik Sachs, Ulrik Sartipy, Veronica Jackson
Summary: The study found that women who undergo pulmonary resections for lung cancer have a significantly better prognosis than men. The absolute survival difference at 1, 5, and 10 years was 3.0%, 10%, and 12% respectively.
Article
Oncology
Vera Ehrenstein, Katrine Eriksen, Aliki Taylor, Leslie Servidio, Erik Jakobsen
Summary: This study described the EGFR testing, patient characteristics, and overall survival (OS) among patients with early-stage NSCLC in Denmark. It found that EGFRm-positive status was associated with lower all-cause mortality.
Article
Health Care Sciences & Services
Wouter A. C. van Amsterdam, Netanja Harlianto, Joost J. C. Verhoeff, Pim Moeskops, Pim A. de Jong, Tim Leiner
Summary: This study investigated the prognostic value of CT-derived muscle quantity for overall survival in patients with non-small-cell lung cancer. The results showed that high muscle quantity was associated with better overall survival, but this association was not observed in patients with fatty degeneration of muscle tissue and low muscle radiodensity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Dongliang Bian, Liangdong Sun, Junjie Hu, Liang Duan, Haoran Xia, Xinsheng Zhu, Fenghuan Sun, Lele Zhang, Huansha Yu, Yicheng Xiong, Zhida Huang, Deping Zhao, Nan Song, Jie Yang, Xiao Bao, Wei Wu, Jie Huang, Wenxin He, Yuming Zhu, Gening Jiang, Peng Zhang
Summary: This study aimed to assess the feasibility of neoadjuvant Afatinib treatment for stage III NSCLC patients. The results showed that Afatinib improved the objective response rate (ORR) in NSCLC patients and caused dynamic changes in the tumor microenvironment.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Yuan Gu, Gianni Pais, Vivien Becker, Christina Korbel, Emmanuel Ampofo, Elke Ebert, Johannes Hohneck, Nicole Ludwig, Eckart Meese, Rainer M. Bohle, Yingjun Zhao, Michael D. Menger, Matthias W. Laschke
Summary: The research demonstrates that miR-22 is highly expressed in ECs and significantly downregulated in NSCLC tissues. Endothelial miR-22 acts as an angiogenesis inhibitor by targeting sirtuin 1 and FGFR1 to inhibit ECs' angiogenic activities, thus suppressing NSCLC growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Pharmacology & Pharmacy
Zhenglian Gao, Jian Xu, Mark Coburn, Daqing Ma, Kun Wang
Summary: This retrospective cohort study found no difference in five-year overall survival and recurrence-free survival after non-small-cell lung cancer surgery between propofol-based total intravenous anesthesia and sevoflurane-based inhalation anesthesia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qing Ye, Nancy Lan Guo
Summary: Currently, there are no accurate biomarkers for optimal treatment selection in early-stage non-small cell lung cancer (NSCLC). This study demonstrates that hub genes in genome-scale regulatory networks are associated with NSCLC tumorigenesis, proliferation, and survival. These findings have implications for prioritizing therapeutic targets to improve patient survival outcomes.
Article
Multidisciplinary Sciences
Deirdre Cronin-Fenton, Tapashi Dalvi, Naimisha Movva, Lars Pedersen, Hanh Hansen, Jon Fryzek, Elizabeth Hedgeman, Anders Mellemgaard, Torben R. Rasmussen, Norah Shire, Stephen Hamilton-Dutoit, Mette Norgaard
Summary: The study found that PD-L1+ immune cells may confer a survival benefit in stage III unresected NSCLC patients, while PD-L1+ tumors did not influence survival. KRASm was not associated with death, while EGFRm was rare in the sample population.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Torsten Dahlen, Jingcheng Zhao, Patrik K. E. Magnusson, Yudi Pawitan, Jakob Lavrod, Gustaf Edgren
Summary: The study estimated the contemporary frequency of misattributed paternity in Sweden to be 1.7%, with a higher prevalence among parents with low educational levels, and decreasing over time to 1%.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Andreas Roos, Gustaf Edgren, Martin J. Holzmann
Summary: This study compared the prognosis of patients with myocardial injury and unstable angina pectoris (UAP) with patients with non-ST-segment myocardial infarction (NSTEMI) with different peak concentrations of high-sensitivity cardiac troponin T (hs-cTnT). The results showed that patients with UAP and myocardial injury had a similar risk of death after discharge compared to patients with NSTEMI with moderately elevated hs-cTnT levels, but a lower risk of recurrent myocardial infarction and a slightly higher risk of heart failure.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andreas Roos, Gustaf Edgren
Summary: This study aimed to investigate whether the relative change between historical hs-cTnT and admission hs-cTnT could improve early identification of patients with a high risk of myocardial infarction (MI) in the emergency department (ED). The results showed that using historical hs-cTnT levels with admission hs-cTnT can improve early risk stratification of MI in the ED.
Article
Hematology
Cecilia Radkiewicz, Johanna B. Bruchfeld, Caroline E. Weibull, Mathias L. Jeppesen, Henrik Frederiksen, Mats Lambe, Lasse Jakobsen, Tarec C. El-Galaly, Karin E. Smedby, Tove Wasterlid
Summary: It is well established that males have a higher risk and poorer survival of most cancers, and this pattern also applies to lymphomas. In this study, researchers used the Swedish Lymphoma Register to investigate sex differences in lymphoma subtype incidence and excess mortality. The findings showed that men had a significantly higher incidence and trend toward higher mortality in most lymphoma subtypes.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Rheumatology
Majd Bairkdar, Enoch Yi-Tung Chen, Paul W. Dickman, Roger Hesselstrand, Helga Westerlind, Marie Holmqvist
Summary: This study conducted a nationwide cohort study to investigate the survival patterns of patients with incident systemic sclerosis (SSc) in Sweden. The results showed that the survival rate of SSc patients diagnosed between 2004 and 2015 was significantly lower compared to the general population, despite advances in understanding and diagnosing the disease.
Article
Medicine, General & Internal
Torsten Dahlen, Huiqi Li, Fredrik Nyberg, Gustaf Edgren
Summary: Individuals with blood groups A, AB, and B are at increased risk of contracting COVID-19 as well as developing more severe forms of the disease. However, this association is greatly attenuated in vaccinated individuals.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Marcus Holmberg, Cecilia Radkiewicz, Cecilia Stromberg, Mikael Oman, Poya Ghorbani, J. -Matthias Lohr, Ernesto Sparrelid
Summary: This study aims to compare the outcomes after resection of invasive intraductal papillary mucinous neoplasm (inv-IPMN) and conventional pancreatic ductal adenocarcinoma (PDAC), and found that the outcomes of inv-IPMN are more favorable in lower stages, but similar or worse in higher stages.
Article
Gastroenterology & Hepatology
Anna-Klara Pettersson, Giola Santoni, Jacinth Yan, Cecilia Radkiewicz, Shaohua Xie, Helgi Birgisson, Eivind Ness-Jensen, My von Euler-Chelpin, Joonas H. Kauppila, Jesper Lagergren
Summary: This article presents the cohort description of the Nordic Helicobacter Pylori Eradication Project (NordHePEP), which aims to investigate the influence of HP eradication treatment on the risk of gastrointestinal cancer. The cohort includes adults who have been prescribed and dispensed HP eradication treatment in any of the five Nordic countries between 1994 and 2020. Individual-level data from multiple national registries have been retrieved and merged to analyze this cohort.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Ida Wiken, Therese M-L Andersson, Cecilia Radkiewicz
Summary: This study investigates the impact of holidays on cancer incidence and survival rates in Sweden. It finds that cancer cases decline during holidays and increase post-holidays for certain types of cancer. The study also reveals higher mortality rates for cancers diagnosed during holidays, emphasizing the need for consistent cancer care throughout the year.
Article
Oncology
Carl Sars, Helena Sackey, Jan Frisell, Paul W. Dickman, Fredrik Karlsson, Isabelle Kindts, Gustavo Nader Marta, Ruffo Freitas-Junior, Tove Filtenborg Tvedskov, Loay Kassem, Ahmed S. Ali, Hanna Ihalainen, Mathias Neron, Michalis Kontos, Orit Kaidar-Person, Icro Meattini, Anne Brecht Francken, Frederieke van Duijnhoven, Ingvild Ona Moberg, Tanja Marinko, Attila Kollar, Mahbubl Ahmed, Dennis Remoundos, Jenny Banks, Reshma Jagsi, Lesly A. Dossett, Ebba K. Lindqvist
Summary: Phyllodes tumors of the breast are rare fibroepithelial lesions classified as benign, borderline or malignant. Current clinical practice in managing these tumors shows considerable variation, indicating a need for education and further research to establish appropriate surgical margins, follow-up time, and a multidisciplinary approach.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Medicine, General & Internal
Andreas Roos, Eva Sedin, Gustaf Edgren
Summary: This study in Sweden found that patients with psychiatric disorders who present with chest pain receive different management and have different outcomes compared to those without psychiatric disorders. Patients with affective or psychotic disorders had a reduced risk of myocardial infarction, but were less likely to receive cardiovascular medications or undergo percutaneous coronary intervention. On the other hand, patients with psychiatric disease had an increased risk of being diagnosed with a myocardial infarction within 30 days after the visit.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Johan Hardvik Akerstrom, Cecilia Radkiewicz
Summary: A 68-year-old white male with a history of left adrenalectomy and distal gastrectomy for gastric adenocarcinoma presented with symptoms of fatigue, unintentional weight loss, hyperkalemia, and a right adrenal mass. It was determined that the patient had primary adrenal insufficiency caused by metastatic invasion of the remaining right adrenal gland. The patient underwent multimodal treatment including glucocorticoid therapy, palliative chemotherapy, and stereotactic body radiotherapy, resulting in long-term survival without evidence of active malignant disease.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Oncology
Cecilia Radkiewicz, Therese M-L Andersson, Jesper Lagergren
Summary: This study calculated years of life lost (YLL) due to the top 10 solid tumors causing the most deaths, using data from the Swedish National Cancer and Cause of Death Registers. The results showed that lung and colorectal cancer remained the leading causes of YLL, while pancreatic and breast cancer moved up in rank. Prostate cancer, on the other hand, moved down in rank. Women consistently lost more life years due to lung and pancreatic cancer, and the decline in colorectal cancer mortality was only reflected as a YLL decline in women. YLL is a simple and intuitive measure that expands our understanding of the cancer burden on society.
JNCI CANCER SPECTRUM
(2023)
Article
Obstetrics & Gynecology
Anne Brynolf, Anna Sandstrom, Gustaf Edgren
Summary: The risk of recurrent maternal red-cell transfusion in delivery is higher for women with a history of red-cell transfusion in previous deliveries. In contrast, women without a history of red-cell transfusion are less likely to require transfusion during delivery.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Hematology
Jenny Ryden, Mark Clements, Agneta Wikman, Eva Hellstrom-Lindberg, Gustaf Edgren, Petter Hoglund
Summary: This study found that alloimmunization against blood group antigens is associated with sex, DAT-positivity, increased transfusion needs, and lower post-transfusion hemoglobin increments in patients with myelodysplastic syndromes (MDS). Further investigation is needed to evaluate the clinical significance of up-front typing and prophylactic antigen matching in these patients.