Article
Clinical Neurology
Frederic Sampedro, Saul Martinez-Horta, Andrea Horta-Barba, Michel J. Grothe, Miguel A. Labrador-Espinosa, Silvia Jesus, Astrid Adarmes-Gomez, Fatima Carrillo, Arnau Puig-Davi, Florinda Roldan-Lora, Miquel Aguilar-Barbera, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots-Foraster, Javier Ruiz-Martinez, Francisco Carrillo-Padilla, Mercedes Pueyo-Morlans, Isabel Gonzalez-Aramburu, Jon Infante-Ceberio, Jorge Hernandez-Vara, Oriol de Fabregues-Boixar, Teresa de Deus Fonticoba, Asuncion Avila, Juan Carlos Martinez-Castrillo, Helena Bejr-Kasem, Antonia Campolongo, Berta Pascual-Sedano, Pablo Martinez-Martin, Diego Santos-Garcia, Pablo Mir, Pedro J. Garcia-Ruiz, Jaime Kulisevsky
Summary: This study explores the neural correlates of reduced facial expression and its relationship with other non-motor symptoms in Parkinson's disease. The severity of hypomimia was found to be closely associated with rigidity and bradykinesia, and significantly related to the severity of apathy. At the neural level, hypomimia was related to several brain regions involved in the recognition and production of facial expressions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Vanessa Fleury, Alkisti Zekeridou, Vladimir Lazarevic, Nadia Gaia, Catherine Giannopoulou, Laurence Genton, Jose Cancela, Myriam Girard, Rachel Goldstein, Julien F. Bally, Andrea Mombelli, Jacques Schrenzel, Pierre R. Burkhard
Summary: The study found changes in the oral microbiome in early and mid-stage PD patients, with good dental and periodontal status in patients, but local inflammation was present in the oral cavity. Further studies are needed to investigate the relationship between oral dysbiosis, inflammation, and the pathogenesis of PD.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hui-Hua Zheng, Chong-Tao Du, Chao Yu, Xin-Yue Tang, Rong-Lei Huang, Yu-Zhu Zhang, Wei Gao, Guang-Hong Xie
Summary: Early diagnosis of canine mammary tumor (CMT) is crucial for prognosis. This study examined the bacterial community in tumor tissues, oral and gut samples from dogs with CMTs, and found significant differences compared to healthy dogs. Bacteroides was identified as a significant microbial biomarker in the oral and gut bacterium community, suggesting a potential route for microbiota to travel from the mouth to the intestine and to distant mammary tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Nobuyuki Araki, Yoshitaka Yamanaka, Anupama Poudel, Yoshikatsu Fujinuma, Akira Katagiri, Satoshi Kuwabara, Masato Asahina
Summary: Patients with early and untreated PD showed irregular EGG waves and high ICDF. EGG demonstrated better accuracy for early PD diagnosis compared to the olfactory test and had similar sensitivity to MIBG scintigraphy.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Christina Andica, Koji Kamagata, Yuya Saito, Wataru Uchida, Shohei Fujita, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Takashi Ogawa, Taku Hatano, Nobutaka Hattori, Shigeki Aoki
Summary: In this study, fiber-specific white matter alterations in nonmedicated patients with early-stage Parkinson's disease were assessed using fixel-based analysis. The results showed significantly increased fiber cross-section in tremor-dominant PD patients compared to healthy controls. This may suggest the presence of white matter neural compensation mechanisms in tremor-dominant PD patients.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Li Jiang, Jiachen Zhuo, Andrew Furman, Paul S. Fishman, Rao Gullapalli
Summary: This study investigates the changes in cerebellar functional connectivity in early-stage drug-naive Parkinson's disease patients. The findings suggest that there are significant alterations in cerebellar connectivity, which are associated with motor and cognitive function. These results provide important insights into the early-stage involvement of the cerebellum in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
G. Pagano, K. I. Taylor, J. Anzures-Cabrera, M. Marchesi, T. Simuni, K. Marek, R. B. Postuma, N. Pavese, F. Stocchi, J. -P. Azulay, B. Mollenhauer, L. Lopez-Manzanares, D. S. Russell, J. T. Boyd, A. P. Nicholas, M. R. Luquin, R. A. Hauser, T. Gasser, W. Poewe, B. Ricci, A. Boulay, A. Vogt, F. G. Boess, J. Dukart, G. D'Urso, R. Finch, S. Zanigni, A. Monnet, N. Pross, A. Hahn, H. Svoboda, M. Britschgi, F. Lipsmeier, E. Volkova-Volkmar, M. Lindemann, S. Dziadek, S. Holiga, D. Rukina, T. Kustermann, G. A. Kerchner, P. Fontoura, D. Umbricht, R. Doody, T. Nikolcheva, A. Bonni
Summary: The study found that prasinezumab had no meaningful effect on global or imaging measures of Parkinson's disease progression and was associated with infusion reactions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Avanthika Rajendran, Akshay J. Reddy, Karol Bisaga, Dillon A. Sommer, Neha Prakash, Vivek T. Pokala, Zeyu Yu, Mark Bachir, Neel Nawathey, Telak Brahmbhatt, Rakesh Patel
Summary: Parkinson's disease (PD) is a prevalent neurodegenerative disorder caused by a decrease in dopamine, leading to nerve cell destruction. Diagnosing PD is challenging due to similar symptoms with aging. PD patients experience impaired motor control and function, dyskinesia, and tremors. Treatments involve administering drugs that increase dopamine in the brain. This study investigates the usage of rotigotine in both early and late stages of PD. The statistical model found no significant difference in rotigotine dosage between late and early-stage PD patients but acknowledges the need for further research to validate or nullify this hypothesis due to potential confounding variables.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Clinical Neurology
Natalia Palacios, Anas Hannoun, Julie Flahive, Doyle Ward, Kelsey Goostrey, Anindita Deb, Kara M. Smith
Summary: In this study, the impact of Levodopa initiation on the gut microbiota of Parkinson's disease patients was investigated through a longitudinal analysis. The results did not show significant changes in microbiota composition before vs. after Levodopa initiation. There was a preliminary observation of a potential association between the abundance of Clostridium group IV and short-term motor symptom response to Levodopa, which warrants further investigation in larger, longer-term studies with control groups.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Jae Woo Chung, Christopher A. Knight, Abigail E. Bower, Justin P. Martello, John J. Jeka, Roxana G. Burciu
Summary: This study investigated deficits in force control in Parkinson's disease, specifically in the upper and lower extremities. It found that individuals with PD demonstrated slower rates of force development and relaxation in the lower limb, and these deficits may worsen with disease progression.
Article
Immunology
Irene Yang, Henry Claussen, Robert Adam Arthur, Vicki Stover Hertzberg, Nicolaas Geurs, Elizabeth J. Corwin, Anne L. Dunlop
Summary: This study aims to understand the structure and diversity of the subgingival microbiome in pregnant Black women and explore its relationship with preterm birth. The study found that although the composition of the subgingival microbiome shifted, the diversity remained stable throughout pregnancy. Additionally, several bacteria were found to be associated with spontaneous early term birth.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Clinical Neurology
Amgad Droby, Shai Nosatzki, Yariv Edry, Avner Thaler, Nir Giladi, Anat Mirelman, Inbal Maidan
Summary: This pilot study investigates the relationship between cognitive disturbances in early-stage Parkinson's disease (PD) and changes in brain functional and structural connectivity. The findings suggest that alterations in functional connectivity may play a role in cognitive changes in early PD, while structural connectivity may be more related to disease progression.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Lan Zhang, Tao Yang, Yuping Chen, Denise Zheng, Dong Sun, Qiang Tu, Jinbai Huang, Junjian Zhang, Zezhi Li
Summary: This study investigated the intrinsic dysconnectivity pattern of whole-brain functional networks in early-stage drug-naive PD patients and its association with cognitive deficit. Results suggest that PD patients show abnormalities in brain functional networks, particularly in areas associated with cognitive dysfunction.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Microbiology
Rosie Broadhead, Laure Craeye, Chris Callewaert
Summary: Research on the skin microbiome has gained attention in recent years, with the textile industry also acknowledging its importance. Antimicrobial finishing in textiles may disrupt the skin microbiome, highlighting the benefits of natural and microbiome-friendly therapies in combating skin conditions, malodour, and skin infections.
Article
Clinical Neurology
Xiaojuan Dan, Yang Hu, Junyan Sun, Linlin Gao, Yongtao Zhou, Jinghong Ma, Julien Doyon, Tao Wu, Piu Chan
Summary: This study found that altered cerebellar functional connectivity in early PD patients during resting state is influenced not only by motor deficits, but also by cognitive deficits, highlighting the interaction between motor and cognitive functioning and possibly reflecting compensatory mechanisms in early PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Sport Sciences
Steven D. Hicks, Paige Jacob, Omar Perez, Matthew Baffuto, Zofia Gagnon, Frank A. Middleton
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Multidisciplinary Sciences
Daria LaRocca, Sarah Barns, Steven D. Hicks, Andrew Brindle, Jeremy Williams, Richard Uhlig, Paul Johnson, Christopher Neville, Frank A. Middleton
Article
Neurosciences
Kristen Swieck, Amanda Conta-Steencken, Frank A. Middleton, Justin R. Siebert, Donna J. Osterhout, Dennis J. Stelzner
Article
Psychology, Developmental
Steven D. Hicks, Randall L. Carpenter, Kayla E. Wagner, Rachel Pauley, Mark Barros, Cheryl Tierney-Aves, Sarah Barns, Cindy Dowd Greene, Frank A. Middleton
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2020)
Article
Cell Biology
Yaxin Liu, Xiaowen Wang, Liam P. Coyne, Yuan Yang, Yue Qi, Frank A. Middleton, Xin Jie Chen
MOLECULAR BIOLOGY OF THE CELL
(2019)
Article
Multidisciplinary Sciences
Aakriti Pandita, Poornima Ramadas, Aarati Poudel, Nibal Saad, Ankit Anand, Alina Basnet, Dongliang Wang, Frank Middleton, Diana M. Gilligan
Article
Biochemistry & Molecular Biology
Rachel E. H. Sager, Adam K. Walker, Frank Middleton, Kate Robinson, Maree J. Webster, Cynthia Shannon Weickert
Summary: The immune system components play a role in regulating synapse formation and refinement in neurodevelopment. The complement pathway, associated with cell lysis and phagocytosis, is involved in synaptic elimination. Changes in complement activity during human development, particularly during adolescence, may be linked to the onset of neurodevelopmental disorders such as autism or schizophrenia.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Education, Special
David Levitskiy, Alexandra Confair, Kayla E. Wagner, Samantha DeVita, Nicole Shea, Elizabeth P. McKernan, Justin Kopec, Natalie Russo, Frank A. Middleton, Steven D. Hicks
Summary: This study identified specific salivary RNAs associated with ASD behaviors in older individuals and found that these RNAs changed as early as three months after therapy initiation in younger children. These findings suggest that salivary RNAs could be potential biomarkers for tracking treatment effectiveness and prognosis in ASD. Further validation is needed to confirm these results.
RESEARCH IN AUTISM SPECTRUM DISORDERS
(2021)
Article
Multidisciplinary Sciences
David A. Larsen, Mary B. Collins, Qian Du, Dustin Hill, Tabassum Z. Insaf, Pruthvi Kilaru, Brittany L. Kmush, Frank Middleton, Abigail Stamm, Maxwell L. Wilder, Teng Zeng, Hyatt Green
Summary: Wastewater surveillance is a rapid method to estimate population-level disease transmission and predict the probability of SARS-CoV-2 transmission in a community. A study in upstate New York found that the intensity of SARS-CoV-2 in wastewater correlated with COVID-19 incidence and test positivity, and when SARS-CoV-2 was not detected in wastewater, there were fewer reported COVID-19 cases.
Article
Psychology, Developmental
Kayla E. Wagner, Jennifer B. McCormick, Sarah Barns, Molly Carney, Frank A. Middleton, Steven D. Hicks
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2020)
Article
Psychology, Clinical
Richard E. Mattson, Nicole Cameron, Frank A. Middleton, Lisa R. Starr, Joanne Davila, Matthew D. Johnson
JOURNAL OF FAMILY PSYCHOLOGY
(2019)