Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors

Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors

(2018) E N Lyukmanova et al.   BRITISH JOURNAL OF PHARMACOLOGY

Augmenting the antinociceptive effects of nicotinic acetylcholine receptor activity through lynx1 modulation

(2018) Neel I. Nissen et al.   PLoS One

Deletion of lynx1 reduces the function of α6* nicotinic receptors

(2017) Rell L. Parker et al.   PLoS One

Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling

(2016) Mohammed H. Al-Wadei et al.   EUROPEAN JOURNAL OF CANCER

Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis

(2016) Venkaiah Betapudi et al.   FASEB JOURNAL

Palmoplantar Keratoderma in Slurp2-Deficient Mice

(2016) Christopher M. Allan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lynx1 and Aβ1–42 bind competitively to multiple nicotinic acetylcholine receptor subtypes

(2016) Morten S. Thomsen et al.   NEUROBIOLOGY OF AGING

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

(2016) Ekaterina N. Lyukmanova et al.   PLoS One

Mal de Meleda: A Focused Review

(2015) Caroline Perez et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1

(2015) Yasuhiro Moriwaki et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium

(2015) Xiao Wen Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Identification and Characterization of a G Protein-binding Cluster in α7 Nicotinic Acetylcholine Receptors

(2015) Justin R. King et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53 Promotes Tumor Cell Malignancy by Both Positive and Negative Regulation of the Transforming Growth Factor β (TGF-β) Pathway

(2015) Lei Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways

(2015) JIE MIN et al.   ONCOLOGY REPORTS

Looking below the surface of nicotinic acetylcholine receptors

(2015) Clare Stokes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pathogenic mechanisms of lung adenocarcinoma in smokers and non-smokers determined by gene expression interrogation

(2015) YUNQIAN HU et al.   Oncology Letters

Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated

(2013) Morten Skøtt Thomsen et al.   Brain Structure & Function

Water-soluble LYNX1 Residues Important for Interaction with Muscle-type and/or Neuronal Nicotinic Receptors

(2013) Ekaterina N. Lyukmanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells

(2013) MASASHI OKADA et al.   ONCOLOGY REPORTS

Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH

(2013) M. Suntsova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium

(2012) Xiao Wen Fu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Nicotinic acetylcholine receptors: From basic science to therapeutics

(2012) Raymond Hurst et al.   PHARMACOLOGY & THERAPEUTICS

Functional Roles of Src and Fgr in Ovarian Carcinoma

(2011) H.-S. Kim et al.   CLINICAL CANCER RESEARCH

Nicotine: specific role in angiogenesis, proliferation and apoptosis

(2011) Alessio Cardinale et al.   CRITICAL REVIEWS IN TOXICOLOGY

NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1

(2011) Ekaterina N. Lyukmanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic Cancer Cells and Normal Pancreatic Duct Epithelial Cells Express an Autocrine Catecholamine Loop that Is Activated by Nicotinic Acetylcholine Receptors  3,  5, and  7

(2011) M. H. Al-Wadei et al.   MOLECULAR CANCER RESEARCH

Bacterial expression of the water-soluble domain of lynx1, an endogenous neuromodulator of human nicotinic receptors

(2011) M. A. Shulepko et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system

(2009) Jian-xin Shen et al.   ACTA PHARMACOLOGICA SINICA

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand

(2009) Yasuhiro Moriwaki et al.   NEUROSCIENCE RESEARCH

Modulation of p53 by mitogen-activated protein kinase pathways and protein kinase C δ during avian reovirus S1133-induced apoptosis

(2009) Ping-Yuan Lin et al.   VIROLOGY

Early adhesion induces interaction of FAK and Fyn in lipid domains and activates raft-dependent Akt signaling in SW480 colon cancer cells

(2008) Gilbert Baillat et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nicotine Promotes Mammary Tumor Migration via a Signaling Cascade Involving Protein Kinase C and cdc42

(2008) J. Guo et al.   CANCER RESEARCH

Activated Cholinergic Signaling Provides a Target in Squamous Cell Lung Carcinoma

(2008) P. Song et al.   CANCER RESEARCH

Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis

(2008) Richard D. Egleton et al.   TRENDS IN PHARMACOLOGICAL SCIENCES