期刊
AQUATIC TOXICOLOGY
卷 170, 期 -, 页码 289-296出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquatox.2015.07.019
关键词
Population; Crustacean; Beta-blockers; Diazepam; Carbamazepine; Neuroendocrine
资金
- Spanish projects [CTM2011-30471-C02-01CTM2014-51985-R]
- FEDER founds
- MINECO [FPI BES-2012-053631]
Assessing the risks of emerging contaminants, such as pharmaceuticals in the environment requires an understanding of their exposure regime and their effects at environmentally relevant concentrations across species. Daphnia magna represents an excellent invertebrate model species to study the mode of action of emerging pollutants, allowing the assessment of effects at different biological levels. The present study aims to test the hypothesis that different families of neuro-active pharmaceuticals at low environmentally relevant concentrations may lead to similar phenotypic responses in D. magna. Phenotypic traits included reproduction and behavioural responses. Selected pharmaceuticals were carbamazepine, diazepam and propranolol, three widely prescribed compounds, already detected at considerable levels in the environment (ng to few mu g/L). Fluoxetine was also included in behavioural assays. The three tested neuro-active pharmaceuticals were able to enhance reproduction at 1 of propranolol, 0.1 mu g/L of diazepam and 1 mu g/L of carbamazepine. Fluoxetine, carbamazepine and diazepam increased positive phototactic behaviour at concentrations ranging from 1, 10 and 100 ng/L, respectively. Reported responses were nonmonotonic, which means that eco-toxicity testing of pharmaceuticals need to assess effects at the range. (C) 2015 Published by Elsevier B.V.
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