Empirical ways to identify novel Bedaquiline resistance mutations in AtpE

Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy

(2018) Malancha Karmakar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

NGL viewer: web-based molecular graphics for large complexes

(2018) Alexander S Rose et al.   BIOINFORMATICS

Bacterial risk factors for treatment failure and relapse among patients with isoniazid resistant tuberculosis

(2018) Phan Vuong Khac Thai et al.   BMC INFECTIOUS DISEASES

Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis

(2018) Ana Trapero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam

(2018) Kathryn E. Holt et al.   NATURE GENETICS

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability

(2018) Carlos HM Rodrigues et al.   NUCLEIC ACIDS RESEARCH

Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae

(2018) Sundeep Chaitanya Vedithi et al.   Scientific Reports

Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis

(2018) Stephanie Portelli et al.   Scientific Reports

Combating mutations in genetic disease and drug resistance: understanding molecular mechanisms to guide drug design

(2017) Amanda T.S. Albanaz et al.   Expert Opinion on Drug Discovery

Examination of bedaquiline- and linezolid-resistant Mycobacterium tuberculosis isolates from the Moscow region

(2017) Danila V. Zimenkov et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro activity of bedaquiline against rapidly growing nontuberculous mycobacteria

(2017) Diana A. Aguilar-Ayala et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

(2017) Harry C Jubb et al.   JOURNAL OF MOLECULAR BIOLOGY

Reply: Call for Regular Susceptibility Testing of Bedaquiline and Delamanid

(2016) Harald Hoffmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Delamanid and Bedaquiline Resistance inMycobacterium tuberculosisAncestral Beijing Genotype Causing Extensively Drug-Resistant Tuberculosis in a Tibetan Refugee

(2016) Harald Hoffmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mutations inpepQConfer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis

(2016) Deepak Almeida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance

(2016) Jody Phelan et al.   BMC Medicine

CSM-lig: a web server for assessing and comparing protein–small molecule affinities

(2016) Douglas E.V. Pires et al.   NUCLEIC ACIDS RESEARCH

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance

(2016) Douglas E. V. Pires et al.   Scientific Reports

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

(2016) Vinayak Singh et al.   ACS Infectious Diseases

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis

(2016) Yumi Park et al.   ACS Infectious Diseases

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity

(2016) Douglas E. V. Pires et al.   Scientific Reports

Better prediction of functional effects for sequence variants

(2015) Maximilian Hecht et al.   BMC GENOMICS

Bedaquiline: 10 years later, the drug susceptibility testing protocol is still pending

(2015) Max Salfinger et al.   EUROPEAN RESPIRATORY JOURNAL

Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis

(2015) Guido V. Bloemberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

(2015) Francesc Coll et al.   Genome Medicine

Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline

(2015) L. Preiss et al.   Science Advances

Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment?

(2015) Stephen K. Field   Therapeutic Advances in Chronic Disease

Bedaquiline

(2014) Elias B. Chahine et al.   ANNALS OF PHARMACOTHERAPY

ATP synthase in mycobacteria: Special features and implications for a function as drug target

(2014) Ping Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Platinum: a database of experimentally measured effects of mutations on structurally defined protein–ligand complexes

(2014) Douglas E.V. Pires et al.   NUCLEIC ACIDS RESEARCH

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

(2014) D. E. V. Pires et al.   NUCLEIC ACIDS RESEARCH

mCSM: predicting the effects of mutations in proteins using graph-based signatures

(2013) Douglas E. V. Pires et al.   BIOINFORMATICS

New Mutations in the Mycobacterial ATP Synthase: New Insights into the Binding of the Diarylquinoline TMC207 to the ATP Synthase C-Ring Structure

(2012) Elena Segala et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

SDM--a server for predicting effects of mutations on protein stability and malfunction

(2011) C. L. Worth et al.   NUCLEIC ACIDS RESEARCH

Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor

(2009) E. Huitric et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY