Article
Oncology
Jae Hyun Kim, Jongwook Yu, Dong Keon Kim, Seunghun Lee, Seung Hyun Lee, Byung Kwon Ahn, Tae Il Kim, Seun Ja Park
Summary: This study suggests that the tumor microbiome may be a potential predictor of postoperative disease recurrence in patients with colorectal cancer. The microbial diversity and abundance differ between tumor and adjacent tissues, and a prediction model using tumor tissue microbiome data performs better than clinical factors, especially in female patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hailun Xie, Lishuang Wei, Mingxiang Liu, Yanren Liang, Guanghui Yuan, Shunhui Gao, Qiwen Wang, Xin Lin, Shuangyi Tang, Jialiang Gan
Summary: This study explored the value of preoperative prognostic immune and nutritional index (PINI) in predicting postoperative complications and long-term outcomes in patients with stage I-III colorectal cancer (CRC). The results showed a positive relationship between PINI and survival in CRC patients, and PINI was found to be associated with disease-free survival, overall survival, and postoperative complications. PINI-based nomograms were constructed to predict postoperative 1-5-year disease-free survival and overall survival.
Article
Oncology
Eun Kyung Choe, Sangwoo Lee, So Yeon Kim, Manu Shivakumar, Kyu Joo Park, Young Jun Chai, Dokyoon Kim
Summary: In this study, the expression and DNA methylation levels of inflammation-related genes in colorectal cancer tissues were evaluated to predict prognosis. The methylation levels of CEP250, RAB21, and TNPO3 were significantly associated with overall survival, suggesting their crucial role in CRC prognosis and potential mechanisms linking inflammation and cancer progression. Integration of expression, methylation, and clinical information was shown to improve the prediction of survival outcomes.
Article
Multidisciplinary Sciences
Thaer S. A. Abdalla, Jan Meiners, Sabine Riethdorf, Alexandra Koenig, Nathaniel Melling, Tobias Gorges, Karl-F. Karstens, Jakob R. Izbicki, Klaus Pantel, Matthias Reeh
Summary: The detection of circulating tumor cells in patients with colorectal cancer before surgery is an independent and strong prognostic factor for overall survival. This study suggests that it could improve the identification of high-risk patients in future clinical trials.
Article
Medicine, General & Internal
Aihong Bi, Sifu Yang, Yang Ding, Yong Yu, Wenming Zhan, Tao Song
Summary: This study investigates the prognostic value of radiotherapy (RT) and chemotherapy (CT) in the management of Merkel cell carcinoma (MCC) patients. The results show that RT is associated with significantly improved overall survival (OS), while CT negatively impacts OS. However, in stage III patients, RT is still a positive factor, and CT is not significantly associated with OS.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hailun Xie, Lishuang Wei, Mingxiang Liu, Yanren Liang, Qiwen Wang, Shuangyi Tang, Jialiang Gan
Summary: This study found a relationship between the Cancer-Inflammation Prognostic Index (CIPI) and disease-free survival (DFS) and overall survival (OS) in patients with colorectal cancer (CRC). Patients with a high CIPI had lower DFS and OS, especially for stage II and III. After multivariate analysis, a high CIPI was identified as an independent risk factor for DFS and OS in CRC patients. The prognostic nomograms integrated multiple factors and showed better predictive performance than traditional TNM staging.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Kohei Yasui, Dai Shida, Yuya Nakamura, Yuka Ahiko, Shunsuke Tsukamoto, Yukihide Kanemitsu
Summary: This study suggests that postoperative changes in inflammation-based prognostic markers are more accurate in predicting overall survival and recurrence-free survival in patients with stage III CRC. The study found that patients with a normalised inflammatory state had better prognosis compared to those with persistently elevated inflammatory state.
BRITISH JOURNAL OF CANCER
(2021)
Article
Surgery
Sungjin Kim, Sung Il Kang, Sohyun Kim, Jae Hwang Kim
Summary: This study investigated the prognostic implications of severe chemotherapy-induced neutropenia (CIN) in patients with stage III colorectal cancer (CRC) who received adjuvant FOLFOX chemotherapy. Results showed that severe CIN did not significantly impact the survival outcomes of patients with stage III CRC.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Dakui Luo, Yufei Yang, Zezhi Shan, Qi Liu, Sanjun Cai, Qingguo Li, Xinxiang Li
Summary: The study aimed to explore prognostic factors in stage I-III colorectal cancer patients who survived for over five years. Factors such as age, pathological stage, and perineural invasion deserve more attention in patients who have survived for over five years. The predictors for prognosis of CRC change over time.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Feifei Bi, Xiaoyan Li, Yong Zhang, Zekun Wang, Qian Dong, Jingdong Zhang, Deyu Sun
Summary: The objective of this study was to analyze the difference between preoperative radiological and postoperative pathological stages in colorectal cancer, as well as explore the feasibility of using elastic lamina invasion as a prognostic marker for patients with stage III colon cancer. The study found poor consistency between the two staging methods and suggested that elastic lamina staining could be used as a stratified indicator of recurrence risk, thus improving patient prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Ke Zhao, Xiaomei Wu, Zhenhui Li, Yingyi Wang, Zeyan Xu, Yajun Li, Lin Wu, Su Yao, Yanqi Huang, Changhong Liang, Zaiyi Liu
Summary: The study developed and validated a modified Immunoscore (IS-mod) system for predicting overall survival in patients with stage I-III colon cancer. The IS-mod was found to be an independent prognostic factor for OS in the discovery cohort, with comparable performance to the Immunoscore-like system. The study suggests that even with a small reference set, the IS-mod demonstrates stable prognostic value, potentially inspiring other institutions to develop a local reference set for more accurate risk stratification of colon cancer.
CHINESE JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Tong Yu, Jinglue Song, Hui Zhou, Tingyu Wu, Zhonglin Liang, Peng Du, Chen-Ying Liu, Guanghui Wang, Long Cui, Yun Liu
Summary: The study highlights the crucial role of TEAD4 and its direct target gene SIX1 in driving colorectal cancer progression, with their aberrant expression predicting poor prognosis in stage I-III CRC patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Xiao-Jing Luo, Qi Zhao, Jia Liu, Jia-Bo Zheng, Miao-Zhen Qiu, Huai-Qiang Ju, Rui-Hua Xu
Summary: The therapeutic strategies for stage II/III colorectal cancer patients post-surgery are still debated, with the need for better biomarkers to stratify patients for adjuvant chemotherapy. Recent advances in sequencing and high-throughput technologies have led to the discovery of novel genetic and epigenetic biomarkers that could aid in prognosis and treatment responses in CRC.
Article
Surgery
Shun Sato, Takayuki Shimizu, Mitsuru Ishizuka, Kotaro Suda, Norisuke Shibuya, Hiroyuki Hachiya, Yukihiro Iso, Kazutoshi Takagi, Taku Aoki, Keiichi Kubota
Summary: Preoperative pan-immune-inflammation value (PIV) can predict the surgical outcomes of patients with stage I-III colorectal cancer.
Review
Medicine, General & Internal
Saar Hommes, Ruben Vromans, Felix Clouth, Xander Verbeek, Ignace de Hingh, Emiel Krahmer
Summary: The study conducted a systematic review on the communicative quality of colorectal cancer patient decision aids. The findings revealed significant variation in the quality of DAs, with issues such as lack of treatment information personalization, verbal communication of outcome probability information, bias towards specific treatments, lengthy content, and lack of plain language writing. Developers should focus on personalization techniques and utilize standardized checklists to improve the quality of DAs for better shared decision making in clinical practice.
Article
Oncology
Xiangde Li, Yun Liu, Shijie Liao, Chengsen Lin, Abu Moro, Jing Liu, Wenyu Feng, Kun Wang, Chunming Wang
Summary: The compound Polyphyllin VII extracted from Paris polyphylla can promote apoptosis in human osteosarcoma cells by upregulating specific genes and affecting intracellular H2O2 levels. In addition, inhibition of autophagy can mitigate the apoptotic effect induced by Polyphyllin VII in U2OS cells.
Article
Oncology
Qing-Hua Du, Yi-Xiu Gan, Ren-Sheng Wang, Wen-Qi Liu, Jian Li, Fei-Fei Liang, Xiang-De Li, Hui-Jun Zhu, Xue Ou, Qiu-Lu Zhong, Dan-Jing Luo, Zhi-Peng Zhu, Shang-Yong Zhu
Summary: The study found that half-brain delineation can provide a convenient and stable method for predicting radiation-induced temporal lobe injury in nasopharyngeal carcinoma patients, reducing contouring variation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yuanfu Luo, Renzhi Deng, Qiulu Zhong, Danjing Luo, Xiangde Li, Xueyuan Chen, Sha Tao, Zhoubin Feng, Liu Jiayi, Yiyun Huang, Jian Li, Wenqi Liu
Summary: The study evaluated the prognostic impact of SII, NLR, and PLR on glioma patients before and after treatment, finding that pre-SII and NLR levels were associated with overall survival, while pre-PLR played a key role in progression-free survival.
Article
Oncology
Yi-xiu Gan, Qing-hua Du, Jian Li, Ye-ping Wei, Xu-wei Jiang, Xue-mei Xu, Hai-ying Yue, Xiang-de Li, Hui-jun Zhu, Xue Ou, Qiu-lu Zhong, Dan-jing Luo, Qian-fu Liang, Yi-ting Xie, Qiang-qiang Zhang, Ge-li Li, Yuan-ting Shang, Wen-qi Liu
Summary: The study suggests that adjuvant radiotherapy can reduce the risk of recurrence for women with early-stage cervical cancer after laparoscopic hysterectomy, especially for patients with stage IB disease, bringing significant survival benefits.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biology
Siqin Zhang, Shaoyong Chen, Pian Ao, Rong Cai, Wenqi Liu, Li Wei
Summary: Laminaria japonica polysaccharides (LJP) have a neuroprotective effect on radiation-induced brain injury mice by preventing neurogenesis damage and alleviating neuroinflammation and collagen IV degradation.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiang-De Li, Qiu-Lu Zhong, Dan-Jing Luo, Qian-fu Liang, Jia-qi Qiu, Qing-Hua Du, Liegang Xiao, Yan-hua Zhou, Yao-Bin Long, Wen-Qi Liu, Jian Li
Summary: The expression of ring finger protein 219 (RNF219) was upregulated in nasopharyngeal carcinoma (NPC) tissues and cells. RNF219 promoted NPC cell invasion, migration, and proliferation by activating the nuclear factor kappa B (NF-kappa B) pathway. Furthermore, RNF219 expression correlated positively with the activity of the NF-kappa B pathway.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Binglin Chen, Xiaowei Xie, Feifeng Lan, Wenqi Liu
Summary: In this study, AURKB, CDC20, TPX2, and KIF2C were identified as potential hub genes associated with non-small cell lung cancer, with high expression correlating with poor patient prognosis. In vitro experiments confirmed that CDC20 knockdown inhibited cell proliferation and growth. These findings suggest that these genes may serve as biomarkers and therapeutic targets for CD8(+) T cell infiltration in NSCLC.
