Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Sanjay Kinra, Shi Wu Wen, Hongying Liu, Xinrui Tan, Aizhong Liu
Summary: This study summarized the associations of different chemokines with T1DM, revealing that circulating concentrations of CCL5 and CXCL1 were significantly higher in T1DM patients compared to controls. Circulating CCL5 ranked highest among all the chemokines investigated in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Rosalind Pate, Noreen Caswell, Kathryn Jane Gardner, Lynda Holyoak
Summary: This study explores the relationships between psychological states (anxiety/worry, fatigue) and diabetes outcomes (diabetes distress, cognitive dysfunction), and finds that resilience mediates these relationships.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Endocrinology & Metabolism
Xuan Chen, Alison H. Affinati, Yungchun Lee, Adina F. Turcu, Norah Lynn Henry, Elena Schiopu, Angel Qin, Megan Othus, Dan Clauw, Nithya Ramnath, Lili Zhao
Summary: This study found that the risk of developing ICI-T1DM is associated with the type of ICI therapy, patient age, and preexisting non-T1DM diabetes. The development of ICI-T1DM does not seem to significantly impact patient survival.
Review
Psychology, Multidisciplinary
Esperanza Varela-Moreno, Monica Carreira Soler, Jose Guzman-Parra, Francisco Jodar-Sanchez, Fermin Mayoral-Cleries, Maria Teresa Anarte-Ortiz
Summary: This systematic review examines the efficacy of psychological interventions delivered through information and communication technologies (ICTs) for improving depressive symptomatology in patients with diabetes. The results show that these interventions have beneficial effects on depressive symptoms at the end of treatment and in the short and long term. However, they do not appear to significantly improve glycemic control.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
Dan Luo, Yubing Wang, Xue Cai, Ruxue Li, Mingzi Li, Haiyan Liu, Jingjing Xu
Summary: This study found a negative correlation between parental resilience and depressive symptoms and diabetes distress. Parents with high resilience reported fewer depressive symptoms, and parental resilience was associated with better pediatric glycaemic control.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Robert French, Dylan Kneale, Justin T. Warner, Holly Robinson, James Rafferty, Adrian Sayers, Peter Taylor, John W. Gregory, Colin M. Dayan
Summary: There is no strong evidence to suggest a significant association between type 1 diabetes and educational outcomes. However, the level of blood glucose control (HbA(1c)) is related to academic achievements.
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Cell & Tissue Engineering
Yanju Li, Feiqing Wang, Huiling Liang, Dongxin Tang, Mei Huang, Jianing Zhao, Xu Yang, Yanqing Liu, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: The meta-analysis included 10 studies with a total of 239 participants, evaluating the efficacy of mesenchymal stem cells (MSCs) therapy in treating diabetes mellitus. The results showed that MSC treatment led to significantly lower HbA1c levels, higher fasting C-peptide levels, and reduced insulin requirement in T1DM patients.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Endocrinology & Metabolism
Maureen Monaghan, Breana L. Bryant, Hailey Inverso, Hailey R. Moore, Randi Streisand
Summary: This review provides an update on behavioral research related to young children with T1D and highlights the need for increased attention and interventions. The use of diabetes technology has shown positive effects on glycemic levels and psychosocial functioning in this age group. However, research with young children in this population remains limited.
CURRENT DIABETES REPORTS
(2022)
Review
Medicine, General & Internal
Xi Peng, Guocheng Rao, Xinqiong Li, Nanwei Tong, Yan Tian, Xianghui Fu
Summary: This article comprehensively summarizes and discusses the applications, advantages, and limitations of commonly used animal models for human T1DM, as well as provides an overview of the latest human tissue bioengineering models for T1DM research. By combining these models with a better understanding of the pathophysiology of T1DM, we can gain deeper insights into disease development and ultimately improve therapeutic responses and outcomes.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Stephen T. O'Brien, Orla M. Neylon, Timothy O'Brien
Summary: Cardiovascular disease is the leading cause of death in Type 1 Diabetes, with the molecular basis for atherosclerosis heavily influenced by hyperglycaemia. Current tools for assessing CVD risk in Type 1 Diabetes patients are limited, posing challenges for selecting appropriate lipid-lowering therapies. Best practice guidance for managing dyslipidaemia in Type 1 Diabetes is mainly based on evidence from Type 2 Diabetes patients and expert opinions.
Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Biochemistry & Molecular Biology
Martina Brunner, Othmar Moser, Reingard Raml, Maximilian Haberlander, Beate Boulgaropoulos, Barbara Obermayer-Pietsch, Eva Svehlikova, Thomas R. Pieber, Harald Sourij
Summary: Methods for glucagon analysis in the past were not specific and had a narrow sensitivity range, leading to inaccurate results. Newer methods have shown that actual glucagon levels are lower than previously thought. This study compared glucagon levels in healthy individuals and diabetes patients using two different methods and found that the choice of method can significantly affect the results.
Review
Biochemistry & Molecular Biology
Jingqian Su, Yingsheng Luo, Shan Hu, Lu Tang, Songying Ouyang
Summary: Diabetes mellitus is a chronic disease with multiple complications and limited treatment options. The development of targeted therapies for type 2 diabetes mellitus is important due to individual variability and resistance to single-target drugs. This review provides an overview of recent therapeutic agents and discusses emerging target-based therapies for T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Kenneth Cusi, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Sandeep R. Das, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Mikhail Kosiborod, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Christopher H. Gibbons, John M. Giurini, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Jennifer K. Sun, Robert A. Gabbay
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay
Article
Psychology, Developmental
Alexa Stern, Brenda Duran, Randi Streisand, Christine H. Wang, Carrie Tully, Lauren Clary, Katherine Gallagher, Fran Cogen, Lefkothea Karaviti, Maureen Monaghan, Marisa E. Hilliard
Summary: The study aimed to describe parent experiences with school/daycare during the first 1.5 years following a young child's T1D diagnosis. It was found that T1D affected children's enrollment, rejection, or removal from school/daycare. Parents of younger children and those with lower subjective socioeconomic status were more likely to face challenges with school/daycare enrollment. Changes are needed to support early childhood education, including providing resources for parents, training for school staff, and better communication between healthcare teams, parents, and schools.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2023)
Article
Endocrinology & Metabolism
Jill Weissberg-Benchell, Anthony T. Vesco, Jenna Shapiro, Peter Calhoun, Edward R. Damiano, Steven J. Russell, Zoey Li, Firas H. El-Khatib, Katrina J. Ruedy, Courtney A. Balliro, Roy W. Beck, Bionic Pancreas Res Grp
Summary: This study evaluated the psychosocial impact and user experience of the insulin-only configuration of iLet bionic pancreas in individuals with type 1 diabetes. The results showed that adults experienced a reduction in diabetes-specific emotional distress and fear of hypoglycemia, as well as improved perceived well-being. Children and teenagers also demonstrated high acceptability and reduced burden with the system, but the improvements in psychosocial outcomes were less clear.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Psychology, Developmental
Marissa N. Baudino, Hailey Inverso, Christine Wang, Carrie Tully, Wendy Levy, Lauren Clary, Katherine A. Gallagher, Maureen Monaghan, Randi Streisand, Marisa E. Hilliard
Summary: This study found that a behavioral intervention targeted at parents of young children newly diagnosed with type 1 diabetes can improve parental depressive symptoms and that parents are highly satisfied with the intervention. Therefore, implementing this intervention as part of routine clinical care is feasible and well-received by parents.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2023)
Article
Endocrinology & Metabolism
Nuha A. ElSayed, Grazia Aleppo, Vanita R. Aroda, Raveendhara R. Bannuru, Florence M. Brown, Dennis Bruemmer, Billy S. Collins, Marisa E. Hilliard, Diana Isaacs, Eric L. Johnson, Scott Kahan, Kamlesh Khunti, Jose Leon, Sarah K. Lyons, Mary Lou Perry, Priya Prahalad, Richard E. Pratley, Jane Jeffrie Seley, Robert C. Stanton, Robert A. Gabbay