Article
Biochemistry & Molecular Biology
Shih-Fang Wu, Chih-Yao Lin, Rong-Kung Tsai, Yao-Tseng Wen, Feng-Huei Lin, Chia-Yu Chang, Ching- Shen, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Chin-San Liu, Yan-Ting Chen, Hong-Lin Su
Summary: Research found that mitochondrial transplantation can moderately attenuate the degeneration of retinal layers in RCS rats. This result was confirmed through histological examination and OCT measurement of retina thickness. VEP analysis showed that the transmission time of electrical signals after mitochondrial transplantation was similar to the normal value. The results suggest that mitochondrial transplantation can improve the degeneration of photoreceptors in RCS rats and have potential for clinical application.
Article
Microbiology
Jeong-Won Kim, Chang-Yeop Kim, Jin-Hwa Kim, Ji-Soo Jeong, Je-Oh Lim, Je-Won Ko, Tae-Won Kim
Summary: This study demonstrated that green tea extract has significant antibacterial activity against pathogenic Escherichia coli and can ameliorate pathogenic E. coli-induced intestinal damage by modulating inflammation and epithelial cell proliferation.
Article
Food Science & Technology
Minji Kang, Ee Hyun Kim, Jeewon Jeong, Hunjoo Ha
Summary: The study found that Heukcha extract can suppress diet-induced hypercholesterolemia and non-alcoholic fatty liver disease, possibly by increasing cholesterol 7 alpha-hydroxylase (CYP7A1) expression.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Chemistry, Medicinal
Jin-Hwa Kim, Jeong-Won Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Won Ko, Tae-Won Kim
Summary: This study aimed to explore the protective mechanisms of green tea extract (GTE) on cigarette smoke condensate (CSC)-induced emphysema by reducing macrophage-induced protease expression. Results showed that GTE significantly reduced macrophage counts and emphysematous lesions in CSC-exposed mice. Furthermore, GTE suppressed CSC-induced ERK/AP-1 phosphorylation and MMP-9 expression. These findings suggest that GTE can be used as a supplementary agent for preventing emphysema progression in COPD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nutrition & Dietetics
Mak-Soon Lee, Jumi Lee, Yangha Kim
Summary: This study aimed to investigate the effects of green tea extract containing Piper retrofractum fruit on dextran-sulfate-sodium induced colitis and its regulatory mechanisms. The results showed that the green tea extract treatment alleviated clinical symptoms of colitis and suppressed miR-21 expression and NF-kappa B activity, indicating its potential as a functional material for improving colitis.
Article
Food Science & Technology
Zhengming Zhou, Ke Li, Jiankui Guo, Yunfeng Wang, Yaoyao Wei, Juan Duan, Muxi Chen, Lei Shi, Wen Hu
Summary: Existing research suggests that (-)-epigallocatechin-3-gallate (EGCG), a natural tea catechin active substance, can protect the liver from injury. However, its mechanism for treating hepatic encephalopathy (HE) is still unclear. This study analyzed the role of EGCG in improving HE in rats and its effect on the microbiota-gut-liver axis. The results showed that EGCG has anti-oxidative stress and anti-inflammatory effects, and it ameliorates HE through the microbiota-gut-liver axis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Environmental Sciences
Rania Samir, Ekrami A. Hassan, Abdullah A. Saber, David S. A. Haneen, Eman M. Saleh
Summary: This study investigated the cardioprotective effects of thermally treated sodium alginate (TTSA) in treating doxorubicin-induced cardiotoxicity. The results showed that TTSA improved cardiac dysfunction and alleviated doxorubicin-induced myocardial apoptosis. Furthermore, TTSA exhibited antioxidant properties and rebalanced the redox state of cardiomyocytes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shasha Guo, Yuxuan Shi, Anan Xu, Yuefei Wang, Ping Xu
Summary: Liubao tea extract (LBTE) exhibits anti-inflammatory effects and alleviates airway inflammatory symptoms in ovalbumin-induced asthmatic mice by modulating the gut microbiota.
Article
Pharmacology & Pharmacy
Hyeonah Kim, Keun-Tae Park, Heejoon Jo, Yuchan Shin, Geehoon Chung, Seong-Gyu Ko, Young-Ho Jin, Woojin Kim
Summary: This study found that ginger extract can alleviate cisplatin-induced anorexia by regulating serotonin levels and the expression of 5-HT3A and 4 receptors in the blood and nodose ganglion tissues. The major components of the ginger extract, [6]-gingerol and [6]-shogaol, were identified and quantified. When treated together, they significantly reduced the decrease in food intake caused by cisplatin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Jose R. Cruz-Munoz, Tonatiuh Barrios-Garcia, Eduardo E. Valdez-Morales, Maria F. Duran-Vazquez, Karen B. Mendez-Rodriguez, Alma Barajas-Espinosa, Fernando Ochoa-Cortes, Maria C. Martinez-Saldana, Yenny A. Gomez-Aguirre, Raquel Guerrero Alba
Summary: The ethanolic extract of Lepidium virginicum L. has anti-inflammatory properties in the treatment of inflammatory bowel disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Subin Oh, Moon Ho Do, Jin A. Shin, Min Jee Lee, Hua Li, Su Yeon Cho, Jong-Moon Jeong
Summary: This study investigated the protective effects of a natural product mixture called BenPros on benign prostatic hyperplasia (BPH). BenPros exhibited inhibitory ability on the expression of androgen receptor, prostate-specific antigen, and 5 alpha-reductase protein, as well as anti-inflammatory effects. The mixture also reduced levels of hormones associated with BPH and showed regulatory effects on BPH markers, leading to a decrease in prostate size and epithelial thickness.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Doaa M. Abdel-Mohsen, Ahmed M. A. Akabawy, Manal F. El-Khadragy, Ahmed Abdel E. Moneim, Hatem K. Amin
Summary: The study investigated the therapeutic potential of green coffee bean extract (GCBE) in the treatment of diabetic hepatic damage induced by a high-fat diet (HFD) and streptozotocin (STZ) administration. A newly stabilized in vivo obese diabetic animal model was created to examine the dose-dependent effect of GCBE in protecting against oxidative stress-induced hepatic damage. The results showed that GCBE improved various parameters, reversed liver changes, and enhanced insulin signaling pathways, indicating its potential in repairing hepatic oxidative damage caused by HFD and STZ.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Biology
Suhayla Hamad Shareef, Ibrahim Abdel Aziz Ibrahim, Abdullah R. Alzahrani, Morteta H. Al-Medhtiy, Mahmood Ameen Abdulla
Summary: This study evaluated the hepatoprotective effects and mechanism of green tea extract in rats with liver fibrosis induced by TAA. Green tea showed potential in inhibiting liver cirrhosis progression, reducing cellular inflammation, and restoring antioxidant enzyme levels.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Luiz Otavio Guimaraes-Ervilha, Luiz Carlos Maia Ladeira, Renner Philipe Rodrigues Carvalho, Isabela Pereira da Silva Bento, Daniel Silva Sena Bastos, Ana Claudia Ferreira Souza, Eliziaria Cardoso Santos, Leandro Licursi de Oliveira, Izabel Regina dos Santos Costa Maldonado, Mariana Machado-Neves
Summary: The study demonstrated that green tea infusion could ameliorate structural and enzymatic damages in the testis and epididymis caused by hyperglycemia, improving spermatogenesis and protecting tissue from diabetic complications. However, green tea infusion did not show efficacy in maintaining testosterone levels, antioxidant enzyme activity, and microminerals content under severe hyperglycemic conditions.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Nutrition & Dietetics
Heba Nageh Gad El-Hak, Hany Salah Mahmoud, Eman A. Ahmed, Heba M. Elnegris, Tahany Saleh Aldayel, Heba M. A. Abdelrazek, Mohamed T. A. Soliman, Menna Allah I. El-Menyawy
Summary: This study found that methanolic date flesh extract (MDFE) has the potential to alleviate cisplatin-induced hepatic injury. In a rat model, pretreatment with MDFE reduced liver damage caused by cisplatin, improved liver function, and reduced inflammation.
Article
Ophthalmology
Dezhi Zheng, Zijing Huang, Weiqi Chen, Qi Zhang, Yi Shi, Jialin Chen, Lingping Cen, Taiping Li
Summary: The study evaluated the repeatability of pupillary light reflex metrics measured by the RAPDx (R) dynamic pupillometer in healthy subjects and its clinical application in patients with unilateral optic neuritis. The results showed good repeatability and interocular symmetry in healthy subjects, and promising preliminary results in patients with unilateral ON, indicating the potential value of the device in optic nerve diseases.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Lili Xie, Ling-Ping Cen, Yiqing Li, Hui-Ya Gilbert, Oleksandr Strelko, Cynthia Berlinicke, Mihaela A. Stavarache, Madeline Ma, Yongting Wang, Qi Cui, Michael G. Kaplitt, Donald J. Zack, Larry I. Benowitz, Yuqin Yin
Summary: Sterile inflammation in the eye can partially reverse the failure of mammalian retinal ganglion cells (RGCs) to regenerate axons and survive after optic nerve injury. This reversal is mediated by the expression of axogenic protein oncomodulin (Ocm) by infiltrative myeloid cells. Additionally, stromal cell-derived factor 1 (SDF1) expressed by infiltrative macrophages plays a central role in enhancing Ocm activity and promoting inflammation-induced regeneration and RGC survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Ophthalmology
Jing Na He, Tsz Kin Ng, Shi Yao Lu, Pancy Oi Sin Tam, Poemen P. Chan, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Wai Kit Chu
Summary: This study investigated the association between the ANGPT2 gene and primary open-angle glaucoma (POAG) in the Chinese population. The results showed that the SNP rs11775442 was associated with normal tension glaucoma (NTG) in the Hong Kong cohort, while rs13269021 was associated with NTG in males in the Shantou cohort. Further studies are needed to confirm the association between the ANGPT2 locus and NTG in Chinese males.
Article
Ophthalmology
Xuehui Lu, Guihua Zhang, Lingping Cen, Yali Du, Lifang Liu, Chuang Jin, Haoyu Chen
Summary: The study aims to analyze choroidal vascular density alteration in high myopia with or without choroidal neovascularization using OCTA. Results showed that patients with choroidal neovascularization had higher age, thinner choroidal thickness, and lower choroidal vascular density than those without. Multivariate analysis revealed that decreased choroidal vascular density and older age were independent factors associated with choroidal neovascularization in high myopic eyes.
JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Shi-Qi Yao, Meng Wang, Jia-Jian Liang, Tsz Kin Ng, Ling-Ping Cen
Summary: This study aimed to explore the transcriptomic changes associated with altered axonal growth capacity and identify key genes associated with axonal regeneration. The results showed that gene expression changed following optic nerve injury in embryonic and neonatal mice, and GO and KEGG pathways related to axonal growth capacity were identified. This study provides new data resources for understanding axonal growth capacity.
Article
Cell Biology
Zijing Huang, Jiajian Liang, Shaolang Chen, Tsz Kin Ng, Marten E. Brelen, Qingping Liu, Rucui Yang, Biyao Xie, Shuping Ke, Weiqi Chen, Dingguo Huang
Summary: Diabetic retinopathy (DR) is a major cause of blindness worldwide, and increasing evidence suggests that neuroinflammation, specifically microglial activation, plays a key role in its early pathogenesis. This study found that activated microglia in the diabetic retina triggered an inflammatory response through a process called necroptosis. The key components of necroptosis were highly expressed in activated microglia, and inhibiting necroptosis improved retinal neuroinflammation and visual function in diabetic mice. These findings highlight the importance of microglial necroptosis in DR and suggest it as a potential therapeutic target for early stage intervention.
CELL DEATH & DISEASE
(2023)
Article
Ophthalmology
Chuhua Zhang, Yun Wang, Yun Chen, Hui Zhou, Qiuxia Hong, Xiuying Yu, Tsz Kin Ng, Ling-Ping Cen
Summary: This study aimed to characterize the clinical manifestations and visual outcomes of patients with acute-onset Vogt-Koyanagi Harada (VKH) disease in southern China. The study found that posterior uveitis was the typical initial manifestation in Chinese VKH patients during the acute phase, followed by mild anterior uveitis. Most patients showed significant visual improvement after receiving systemic corticosteroid therapy in the acute phase. Detecting the clinical features at the initial onset of VKH could facilitate early treatment and better vision improvement.
Review
Biochemistry & Molecular Biology
Tsz Kin Ng, Kai On Chu, Chi Chiu Wang, Chi Pui Pang
Summary: Glaucoma is the leading cause of irreversible blindness and visual impairment worldwide, with over 80 million affected individuals. The main pathogenesis of glaucoma involves oxidative stress and inflammation-induced neurodegeneration of retinal ganglion cells, which have limited regenerative capacity. Currently, there is a lack of clinically effective treatments to rescue the degeneration of retinal ganglion cells. Green tea catechins, with their proven antioxidant and anti-inflammatory properties, offer potential as a treatment to ameliorate retinal ganglion cell degeneration. This review summarizes the chemistry, pharmacokinetics, therapeutic properties, and clinical potentials of green tea catechins for glaucoma treatment.
Article
Medicine, General & Internal
Jianhao Cai, Cangeng Xu, Tsz Kin Ng, Zeyi Li
Summary: This study used in vivo confocal microscopy to investigate the microscopic structure and characteristics of nevi on the conjunctiva of the lacrimal caruncle. Four patients with nevi were evaluated using in vivo confocal microscopy before surgery, and the results were compared with histopathological analyses. The results showed that the nevi were located on the conjunctiva of the lacrimal caruncle, with a slightly nodular surface, mixed black and brown color, and clear boundary. The nevi cells were observed to be clustered in nests with irregular boundaries under in vivo confocal microscopy.
FRONTIERS IN MEDICINE
(2023)
Article
Ophthalmology
Yi-Wen Tang, Jie Ji, Jian-Wei Lin, Ji Wang, Yun Wang, Zibo Liu, Zhanchi Hu, Jian-Feng Yang, Tsz Kin Ng, Mingzhi Zhang, Chi Pui Pang, Ling-Ping Cen
Summary: This study aims to develop a multilabel-based deep learning algorithm for automatic detection and categorization of clinically significant peripheral retinal lesions. The algorithm showed good performance and accuracy in diagnosing and classifying different retinal lesions.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Xin Wen, Tsz Kin Ng, Qingping Liu, Zhenggen Wu, Guihua Zhang, Mingzhi Zhang
Summary: Diabetic retinopathy (DR) is a microvascular ocular complication of diabetes mellitus (DM) that can cause irreversible blindness and visual impairment. This study aimed to identify the metabolomics signature in tears collected from Chinese type-2 DM patients with DR.
Article
Ophthalmology
Zhen Qian, Ke Zheng, Yanxuan Xu, Si Chen, Shaowan Chen, Jiajian Liang, Yingjie Cao, Tsz Kin Ng, Kunliang Qiu
Summary: This study evaluated the structural changes in retinal ganglion cells (RGCs) in EAE mice using in vivo imaging, providing a platform for monitoring RGC treatment outcomes.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhenggen Wu, Chukai Huang, Yuqian Zheng, Xiang-Ling Yuan, Shaowan Chen, Yanxuan Xu, Li Jia Chen, Chi Pui Pang, Mingzhi Zhang, Tsz Kin Ng
Summary: This study aimed to fine map the association pattern of the FOXC1 locus with POAG and determine the correlations of FOXC1, ABCA1, and CAV1 variants with ocular and lipidemic parameters in the southern Chinese population. It was found that variants in FOXC1 and ABCA1 were significantly associated with POAG, and different genotypes affected lipid profiles.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Endocrinology & Metabolism
Zijing Huang, Wai Kit Chu, Tsz Kin Ng, Shaolang Chen, Jiajian Liang, Chong-Bo Chen, Yanxuan Xu, Biyao Xie, Shuping Ke, Qingping Liu, Weiqi Chen, Dingguo Huang
Summary: The study suggests that nattokinase (NK) has therapeutic potential for early diabetic retinopathy (DR) by improving the blood-retinal barrier function, protecting retinal neurons and inhibiting inflammation caused by diabetes.
JOURNAL OF DIABETES
(2023)
Article
Medicine, General & Internal
Jian-Feng Yang, Yun Wang, Lingling Zhou, Shaoying Tan, Zhanchi Hu, Tsz Kin Ng, Ling-Ping Cen
Summary: This study aimed to evaluate the feasibility of using 1% fluorescein sodium for detecting diabetic retinopathy (DR). The results showed that 1% fluorescein sodium was comparable to the regular dosage in detecting DR. This study has high clinical relevance.
