期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 23, 期 8, 页码 1686-1694出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.9b00199
关键词
alkenes; alkylarylation; 1,1-diarylalkanes; dicarbofunctionalization; FLAP inhibitor; three-component
资金
- University of New Mexico (UNM)
- NSF CRIF:MU award [CHE04-43580]
- NSF [CHE08-40523, CHE09-46690]
We report a five-step synthesis of the biologically important 1,1-diarylalkane 1, a potential 5-lipoxygenase activating protein (FLAP) inhibitor that was synthesized previously in 12 steps. In this synthesis, we apply a three-component alkene dicarbofunctionalization reaction as a key final step to assemble the potential FLAP inhibitor 1 from commercially available starting materials. In addition, we also report the synthesis of a variety of new analogs of the inhibitor 1 and its regioisomer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据