期刊
ORGANIC LETTERS
卷 21, 期 15, 页码 6040-6044出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02199
关键词
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资金
- 1000 Yonth Talents Plan
- Tongji University
- Shanghai Pujiang Program
- NFS of China [21801188]
A copper-catalyzed intramolecular enantioselective and diastereoselective borylative coupling of styrenes and ketones was achieved by merging desymmetrization strategy and olefin difunctionalization. The reaction proceeds through an initial enantioselective borylcupration of styrenes, followed by a highly selective direct addition to 1,3-diketones. The bicyclic scaffolds with three chiral carbon centers, including two tetrasubstituted carbons, were generated in excellent yields, diastereoselectivities, and enantioselectivities. This catalytic tandem reaction has great potential for further synthetic application of the chiral polycyclic compounds, because of the versatility of the functional groups in the products.
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