☆ 4.8 Article

Rhodium(III)-Catalyzed C-H Activation: Ligand-Controlled Regioselective Synthesis of 4-Methyl-Substituted Dihydroisoquinolones

ORGANIC LETTERS (2019)

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ORGANIC LETTERS

卷 21, 期 14, 页码 5689-5693

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AMER CHEMICAL SOC

DOI: 10.1021/acs.orglett.9b02029

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Chemistry, Organic

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Rh-catalyzed C-H functionalization of O-pivaloyl benzhydroxamic acids with propene gas provides access to 4-methyl-substituted dihydroisoquinolones. Good to excellent levels of regioselectivity are achieved using [(CpRhCl2)-Rh-t](2) as a precatalyst under optimized conditions. Thorough examination of aryl/heteroaryl O-pivaloyl hydroxamic acid substrates, ligand effects on C-H site selectivity, alkene scope, and demonstration of scale are discussed within.

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