Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Article
Cell Biology
Gehao Liang, Yun Ling, Qun Lin, Yu Shi, Qing Luo, Yinghuan Cen, Maryam Mehrpour, Ahmed Hamai, Jun Li, Chang Gong
Summary: In this study, the high expression of circCDYL in HER2(+) breast cancer tissue was found to promote cell proliferation independent of the miR-1275-ULK1/ATG7 autophagic axis. MiR-92b-3p was shown to cleave circCDYL in a silencing-dependent manner, and both circCDYL and miR-92b-3p were identified as potential biomarkers for predicting clinical outcomes in HER2(+) breast cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Binbin Song, Ce Xu, Yi Zhang, Yuanyuan Shan
Summary: Recent research has found that circRNAs, particularly circ_ATAD3B, can be potential therapeutic targets for breast cancer (BC). However, the biological role of circ_ATAD3B in BC remains unclear. This study aimed to understand the function of circ_ATAD3B in BC development. Through analyzing expression profiles, it was discovered that circ_ATAD3B acts as a miR-570-3p sponge, suppressing cell survival and proliferation in BC. The tumor suppressor circ_ATAD3B regulates the miR-570-3p/MX2 pathway, preventing cancer progression in BC cells.
PREVENTIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ying Wang, Shifeng Xu, Shuyue Wang, Zhenbo Song, Lihua Zheng, Guannan Wang, Ying Sun, Yongli Bao
Summary: The study revealed that miR-4709-3p could inhibit breast cancer cell proliferation by targeting TSP50, suggesting a potential therapeutic role in breast cancer.
DNA AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang-Yu Guo, Tian-Tian Liu, Wen-Jie Zhu, Hai-Ting Liu, Guo-Hao Zhang, Lin Song, Rui-Nan Zhao, Xu Chen, Peng Gao
Summary: This study reveals the tumor-suppressor role of circKDM4B in breast cancer, especially in inhibiting tumor growth, metastasis, and angiogenesis, making it a potential therapeutic target for breast cancer progression.
Article
Oncology
Zhongrui Wang, Xiqian Zhou, Xiaochong Deng, Danrong Ye, Diya Liu, Baian Zhou, Wenfang Zheng, Xuehui Wang, Yuying Wang, Oyungerel Borkhuu, Lin Fang
Summary: Breast cancer is the most common cancer type in women worldwide. This study demonstrates that miR-186-5p inhibits proliferation and induces apoptosis in breast cancer cells by targeting ANXA9. These findings provide a potential therapeutic target for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Xiuhui Shi, Jingxuan Yang, Mingyang Liu, Yuqing Zhang, Zhijun Zhou, Wenyi Luo, Kar -Ming Fung, Chao Xu, Michael S. Bronze, Courtney W. Houchen, Min Li
Summary: This study identified circANAPC7 as a novel tumor suppressor that functions through the CREB-miR-373-PHLPP2 axis, leading to AKT dephosphorylation, down-regulation of cyclin D1 and transforming growth factor-b, and ultimately suppressing tumor growth and muscle wasting in pancreatic cancer.
Article
Oncology
Jing Song, Yongyao Tang, Fangzhou Song
Summary: In this study, lnc-RGS5 was found to be upregulated in breast cancer tissues and associated with the overall survival of patients with triple-negative breast cancer. Functionally, upregulation of lnc-RGS5 promoted breast cancer cell proliferation. Mechanistically, lnc-RGS5 acted as a competing endogenous RNA to sponge miR-542-5p and upregulate the FoxM1 and VEGFA/Neuropilin 1 axis, thereby promoting breast cancer cell proliferation.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Oncology
Yuxing Wang, Xiaohua Pan, Yanjun Li, Ru Wang, Yuanyuan Yang, Baichun Jiang, Gongping Sun, Changshun Shao, Molin Wang, Yaoqin Gong
Summary: CUL4B promotes TAM resistance in breast cancer cells by upregulating ER-alpha 36 expression through the regulation of miR-32-5p. This mechanism involves epigenetic modifications mediated by CRL4B, PRC2, and HDAC complexes, and targeting these complexes can increase sensitivity to TAM in breast cancer cells.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xue-Zhong Chen, Wen-Xing He, Rong-Guang Luo, Guo-Jin Xia, Jin-Xiu Zhong, Qing-Jie Chen, Yu-Ying Huang, Yan-Xing Guan
Summary: MiR-1283 acts as a tumor suppressor in HER2-positive breast cancer by regulating cell proliferation through targeting TFAP2C and being regulated by KLF14. These findings provide novel insights into the mechanistic exploration of breast cancer.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Ziming Wang, Siyuan Hu, Xinyang Li, Zhiwei Liu, Danyang Han, Yukun Wang, Limin Wei, Guangping Zhang, Xinshuai Wang
Summary: The study identified miR-16-5p as a regulator of ANLN in breast cancer cells, influencing proliferation, migration, invasion, cell cycle, and apoptosis. This provides novel candidate biomarkers for the diagnosis and treatment of breast cancer.
Article
Multidisciplinary Sciences
Sevan Omer Majed, Suhad Asad Mustafa
Summary: This study aimed to identify differentially expressed genes and ncRNAs in breast cancer tissues compared to normal adjacent tissues, and found miR-4510 as a potential biomarker for breast cancer. The study used MACE-Seq and small RNA-Seq to analyze gene expression and identified miR-4510 as significantly down-regulated in breast cancer. Experimental data suggested that miR-4510 may function as a tumor suppressor in breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei Xiao, Lihong Shi, Hongli Li, Chonggao Yin, Hao Luo, Chong Hao, Wenhao Wang, Baogang Zhang
Summary: Studies compared the effects of CAFs-derived exosomes and NFs-derived exosomes on breast cancer cells, finding that CAFs-derived exosomes had a stronger enhancing effect on migration and invasion.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Hongxu Zhang, Minghui Wang, Zhiqiang Lang, Haiwang Liu, Jianping Liu, Lihui Ma
Summary: This study found that miR-135a-5p regulates the growth, migration, invasion, and cell cycle progression of breast cancer cells by targeting the BAG3 gene.
Article
Oncology
Masanori Oshi, Yoshihisa Tokumaru, Matthew G. K. Benesch, Nobuhiko Sugito, Rongrong Wu, Li Yan, Akimitsu Yamada, Takashi Chishima, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe
Summary: In this study, the clinical relevance of miR-99b expression in breast cancer was investigated. High miR-99b expression was found to be associated with mTORC1 signaling, cell proliferation, and decreased patient survival in breast cancer, particularly in the estrogen receptor-positive/human epidermal growth factor 2-negative subtype.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Oncology
Haoming Xia, Ziyue Huang, Zhensheng Wang, Shuqiang Liu, Xudong Zhao, Junqi You, Yi Xu, Judy Wai Ping Yam, Yunfu Cui
Summary: Glucometabolic reprogramming plays a significant role in the development and treatment of hepatocellular carcinoma (HCC). By altering the glucose metabolism pathway, HCC cells can survive and thrive in nutrient-poor tumor microenvironments and evade immune surveillance. Targeted interventions against glucose metabolism and signaling pathways hold promising prospects for HCC therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Haoming Xia, Ziyue Huang, Yi Xu, Judy Wai Ping Yam, Yunfu Cui
Summary: This study systematically reviewed the glucometabolic reprogramming in hepatocellular carcinoma (HCC) and explored its association with cancerous mechanisms, immune suppression, and oxidative stress adaptation. The findings provide insights for future basic and clinical research.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Yan Guo, Haoming Xia, Xiaoyang Zhao, Longxin Qiao, Yaochen Qin
Summary: Timely and accurate identification and mapping of garlic are crucial for garlic yield prediction and market management. This study determined the optimal identification strategy and earliest identifiable phenophase for garlic using Landsat 8/9 time series imagery. The generated early-season garlic distribution map provides timely data support for various stakeholders.
Article
Environmental Sciences
Xutong Ru, Hongquan Song, Haoming Xia, Shiyan Zhai, Yaobin Wang, Ruiqi Min, Haopeng Zhang, Longxin Qiao
Summary: Land use and land cover change (LUCC) has an impact on temperature changes in the Yellow River Basin, with urban expansion and conversion of farmland to grassland leading to a rise in temperature.
Review
Gastroenterology & Hepatology
Ziyue Huang, Haoming Xia, Yunfu Cui, Judy Wai Ping Yam, Yi Xu
Summary: This review discusses the potential role of ferroptosis in HCC, including its interaction with HCC-related signaling pathways, providing a theoretical basis for the treatment of HCC.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Medical Laboratory Technology
Ziyue Huang, Zhensheng Wang, Haoming Xia, Ziqiang Ge, Liang Yu, Jiehan Li, Haolin Bao, Zixin Liang, Yunfu Cui, Yi Xu
Summary: By regulating the expression of HAND2-AS1, it can affect the proliferation, apoptosis, metastasis, invasion, metabolism, and drug resistance of tumor cells. Aberrant expression of HAND2-AS1 is closely related to the clinical pathological characteristics of cancer patients and can serve as a diagnostic and prognostic biomarker for tumors.
CLINICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Rumeng Li, Haoming Xia, Xiaoyang Zhao, Xiqing Bian, Yan Guo, Yaochen Qin
Summary: This study explores the spatiotemporal variation characteristics of snow depth in China from 1979 to 2019 using various analysis methods. The results show that the distribution of snow depth in China is spatially heterogeneous, and there has been a decreasing trend in snow depth in the past few decades. The driving factors for snow depth also vary in different regions and seasons.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Oncology
Ni Qiu, Huan Jin, Lulu Cui, Yong-tao Zhan, Hao-ming Xia, Ming Jiang, Jie Zhou, Hong-ling Liang, Xiang Ao, Zhi-min He, Hong-sheng Li
Summary: System paclitaxel-based chemotherapy is the first-line treatment for breast cancer, but chemotherapy resistance remains a major challenge. Our study shows that IFT20 is associated with shorter relapse-free survival in patients receiving paclitaxel chemotherapy. High expression of IFT20 in breast cancer cells increases resistance to paclitaxel-induced cell death, while IFT20 knockdown enhances apoptosis. Mechanistically, IFT20 modulates ASK1 signaling to drive paclitaxel resistance. IFT20 may serve as a potential molecular biomarker for predicting response to paclitaxel therapy in breast cancer.
MOLECULAR CANCER RESEARCH
(2023)
Article
Food Science & Technology
Youkuo Chen, Yan Guo, Longxin Qiao, Haoming Xia
Summary: This study proposes an automatic garlic mapping framework using optical and synthetic aperture radar (SAR) images. The method accurately identifies garlic and generates a map of garlic distribution. Experimental results show that the combination of optical and SAR images improves the accuracy of the mapping.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2022)
Article
Biodiversity Conservation
Rumeng Li, Haoming Xia, Xiaoyang Zhao, Yan Guo
Summary: Evergreen forests play a crucial role in the exchange of carbon, water, and energy in terrestrial ecosystems and are sensitive to climate change. However, the lack of fine-resolution maps of evergreen forests hampers our understanding of their spatiotemporal patterns. Therefore, it is necessary to map evergreen forests with high spatial resolution in a timely and accurate manner.
ECOLOGICAL INDICATORS
(2023)
Article
Remote Sensing
Haoming Xia, Xiqing Bian, Li Pan, Rumeng Li
Summary: The study proposes a phenology-based algorithm that utilizes temporal data and phenological indicators to extract tea plantation areas. By generating an evergreen vegetation map and dividing the tea plant growth period into seven parts based on high-quality time series curves, the tea plantation in the study area was successfully extracted. The overall accuracy of the algorithm is 87.59%, with a Kappa coefficient of 0.80.
INTERNATIONAL JOURNAL OF REMOTE SENSING
(2023)
Article
Multidisciplinary Sciences
Yaobin Wang, Feng Wang, Ruiqi Min, Genxin Song, Hongquan Song, Shiyan Zhai, Haoming Xia, Haopeng Zhang, Xutong Ru
Summary: In this study, the spatial and temporal processes of a PM pollution episode in Zhengzhou, China were simulated. The anthropogenic emissions from the south of Zhengzhou were found to be the main causes of high PM concentrations, contributing 14.39% and 16.34% to PM2.5 and PM10, respectively. The anthropogenic emissions from Zhengzhou itself contributed 7.94% and 7.29% to PM2.5 and PM10 concentrations, respectively. The anthropogenic emissions from the northeast of Zhengzhou contributed 7.42% and 7.18% to PM2.5 and PM10 concentrations, respectively.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Qingfu Dong, Haolin Bao, Jiangang Wang, Wujiang Shi, Xinlei Zou, Jialin Sheng, Jianjun Gao, Canghai Guan, Haoming Xia, Jinglin Li, Pengcheng Kang, Yi Xu, Yunfu Cui, Xiangyu Zhong
Summary: In recent years, the prevalence of metabolic-associated fatty liver disease (MAFLD) has become a major cause of liver fibrosis worldwide. The progression of liver fibrosis is associated with severe liver-related and cardiovascular events, as well as mortality in MAFLD patients. Multiple pathways are involved in promoting the progression of liver fibrosis in MAFLD, leading to an increased interest in multi-drug combination therapy strategies. This review discusses the mechanisms of MAFLD-related liver fibrosis, current intervention and treatment methods, and explores safer and more effective strategies for multi-drug combination therapy in MAFLD and its subsequent liver fibrosis.
FRONTIERS IN MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Xudong Zhao, Yudan Wang, Haoming Xia, Shuqiang Liu, Ziyue Huang, Risheng He, Liang Yu, Nanfeng Meng, Hang Wang, Junqi You, Jinglin Li, Judy Wai Ping Yam, Yi Xu, Yunfu Cui
Summary: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, and effective diagnosis and treatment measures are urgently needed. Microvascular invasion (MVI) has been identified as an independent risk factor for poor prognosis after hepatectomy. Abnormal expression of biomacromolecules in HCC patients, such as circRNAs, lncRNAs, STIP1, and PD-L1, is strongly associated with MVI. These biomarkers play important roles in the progression and development of HCC cells through multiple complex mechanisms.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Review
Oncology
Junqi You, Haoming Xia, Ziyue Huang, Risheng He, Xudong Zhao, Jiali Chen, Sidi Liu, Yi Xu, Yunfu Cui
Summary: Hepatocellular carcinoma (HCC) is a highly malignant tumor with a high incidence and mortality rate. Early detection and treatment are crucial for improving prognosis. Alpha-fetoprotein (AFP) is commonly used for HCC diagnosis, but its accuracy is limited. Surgery and liver transplantation are main treatments, while drug therapy and local interventions are better options for advanced HCC. Non-coding RNA has been found to play a role in tumor development and can serve as a biomarker for diagnosis, prognosis, and treatment assessment. This article explores the unique role of circulating noncoding RNA in HCC from various perspectives.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
