Article
Pharmacology & Pharmacy
Yong-Hwi Kang, Jing-Hua Wang, Jin-Seok Lee, Nam-Hun Lee, Chang-Gue Son
Summary: Colorectal cancer is the second most lethal malignancy worldwide, and its high mortality rate is largely due to cancer metastasis. Suppression of epithelial-to-mesenchymal transition (EMT) has emerged as a promising strategy for treating metastatic cancer. This study evaluated the antimetastatic effect of Coptidis Rhizoma, a traditional Chinese medicine, on drug-resistant colon cancer cells and found that it inhibits EMT through the TGF-beta signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bahram Yavari, Seyyed Shamsadin Athari, Yadollah Omidi, Akram Jalali, Rezvan Najafi
Summary: EpCAM aptamer-activated nanoparticles were synthesized to enhance treatment efficiency in colorectal cancer. The nanoparticles showed superior cytotoxicity in vitro and effectively inhibited tumor growth in vivo without causing significant side effects.
JOURNAL OF DRUG TARGETING
(2023)
Article
Chemistry, Physical
Unes Sahebi, Hamid Gholami, Behafarid Ghalandari, Farideh Badalkhani-khamseh, Abdolrahim Nikzamir, Adeleh Divsalar
Summary: The study examined the simultaneous binding effects of 5-Fluorouracil (5-FU) and Irinotecan with milk globular whey protein, beta-lactoglobulin (BLG). Results showed that the drugs interacted with BLG in different locations within the beta-barrel cavity. The interaction led to secondary structural changes in BLG and the quenching of BLG intrinsic fluorescence.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Immunology
Rohitashw Kumar, Isolde Gina Rojas, Mira Edgerton
Summary: Candida albicans Sap6, a secreted aspartyl protease, activates immune cells through its protease activity and binding to host integrins. It has been found that Sap6 can interact with and activate human oral epithelial cells (OECs) through the PAR2 signaling pathway and its RGD domain. The study provides new insights into the mechanisms of Candida albicans oral infection and suggests potential drug targets for intervention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haniyeh Ghasemizadeh, Mehrab Pourmadadi, Fatemeh Yazdian, Hamid Rashedi, Mona Navaei-Nigjeh, Abbas Rahdar, Ana M. Diez-Pascual
Summary: This study synthesized a pH-responsive nanocomposite based on halloysite nanotube (HNT) coated with carboxymethyl cellulose (CMC)/polyethylene glycol (PEG) hydrogel using the water-in-oil-in-water (W/O/W) technique for the controlled delivery of 5-Fluorouracil (5-FU), a hydrophobic chemotherapy drug prescribed for different types of cancers. The nanocomposite showed high drug entrapment and loading efficiency, and demonstrated improved and sustained release of 5-FU in an acid environment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Aranka Brockmueller, Sosmitha Girisa, Ajaikumar B. B. Kunnumakkara, Mehdi Shakibaei
Summary: Resveratrol can enhance the sensitivity of colorectal cancer cells to 5-FU by regulating the beta 1-integrin/HIF-1α signaling axis, leading to suppression of cancer cell growth and invasion, inhibition of inflammation and cancer stem cell production. These findings highlight the potential application of resveratrol in the treatment of colorectal cancer by overcoming chemoresistance to 5-FU.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mitali Das, Sujay Subbayya Ithychanda, Edward F. Plow
Summary: Plasminogen and its receptors, including histone 2B (H2B), play important roles in the responses of various cell types. This study investigated the involvement of H2B in plasminogen-induced endothelial cell migration. The results showed that H2B is present on viable endothelial cells and its antibody blockade inhibited plasminogen-dependent migration. Furthermore, H2B was found to interact with PAR1 and PAR2, suggesting a mechanism for linking plasminogen to wound healing and angiogenesis.
Article
Biochemistry & Molecular Biology
Jingjing Liu, Qi Zhang, Jiyu Wang, Changli Wang, Tian Lan, Tianyi Wang, Bing Wang
Summary: Knockdown of BAP31 in colorectal cancer cells enhances chemosensitivity to 5-FU and reduces stemness, potentially through the inhibition of the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Jaya R. Lakkakula, Rui Werner Macedo Krause, Deepika Divakaran, Sagar Barage, Rohit Srivastava
Summary: The circulation time and solubility of 5-Fluorouracil have been prolonged and increased by complexing it with cyclodextrin and conjugating it onto gold nanoparticles to form 5Fu ICAu. The 5Fu-ICAu system showed higher cell inhibition rate on breast cancer cell lines due to the enhanced EPR effect allowing selective accumulation of nanoparticles at tumor sites.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Medicinal
Jordan C. LeSarge, Pierre Thibeault, Lihai Yu, Marina D. Childs, Victor M. Mirka, Qi Qi, Matthew S. Fox, Michael S. Kovacs, Rithwik Ramachandran, Leonard G. Luyt
Summary: This article reports the strategic design, synthesis, and biological evaluation of a series of novel 4-fluorobenzoylated PAR2-targeting peptides, with Isox-Cha-Chg-Ala-Arg-Dpr(4FB)NH2 being the lead candidate. This 18F-labeled tracer is the first reported PAR2 imaging agent with potential for use in vivo.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yu Wang, Haihong Hu, Lushan Yu, Su Zeng
Summary: The purpose of this study was to establish physiologically based pharmacokinetic (PBPK) models of capecitabine-metabolites and 5-FU-metabolites to describe their pharmacokinetics in tumor and plasma of cancer patients with liver impairment. The models were successfully constructed and validated using data from cancer patients. The models showed that tumor blood flow rate is critical for 5-FU concentration in tumor, and dosage adaptation of capecitabine or 5-FU is not required for cancer patients with hepatic impairment.
PHARMACEUTICAL RESEARCH
(2023)
Article
Oncology
Wing-Lok Chan, Cheuk-Wai Choi, Ian Yu-Hong Wong, Terence Hon-Ting Tsang, Adrian Tin-Chung Lam, Rosa Pui-Ying Tse, K. K. Chan, Claudia Wong, Betty Tze-Ting Law, Emina Edith Cheung, Siu-Yin Chan, Ka-On Lam, Dora Kwong, Simon Law
Summary: This study reviewed the long-term clinical outcomes and safety data of induction chemotherapy followed by surgery or definitive chemoradiotherapy in patients with locally advanced unresectable esophageal cancer. The results showed that patients who received subsequent surgery had significantly longer median overall survival compared to those who had definitive chemoradiotherapy or no definitive treatment. Induction chemotherapy followed by conversion surgery offered a chance of cure with long-term survival benefit and manageable toxicities in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Polymer Science
Tz-Feng Lin, Shih-Hsuan Yeh
Summary: Chemotherapy is a crucial method in cancer treatment that often requires high concentrations of drugs. Research on using polymer composites for local and sustained drug release has been developed to minimize side effects caused by high-concentration chemotherapy drugs.
Article
Pathology
Yu-Ling Qu, Xiao-Li Liu, Shan-Yu Zhao, Xue-Feng Zhai
Summary: This study found that SPOCK1 is upregulated in 5-FU-resistant CRC cells and that knockdown of SPOCK1 increases their sensitivity to 5-FU. Conversely, overexpression of SPOCK1 enhances CRC cell resistance to 5-FU and reduces cell apoptosis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Engineering, Environmental
Peng He, Sha Yi, Jianzhong Zhang, Chengchao Chu, Xuqi Peng, Changhong Li, Xinfei Sun, Yang Zhang, Hongwei Cheng, Xia Xiong, Gang Liu
Summary: This study developed a novel formulation of 5-fluorouracil (5-Fu) called carrier-free pure 5-Fu nanoparticles (nano 5-Fu) for scar management. In vitro and in vivo tests showed that nano 5-Fu had superior efficacy in inactivating scar cells and longer retention time in soft tissues compared to free 5-Fu. Animal experiments and a first-in-human trial demonstrated that nano 5-Fu significantly reduced scar elevation, collagen fiber deposition, and microvessels, with excellent and stable efficacy and fewer side effects.
CHEMICAL ENGINEERING JOURNAL
(2023)