Article
Medicine, Research & Experimental
Sherien M. El-Daly, Mahmoud T. Abo-elfadl, Jihan Hussein, Mona A. M. Abo-Zeid
Summary: This study investigates the impact of suppressing the activity of the PI3K/Akt/mTOR signaling pathway on the chemosensitivity of colorectal cancer cells to 5-FU. The results demonstrate that combining a low dose of 5-FU with a PI3K inhibitor can significantly enhance cytotoxicity and reduce the expression of specific drug transporters. Additionally, the recommended combination treatment induces cell apoptosis and reduces cell migration ability.
Article
Biochemistry & Molecular Biology
Wenwen Zhang, Shuofei Yang, Datian Chen, Daolu Yuwen, Juan Zhang, Xiaowei Wei, Xin Han, Xiaoxiang Guan
Summary: The study revealed that PAI-1 induced lncRNA SOX2-OT can promote TNBC cell metastasis and activate the PI3K/Akt signaling pathway through the miR-942-5p/PIK3CA signaling pathway. These findings highlight the potential of developing new therapies for TNBC based on targeting SOX2-OT.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Wei Wang, Da Liu, Liyun Yang, Lixia Chen, Mengdan Miao, Yongsheng Liu, Yajuan Yin, Mei Wei, Gang Liu, Yonghui An, Mingqi Zheng
Summary: This study aimed to investigate whether Compound Kushen injection (CKI) alleviates heart failure (HF) by attenuating cardiomyocyte apoptosis via the inhibition of the PI3K/Akt pathway. The results showed that CKI promoted healthy cardiac function, reduced myocardial structural damage, and attenuated the rate of cardiomyocyte apoptosis. CKI significantly suppressed the expression of apoptosis-related proteins in the PI3K/Akt pathway. In conclusion, CKI reduces cardiomyocyte apoptosis, improves cardiac function, and attenuates Ang II-mediated HF, possibly through the inhibition of the PI3K/Akt pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Morales-Guadarrama, Edgar A. Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Maria J. Ibarra-Sanchez, Jose Esparza-Lopez, Rocio Garcia-Becerra, Fernando Larrea, Lorenza Diaz
Summary: This study investigates the role of endothelial cells in vasculogenic mimicry (VM) in triple-negative breast cancer (TNBC) and the involvement of the FGFR/PI3K/Akt pathway. Results show that endothelial cells play a predominant role in inducing VM, and the FGFR/PI3K/Akt pathway is implicated in this process. Targeting this pathway may hold promise for treating and preventing VM in TNBC tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Carlos Luan A. Passos, Renata Madureira Polinati, Christian Ferreira, Nathalia Alexia Nascimento dos Santos, Daniel Galinis V. Lima, Jerson Lima da Silva, Eliane Fialho
Summary: Curcumin and melphalan combination therapy has anticancer effects on breast cancer cells and represents a promising approach for clinical testing.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Adrian Zajac, Joanna Sumorek-Wiadro, Ewa Langner, Iwona Wertel, Aleksandra Maciejczyk, Bozena Pawlikowska-Pawlega, Jaroslaw Pawelec, Magdalena Wasiak, Monika Hulas-Stasiak, Dorota Badziul, Wojciech Rzeski, Michal Reichert, Joanna Jakubowicz-Gil
Summary: Inhibition of the PI3K/Akt/mTOR pathway sensitizes glioma cells to apoptosis with temozolomide treatment, while Hsp27 increases resistance to cell death. Different cell lines showed varying responses to LY294002 and temozolomide treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Austin D. Fergusson, Rui Zhang, Judy S. Riffle, Richey M. Davis
Summary: Flash nanoprecipitation (FNP) is a reliable method for producing polymer nanoparticles loaded with hydrophobic drugs. By incorporating ion pairing agents (IPs) into the FNP formulation, hydrophobic drug salts can be efficiently precipitated. In this study, we investigated the effects of two hydrophobic IPs, palmitic acid (PA) and hexadecylphosphonic acid (HDPA), on the loading and size of LY294002-loaded nanoparticles. HDPA resulted in well-defined colloidally stable particles, while PA resulted in ill-defined aggregates. This approach opens up possibilities for intravenous administration of previously unusable hydrophobic drugs.
Article
Pharmacology & Pharmacy
Jin-Long Pang, Lian-Song Xu, Qian Zhao, Wen-Wen Niu, Xiang-Yu Rong, Shan-Shan Li, Xian Li
Summary: This study found that sodium cantharidate (SCA) promotes apoptosis of breast cancer cells by inhibiting the PI3K-Akt-mTOR pathway and inducing autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Shijie Wei, Yubao Zhang, Xiaoran Ma, Yan Yao, Qinqin Zhou, Wenfeng Zhang, Chao Zhou, Jing Zhuang
Summary: This study reveals that matrine, an alkaloid from the medicinal plant Sophora flavescens, has strong anticancer effects and can be explored as a new therapeutic agent for triple-negative breast cancer (TNBC). Through bioinformatics analysis and network pharmacology, researchers found that matrine inhibits the PI3K/AKT pathway, suppresses cell proliferation and invasion, induces apoptosis and autophagy, effectively inhibiting the growth and spread of TNBC.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Lin Lin, Yunan Gao, Xiaochen Hu, Jiabao Ouyang, Chunbo Liu
Summary: Pentamidine inhibits proliferation, migration, and invasion of endometrial cancer cells through the suppression of the PI3K/AKT signaling pathway. These findings suggest that Pentamidine may be a potential candidate for treating endometrial cancer.
Review
Oncology
Alicia S. Ombredane, Vitoria R. P. Silva, Laise R. Andrade, Willie O. Pinheiro, Mayara Simonelly, Jaqueline Oliveira, Andreia C. Pinheiro, Gabriel F. Goncalves, Gisela J. Felice, Monica P. Garcia, Patricia M. Campos, Glecia V. S. Luz, Graziella A. Joanitti
Summary: The systematic review summarized evaluations on the efficacy and safety of curcumin nanoparticles (Cur-NPs) in in vivo models of breast cancer. Studies showed that Cur-NPs significantly reduced tumor volume/weight, inhibited cancer cell proliferation, increased tumor apoptosis and necrosis, and decreased cancer stem cell population and angiogenesis. The findings suggest that Cur-NPs are an effective and safe therapeutic approach for breast cancer treatment in in vivo models, warranting further investigation in clinical trials.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hai-lan Zheng, Hai-yue Zhang, Chun-lian Zhu, Hui-ying Li, Sheng Cui, Jian Jin, Shang-guo Piao, Yu-ji Jiang, Mei-ying Xuan, Ji-zhe Jin, Ying-shun Jin, Jung-pyo Lee, Byung-ha Chung, Bum-soon Choi, Chul-woo Yang, Can Li
Summary: L-carnitine (LC) can protect against chronic tacrolimus (TAC) nephropathy by interfering with the PI3K/AKT/PTEN signaling pathway, improving renal function, inhibiting oxidative stress and inflammation, reducing programmed cell death, and promoting cell survival.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Engineering, Biomedical
Reza Mahmoudi, Seyedeh Ashraf Mirahmadi-Babaheidri, Hamdollah Delaviz, Mohamad Hassan Fouani, Mohsen Alipour, Mehrzad Jafari Barmak, Gunna Christiansen, Hassan Bardania
Summary: The study found that encapsulating curcumin into RGD modified liposomes significantly increased its cytotoxic effect on breast cancer cells, leading to the induction of apoptosis in a more pronounced manner.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Multidisciplinary Sciences
Nadar Manimaran Vinita, Umapathy Devan, Sabapathi Durgadevi, Selvaraj Anitha, Dhamodharan Prabhu, Sundarraj Rajamanikandan, Muthusamy Govarthanan, Ananthanarayanan Yuvaraj, Muniyandi Biruntha, Arockiam Antony Joseph Velanganni, Jeyaraman Jeyakanthan, Pitchan Arul Prakash, Mohamed Sultan Mohamed Jaabir, Ponnuchamy Kumar
Summary: This study reports the use of gold nanotriangles (AuNTs) with anionic and cationic surface charge conjugating triphenylphosphonium (TPP) for targeting breast cancer cells with 5-aminoleuvinic acid (5-ALA) based photodynamic therapy (PDT). The optimized surface charge of AuNTs can kill breast cancer cells, and when combined with 5-ALA and PDT, the cationic AuNTs with TPP show improved cellular toxicity and induce mitochondrial dependent apoptosis. These findings demonstrate that cationic AuNTs with TPP can selectively target breast cancer cells in the presence of 5-ALA and PDT.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Dongjun Jiang, Jiaqi Xu, Sitong Liu, Moussa Nasser, Wei Wei, Tianjiao Mao, Xintong Liu, Xiaopan Zou, Jiang Li, Xiaomeng Li
Summary: Rosmanol demonstrates anti-cancer potential by inhibiting the proliferation of breast cancer cells and promoting apoptosis, particularly through modulating apoptotic pathways and the generation of ROS.
Article
Biochemistry & Molecular Biology
Ozge Rencuzogullari, Pinar Obakan Yerlikaya, Ajda Coker Gurkan, Elif Damla Arisan, Dilek Telci
Summary: The study reveals that palbociclib can regulate AMPK/mTOR signaling through modulation of intracellular miR-33a levels, effectively inhibiting fatty acid metabolism in MiaPaCa-2 cells. Additionally, there is a higher increase of miR-33a in MiaPaCa-2 cells compared to Panc-1 cells when treated with palbociclib.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Review
Oncology
Yunus Akkoc, Nesibe Peker, Arzu Akcay, Devrim Gozuacik
Summary: Metastasis and relapse are the main causes of cancer-related deaths. Dormant cancer cells are able to evade conventional treatments, with autophagy playing a crucial role in the adaptation, survival, and reactivation of these cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Dilara Uzuner, Yunus Akkoc, Nesibe Peker, Pinar Pir, Devrim Gozuacik, Tunahan Cakir
Summary: The study investigated 10 transcriptomic datasets, identifying 139 genes and 1974 interactions, constructing a dormancy interaction network contributing to the elucidation of cellular mechanisms orchestrating cancer dormancy, paving the way for improvements in the diagnosis and treatment of metastatic cancer.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ajda Coker-Gurkan, Kadriye Koyuncu, Pinar Obakan Yerlikaya, Elif Damla Arisan
Summary: GH gene mutations play a critical role in cell proliferation and differentiation by affecting PA metabolism and EMT pathway. MiR27a can modulate the GH signaling pathway, influencing the expression of ODC and STAT5 in cells, thereby regulating cell survival and growth.
Article
Biochemistry & Molecular Biology
Maria Mortoglou, Francesc Miralles, Elif Damla Arisan, Alwyn Dart, Stipo Jurcevic, Sigrun Lange, Pinar Uysal-Onganer
Summary: This study investigated the role of miR-21 in cancer stem cells (CSCs) and its association with the aggressiveness of PDAC. Knockout of miR-21 resulted in reversed expressions of CSC markers and suppressed cellular invasion and proliferation. These findings suggest that miR-21 is involved in the stemness of PDAC cells, may play roles in mesenchymal transition, and serves as a novel functional biomarker for PDAC aggressiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Burcu Ayhan-Sahin, Zeynep-Elif Apaydin, Pinar Obakan-Yerlikaya, Elif-Damla Arisan, Ajda Coker-Gurkan
Summary: In this study, we synthesized 24 putative X-aptamers against both GHRH NH2 (1-44) and NH2 (1-29) peptides and demonstrated that three of them had high serum stability and low target binding affinity.
Article
Oncology
Pelin Ozfiliz-Kilbas, Ozlem Sonmez, Pinar Obakan-Yerlikaya, Ajda Coker-Gurkan, Narcin Palavan-Unsal, Pinar Uysal-Onganer, Elif Damla Arisan
Summary: The study shows that miR-33a expression levels play a critical role in regulating lipid biosynthesis pathways in breast cancer cells, with different responses observed under different hormonal treatments.
Review
Oncology
Yunus Akkoc, Devrim Gozuacik
Summary: The goal of successful cancer treatment is to eradicate cancer cells, but dormant cells may still exist. Dormant cells can be re-activated under certain conditions, and autophagy may play a crucial role in this process. The hepatic microenvironment may favor cancer cell dormancy.
JOURNAL OF GASTROINTESTINAL CANCER
(2021)
Article
Multidisciplinary Sciences
Sinem Demirbag-Sarikaya, Yunus Akkoc, Sila Turgut, Secil Erbil-Bilir, Nur Mehpare Kocaturk, Joern Dengjel, Devrim Gozuacik
Summary: The maintenance of cellular homeostasis requires a balance between anabolic and catabolic reactions. Autophagy, a major catabolic reaction, is activated by various stressors, including DNA damage. This study demonstrates a novel interaction between the autophagy protein ATG5 and the DNA repair protein Ku70, which is crucial for DNA repair and recovery from genotoxic stress.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Yunus Akkoc, Kubilay Dalci, Hacer Ezgi Karakas, Secil Erbil-Bilir, Orcun Yalav, Gurhan Sakman, Faruk Celik, Soykan Arikan, Umit Zeybek, Melek Ergin, Hikmet Akkiz, Ece Dilege, Joern Dengjel, A. Isin Dogan-Ekici, Devrim Gozuacik
Summary: Macroautophagy/autophagy is a conserved cellular stress response mechanism that plays a role in supporting tumor growth and metastasis. The activation of autophagy in the tumor microenvironment by CTF1/CT-1 promotes fibroblast activation and breast cancer cell migration and invasion. Furthermore, the expression of CTF1 is correlated with autophagy in the tumor stroma and lymph node metastasis in breast cancer patients.
Article
Cell Biology
Nur Mehpare Kocaturk, Nesibe Peker, Karin Eberhart, Yunus Akkoc, Gamze Deveci, Joern Dengjel, Devrim Gozuacik
Summary: Autophagy is a cellular mechanism that degrades and recycles cytosolic fragments, proteins, and organelles. This study identifies novel protein complexes involving autophagy protein ATG5 and ubiquitin-proteasome system (UPS) components. The results suggest that these proteins interact and participate in various protein complexes during mitochondrial stress. Interestingly, specific protein components play important roles in PARK2-PARK6-mediated mitophagy and proteasome activity following mitochondrial stress.
CELL DEATH & DISEASE
(2022)
Article
Biology
Pelin Ozfiliz Kilbas, Gizem Alkurt, Pinar Obakan Yerlikaya, Ajda Coker Gurkan, Gizem Dinler Doganay, Elif Damla Arisan
Summary: The BAG-1 protein plays multiple roles in promoting breast cancer cell survival, and its interaction with other proteins determines its cellular function. This study compared the expression levels of microRNAs in breast cancer cells with or without BAG-1 protein, and identified hsa-miR-429 as a potential microRNA that targets multiple signaling pathways.
TURKISH JOURNAL OF BIOLOGY
(2022)
Article
Biology
Sinem Demirbag-Sarikaya, Hatice Cakir, Devrim Gozuacik, Yunus Akkoc
Summary: Autophagy and DNA repair are essential biological mechanisms for maintaining cellular homeostasis, with connections and interactions between them that are not fully understood. This review article documents and discusses the current status of the associations and crosstalk between autophagy and DNA repair systems.
TURKISH JOURNAL OF BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)