期刊
NEUROSCIENCE RESEARCH
卷 151, 期 -, 页码 1-14出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2019.05.007
关键词
Evolution; Cerebral cortex; Corticogenesis; Development; Neurogenesis; Neural progenitor; Gene duplication; Regulatory evolution; De novo genes; NOTCH2NL
资金
- Leading Initiative for Excellent Young Researchers program of MEXT, Japan [201890104]
One of the most important questions in human evolutionary biology is how our ancestor has acquired an expanded volume of the cerebral cortex, which may have significantly impacted on improving our cognitive abilities. Recent comparative approaches have identified developmental features unique to the human or hominid cerebral cortex, not shared with other animals including conventional experimental models. In addition, genomic, transcriptomic, and epigenomic signatures associated with human- or hominid-specific processes of the cortical development are becoming identified by virtue of technical progress in the deep nucleotide sequencing. This review discusses ontogenic and phylogenetic processes of the human cerebral cortex, followed by the introduction of recent comprehensive approaches identifying molecular mechanisms potentially driving the evolutionary changes in the cortical development. (C) 2019 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
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