Review
Biochemistry & Molecular Biology
Shofiul Azam, Md. Jakaria, JoonSoo Kim, Jaeyong Ahn, In-Su Kim, Dong-Kug Choi
Summary: Metabotropic glutamate receptors (mGluRs), especially mGluR5, play important roles in neurodegenerative diseases and neuropsychiatric disorders. Recent research suggests that mGluR5 radioligands could be used to assess disease progression and track drug properties.
Article
Clinical Neurology
Danika L. Paulo, Helen Qian, Deeptha Subramanian, Graham W. Johnson, Zixiang Zhao, Kilian Hett, Hakmook Kang, C. Chris Kao, Noah Roy, Jessica E. Summers, Daniel O. Claassen, Kaltra Dhima, Sarah K. Bick
Summary: Cognitive impairment in Parkinson's disease is related to deficits in cognitive functions such as working memory. The role of beta oscillations in cognitive impairment is not well understood. Decreased dopamine in motor CSTC circuits results in increased beta oscillatory power and motor symptoms. Similar changes in cognitive CSTC circuits involving the caudate and DLPFC may contribute to cognitive impairment in Parkinson's disease.
Article
Neurosciences
Yan Feng, Shifang Zhou, Jian Sun
Summary: The study shows that exercise intervention significantly improves motor dysfunction in PD model rats by increasing the reuptake of Glu in the striatum, and upregulating the expression levels of GLT-1 and GS proteins and GS mRNA.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Deepa Gautam, Ulhas P. Naik, Meghna U. Naik, Santosh K. Yadav, Rameshwar Nath Chaurasia, Debabrata Dash
Summary: This paper explores the role of platelets in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as the critical role of glutamate receptors in the pathophysiology of these diseases. By reviewing data from clinical trials, animal models, and cellular studies, it reveals the involvement of glutamate receptor dysfunction in neurodegenerative processes and provides an overview of current treatments, including glutamate receptor antagonists, for AD and PD.
Review
Chemistry, Medicinal
Giovanni Abbruzzese, Paolo Barone, Leonardo Lopiano, Fabrizio Stocchi
Summary: Safinamide is a recently approved drug for fluctuating Parkinson's patients with a unique dual mechanism of action. Research suggests it can improve motor functions and fluctuations, as well as some non-motor symptoms, benefiting patients' quality of life.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Neurosciences
Cheng Zhao, Chunyu Wang, Hainan Zhang, Weiqian Yan
Summary: Parkinson's disease (PD) is a common neurodegenerative disease associated with multiple neurotransmitter pathways. Glutamate, the central excitatory neurotransmitter, plays a critical role in neuronal activity control. This review highlights the role of vesicular glutamate transporters (VGLUTs) in neurotransmitter and synaptic communication, as well as the significant alterations in Glutamate transmission and VGLUTs levels in PD.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Michael F. Salvatore, Isabel Soto, Ella A. Kasanga, Rachael James, Marla K. Shifflet, Kirby Doshier, Joel T. Little, Joshia John, Helene M. Alphonso, J. Thomas Cunningham, Vicki A. Nejtek
Summary: By studying cardiovascular parameters in Parkinson's disease patients and rat models, we can evaluate the impact of aerobic exercise on specific motor or cognitive functions. A moderate intensity exercise regimen is suitable for early-stage Parkinson's disease patients.
JOURNAL OF PARKINSONS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Jingwen Li, Yanli Xu, Tingting Liu, Yuxiang Xu, Xiantao Zhao, Jianshe Wei
Summary: Parkinson's disease (PD) is the second most common rapidly progressive neurodegenerative disease with significant health and socio-economic consequences. Mitochondrial dysfunction is closely linked to PD and using mitochondria as a target for therapy has gained recognition and application. This review examines the relationship between exercise, mitochondrial proteostasis, and PD, exploring the role and mechanisms of mitochondrial proteostasis in delaying PD through exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Xiang Li, Wenjun Wang, Jianghong Yan, Fancai Zeng
Summary: This review discusses the role of glutamate transporters in Parkinson's disease, comparing the expression of different types of glutamate transporter genes using bioinformatics and suggesting that they may be potential targets for the treatment of PD.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Ying Xing, Anjing Zhang, Congqin Li, Jing Han, Jun Wang, Lu Luo, Xuechun Chang, Zhanzhuang Tian, Yulong Bai
Summary: This study observed that the neural connection between the cortical motor area and the striatum in rats can help improve motor ability and reduce anxiety-like behavior during exercise. Additionally, cortical neurons regulate exercise-induced functional recovery through the GABA pathway. These results reveal the influence of cortical neurons on GABA levels in the striatum, playing a critical role in modulating improvement of motor and anxiety-like behavior.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Nijee S. Luthra, Demetra D. Christou, Angela Clow, Daniel M. Corcos
Summary: Parkinson's Disease (PD) is a complex neurodegenerative condition with no current disease-modifying treatments. Exercise has been shown to reduce symptoms of PD and potentially have a neuroprotective effect. This review focuses on how exercise regulates the neuroendocrine system and discusses the role of certain hormones as potential biomarkers for tracking the effects of exercise in PD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Thomas Steinkellner, William S. Conrad, Imre Kovacs, Robert A. Rissman, Edward B. Lee, John Q. Trojanowski, Zachary Freyberg, Subhojit Roy, Kelvin C. Luk, Virginia M. Lee, Thomas S. Hnasko
Summary: VGLUT2-expressing dopamine neurons exhibit resilience to degeneration and may be part of a neuroprotective response in Parkinson's disease.
Article
Clinical Neurology
Yang Yang, Lifeng Chen, Jiarui Yao, Na Wang, Dandan Liu, Yuliang Wang, Dan Liu, Weiping Wu, Tianyu Jiang, Zhenfu Wang
Summary: The study demonstrates that implementing an exercise regimen can significantly improve motor abilities and quality of life in PD patients, especially in those who start exercise early.
NEUROLOGICAL SCIENCES
(2022)
Article
Rehabilitation
Amanda L. Penko, Nicole M. Zimmerman, Michael Crawford, Susan M. Linder, Jay L. Alberts
Summary: The study found that aerobic exercise may improve peak and submaximal cardiopulmonary function in individuals with PD. Factors such as lower age, higher exercise cadence, and lower baseline VO(2)peak were most predictive of improved VO(2)peak in the exercise cohort. The improvements in aerobic capacity were observed after a relatively short aerobic cycling intervention.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Review
Cell Biology
Tianyou Wang, Yingqi Sun, Ulf Dettmer
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons. This review highlights the roles of astrocytes in PD and how their properties can be utilized to increase neuron survivability. Astrocytes normally have protective functions but can become dysfunctional and contribute to neurotoxicity in PD. Restoring healthy astrocyte function and maximizing their beneficial effects represent promising therapeutic approaches.
Article
Neurosciences
Kaixuan Shi, Xiaoli Liu, Decai Qiao, Lijuan Hou
Article
Multidisciplinary Sciences
Lijuan Hou, Ke Li, Yanru Hu, Yijun Bian, Wei Ji, Kaixuan Shi, Yiting Li, Mengjiao Chen, Jiaxin Li, Xiaoli Liu, Decai Qiao
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2019)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)