Editorial Material
Neurosciences
Bin Xiao, Eng-King Tan
Summary: In a recent study, researchers including Zhang and Roy discovered that neurons in the parafascicular thalamus project to three distinct neural structures in the basal ganglia. These neural circuits were found to be associated with specific motor and non-motor symptoms in a Parkinson's disease mouse model. The findings offer potential therapeutic targets for the treatment of this disease.
TRENDS IN NEUROSCIENCES
(2023)
Article
Medicine, Research & Experimental
AmirAli Farokhniaee, Sara Marceglia, Alberto Priori, Madeleine M. Lowery
Summary: The study investigates the effects of medication and deep brain stimulation on neural activity in Parkinson's disease. The results reveal that the stimulation leads to changes in brain activity, while medication has no significant effect.
Article
Clinical Neurology
Alberto Averna, Sara Marceglia, Mattia Arlotti, Marco Locatelli, Paolo Rampini, Alberto Priori, Tommaso Bocci
Summary: This study evaluated the spectrum of local field potentials (LFP) obtained from different contacts within the subthalamic nucleus in Parkinson's disease patients, and their correlations with clinical symptoms. The results showed differences in spectral patterns and correlations with motor symptoms between LFP12 and LFP03 before and after levodopa administration, suggesting potential for optimizing adaptive deep brain stimulation protocols for Parkinson's disease.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Masataka Tanaka, Takufumi Yanagisawa, Ryohei Fukuma, Naoki Tani, Satoru Oshino, Masahito Mihara, Noriaki Hattori, Yuta Kajiyama, Ryota Hashimoto, Manabu Ikeda, Hideki Mochizuki, Haruhiko Kishima
Summary: The study utilized magnetoencephalographic signals to demonstrate that patients with Parkinson's disease exhibit significant phase-amplitude coupling across the whole brain, while healthy participants only showed this in specific regions. There were significant differences in beta and gamma band power between the two groups, and the phase-amplitude coupling in the sensorimotor cortices correlated with motor symptoms of Parkinson's disease.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Zixiao Yin, Ruoyu Ma, Qi An, Yichen Xu, Yifei Gan, Guanyu Zhu, Yin Jiang, Ning Zhang, Anchao Yang, Fangang Meng, Andrea A. Kuehn, Hagai Bergman, Wolf-Julian Neumann, Jianguo Zhang
Summary: Parkinson's disease is associated with excessive beta activity in the basal ganglia. Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive stimulation. Sleep disturbance is one of the most common non-motor symptoms in PD, but its relationship with beta activity is unknown.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Fenghua Chen, Junliang Qian, Zhongkai Cao, Ang Li, Juntao Cui, Limin Shi, Junxia Xie
Summary: In this study, a decrease in the number of GABAergic neurons in the brain region of 6-hydroxydopamine-induced PD mice was found. Activation and inhibition of GABAergic neurons through chemogenetics and optogenetics significantly improved motor function in PD mice and increased dopamine content in the striatum.
Article
Neurosciences
Eileen Gulke, Leon Juarez Paz, Heleen Scholtes, Christian Gerloff, Andrea A. Kuehn, Monika Potter-Nerger
Summary: This study evaluated the feasibility of a semi-automatic algorithm-guided programming approach for beneficial stimulation settings in Parkinson's disease patients. The results showed significant improvement in clinical effectiveness compared to standard care procedures. This method represents an important step towards future closed-loop DBS optimization systems.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Vasiliki Bougou, Michael Vanhoyland, Thomas Decramer, Anais Van Hoylandt, Steven Smeijers, Bart Nuttin, Philippe De Vloo, Wim Vandenberghe, Alice Nieuwboer, Peter Janssen, Tom Theys
Summary: This study investigated the neural activity changes during cycling in patients with Parkinson's disease. The results showed that both active and passive cycling caused suppression of beta activity, while active cycling also led to stronger high gamma band activity. Furthermore, patients with freezing of gait exhibited stronger beta suppression during passive cycling.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Stefanie T. Jost, Lena Strobel, Alexandra Rizos, Philipp A. Loehrer, Keyoumars Ashkan, Julian Evans, Franz Rosenkranz, Michael T. Barbe, Gereon R. Fink, Jeremy Franklin, Anna Sauerbier, Christopher Nimsky, Afsar Sattari, K. Ray Chaudhuri, Angelo Antonini, Lars Timmermann, Pablo Martinez-Martin, Monty Silverdale, Elke Kalbe, Veerle Visser-Vandewalle, Haidar S. Dafsari
Summary: Previous studies have shown that women with Parkinson's disease (PD) have less access to deep brain stimulation (DBS) compared to men. This study observed and compared a total of 505 patients and found that women with PD were less likely to be referred for DBS, but more likely to be approved for the treatment. The study also found that women and men with PD had different preoperative symptoms and characteristics. However, both genders had similar improvements in clinical outcomes after the surgery.
NPJ PARKINSONS DISEASE
(2022)
Article
Neurosciences
Bei Luo, Yue Lu, Chang Qiu, Wenwen Dong, Chen Xue, Li Zhang, Weiguo Liu, Wenbin Zhang
Summary: Using rs-fMRI, this study found changes in brain activity and networks in PD patients during the microlesion period after DBS, with brain regions showing significantly different ALFF scores demonstrating abnormal functional connectivity. These findings provide new insights into the mechanism of MLE.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Anesthesiology
Yu-Chen Chen, Shin-Yuan Chen, Tsung-Ying Chen, Jiann-I Pan, Sheng-Tzung Tsai
Summary: Desflurane and sevoflurane produced different neurophysiological profiles in STN during deep brain stimulation (DBS) surgery in patients with Parkinson's disease. Desflurane resulted in lower neuronal firing rate while sevoflurane entrained greater gamma oscillation power. The choice of anesthetic did not affect STN mapping accuracy or the clinical outcome of DBS electrode implantation.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Clinical Neurology
Satoko Sekimoto, Genko Oyama, Kotatsu Bito, Masaru Tsuchiya, Sho Kikuchi, Baku Takimoto, Toshiki Ichihashi, Juan Miguel P. Bautista, Maierdanjiang Nuermaimaiti, Fuyuko Sasaki, Ryota Nakamura, Hirokazu Iwamuro, Masanobu Ito, Atsushi Umemura, Nobutaka Hattori
Summary: This study evaluates the effect of deep brain stimulation (DBS) on gait performance in patients with Parkinson's Disease (PD), using a three-dimensional gait analysis system. The results suggest that directional current steering can improve gait in PD patients and minimize side effects.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Ruxue Gong, Mirko Wegscheider, Christoph Muehlberg, Richard Gast, Christopher Fricke, Jost-Julian Rumpf, Vadim V. Nikulin, Thomas R. Knoesche, Joseph Classen
Summary: Abnormal phase-amplitude coupling between beta and broadband-gamma activities has been identified in recordings from patients with Parkinson's disease, particularly in specific brain regions involved in motor control. The coupling between beta and gamma signals from different components appears to have pathophysiological significance, and therapeutic approaches targeting abnormal lateral coupling between neuronal circuits may be more promising.
Article
Clinical Neurology
Ruxue Gong, Mirko Wegscheider, Christoph Muehlberg, Richard Gast, Christopher Fricke, Jost-Julian Rumpf, Vadim V. Nikulin, Thomas R. Knoesche, Joseph Classen
Summary: Abnormal phase-amplitude coupling between beta and gamma activities has been found in Parkinson's disease patients, with enhancements in specific cortical regions related to motor control. The coupling between different neural networks appears to have pathophysiological significance and may be more promising as a therapeutic target than targeting phase-amplitude coupling per se.
Article
Biology
Peter M. Lauro, Shane Lee, Daniel E. Amaya, David D. Liu, Umer Akbar, Wael F. Asaad
Summary: This study decodes the neural activity of patients with Parkinson's disease, revealing distinct neural signatures for tremor and bradykinesia, and demonstrating the importance of signal type and location in understanding these motor states. The results suggest the potential for utilizing neurophysiology to improve the treatment of Parkinson's disease.
Article
Neurosciences
Jiawei Li, Bo Hong, Guido Nolte, Andreas K. Engel, Dan Zhang
Summary: The study aimed to identify the neural signatures of preparatory processing of upcoming speech by analyzing the delta and alpha band phase responses. The results showed distinct neural signatures for attentional modulation through TRF-based amplitude responses, revealing how the brain gets prepared to process upcoming speech in a naturalistic context.
COGNITIVE NEURODYNAMICS
(2022)
Article
Clinical Neurology
Marina Fiene, Jan-Ole Radecke, Jonas Misselhorn, Malte Sengelmann, Christoph S. Herrmann, Till R. Schneider, Bettina C. Schwab, Andreas K. Engel
Summary: The study found that modulating the temporal pattern of neural excitability in the visual cortex through transcranial alternating current stimulation can affect human brightness perception of rhythmic visual stimuli. The results show that brightness perception is modulated depending on the phase shift between sensory and electrical stimulation, and the modulatory effects depend on neural phase stability.
Editorial Material
Clinical Neurology
Anelia Dietmann, Eugenie Colin-Benoit, Gerd Tinkhauser, Thomas Raphael Meinel, Olivier Scheidegger
Summary: This case report presents a cat owner with neuralgic amyotrophy caused by cat scratch disease. The patient initially presented with hand swelling, followed by lymphadenopathy and fever, and subsequently developed bilateral neuralgic amyotrophy. After thorough examination and treatment, the patient showed an excellent response to intravenous immunoglobulin.
Article
Neurosciences
Jonas R. Wagner, Miriam Schaper, Wolfgang Hamel, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Christian K. E. Moll, Alessandro Gulberti, Monika Poetter-Nerger
Summary: The study demonstrates that STN+SN DBS is more effective than conventional STN DBS in improving gait impairment in Parkinson's disease patients. The cortical activity of patients during resting and effective stepping shows excessive synchronization in certain frequency bands, which is reduced by DBS. Different patterns of cortical activity are observed during freezing episodes with STN DBS and STN+SN DBS.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Eileen Guelke, Mohammad Alsalem, Maja Kirsten, Eik Vettorazzi, Chi-un Choe, Ute Hidding, Simone Zittel-Dirks, Carsten Buhmann, Miriam Schaper, Alessandro Gulberti, Christian K. E. Moll, Wolfgang Hamel, Johannes Koeppen, Christian Gerloff, Monika Poetter-Nerger
Summary: This study identifies the MoCA as an alternative test for the preoperative evaluation of PD patients, which can be used to detect neuropsychological deficits and predict postoperative improvement in quality of life.
Editorial Material
Computer Science, Artificial Intelligence
Jianwei Zhang, Stefan Wermter, Fuchun Sun, Changshui Zhang, Andreas K. Engel, Brigitte Roeder, Xiaolan Fu, Gui Xue
FRONTIERS IN NEUROROBOTICS
(2022)
Article
Neurosciences
Zhuoran Li, Bo Hong, Daifa Wang, Guido Nolte, Andreas K. Engel, Dan Zhang
Summary: As the world becomes increasingly globalized, non-native language communication is in higher demand; however, the presence of background noise in everyday life poses a significant challenge to non-native speech comprehension. This study used an interbrain approach based on functional near-infrared spectroscopy (fNIRS) to investigate how individuals adapt to comprehend non-native speech information in noisy environments. The findings demonstrated a significant neural coupling in the right hemisphere between listeners and speakers during the processing of non-native speech. Furthermore, certain neural couplings in the listener's right superior temporal gyrus, the right middle temporal gyrus, and the right postcentral gyrus were positively correlated with individual comprehension performance at the strongest noise level.
Editorial Material
Neurosciences
Andreas K. Engel, Paul F. M. J. Verschure, Danica Kragic, Daniel Polani, Alfred O. Effenberg, Peter Koenig
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Alexander Maye, Marvin Mutz, Andreas K. Engel
Summary: The spatially-coded SSVEP BCI uses the retinotopic map in the human visual pathway to infer gaze direction, providing advantages of reducing visual fatigue and improving user comfort. By incorporating a feedback channel, the BCI is able to accumulate valid training data while solving a spatial navigation task. The results show that the spatially-coded BCI achieves an average accuracy of 69 +/- 15% initially, which improves to 87 +/- 9% after multiple task completions.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Neurosciences
Arzu Ceylan Has Silemek, Guido Nolte, Jana Poettgen, Andreas K. Engel, Christoph Heesen, Stefan M. Gold, Jan-Patrick Stellmann
Summary: This study aimed to explore the longitudinal reorganization of brain networks in multiple sclerosis (MS) patients over a period of 2 years, and analyze its association with cognition. The results showed a decline in hub connectivity and global connectivity at a structural level in MS patients, while the hub connectivity in the default-mode network was preserved. In addition, the network models based on functional MRI and magnetoencephalography were similar to diffusion tensor imaging, but had weaker associations with cognition in MS patients.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Clinical Neurology
Alessandro Gulberti, Jonas R. Wagner, Martin A. Horn, Jacob H. Reuss, Miriam Heise, Johannes A. Koeppen, Hans O. Pinnschmidt, Manfred Westphal, Andreas K. Engel, Christian Gerloff, Andrew Sharott, Wolfgang Hamel, Christian K. E. Moll, Monika Poetter-Nerger
Summary: In this study, the role of subthalamic and nigral neurons in the control of parkinsonian gait was assessed using intraoperative microelectrode recordings. The results suggest that subthalamic nucleus neurons are involved in motor aspects of gait control, while substantia nigra neurons are associated with attentional aspects.
Article
Clinical Neurology
Ines Debove, Katrin Petermann, Andreas Nowacki, Thuy-Anh Khoa Nguyen, Gerd Tinkhauser, Joan Philipp Michelis, Julia Muellner, Deborah Amstutz, Panagiotis Bargiotas, Jens Fichtner, Janine Ai Schlaeppi, Paul Krack, Michael Schuepbach, Claudio Pollo, Martin Lenard Lachenmayer
Summary: Directional deep brain stimulation (DBS) allows for steering the stimulation field, but extensive testing is necessary to determine its advantage. To reduce programming time, additional testing should be done initially only on ring-level contacts with a therapeutic window of less than 2.0 mA.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Wolf-Julian Neumann, Roee Gilron, Simon Little, Gerd Tinkhauser
Summary: Closed-loop adaptive deep brain stimulation (aDBS) has the potential to provide individualized therapy for neurological disorders with unprecedented temporal precision, but translation to clinical practice remains challenging.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Xinmiao Zhang, Jiawei Li, Zhuoran Li, Bo Hong, Tongxiang Diao, Xin Ma, Guido Nolte, Andreas K. Engel, Dan Zhang
Summary: This study investigated the neural tracking of acoustic and semantic speech information during speech comprehension in noisy environments. The results showed that the neural responses to both acoustic and semantic features of speech were relatively stable regardless of the level of noise. In particular, the study revealed robust leading responses to speech semantics, suggesting a possible predictive mechanism for maintaining reliable speech comprehension in noisy environments.
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)