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Oncology
Mengmeng Song, Ye Li, Zhewen Chen, Jie Zhang, Liuqing Yang, Fan Zhang, Chunhua Song, Mingyong Miao, Wenjun Chang, Hanping Shi
Summary: Accumulating evidence suggests that lncRNAs play important roles as potential biomarkers and regulators in tumor development and progression. This study identifies FAM222A-AS1 as an upregulated lncRNA in colorectal cancer (CRC) and demonstrates its role in promoting CRC progression through inhibiting the miR-let-7f/MYH9 axis. The findings provide a novel therapeutic target for CRC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Minhong Shen, Shanshan Xie, Michelle Rowicki, Sven Michel, Yong Wei, Xiang Hang, Liling Wan, Xin Lu, Min Yuan, John F. Jin, Frank Jaschinski, Tianhua Zhou, Richard Klar, Yibin Kang
Summary: The study found that MTDH promotes the progression of colorectal and lung cancers by facilitating Wnt activation and inducing T-cell exhaustion. Treatment with MTDH antisense oligonucleotides effectively suppresses MTDH expression and significantly attenuates the progression and metastasis of these cancers.
Article
Cell Biology
Dan Song, Qian Zhang, Hao Zhang, Liangliang Zhan, Xinchen Sun
Summary: The study reveals that miR-130b-3p is upregulated in colorectal cancer (CRC) tissues and cells and can be detected in the feces of CRC patients. Inhibition of miR-130b-3p suppresses CRC cell proliferation and tumor growth in vivo. The mechanism involves direct targeting of chromodomain helicase DNA binding protein 9 (CHD9) by miR-130b-3p.
Article
Oncology
Sheng-Hui Lan, Shu-Ching Lin, Wei-Chen Wang, Yu-Chan Yang, Jenq-Chang Lee, Pei-Wen Lin, Man-Ling Chu, Kai-Ying Lan, Roberto Zuchini, Hsiao-Sheng Liu, Shan-Ying Wu
Summary: The study revealed a novel mechanism in which autophagy utilizes the miR-449a-LEF1-cyclin D1 axis to suppress colorectal cancer tumorigenesis. The findings suggest that miR-449a has the potential to be a prognostic biomarker for colorectal cancer patients and open avenues for prognosis and treatment by manipulating the autophagy-miR-449a axis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mengyuan Shi, Guo An, Nan Chen, Jinying Jia, Xinxin Cui, Tiancheng Zhan, Dengbo Ji
Summary: This study analyzed the prognosis of colorectal cancer (CRC) through immunohistochemistry and compared genetic changes between the high UVRAG expression group and the low UVRAG expression group using RNA sequencing data. The results showed that UVRAG could enhance tumor migration, drug resistance, and CCL2 expression to recruit macrophages by upregulating SP1 expression, leading to poor prognosis in CRC patients. Additionally, UVRAG could upregulate the expression of PD-L1. In conclusion, this study explored the relationship between UVRAG expression and the prognosis of CRC patients, as well as potential mechanisms in CRC, providing evidence for CRC treatment.
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Oncology
Lin Chen, Wei Chen, Changjie Zhao, Qi Jiang
Summary: The study found that LINC01224 was up-regulated in CRC tissues and cells, promoting CRC progression through sponging miR-2467, and may serve as a potential diagnostic biomarker and therapeutic target for CRC patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Genetics & Heredity
Lin Han, Yanjun Sun, Cansheng Lu, Chungeng Ma, Jian Shi, Dengqun Sun
Summary: MiR-3614-5p is associated with colorectal cancer, with low expression predicting poor survival rate and correlating with N, M, pathologic stage, neoplasm type, and lymphatic invasion. High expression enriches the P53 pathway and enhances NK T cell activation.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Jiahui Zhou, Lu Wang, Qingyang Sun, Ranran Chen, Chuan Zhang, Peng Yang, Yuqian Tan, Chaofan Peng, Tuo Wang, Chi Jin, Jiangzhou Ji, Kangpeng Jin, Yueming Sun
Summary: Hsa_circ_0001666 is downregulated in CRC and its higher expression level is associated with better clinical prognosis. Through regulation of the miR-576-5p/PCDH10 axis, hsa_circ_0001666 suppresses the progression of CRC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Genetics & Heredity
Long Zhao, Bo Wang, Changjiang Yang, Yilin Lin, Zhen Zhang, Shan Wang, Yingjiang Ye, Zhanlong Shen
Summary: The study found that TDO2 expression level in colorectal cancer is associated with tumor clinical stage, with high expression correlating with poor outcome. Inhibition of TDO2 expression significantly reduces proliferation, migration, and invasion abilities of CRC cells.
Article
Genetics & Heredity
Zhu Yufeng, Qi Ming, Wu Dandan
Summary: miR-320d inhibits the malignant phenotype of EGFR-positive CRC by targeting TUSC3, reducing proliferation and invasion abilities, with therapeutic potential.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Jingfeng Gu, Liang Dong, Yun Wang, Wenjia Nie, Wencong Liu, Ji-an Zhao
Summary: YY1-induced LINC01224 regulates CRC development by modulating the miR-485-5p/MYO6 axis. LINC01224 sponges miR-485-5p to influence its regulation on CRC, while upregulation of miR-485-5p suppresses proliferation, migration, and invasion of CRC cells and promotes apoptosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Weitong Zhang, Zhenfen Wang, Guohao Cai, Ping Huang
Summary: This study revealed that circ_DOCK1 plays a role in colorectal cancer progression by regulating the miR-132-3p/USP11 axis, with circ_DOCK1 knockdown inhibiting cell growth and metastasis while promoting apoptosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yu Liu, Wentao Tang, Li Ren, Tianyu Liu, Meng Yang, Ye Wei, Yijiao Chen, Meiling Ji, Guosong Chen, Wenju Chang, Jianmin Xu
Summary: miR-500a-3p is downregulated in CRC and inhibits cancer cell proliferation and glycolysis by targeting CDK6.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
Xia Gao, Guangxin Wang, Min Zhang, Xinxin Zhang, Shuosheng Zhang, Haocheng Long
Summary: LINC01485 plays an important role in the development of colorectal cancer (CRC) by regulating the expression of the miR-383-5p/KRT80 axis and enhancing the proliferative capacity of CRC cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhi Miao, Xiaomeng Zhao, Xiang Liu
Summary: This study investigated the effect and mechanism of a novel circRNA (circCOL1A2) in colorectal cancer (CRC). The study found that circCOL1A2 was highly expressed in CRC cells and could be transferred via exosomes. Reduction of exosomal circCOL1A2 inhibited cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) properties. Mechanism studies demonstrated the binding of miR-665 with circCOL1A2 or LASP1. Animal studies confirmed the oncogenic function of exosomal circCOL1A2 in CRC tumorigenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mulin Liu, Wei Wu, Qun Zhao, Qiupeng Feng, Wenbin Wang
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2015)
Article
Medicine, Research & Experimental
Mulin Liu, Aman Xu, Xiao Yuan, Qiao Zhang, Taotao Fang, Wenbin Wang, Chenglong Li
JOURNAL OF TRANSLATIONAL MEDICINE
(2015)
Article
Peripheral Vascular Disease
Wenbin Wang, Xiao Yuan, Aman Xu, Xingyang Zhu, Yanqing Zhan, Shuanhu Wang, Mulin Liu
MICROVASCULAR RESEARCH
(2018)
Article
Oncology
Bing Zhu, Jie Luo, Yiyao Jiang, Luhua Yu, Mulin Liu, Jun Fu
Article
Peripheral Vascular Disease
Wenbin Wang, Xingyang Zhu, Xiaolong Du, Aman Xu, Xiao Yuan, Yanqing Zhan, Mulin Liu, Shuanhu Wang
MICROVASCULAR RESEARCH
(2019)
Article
Multidisciplinary Sciences
Bo Shi, Lili Wang, Chang Yan, Deli Chen, Mulin Liu, Peng Li
SCIENTIFIC REPORTS
(2019)
Article
Pharmacology & Pharmacy
Deli Chen, Sitang Ge, Lugen Zuo, Shuanhu Wang, Mulin Liu, Shiqing Li
Article
Multidisciplinary Sciences
Dengzhong Sun, Yongzhi Miao, Wu Xu, Weijun Shi, Lili Wang, Tianwen Chen, Hexin Wen, Huazhang Wu, Mulin Liu
Article
Oncology
Lili Wang, Yongzhi Miao, Tianwen Chen, Dengzhong Sun, Sitang Ge, Lugen Zuo, Mulin Liu
MOLECULAR AND CLINICAL ONCOLOGY
(2020)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)