Review
Immunology
Yulin Wang, Dongxu Song, Lin Tang
Summary: Mitophagy is a crucial mechanism involved in the regulation of mitochondrial quality control and cell damage. Inflammasomes, newly discovered inflammation-related factors, play an important role in kidney diseases. This review focuses on the progress of mitophagy, inflammasomes, and their interaction in kidney diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Paula Anton-Pampols, Clara Diaz-Requena, Laura Martinez-Valenzuela, Francisco Gomez-Preciado, Xavier Fulladosa, Anna Vidal-Alabro, Joan Torras, Nuria Lloberas, Juliana Draibe
Summary: This review describes the characteristics, activation mechanisms, regulation, and functions of different inflammasomes, and discusses the latest findings on the role of the inflammasome in several glomerulonephritis from in vitro, animal, and human studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kaori Oda, Satoshi Miyamoto, Ryo Kodera, Jun Wada, Kenichi Shikata
Summary: Inhibition of NLRP3 inflammasome activity with suramin can protect against the progression of diabetic kidney disease.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Jiajia Zhang, Stefan Wirtz
Summary: This article reviews the molecular mechanisms of pyroptosis and discusses its possible role in inflammasome-related disorders, providing new insights for future therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Paulina Mertowska, Sebastian Mertowski, Iwona Smarz-Widelska, Ewelina Grywalska
Summary: The increasing number of late-diagnosed kidney disease patients has become a serious problem affecting people from all backgrounds. The full etiology of this issue is not yet fully understood, although genetic susceptibility, infections, immune disorders, or high blood pressure have been suggested as contributing factors. Difficulties in timely and accurate diagnosis are due to the lack of research on early molecular markers and insufficient educational and preventive efforts among the public, resulting in delayed detection of kidney diseases. Interleukins play an important role in homeostasis and disease progression, including kidney diseases, by performing various biological functions and interacting with other cells and tissues in the body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Samo Roskar, Iva Hafner-Bratkovic
Summary: Osteoarthritis is a common age-related form of arthritis characterized by cartilage loss and synovial inflammation, while inflammation plays an important role in disease progression. Inflammasomes, inflammatory multiprotein complexes, are implicated in secondary arthritis and may also be involved in primary osteoarthritis. Targeted therapies against inflammasomes could be a promising strategy for these debilitating diseases.
Review
Neurosciences
Luting Poh, Wei Liang Sim, Dong-Gyu Jo, Quynh Nhu Dinh, Grant R. Drummond, Christopher G. Sobey, Christopher Li-Hsian Chen, Mitchell K. P. Lai, David Y. Fann, Thiruma V. Arumugam
Summary: This review aims to provide a comprehensive insight into the molecular and cellular mechanisms involved in the pathogenesis of chronic cerebral hypoperfusion-induced inflammasome signaling in vascular cognitive impairment (VCI).
MOLECULAR NEURODEGENERATION
(2022)
Review
Immunology
Qi Ke, Ashley Nicole Greenawalt, Veera Manukonda, Xingqi Ji, Roland Michael Tisch
Summary: Inflammasome molecules are receptors that trigger proinflammatory responses against microbial infections. Dysregulation of inflammasome activity has been associated with chronic inflammation and autoimmune diseases. Inflammasome activation affects both innate and adaptive immune effectors as well as resident cells in target tissues, contributing to autoimmune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jianjun Gao, Zhaoyan Gu
Summary: Peroxisome proliferator-activated receptors (PPARs), a type of ligand-activated transcription factor, may play an important role in the pathogenesis of kidney disease and could serve as potential therapeutic targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Ling Wu, Hongsheng Lu, Yin Pan, Chen Liu, Jinyan Wang, Baofu Chen, Yichao Wang
Summary: Pyroptosis, a type of programmed cell death, has different effects on breast cancer and is associated with tumor immunotherapy. A comprehensive summary of the role of pyroptosis in cancer, specifically in breast cancer, is crucial for harnessing its potential in enhancing immunotherapy efficiency.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Saurav Prashant Kadatane, Matthew Satariano, Michael Massey, Kai Mongan, Rupesh Raina
Summary: Chronic kidney disease (CKD) is a common condition worldwide, and low-grade inflammation plays a significant role in its development and progression. Dysregulation of pro- and anti-inflammatory markers leads to persistent low-grade inflammation, which is associated with increased mortality and cardiovascular problems. Various factors such as immune system activation, reactive oxygen species production, periodontal disease, dysregulation of anti-inflammatory systems, and intestinal dysbiosis contribute to the dysregulation of this balance. This inflammation has detrimental effects on hypertension, renal fibrosis, renal function decline, and even malignancy. Dialysis, a common treatment for CKD, also has a bidirectional relationship with persistent inflammation. Treatment options for inflammation in CKD include cytokine inhibitors, statins, and diets, but further research is needed for a standardized management plan.
Review
Biochemistry & Molecular Biology
Magdalena Ciazynska, Irmina Olejniczak-Staruch, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Inflammasomes play a significant role in the pathogenesis of psoriasis, contributing to the cleavage and activation of proinflammatory cytokines. Despite recent advances, the immune response triggers of psoriasis are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Gangyu Long, Rui Gong, Qian Wang, Dingyu Zhang, Chaolin Huang
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a severe respiratory failure, and the oxidized form of mitochondrial DNA is believed to play a significant role in its development. This review discusses the mechanisms of mitochondrial DNA release and how they can induce inflammation and worsen lung injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Xiaolin Lu, Qihong Tan, Jianyong Ma, Jing Zhang, Peng Yu
Summary: This article discusses the role of long non-coding RNAs (lncRNAs) in regulating NLRP3 inflammasome activity and its involvement in diabetes and diabetic complications. Research suggests that regulating lncRNAs on NLRP3 inflammasome is critical for the development and progression of diabetes and its complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Saiqi Qi, Jie Song, Linjun Chen, Huachun Weng
Summary: This article addresses the important roles of m6A modification in kidney diseases and its molecular mechanisms. The m6A modification has been shown to regulate RNA expression through splicing, export, attenuation, and translation initiation efficiency. Understanding the impact of m6A modification in kidney diseases can provide valuable insights for diagnosis and clinical management.
MOLECULAR MEDICINE
(2023)