Review
Cardiac & Cardiovascular Systems
Danilo Neglia, Natallia Maroz-Vadalazhskaya, Nazario Carrabba, Riccardo Liga
Summary: In recent decades, effective management of cardiovascular risk factors has led to a decrease in coronary artery disease prevalence. However, coronary heart disease remains a leading cause of death globally, and chronic coronary syndromes continue to be targets of cardiac imaging and invasive procedures. Current guidelines recommend non-invasive imaging for CCS patients to identify high-risk individuals for referral to invasive procedures, but recent studies have raised questions about the efficacy of coronary revascularization. The role of imaging in these patients, including those with ischemic cardiomyopathy, remains debated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
David Feldman, Jacqueline Latina, Jana Lovell, Roger S. Blumenthal, Armin Arbab-Zadeh
Summary: The treatment of coronary artery disease focuses on managing symptoms and preventing cardiovascular events. Coronary CTA has emerged as the first line noninvasive imaging modality for evaluating coronary atherosclerosis, improving diagnostic accuracy and patient outcomes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kiyotaka Hao, Jun Takahashi, Yoku Kikuchi, Akira Suda, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Tomohiko Shindo, Kensuke Nishimiya, Shohei Ikeda, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa
Summary: The study found that while the incidence of major adverse cardiovascular events was low among patients with vasospastic angina (VSA), those with significant coronary stenosis in the low-FFR group had a poor prognosis. The combination treatment of calcium channel blockers and percutaneous coronary intervention significantly improved the outcomes for VSA patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Medicine, General & Internal
Alexandra N. Nowbar, Christopher Rajkumar, Rasha K. Al-Lamee, Darrel P. Francis
Summary: Recent randomised controlled trials have overturned traditional beliefs about necessary hospital procedures for stable coronary artery disease patients, leading to discussions about the implications for physicians and patients.
Article
Microbiology
Jing Zhong, Dingfeng Wu, Yuanyuan Zeng, Gaosong Wu, Ningning Zheng, Wenjin Huang, Yan Li, Xin Tao, Weize Zhu, Lili Sheng, Xiaoxu Shen, Weidong Zhang, Ruixin Zhu, Houkai Li
Summary: Growing evidence suggests a link between gut dysbiosis and coronary artery disease (CAD). This study focuses on the pathogenesis mechanisms of stable CAD (SCAD) based on microbe-host metabolism interactions. Disturbances in gut microbiome were observed in SCAD patients, accompanied by differences in serum metabolome, suggesting a reduced cardiac fatty acid oxidation. Further analysis identified Ralstonia pickettii as the core strain responsible for impaired gut microbial function in SCAD patients and the decrease of host unsaturated fatty acid levels, highlighting the importance of unsaturated fatty acids and R. pickettii in the pathogenesis of SCAD.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, General & Internal
Yasemin Dogan, Yucel Yilmaz, Saban Kelesoglu, Bekir Calapkorur, Salim Neselioglu, Ozcan Erel, Nihat Kalay
Summary: The aim of this study was to investigate the relationship between thiol, the main component of the antioxidant system, and coronary collateral circulation (CCC). The results showed that patients with stable coronary artery disease (sCAD) who developed poor CCC had lower levels of native thiol, total thiol, and disulfide compared to those with good CCC. Additionally, DM, total thiol, and disulfide were identified as independent predictors of poor CCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Guillermo Romero-Farina, Santiago Aguade-Bruix
Summary: Cardiovascular disease remains the leading cause of death globally, with an increasing prevalence of coronary artery disease (CAD). Planning the follow-up of patients with stable chronic CAD requires a comprehensive understanding of clinical history, utilization of imaging techniques for risk stratification, and the need for further studies to improve follow-up planning for scCAD patients in the future.
Article
Cardiac & Cardiovascular Systems
Nadia Bouabdallaoui, Nathan Messas, Nicola Greenlaw, Roberto Ferrari, Ian Ford, Kim M. Fox, Michal Tendera, Datshana P. Naidoo, Christian Hassager, P. Gabriel Steg, Jean-Claude Tardif
Summary: Research shows that compared with never-smokers, current smokers and former smokers have higher risks of all-cause mortality and cardiovascular mortality in patients with stable coronary artery disease. Even after quitting smoking, cardiovascular risk remains elevated compared to never-smokers but lower than current smokers, emphasizing the importance of smoking cessation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ziwei Xi, Jianan Li, Hong Qiu, Tingting Guo, Yong Wang, Yang Li, Jianfeng Zheng, Kefei Dou, Bo Xu, Yongjian Wu, Shubin Qiao, Weixian Yang, Yuejin Yang, Runlin Gao
Summary: This study demonstrates that in patients with SCAD undergoing complex PCI, ticagrelor can significantly reduce the risk of adverse cardiovascular events compared to clopidogrel, without an increased risk of major bleeding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Akira Taruya, Yuki Nakajima, Atsushi Tanaka, Manabu Kashiwagi, Takashi Tanimoto, Akio Kuroi, Yasutsugu Shiono, Kunihiro Shimamura, Takashi Kubo, Hiromichi Sougawa, Tomizo Masuno, Yuichi Ozaki, Keisuke Satogami, Shingo Ota, Yosuke Katayama, Yasushi Ino, Hironobu Hoshiya, Takashi Akasaka
Summary: This study found that cancer survivors with coronary artery disease (CAD) have distinct lesion morphologies and poorer outcomes compared to non-cancer controls, likely due to underlying inflammation and presence of high-risk lesions such as thrombi and layered fibrotic plaques. These findings may provide insights for the management of CAD in cancer patients in terms of secondary prevention.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Markus Malmberg, Jarmo Gunn, Paivi Rautava, Jussi Sipila, Ville Kyto
Summary: Patients with myocardial infarction have poorer short- and long-term outcomes compared to stable coronary artery disease patients after coronary artery bypass grafting (CABG). Higher risk of death continues also in stabilized first-year myocardial infarct survivors. Efficient secondary prevention and follow-up are important in the post-myocardial infarct population after CABG.
ANNALS OF MEDICINE
(2021)
Article
Hematology
Oliver Buchhave Pedersen, Erik Lerkevang Grove, Peter H. Nissen, Sanne Bojet Larsen, Leonardo Pasalic, Steen Dalby Kristensen, Anne-Mette Hvas
Summary: This study aimed to investigate whether the expression of selected candidate miRNAs can predict cardiovascular events in stable CAD patients. Among 749 patients, adding miR-223-3p expression to traditional cardiovascular risk factors improved the predictive value of ST, the primary composite endpoint, and the secondary endpoint of the composite of nonfatal MI and ST. Clinical trials are needed to confirm these findings.
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Cardiac & Cardiovascular Systems
Shun Kohsaka, Kenji Fukushima, Ippei Watanabe, Susumu Manabe, Nozomi Niimi, Yodo Gatate, Mitsuaki Sawano, Shintaro Nakano
Summary: Coronary artery disease remains a major cause of mortality and morbidity in developed countries. While urgent revascularization is critical for acute coronary syndrome management, recent large-scale clinical trials suggest that mechanically 'fixing' a narrowed artery may not be clearly beneficial for stable CAD patients. Differentiating between ACS and stable CAD is important for modifying diagnostic pathways, non-imaging evaluations, optimal timing for invasive coronary angiography and revascularization, and implementing medical therapy during the work-up.
CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Teng Ma, Jian Zhao, Yechao Yan, Junying Liu, Jie Zang, Yaqi Zhang, Kun Ruan, Hong Xu, Wan He
Summary: This study observed 3,766 patients with stable coronary artery disease and found that higher plasma OPG levels were associated with an increased incidence of all-cause death, cardiovascular death, and heart failure. This suggests that elevated plasma OPG levels are associated with poor prognosis in patients with stable coronary artery disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yan Liang, Jun Zhu, Lisheng Liu, Sonia S. Anand, Stuart J. Connolly, Jackie Bosch, Tomasz J. Guzik, Martin O'Donnell, Gilles R. Dagenais, Keith Aa Fox, Olga Shestakovska, Scott D. Berkowitz, Eva Muehlhofer, Lars Keller, Salim Yusuf, John W. Eikelboom
Summary: In patients with stable coronary artery disease or peripheral artery disease, the combination of rivaroxaban (2.5 mg twice daily) and aspirin compared with aspirin alone appears to produce consistent benefits in women and men, independent of baseline cardiovascular risk. There was no significant interaction between randomized treatment and baseline cardiovascular risk for major adverse cardiovascular events or major bleeding.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
John Hung, Andreas Roos, Erik Kadesjo, David A. McAllister, Dorien M. Kimenai, Anoop S. Shah, Atul Anand, Fiona E. Strachan, Keith A. A. Fox, Nicholas L. Mills, Andrew R. Chapman, Martin J. Holzmann
Summary: The GRACE 2.0 score showed good discrimination for predicting all-cause death at 1 year in patients with type 1 myocardial infarction, but only moderate discrimination for those with type 2 myocardial infarction.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Francois Schiele, Suleman Aktaa, Xavier Rossello, Ingo Ahrens, Marc J. Claeys, Jean-Philippe Collet, Keith A. A. Fox, Chris P. Gale, Kurt Huber, Zaza Iakobishvili, Alan Keys, Ekaterini Lambrinou, Sergio Leonardi, Maddalena Lettino, Frederick A. Masoudi, Susanna Price, Tom Quinn, Eva Swahn, Holger Thiele, Adam Timmis, Marco Tubaro, Christiaan J. M. Vrints, David Walker, Hector Bueno, Sigrun Halvorsen, Tomas Jernberg, Jarle Jortveit, Mai Blondal, Borja Ibanez, Christian Hassager
Summary: Updated quality indicators for the management of acute myocardial infarction were developed based on contemporary knowledge and accumulated experience, aiming to evaluate and improve the quality of care for myocardial infarction.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew A. Cavender, Michelle L. O'Donoghue, Antonio Abbate, Philip Aylward, Keith Aa Fox, Ruchira X. Glaser, Jeong-Gun Park, Jose Lopez-Sendon, Ph Gabriele Steg, Marc S. Sabatine, David A. Morrow
Summary: Losmapimod attenuated inflammatory response in patients with STEMI but not in those with NSTEMI. Differences in outcomes between the two patient groups suggest a potential need for separate strategies in managing inflammation in MI, with a stronger focus on heart failure.
AMERICAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Sonia S. Anand, Will Hiatt, Leanne Dyal, Rupert Bauersachs, Scott D. Berkowitz, Kelley R. H. Branch, Sebastian Debus, Keith A. A. Fox, Yan Liang, Eva Muehlhofer, Mark Nehler, Lloyd P. Haskell, Manesh Patel, Michael Szarek, Salim Yusuf, John Eikelboom, Marc P. Bonaca
Summary: Among peripheral artery disease (PAD) patients, low-dose rivaroxaban plus aspirin is superior to aspirin alone in reducing cardiovascular and limb events, including acute limb ischemia and major vascular amputation. Despite an increased risk of major bleeding, there is no significant increase in severe bleeding with the combination therapy.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Fernando Montenegro Sa, Joao Moraisb
REVISTA PORTUGUESA DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Jose Silva-Cardoso, Candida Fonseca, Fatima Franco, Joao Morais, Jorge Ferreira, Dulce Brito
Summary: The Portuguese HF expert panel contributed to the ongoing debate regarding HFrEF management by highlighting three key principles: the preference for sacubitril/valsartan as first-line therapy, the importance of four foundation HFrEF drugs regardless of diabetes status, and the introduction and dose up-titration of these drugs over specific timeframes guided by a safety protocol.
REVISTA PORTUGUESA DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Keith A. A. Fox, Saverio Virdone, Karen S. Pieper, Jean-Pierre Bassand, A. John Camm, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Gloria Kayani, Ali Oto, Frank Misselwitz, Jonathan P. Piccini, Frederik Dalgaard, Alexander G. G. Turpie, Freek W. A. Verheugt, Ajay K. Kakkar
Summary: This study confirms the effectiveness of the GARFIELD-AF integrated risk tool in predicting mortality, stroke, and bleeding in patients with atrial fibrillation, and compares it with the traditional predictors CHA(2)DS(2)-VASc and HAS-BLED.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Medicine, General & Internal
Keith A. A. Fox, Saverio Virdone, Jean-Pierre Bassand, A. John Camm, Shinya Goto, Samuel Z. Goldhaber, Sylvia Haas, Gloria Kayani, Yukihiro Koretsune, Frank Misselwitz, Seil Oh, Jonathan P. Piccini, Alex Parkhomenko, Jitendra Pal Singh Sawhney, Janina Stepinska, Alexander G. G. Turpie, Freek W. A. Verheugt, Ajay K. Kakkar
Summary: The variability in outcomes for patients with newly diagnosed AF across countries cannot be explained by baseline characteristics and antithrombotic treatments. Mortality rates are correlated with Healthcare Access and Quality indices.
Letter
Cardiac & Cardiovascular Systems
Nana Pogosova, Jacqueline Bosch, Deepak L. Bhatt, Keith A. A. Fox, Stuart J. Connolly, Marco Alings, Peter Verhamme, Eva Muehlhofer, Olga Shestakovska, Salim Yusuf, John W. Eikelboom
Editorial Material
Cardiac & Cardiovascular Systems
Sara I. L. Fernandes, Luis M. G. Santos, Maria F. A. Saraiva, Jose A. S. Antunes, Helia A. F. Martins, Joao C. A. Morais
CORONARY ARTERY DISEASE
(2022)
Review
Cardiac & Cardiovascular Systems
Felicita Andreotti, Tobias Geisler, Jean-Philippe Collet, Bruna Gigante, Diana A. Gorog, Sigrun Halvorsen, Gregory Y. H. Lip, Joao Morais, Eliano Pio Navarese, Carlo Patrono, Bianca Rocca, Andrea Rubboli, Dirk Sibbing, Robert F. Storey, Freek W. A. Verheugt, Gemma Vilahur
Summary: This study aims to provide a concise yet comprehensive tool for understanding the bases of antithrombotic therapy in older patients, considering the complexities of comorbidities, comedications, and the uncertain balance between ischemic and bleeding risks.
EUROPEAN HEART JOURNAL
(2023)
Letter
Cardiac & Cardiovascular Systems
Alexandre Antunes, Margarida Cabral, Joao Morais
REVISTA PORTUGUESA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Josephine Harrington, Anthony P. Carnicelli, Kaiyuan Hua, Lars Wallentin, Manesh R. Patel, Stefan H. Hohnloser, Robert P. Giugliano, Keith A. A. Fox, Ziad Hijazi, Renato D. Lopes, Sean D. Pokorney, Hwanhee Hong, Christopher B. Granger
Summary: Through meta-analysis of multiple research databases, it was found that standard-dose DOACs are safer and more effective than warfarin in patients with kidney dysfunction. While lower-dose DOACs do not significantly lower the incidence of bleeding or intracranial hemorrhage compared to standard-dose DOACs, they are associated with a higher incidence of stroke and systemic embolism as well as death. Therefore, these findings support the use of standard-dose DOACs over warfarin in patients with kidney dysfunction.
Editorial Material
Cardiac & Cardiovascular Systems
Florian A. Wenzl, Keith A. A. Fox, Thomas F. Luescher
EUROPEAN HEART JOURNAL
(2023)