期刊
MOLECULAR BIOLOGY OF THE CELL
卷 30, 期 12, 页码 1536-1543出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E18-12-0792
关键词
-
类别
资金
- National Institutes of Health (NIH) [DK52057, DK107498]
- NIH [2T32DK007201]
In fat and skeletal muscle cells, insulin-responsive amino peptidase (IRAP) along with glucose transporter 4 (Glut4) and sortilin, represents a major component protein of the insulin-responsive vesicles (IRVs). Here, we show that IRAP, similar to Glut4 and sortilin, is retrieved from endosomes to the trans-Golgi network by retromer. Unlike Glut4, retrograde transport of IRAP does not require sortilin, as retromer can directly bind to the cytoplasmic tail of IRAP. Ablation of IRAP in 3T3-L1 adipocytes shifts the endosomal pool of Glut4 to more acidic endosomes, but does not affect IRV targeting, stability, and insulin responsiveness of Glut4.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据