Review
Chemistry, Multidisciplinary
Ji Hyeon Kim, Dong Won Kang, Hongyeol Yun, Minjung Kang, Nem Singh, Jong Seung Kim, Chang Seop Hong
Summary: Porous organic polymers (POPs) are prepared through crosslinked polymerization of multidimensional rigid aromatic building blocks, and can be classified into crystalline COFs and other porous polymers. Due to their outstanding properties, such as high porosity and stability, POPs are being developed for applications in various scientific fields. The recently developed post-synthetic modification (PSM) strategies have allowed for advanced applications of POPs, particularly in biomedical applications, leading to a resurgence in their diverse functions.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Applied
Junli Zhou, Yite Li, Lei Wang, Zhigang Xie
Summary: The study synthesized ACF@PCN-222@MnO2-PEG (APM) nanoparticles with good colloidal stability, biocompatibility and H2O2-triggered drug releasing. The amorphous MnO2 layer on APM's surface quickly decomposes after reacting with endogenous H2O2 to generate abundant oxygen, compensating for the oxygen consumed during photodynamic process.
Article
Nanoscience & Nanotechnology
Yunsu Ma, Huanghuang Xu, Bo Sun, Silin Du, Shuai Cui, Li Zhang, Ning Ding, Dongzhi Yang
Summary: The study designed a pH-responsive nanosystem that combines photodynamic therapy and chemodynamic therapy for wound infection. The system showed a combined PDT/CDT effect, killing bacteria through oxidative stress and enhancing therapeutic effects by activating the immune response.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Kaiyue Tan, Qingqing Zhang, Qing Wang, Xue Gong, Shanshan Yu, Ruomeng Li, Xiaoqing Liu, Fuan Wang
Summary: Programmable chiral biocatalysis is a promising therapeutic strategy for precise control over biotransformation processes. This study reports an efficient ATP-stimulated disassembly method to sustain l-DNAzyme-amplified photodynamic therapy. The self-sufficient l-therapeutic platform can intelligently release l-DNAzyme probe and supply l-His DNAzyme cofactors via endogenous ATP.
Review
Biochemistry & Molecular Biology
Marco Agnes, Elisabetta Pancani, Milo Malanga, Eva Fenyvesi, Ilse Manet
Summary: Cyclodextrin-based polymers can be prepared using green and low-cost methods, allowing for fine-tuning of functionality. They have superior solubility and solubilizing power, and enable combination therapy with multiple therapeutic agents. A significant amount of scientific data is available, indicating potential in biomedical applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jie Yu, Hua Xiao, Zuo Yang, Chaoqiang Qiao, Bin Zhou, Qian Jia, Zhongdi Wang, Xiaofei Wang, Ruili Zhang, Yang Yang, Zhongliang Wang, Jianxiong Li
Summary: The excessive production of glutathione (GSH) by tumor cells hinders the efficacy of photodynamic therapy and chemotherapy. A novel GSH-inhibiting nanosystem (PCNPs) is reported here for persistent synergistic cancer therapy, offering sustained suppression of GSH biosynthesis and improved drug utilization. The PCNPs also act as efficient singlet oxygen radical generators, enhancing photodynamic therapy.
Article
Chemistry, Multidisciplinary
Xiujun Zheng, Blandine Lordon, Anne-Francoise Mingotaud, Patricia Vicendo, Rachel Brival, Isabelle Fourquaux, Laure Gibot, Guilhem Gallot
Summary: Methods for real-time observation of complex processes along living cell membranes, such as cell permeabilization, are limited. However, terahertz spectroscopy has been successfully used to reveal early events in plasma membrane alteration during photodynamic therapy (PDT) protocols, which are not observable using conventional biological techniques. This technique provides valuable real-time information about membrane defects and their relative number after PDT.
Article
Engineering, Biomedical
Xueying Ge, Raymond Wong, Anee Anisa, Shengqian Ma
Summary: Reducing the size of metal-organic framework (MOF) composites to the nanoscale has presented unique opportunities for enhanced properties. MOF-based nanocomposites offer limitless possibilities for biomedical applications. This review focuses on the recent development, classification, and construction methods of MOF-based nanocomposites for biomedical applications.
Article
Chemistry, Multidisciplinary
Yuzhi Xu, Si-Yang Liu, Leli Zeng, Hansu Ma, Yanfei Zhang, Huihui Yang, Yuchen Liu, Shuo Fang, Jing Zhao, Yunsheng Xu, Charles R. Ashby, Yulong He, Zong Dai, Yihang Pan
Summary: Cuproptosis, a copper-dependent form of regulated cell death, offers great opportunities for cancer treatment. In this study, a glucose oxidase (GOx)-engineered nonporous copper(I) 1,2,4-triazolate ([Cu(tz)]) coordination polymer (CP) nanoplatform, denoted as GOx@[Cu(tz)], is developed for starvation-augmented cuproptosis and photodynamic synergistic therapy. In vivo experimental results show its effectiveness in inhibiting tumor growth.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Marie L. Mortensen, Joanna N. Vo, Maxwell U. Hyder, Ashutosh Shrivasta, Gregory T. Mccandless, Kenneth J. Balkus Jr
Summary: A new copper complex and two new copper coordination polymers were synthesized and used to construct metal organic frameworks (MOFs).
Article
Chemistry, Multidisciplinary
P. Rafael Donnarumma, Sahara Frojmovic, Paola Marino, Hudson A. Bicalho, Hatem M. Titi, Ashlee J. Howarth
Summary: For the first time, rare-earth (RE) analogues of UiO-66 with non-functionalised 1,4-benzenedicarboxylate linkers have been synthesized, and a series of synthetic approaches provided to troubleshoot the synthesis. These RE-UiO-66 analogues are fully characterized and exhibit high crystallinity, high surface area, and thermal stability, consistent with the UiO-66 archetype.
CHEMICAL COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Sebastian Makuch, Mateusz Drozdz, Alicja Makarec, Piotr Ziolkowski, Marta Wozniak
Summary: Psoriasis is an immune-mediated skin disease that affects patient quality of life. Photodynamic therapy (PDT) shows promise in treating psoriatic lesions, but its clinical utilization remains limited. Further research is needed to evaluate the efficacy of a wider range of photosensitizers and the potential of nanotechnology in psoriasis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Xuelian Xin, Yanjiao Jing, Panpan Li, Xian Zhang, Ji Li, Linsen Li, Liangliang Zhang
Summary: An imidazole-functionalized MOF, HBU-168, has been synthesized and has shown excellent optical sensing properties for nitroaromatic compounds and metal ions. It exhibits a distinct red shift in the presence of picric acid, making it a promising fluorescent sensor.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Xia-Lu Huang, Yi-Qing Chen, Ge-Hua Wen, Song-Song Bao, Li-Min Zheng
Summary: It is well known that hydrated metal ions can act as Bronsted acids, increasing proton concentration and conductivity. However, relating proton conductive properties to the inherent Lewis acidity of metal ions is challenging. This study provides insights into the impact of different hydrated metal ions on proton conduction.
Article
Chemistry, Multidisciplinary
Wenjia Hao, Jinhao Zhang, Liqiong Luo, Quancheng Liu, Hu Deng, Juan Shen, Rufang Peng, Bo Jin
Summary: This article introduces two high-density energetic metal-organic frameworks (EMOFs) prepared by a hydrothermal method. The EMOFs exhibit good thermal stability and explosive properties similar to RDX. One of the EMOFs shows sensitivity to laser stimulation and excellent initiation performance.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Applied
Chiteri Gautam, Ayushi Singh, Suresh W. Gosavi, Ratna Chauhan, Vinod K. Sharma, Abdullah Alarifi, Mohd Afzal, Mohd Muddassir, Abhinav Kumar
Summary: Three complexes containing ferrocenyl-2-pyridylimine with Zn(II), Cd(II), and Hg(II) transition metal centers were synthesized and characterized. These complexes showed distorted tetrahedral coordination geometries and were evaluated for their application in dye sensitized solar cells (DSSCs), with the Zn-Fc/N719 assembly demonstrating superior performance compared to setup using solely N719.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Gang Li, Zhen Liu, Wanping Wang, Dong Liu, Meng-Qi Shen, Jun-Cheng Jin, Ayushi Singh, Abhinav Kumar
Summary: A new Cu(II) coordination polymer has been synthesized and demonstrated to exhibit excellent photocatalytic performance, with particular effectiveness in the catalytic degradation of methylene blue (MB). The proposed photocatalytic mechanism involves the generation of ∙OH as the main reactive oxygen species in the photodecomposition process.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Amita Singh, Gabriele Kociok-Kohn, Ratna Chauhan, Mohd Muddassir, Suresh W. Gosavi, Abhinav Kumar
Summary: Two extensively conjugated asymmetric ferrocene-appended compounds with azine spacers have been synthesized and characterized. These compounds were used as sensitizers in dye-sensitized solar cells, with one of them demonstrating better cell performance with higher J(SC), V-OC, and efficiency.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Applied
Ayushi Singh, Amita Singh, Gabriele Kociok-Kohn, Rajasekhar Bhimireddi, Anar Singh, Ashish Kumar Singh, Abhinav Kumar, Mohd Muddassir
Summary: A trinuclear heterobimetallic complex has been synthesized and successfully grafted onto 2D materials, serving as electrocatalysts for oxygen evolution reaction (OER). The modified electrodes show notable electrocatalytic activity toward OER.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biophysics
Rouqiao Zheng, Junru Guo, Xinyi Cai, Lianjie Bin, Chengyu Lu, Amita Singh, Manoj Trivedi, Abhinav Kumar, Jianqiang Liu
Summary: Manganese-based Metal-organic Frameworks (Mn-MOFs) have significant potential in biomedical applications, especially in imaging, anti-tumor therapy, and antimicrobial applications. The low toxicity, oxidative ability, and biocompatibility of Mn-MOFs make them highly desirable in medical field. Manganese complexes also show promising prospects in drug targeting.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Congying Rao, Donghui Liao, Ying Pan, Yuyu Zhong, Wenfeng Zhang, Qin Ouyang, Alireza Nezamzadeh-Ejhieh, Jianqiang Liu
Summary: This review aims to summarize recent advances in the development of MOFs for drug delivery, in particular, focusing on its ability to deliver various drugs and their release mechanism, as well as the in vivo and in vitro biological evaluation. Moreover, the future research directions of MOFs for clinical treatment are also outlined.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Chemistry, Physical
Congying Rao, Luyi Zhou, Ying Pan, Chengyu Lu, Xiangyang Qin, Hiroshi Sakiyama, Mohd. Muddassir, Jianqiang Liu
Summary: In this study, Cu/C composites were prepared by calcining synthesized metal-organic nanocapsules precursors and their photocatalytic performance was evaluated for methyl violet degradation. The influence of calcination temperature and time on catalytic activity was investigated, and the Cu@C-100 0-4 composites showed the highest photodegradation performance. The possible mechanism for the degradation of MV dye by Cu/C-100 0-4 composite was analyzed using LC-MS methodology.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Multidisciplinary
Minyue Zheng, Jinyi Chen, Lu Zhang, Ying Cheng, Chengyu Lu, Yafen Liu, Amita Singh, Manoj Trivedi, Abhinav Kumar, Jianqiang Liu
Summary: This review discusses the application of metal-organic frameworks (MOFs) in removing drugs from wastewater and the related mechanisms. It also explores rational approaches for constructing water-stable MOFs with improved drug adsorption efficiency.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Jun-Cheng Jin, Jue Wang, Jian Guo, Mei-Hua Yan, Jun Wang, Devyani Srivastava, Abhinav Kumar, Hiroshi Sakiyama, Mohd. Muddassir, Ying Pan
Summary: A 3D rare cubane-like tetrameric Cu(II)-based MOF 1 has been synthesized, characterized, and shown to effectively catalyze the photodegradation of various dyes under UV light irradiation. Among the dyes investigated, MOF 1 exhibits the best photocatalytic activity for the basic green dye.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Biochemistry & Molecular Biology
Min Xiong, Ying-Gui Xia, Lu Lu, Jun Wang, A. Mohanty, Yu Wu, Hiroshi Sakiyama, Mohd. Muddassir, Ying Pan
Summary: Nowadays, the efficient removal of organic contaminants from wastewater is a prominent area of study due to its biological as well as environmental significance. Antibiotics are now found in wastewater because of their high use, which has become a source of aquatic pollution. These antibiotics have dangerous implications for people's health. Hence, effective pharmaceutical removal from wastewater and contaminated water bodies, especially the removal of antibiotics, is of major interest to global research organizations. It is necessary to investigate this class of toxic material in wastewater discharge.
Review
Materials Science, Multidisciplinary
Minmin Li, Zhixin Zhang, Yamei Yu, Hui Yuan, Alireza Nezamzadeh-Ejhieh, Jianqiang Liu, Ying Pan, Qian Lan
Summary: This study reviews the application of zinc-based MOFs in cancer treatment, including various treatment methods, and discusses their advantages, disadvantages, and application prospects. The synthesis of typical Zn-MOFs is also reviewed.
MATERIALS ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Xiuyan Dong, Duqingcuo Li, Yuyan Li, Hiroshi Sakiyama, Mohd Muddassir, Ying Pan, Devyani Srivastava, Abhinav Kumar
Summary: The study demonstrates that metal-organic frameworks can serve as luminescent sensors for sensitive detection of antibiotics in water. Through experimental and theoretical calculations, researchers have revealed a sensing mechanism involving photoinduced electron transfer and competitive absorption.
Review
Chemistry, Multidisciplinary
Si Liu, Yuzhi Qiu, Yafen Liu, Wenfeng Zhang, Zhong Dai, Devyani Srivastava, Abhinav Kumar, Ying Pan, Jianqiang Liu
Summary: Bimetallic metal-organic frameworks (MOFs) exhibit synergistic effects and enhanced properties, and have applications in gas adsorption, catalysis, energy storage and conversion, and luminescence sensing. These MOFs still face challenges such as high moisture sensitivity, easy oxidation, and possible metal leaching.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Environmental
Ying Pan, Congying Rao, Xiaolin Tan, Yun Ling, Ayushi Singh, Abhinav Kumar, Baohong Li, Jianqiang Liu
Summary: In this study, Co@C composites with incredibly high adsorption capacity for CPZ removal were successfully designed and fabricated. The composites exhibited interconnected micro-and mesoporous structures, well-dispersed Co adsorption active sites, and superior recycling ability.
CHEMICAL ENGINEERING JOURNAL
(2022)
