Article
Chemistry, Physical
Brijith Thomas, Daniel Jardon-Alvarez, Raanan Carmieli, Johan van Tol, Michal Leskes
Summary: In DNP-NMR experiments, the polarization of unpaired electrons is transferred to nuclei, increasing the sensitivity of NMR signal. While this method is efficient in crystalline inorganic oxides, it is less effective in oxide glasses. The difference in efficiency can be attributed to shorter relaxation times and dielectric properties in glasses. These findings provide guidance in identifying suitable materials for the DNP approach.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Organic
Trinadh Kaicharla, Bhavani Shankar Chinta, Thomas R. Hoye
Summary: This article provides examples that demonstrate the value of using properly designed and easily performed doping experiments to gain insights about the nature of analytes in a H-1 NMR sample. By conducting doping experiments on a complex mixture and a simple mixture, multiple compounds were successfully identified, highlighting the advantage of doping experiments over comparing spectra from separate samples containing the same analyte.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Laura A. Voelker, Konstantin Herb, Erika Janitz, Christian L. Degen, John M. Abendroth
Summary: In this study, a quantum sensing scheme is introduced to directly measure the hypothesized spin polarization in radical pairs using shallow nitrogen-vacancy (NV) centers in diamond. This method provides fresh insights into spin selectivity in electron transfer reactions.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Multidisciplinary Sciences
K. S. Cujia, K. Herb, J. Zopes, J. M. Abendroth, C. L. Degen
Summary: The study extends nuclear magnetic resonance imaging to large nuclear spin clusters by combining weak quantum measurements, phase encoding, and simulated annealing. This method allows for the simultaneous detection of three-dimensional positions from multiple nuclei, with spatial selectivity and successful imaging of clusters containing multiple nuclear spins at room temperature.
NATURE COMMUNICATIONS
(2022)
Article
Physics, Multidisciplinary
Ainitze Biteri-Uribarren, Pol Alsina-Bolivar, Carlos Munuera-Javaloy, Ricardo Puebla, Jorge Casanova
Summary: This study tackles the detection of individual molecules by combining a hybrid sensor-a nitrogen vacancy center (NV) and a dangling bond on the diamond surface-with a multi-tone dynamical decoupling sequence. Via numerical simulations, the authors prove that the sequence minimizes the impact of decoherence, which allows using the dangling-bond as a signal amplifier.
COMMUNICATIONS PHYSICS
(2023)
Article
Physics, Multidisciplinary
Wentian Zheng, Ke Bian, Xiakun Chen, Yang Shen, Shichen Zhang, Rainer Stohr, Andrej Denisenko, Jorg Wrachtrup, Sen Yang, Ying Jiang
Summary: An efficient method was developed to engineer the electrostatic environment of near-surface nitrogen vacancy center qubits, increasing their coherence and sensitivity.
Article
Nutrition & Dietetics
Kate M. Bermingham, Mohsen Mazidi, Paul W. Franks, Tyler Maher, Ana M. Valdes, Inbar Linenberg, Jonathan Wolf, George Hadjigeorgiou, Tim D. Spector, Cristina Menni, Jose M. Ordovas, Sarah E. Berry, Wendy L. Hall
Summary: This study characterized the variability and correlations of postprandial metabolite changes in a large cohort. The majority of metabolites showed significant changes after a meal, particularly in very large lipoprotein particles and ketone bodies. Strong correlations were observed between fasting and postprandial metabolites, although some metabolites showed weak correlations.
Article
Chemistry, Multidisciplinary
Michele Porto, Paolino Caputo, Abraham A. Abe, Valeria Loise, Cesare Oliviero Rossi
Summary: This study identified the underlying causes of the non-emulsionability of bitumen through Nuclear Magnetic Resonance (NMR) and Dynamic Shear Rheology (DSR) analysis. The research also investigated the importance of additives in improving bitumen's emulsionability and discovered an uncommon method of determining acid number in bitumen as a factor influencing its emulsionability.
APPLIED SCIENCES-BASEL
(2021)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Nutrition & Dietetics
Erwin Garcia, Irina Shalaurova, Steven P. Matyus, Joelle C. Schutten, Stephan J. L. Bakker, Robin P. F. Dullaart, Margery A. Connelly
Summary: The study found that ionized magnesium levels measured by an optimized nuclear magnetic resonance method were associated with type 2 diabetes. In IRAS participants, ionized magnesium levels were significantly lower in prediabetes and type 2 diabetes patients, possibly influenced by gender, and predicted the development of future type 2 diabetes.
Article
Agriculture, Dairy & Animal Science
Matthew Barden, Marie M. Phelan, Robert Hyde, Alkiviadis Anagnostopoulos, Bethany E. Griffiths, Cherry Bedford, Martin Green, Androniki Psifidi, Georgios Banos, Georgios Oikonomou
Summary: The strongest evidence of being associated with sole lesions corresponded to phenylalanine and 4 unlabeled metabolites. The serum metabolome, as characterized by proton nuclear magnetic resonance spectroscopy, cannot predict the presence or future development of sole lesions. A small number of metabolites may be associated with sole lesions, but they can only explain a small proportion of the differences between affected and unaffected animals due to poor prediction accuracies. Future metabolomic studies should effectively control for interanimal and extraneous sources of spectral variation to reveal underlying metabolic mechanisms of sole lesion etiopathogenesis in dairy cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Veterinary Sciences
Olivia Chiu, Moran Tal, Abbinash Sanmugam, Myriam Hesta, Diego E. Gomez, Jeffrey Scott Weese, Adronie Verbrugghe
Summary: This study investigated the effect of ambient temperature exposure on microbial-derived metabolites of feline fecal samples. The results showed that short-term (up to 4 h) exposure to ambient temperature seems to be acceptable.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Huu Trong Phan, Victor Passos Gibson, Aurore Guedin, Emmanuel Ibarboure, Nadia El Mammeri, Axelle Grelard, Jean-Francois Le Meins, Erick J. Dufourc, Antoine Loquet, Suzanne Giasson, Jeanne Leblond Chain
Summary: It has been found that using conformationally pH-switchable lipids can greatly improve the cytosolic drug delivery of lipid vesicles. Understanding how these pH-switchable lipids disrupt the lipid assembly of nanoparticles and trigger cargo release is vital for optimizing their design. By combining morphological observations, physicochemical characterization, and phase behavior studies, we propose a mechanism of pH-triggered membrane destabilization. It is demonstrated that the switchable lipids are uniformly incorporated with other co-lipids and promote a temperature-insensitive liquid-ordered phase. The protonation of these switchable lipids upon acidification leads to conformational changes, causing fluctuations and local defects in the lipid vesicles and ultimately affecting the membrane permeability and cargo release.
Article
Agriculture, Dairy & Animal Science
Alice Fatet, Lydie Nadal-Desbarats, Karine Boissard, Catherine Antar, Sandrine Freret, Maria-Teresa Pellicer-Rubio, Danielle Monniaux, Ghylene Goudet
Summary: This study analyzed the serum metabolome of female goat kids before sexual maturation, identifying significant changes in citrate and 3-hydroxy-isobutyrate levels during maturation. However, further research is needed to confirm the potential link between metabolites and reproductive performance.
Article
Chemistry, Analytical
Klaudia W. Milc, Thomas Oerther, Joshua A. Dijksman, John P. M. van Duynhoven, Camilla Terenzi
Summary: A pressure-driven high-field MRI velocimetry platform was developed to accurately predict cooperative flow in strongly confined flow. Experimental observations showed that the cooperative flow of Carbopol in a 100 μm capillary was independent of flow conditions, while the cooperative flow of heterogeneous fat crystal dispersion (FCD) increased with gap size and applied pressure.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Alessandro Sicorello, Geoff Kelly, Alain Oregioni, Jiri Novacek, Vladimir Sklenar, Annalisa Pastore
BIOPHYSICAL JOURNAL
(2018)
Article
Agriculture, Multidisciplinary
Christos Fryganas, Christopher Drake, Honorata M. Ropiak, Marina Mora-Ortiz, Lydia M. J. Smith, Irene Mueller-Harvey, Radoslaw M. Kowalczyk
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Review
Food Science & Technology
Giulia Mancano, Marina Mora-Ortiz, Sandrine P. Claus
CURRENT OPINION IN FOOD SCIENCE
(2018)
Review
Plant Sciences
M. Mora-Ortiz, L. M. J. Smith
PLANT GENETIC RESOURCES-CHARACTERIZATION AND UTILIZATION
(2018)
Article
Endocrinology & Metabolism
Marina Mora-Ortiz, Marianne Trichard, Alain Oregioni, Sandrine P. Claus
Article
Multidisciplinary Sciences
Daniel S. Gutmans, Sara B-M Whittaker, Karishma Asiani, R. Andrew Atkinson, Alain Oregioni, Mark Pfuhl
Article
Immunology
Zoe Christoforidou, Marina Mora Ortiz, Carlos Poveda, Munawar Abbas, Gemma Walton, Michael Bailey, Marie C. Lewis
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Microbiology
Sokratis Stergiadis, Irene Cabeza-Luna, Marina Mora-Ortiz, Robert D. Stewart, Richard J. Dewhurst, David J. Humphries, Mick Watson, Rainer Roehe, Marc D. Auffret
Summary: Comparing rumen microbiome in cows producing milk with different fatty acid profiles revealed that cows with higher SFA content in milk had increased abundances of lactic acid bacteria and acetogenic Proteobacteria in their rumen. Microbial genes correlated with milk fatty acids were found to influence rumen metabolite concentrations, explaining a significant portion of the variation in milk fatty acid profiles. Metagenomics and metabolomics analyses highlighted differences in rumen metabolic activities among cows with contrasting FA profiles, indicating adaptations to factors like reduced rumen pH and carbohydrate fermentation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Marina Mora-Ortiz, Juan F. Alcala-Diaz, Oriol Alberto Rangel-Zuniga, Antonio Pablo Arenas-de Larriva, Fernando Abollo-Jimenez, Diego Luque-Cordoba, Feliciano Priego-Capote, Maria M. Malagon, Javier Delgado-Lista, Jose M. Ordovas, Pablo Perez-Martinez, Antonio Camargo, Jose Lopez-Miranda
Summary: This study identified 12 endogenous metabolites with the potential to predict T2DM remission. These metabolites, combined with clinical variables, can be used to provide more precise therapy.
Review
Endocrinology & Metabolism
Jose Antonio Santos-Marcos, Marina Mora-Ortiz, Manuel Tena-Sempere, Jose Lopez-Miranda, Antonio Camargo
Summary: Metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes, show sex differences in their development and prevalence, with sex hormones playing a role in sexual dimorphism. The interaction between steroid hormones and the gut microbiota influences these diseases, leading to a potential new therapeutic approach targeting the gut microbiota. This review focuses on the role of sex hormones in the development of metabolic diseases and their interaction with the gut microbiota, highlighting factors such as gut barrier integrity, inflammatory status, and the gut-brain axis.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Alejandro Villasanta-Gonzalez, Marina Mora-Ortiz, Juan F. Alcala-Diaz, Lorenzo Rivas-Garcia, Jose D. Torres-Pena, Asuncion Lopez-Bascon, Monica Calderon-Santiago, Antonio P. Arenas-Larriva, Feliciano Priego-Capote, Maria M. Malagon, Fabian Eichelmann, Pablo Perez-Martinez, Javier Delgado-Lista, Matthias B. Schulze, Antonio Camargo, Jose Lopez-Miranda
Summary: This study identified a lipid profile associated with the development of type 2 diabetes mellitus in coronary heart disease patients. A highly sensitive model combining clinical variables and lipid species was established to identify patients at risk of developing type 2 diabetes mellitus.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Agronomy
Irene Mueller-Harvey, Giuseppe Bee, Frigga Dohme-Meier, Herve Hoste, Maarit Karonen, Roland Koelliker, Andreas Luescher, Vincent Niderkorn, Wilbert F. Pellikaan, Juha-Pekka Salminen, Leif Skot, Lydia M. J. Smith, Stig M. Thamsborg, Paul Totterdell, Ian Wilkinson, Andrew R. Williams, Blasius N. Azuhnwi, Nicolas Baert, Anja Grosse Brinkhaus, Giuseppe Copani, Olivier Desrues, Chris Drake, Marica Engstrom, Christos Fryganas, Marion Girard, Nguyen T. Huyen, Katharina Kempf, Carsten Malisch, Marina Mora-Ortiz, Jessica Quijada, Aina Ramsay, Honorata M. Ropiak, Garry C. Waghorn