Article
Pharmacology & Pharmacy
Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao Pi
Summary: The study established a sporadic AD mouse model by gavage administration of acrolein, which effectively exhibited classic pathologies of AD. This model could be crucial for investigating the mechanism of AD onset and developing anti-AD drugs.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Aiko Robert, Michael Scholl, Thomas Vogels
Summary: Recent research has shown that injecting purified tau aggregates from human tauopathy patients can replicate the structural features and cell type specificity of the original tau pathology. These models may have unique translational value in studying the functional consequences of tau pathology, tau-based diagnostics, and tau-targeting therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Asgeir Kobro-Flatmoen, Thea Meier Hormann, Gunnar Gouras
Summary: This study characterizes the expression of Aβ(42) in the brains of outbred Wistar rats and compares it to the brains of human subjects without neurological disease. The results show that Aβ(42) is expressed in neurons throughout the brain of healthy Wistar rats, with the highest levels found in certain brain regions. These findings are consistent with the expression of Aβ(42) in human subjects, indicating that the McGill-R-Thy1-APP rat model for AD accurately represents the normal vulnerability to Aβ(42) accumulation in wild-type neuronal populations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Bei Zhang, Hong-Xiang Yu, Nan Zhi, Can Cui, Ying-Ying Han, Min Hu, Hao Shen, Huan Bao, Gang Li
Summary: The study discovered associations between HMOX-1 and Alzheimer's disease (AD), particularly in the dominant and recessive models of the gene after adjusting for age, gender, and education. This suggests a potential link between HMOX1 rs2071746 and AD, especially late-onset AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Julian Henao-Restrepo, Carolina Lopez-Murillo, Pablo Valderrama-Carmona, Natalia Orozco-Santa, Johana Gomez, Johanna Gutierrez-Vargas, Renato Moraga, Jorge Toledo, Jessica Lisa Littau, Steffen Haertel, Joseph F. Arboleda-Velasquez, Diego Sepulveda-Falla, Francisco Lopera, Gloria Patricia Cardona-Gomez, Andres Villegas, Rafael Posada-Duque
Summary: This study provides insights into the role of astrocytes in the development and protection of Alzheimer's disease. The study reveals differences in astrocyte reactions in different forms of the disease and suggests the potential relevance of the gliovasculature.
Article
Multidisciplinary Sciences
Hao Wang, Jonathan L. Robinson, Pinar Kocabas, Johan Gustafsson, Mihail Anton, Pierre-Etienne Cholley, Shan Huang, Johan Gobom, Thomas Svensson, Mattias Uhlen, Henrik Zetterberg, Jens Nielsen
Summary: Genome-scale metabolic models (GEMs) are extensively used for analyzing mechanisms of human diseases and metabolic disorders. A unified platform of GEMs covering five major model animals was presented, providing comprehensive metabolic network coverage and revealing a potential biomarker for early diagnosis of Alzheimer's disease through integrative analysis of RNA-sequencing and proteomics data.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Anatomy & Morphology
J. J. Rodriguez, F. Zallo, E. Gardenal, Joan Cabot, X. Busquets
Summary: This study provides a 3-D immunohistochemical and microstructural analysis of astrocytes in the brains of patients with sporadic and familial Alzheimer's disease. The findings suggest that there is noticeable atrophy in these astrocytes, which may contribute to the pathological processes and cognitive alterations observed in Alzheimer's disease.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Anatomy & Morphology
J. J. Rodriguez, F. Zallo, E. Gardenal, Joan Cabot, X. Busquets
Summary: The pathophysiology of sporadic Alzheimer's disease (SAD) and familial Alzheimer's disease (FAD) is still poorly understood, especially the role of neuroglia, specifically astroglia. This study investigated the astrocytes in the entorhinal cortex (EC) of human SAD and FAD samples using a 3-D immunohistochemical and microstructural analysis. The results showed prominent atrophic changes in astrocytes in both SAD and FAD cases, characterized by a decrease in area and volume. Contrary to previous hypotheses, there was no astrocytic loss or gliosis observed. These findings suggest that astrocyte atrophy may play a significant role in the pathological processes of AD.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Food Science & Technology
Leonardo R. Ancheta, Patrick A. Shramm, Raschel Bouajram, Denise Higgins, Douglas A. Lappi
Summary: Saporin is a ribosome-inactivating protein that can inhibit protein synthesis and cause cell death when delivered inside a cell. Using the technology of molecular surgery, Saporin has been developed as a safe and simple molecule for various purposes. It can be delivered to targeted cells through experimental molecules, such as peptides, protein ligands, antibodies, or DNA fragments, mimicking cell-binding ligands.
Article
Neurosciences
Konstantinos Chiotis, Charlotte Johansson, Elena Rodriguez-Vieitez, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Caroline Graff, Agneta Nordberg
Summary: Plasma GFAP concentration and astrocyte 11C-DED brain binding levels showed a negative correlation in both sporadic and Autosomal Dominant Alzheimer's disease. It suggests that they may reflect different states or subtypes of astrogliosis. Increased 11C-DED brain binding appears to occur earlier in the progression of Alzheimer's disease than increased plasma GFAP concentration.
MOLECULAR NEURODEGENERATION
(2023)
Article
Neurosciences
Wanrui Li, Xuanyi Pan, Ming Li, Li Ling, MengMeng Zhang, Ziming Liu, Ke Zhang, Jiguang Guo, Hongjie Wang
Summary: The study investigated the impact of age on the rotenone-induced PD model in Drosophila. The results showed that older flies displayed typical PD features, including the loss of DA neurons, decreased TH expression levels, and decreased locomotive ability. In contrast, 1-day-old flies showed unstable motor deficits and minimal TH expression changes after rotenone exposure. Additionally, the death rate of flies rapidly increased with increasing starting age after 7 days of rotenone exposure.
NEUROSCIENCE LETTERS
(2023)
Review
Neurosciences
Zhao-Di Xia, Ruo-Xin Ma, Jin-Feng Wen, Yu-Fei Zhai, Yu-Qi Wang, Feng-Yun Wang, Dan Liu, Xiao-Long Zhao, Bao Sun, Pu Jia, Xiao-Hui Zheng
Summary: This article reviews the complex pathophysiological mechanisms of Alzheimer's disease, including classical and recently proposed possible pathogenesis. It also outlines common animal models used in AD research and examines their prospects for the future. Additionally, the article summarizes clinical trials and drugs available for AD treatment.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Cell Biology
Bingxiu Ren, Jinxin Ma, Min Tao, Gongwei Jing, Sheng Han, Chengyi Zhou, Xin Wang, Jiaoya Wang
Summary: This study aimed to explore the relationship between the early stage of Alzheimer's disease (AD) and local thyroid hormone and its receptors in the brain. The results showed that compared to the control group, the experimental group of AD mice had significantly increased levels of thyroid hormone and its receptors in the brain, as well as increased levels of thyroid hormone in the serum. This suggests that early AD may be associated with local and systemic thyroid dysfunction.
Article
Chemistry, Multidisciplinary
Xianwei Chen, Guoqiang Sun, E. Tian, Mingzi Zhang, Hayk Davtyan, Thomas G. Beach, Eric M. Reiman, Mathew Blurton-Jones, David M. Holtzman, Yanhong Shi
Summary: This study established a human brain organoid-based sAD model using hiPSC-derived 3D brain organoids to mimic the serum exposure consequence of blood-brain barrier breakdown in AD patients. The model successfully recapitulated AD-like pathologies and could serve as a powerful platform for mechanistic study and therapeutic development in the future.
Review
Cell Biology
Jesus Andrade-Guerrero, Paola Rodriguez-Arellano, Nayeli Barron-Leon, Erika Orta-Salazar, Carlos Ledesma-Alonso, Sofia Diaz-Cintra, Luis O. Soto-Rojas
Summary: Alzheimer's disease is a neurodegenerative disorder with multiple pathophysiological features. Physical exercise has emerged as a promising non-pharmacological intervention for Alzheimer's disease, exerting neuroprotective effects through various mechanisms.
Article
Computer Science, Information Systems
Elahe Nasiri, Kamal Berahmand, Yuefeng Li
Summary: Link prediction is a widely studied problem in complex network analysis. The existing methods often overlook the potential of nodal attributes and only focus on the network's topological structure. To address this limitation, a novel method called RGNMF-AN was proposed, which models both the topological structure and nodal attributes for link prediction. The method combines network topology and nodal attribute information and calculates high-order proximities using the SARWS method. Empirical findings on real-world complex network datasets show that the combination of attributed and topological information significantly improves prediction performance compared to baseline and other NMF-based algorithms.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Oncology
Caicun Zhou, Dingzhi Huang, Yun Fan, Xinmin Yu, Yunpeng Liu, Yongqian Shu, Zhiyong Ma, Ziping Wang, Ying Cheng, Jie Wang, Sheng Hu, Zhihua Liu, Elena Poddubskaya, Umut Disel, Andrey Akopov, Mikhail Dvorkin, Wenjuan Zheng, Yiyuan Ma, Yan Wang, Songzi Li, Cunjing Yu, Gareth Rivalland
Summary: This article reports the results of the RATIONALE-303 trial, which investigated the efficacy and safety of tislelizumab versus docetaxel in pretreated patients with advanced NSCLC. The results showed that tislelizumab had a significantly improved overall survival compared to docetaxel.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Zhongyao Cao, Yue Li, Zhijun Zhang, Magdy F. Iskander
Summary: This article proposes a mechanically reconfigurable 1-D reflectarray that is actuated by a single motor. The reflectarray consists of metal tubes lifted by ejectors, and utilizes the discontinuity of the Archimedean spiral to achieve continuous phase growth. A novel drive mechanism, consisting of Archimedean spiral cams and followers, is designed to convert the motor rotation to linear motion of the elements. The reflectarray, supported by low-cost acrylic plates, achieved a beam steering range of -60 degrees to 60 degrees in one dimension at 5 GHz and showed a significant improvement in the received signal level in a multipath environment.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Engineering, Electrical & Electronic
Weiquan Zhang, Yue Li, Kunpeng Wei, Zhijun Zhang
Summary: This paper presents two dual-band back-to-back planar inverted-F antennas (PIFAs) for WLAN applications, which can simultaneously radiate at the 2.4 GHz and 5 GHz bands by etching a slot on the PIFA. A decoupling process using long and short slots on the ground is discussed to reduce mutual coupling. The fabricated and measured antennas show good coverage of the 2.4 and 5 GHz WLAN bands with isolation improved to higher than 20 dB at both bands.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Biochemistry & Molecular Biology
Yang Yang, Ma Yue, Han Jing, Weijia Peng, Rongbiao Pi, Yang Bo, Zeyu Zhu
Summary: The role of dietary fiber in highland barley, specifically its effects on diabetes and diabetic nephropathy, has been overlooked in recent studies. This article aimed to investigate the effects of a high-quality natural dietary fiber powder from highland barley bran (T-fiber) on hyperglycemia in diabetic mice. The results showed that T-fiber significantly reduced blood glucose levels, improved glucose tolerance, and mitigated liver and renal damage in the diabetic mouse model. These findings highlight the potential of T-fiber as a promising intervention for alleviating diabetes symptoms and improving the economic value of highland barley.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Optics
Wendi Yan, Ziheng Zhou, Hao Li, Wangyu Sun, Qihao Lv, Yue Li
Summary: Different from classical periodic-resonator-based metamaterials, epsilon-near-zero (ENZ) metamaterials achieve equivalent electromagnetic characteristics in deep subwavelength scales. By substituting dielectric dopants with metal-layer dopants, a dielectric-free approach is used to construct a low-loss resonant cavity, enabling the largest tuning range of the effective permeability mu(eff). The low-loss benefits of layer-type ENZ metamaterials are demonstrated in integrated microfluidic switches and high-sensitivity sensors, showing universal significance for wide-range applications in extreme-small-volume devices and systems.
LASER & PHOTONICS REVIEWS
(2023)
Article
Engineering, Electrical & Electronic
Xiaopeng Zhang, Dawei Zhou, Shichao Li, Yue Li, Kunpeng Wei, Zhijun Zhang
Summary: A high-gain, broadband, and +/- 45 degrees polarized patch antenna array for Wi-Fi 6/6E application with a simple configuration is proposed. The antenna is composed of a substrate board and a metal layer, with all patches and feeding circuits printed on the bottom surface of the board. T-shaped dipoles driven by parallel dual lines are used to excite the patches, and their parameters are designed to achieve broadband coverage of both 5 and 6 GHz bands of Wi-Fi 6/6E. A prototype is fabricated and tested, showing measured bandwidth and gains in agreement with simulated results. The proposed antenna offers advantages in high gain, low cost, and easy processing compared to other unidirectional antennas.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Weihao Diao, Yue Li, Zhijun Zhang
Summary: In this paper, an antenna design for unmanned aerial vehicles with a null-filled axisymmetric secant-square-shaped beam is proposed. The antenna consists of four monopoles with sequentially rotated feed and a coupling-fed grooved circular patch. The radiation power ratio is utilized for beam shaping, and the ground effect is also examined. A prototype is manufactured to validate the proposed method and antenna performance. The gain curves of the antenna align well with the secant-squared curve in the 0 to 60 degree range, with an RMSE below 1.35 dB at 5.5-5.7 GHz.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Weiquan Zhang, Yue Li, Kunpeng Wei, Zhijun Zhang
Summary: This article presents a compact multiple-input-multiple-output (MIMO) microstrip antenna system that covers the 2.4 and 5 GHz wireless local area network (WLAN) bands. The dual-band characteristics are achieved by exciting the TM01 and TM03 modes of a microstrip antenna, using a rectangular slot to improve the radiation capability of the TM03 mode, and utilizing two probes to tune the resonant frequency of the TM01 mode. High interport isolation at the two WLAN bands is achieved through isolation enhancement at the lower and upper-frequency bands, introducing split loops to reduce mutual coupling at the 2.4 GHz band, and adding dipole elements in the rectangular slot for high isolation at the 5 GHz band. The proposed antenna system operates at 2.25-2.63 and at 5.14-6.06 GHz, with measured maximum mutual coupling of less than -15.3 dB at both operating frequency bands.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Engineering, Electrical & Electronic
Shan Gao, Le Chang, Anxue Zhang, Yue Li, Zhijun Zhang
Summary: This article addresses the issue of exact coverage problem of unbalanced Wi-Fi 6 bands by engineering the TM0.5,0 and TM0.5,1 modes of the half-mode patch while maintaining small volume. The design guideline includes selecting proper patch size, optimizing feeding positions, and using lumped components. The proposed half-mode patch with the smallest volume among reported Wi-Fi 6 dual-band patch antennas fully covers the Wi-Fi 6 bands and suits the optimal Wi-Fi 6 RF front-end architecture.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Engineering, Electrical & Electronic
Mingzhe Hu, Yue Li
Summary: This paper proposes a wideband and low-profile microstrip antenna for MIMO applications, which simultaneously excites three modes to achieve wideband radiation. The proposed antenna has a compact size and low profile, making it suitable for 5G mobile MIMO applications.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Engineering, Electrical & Electronic
Xiaopeng Zhang, Dawei Zhou, Shichao Li, Yue Li, Zhijun Zhang
Summary: A simple approach is proposed to reshape the radiation patterns of the third mode of dipole and slot antennas by adding short parasitic strips or slots to both sides of the antennas. The reversed current or E-field in the third mode is canceled out by the induced current or E-field on the added parasitic elements, resulting in reshaped omnidirectional or bidirectional radiation patterns. The effects of parasitic element length, spacing, and position on radiation patterns have also been studied. Two prototypes with parasitic elements were fabricated and tested, validating the concept with good agreement between measured and simulated results.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Engineering, Electrical & Electronic
Weiquan Zhang, Yue Li, Kunpeng Wei, Zhijun Zhang
Summary: A compact dual-band multibeam antenna system with high gain is proposed for MIMO Wi-Fi application. The system consists of four rotationally symmetric antenna panels and two series-fed microstrip patch antenna arrays operating at the 5GHz band. Two dual-function metasurfaces are placed between the antenna arrays to improve the gain and provide 2.4GHz antenna functionality. The antenna system demonstrates 360 degrees pattern coverage in azimuth and high gain characteristics.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Nanoscience & Nanotechnology
Xu Qin, Yijing He, Wangyu Sun, Pengyu Fu, Shuyu Wang, Ziheng Zhou, Yue Li
Summary: This study investigates the concept of stepped waveguide metamaterials as low-loss effective replicas of surface plasmon polaritons (SPPs). The proposed structure maintains the same field configuration as regular SPPs but avoids inherent losses, outperforming regular low-loss SPP designs with natural plasmonic materials in terms of propagation lengths. Furthermore, the stepped waveguide metamaterial exhibits excellent compatibility in direct interconnections with arbitrary regular SPPs, potentially leading to new SPP devices with low-loss advantages.
Article
Engineering, Electrical & Electronic
Zhenyu Liu, Yijing He, Yue Li
Summary: This paper proposes a general approach to enhance the beamwidth of microstrip antennas for wide beam coverage in both E- and H-planes. By introducing vertical currents brought by capacitive metalized vias, the half-power beamwidth (HPBW) is effectively broadened compared to regular microstrip antennas. In addition, the use of low-loss air medium and two arrays of via fences allows for high radiation efficiency. A fabricated and tested prototype validates the proposed design, showing enhanced HPBWs of 100(degrees) and 90(degrees) in E- and H-planes, respectively. Compared to existing 2.4-GHz antennas, the proposed antenna offers the advantages of wide beamwidth and high radiation efficiency, making it suitable for space-limited mobile devices with wide coverage requirements.
IEEE OPEN JOURNAL OF ANTENNAS AND PROPAGATION
(2023)
