Article
Engineering, Biomedical
Limei Li, Mali Yu, Yao Li, Qing Li, Hongcai Yang, Meng Zheng, Yi Han, Di Lu, Sheng Lu, Li Gui
Summary: This study developed nano-hydroxyapatite/resveratrol/chitosan composite microspheres for promoting bone formation and inflammation reduction. The controlled release of resveratrol improved cell adhesion, proliferation, and osteogenic differentiation, leading to enhanced bone regeneration and fracture healing in osteoporotic conditions, indicating promising multifunctional fillers for osteoporotic bone defect/fracture treatment.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Zhuyun Cai, Heng Jiang, Tao Lin, Ce Wang, Jun Ma, Rui Gao, Yingying Jiang, Xuhui Zhou
Summary: Microspheres and microsphere-based scaffolds have shown great potential in translational medicine. This review summarizes the various fabrication methods for microspheres, discusses the limitations of existing techniques, and describes the appropriate materials and surface-modification strategies to enhance the biological properties of microspheres. The key application of microsphere-functionalized scaffolds for bone tissue engineering is also discussed.
MATERIALS TODAY ADVANCES
(2022)
Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Review
Engineering, Biomedical
Mahsa Janmohammadi, Zahra Nazemi, Amin Orash Mahmoud Salehi, Amir Seyfoori, Johnson John, Mohammad Sadegh Nourbakhsh, Mohsen Akbari
Summary: Cellulose-based scaffolds have great potential in bone tissue engineering due to their non-toxicity, biocompatibility, renewable nature, and low cost. They can deliver growth factors and antibiotics directly to the site of impaired bone tissue to promote tissue repair. This review focuses on the various types of cellulose-based composite scaffolds used for bone drug delivery systems and bone regeneration, highlighting their physicochemical, mechanical, and biological properties.
BIOACTIVE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Eduardo Anitua, Mar Zalduendo, Maria Troya, Itsasne Erezuma, Izeia Lukin, Raquel Hernaez-Moya, Gorka Orive
Summary: The study investigated the potential of three different bioinks based on gelatin and alginate for regenerative medicine. The bioinks containing hydroxyapatite and PRGF showed the highest cell compatibility and promoted osteogenic differentiation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
JiUn Lee, Dongyun Kim, Chul Ho Jang, Geun Hyung Kim
Summary: This study attempted to fabricate a 3D printed scaffold with excellent mechanical properties and recoverable behavior, using human placental extracts as bioactive components. In vitro and in vivo results suggested that the G/H/hPE scaffold is a potential candidate for use in bone tissue engineering.
Article
Chemistry, Applied
Ziqi Liu, Tianxiao Wang, Yingchao Xu, Chen Liang, Guangyu Li, Yunting Guo, Zhihui Zhang, Jianshe Lian, Luquan Ren
Summary: A double-layer dicalcium phosphate dihydrate (DCPD) sandwiched siloxane composite coating was prepared on Mg alloy via chemical conversion, immersion treatment, and biomimetic deposition methods to solve the problem of fast degradation of magnesium alloy. The composite coated sample exhibited a much smaller corrosion current density compared to Mg alloy, and the coating provided continuous protection to the sample. The hydrogen evolution of the optimal coating was significantly lower than that of Mg alloy, and the coated sample demonstrated good biomineralization ability and biocompatibility in cell experiments.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Polymer Science
Lei Li, Pengfei Lu, Yuting Liu, Junhe Yang, Shengjuan Li
Summary: In this study, 3D bioactive glass/lignocellulose composite scaffolds were successfully fabricated by 3D-printing with NMMO as the ink solvent. The scaffolds showed uniform macropores and rough surfaces, with excellent mechanical properties and hydroxyapatite-forming capability. They also exhibited low cytotoxicity to human bone marrow mesenchymal stem cells. These 3D-printed BG/cellulose scaffolds have potential applications in bone tissue engineering.
Article
Materials Science, Coatings & Films
Jorgimara de O. Braga, Diogo M. M. dos Santos, Fernando Cotting, Vanessa F. C. Lins, Nadia M. Leao, Daniel C. F. Soares, Eric M. Mazzer, Manuel Houmard, Roberto B. Figueiredo, Eduardo H. M. Nunes
Summary: Magnesium and its alloys are suitable for bone tissue engineering due to their good biocompatibility and mechanical stability. The fast biodegradation of magnesium in physiological media limits its use as a bone graft material. This study introduces a simple, environmentally friendly, safe, and easily scalable coating method that significantly improves the corrosion resistance and biocompatibility of magnesium through the deposition of a dicalcium phosphate dihydrate coating and a polyvinyl alcohol-bioactive glass composite coating.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Engineering, Chemical
K. Venkatesan, Ann Mary Mathew, P. V. Sreya, Subina Raveendran, Archana Rajendran, B. Subramanian, Deepak K. Pattanayak
Summary: A technique to develop silver nanoparticles decorated calcium titanate-titania nanostructured layer over Ti6Al4V alloy powder was successfully developed using a simple chemical and heat treatment approach, resulting in biocompatibility and antimicrobial activity. The modified alloy powders were blended with polymethyl methacrylate to develop a composite scaffold, which can be used as a scaffold or bone cement in various bone tissue engineering applications.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Engineering, Biomedical
Wentao Wang, Xiaolong Liang, Kai Zheng, Gaoran Ge, Xu Chen, Yaozeng Xu, Jiaxiang Bai, Guoqing Pan, Dechun Geng
Summary: Exosomes, small vesicles with the ability of vesicle-mediated intercellular signal transmission, have played an important role in bone tissue engineering. Compared to cells, exosomes have the advantage of cell-free therapy, which can promote bone regeneration and overcome immune rejection.
MATERIALS TODAY BIO
(2022)
Article
Polymer Science
Nadia Z. Shaban, Marwa Y. Kenawy, Nahla A. Taha, Mona M. Abd El-Latif, Doaa A. Ghareeb
Summary: This study aimed to evaluate the efficacy of novel CA composite nanofibers (CA/HA/BER and CA/HA/ME) for bone scaffolds in bone regeneration process. The results indicated that these composite nanofibers can reduce bone cell death, promote bone regeneration, with CA/HA/BER showing a better treatment effect.
Article
Materials Science, Multidisciplinary
Yong Sang Cho, Min-Soo Ghim, Myoung Wha Hong, Young Yul Kim, Young-Sam Cho
Summary: This study aimed to guide the endogenous regeneration of bone defects by designing collagen patterns loaded with bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2) on a 3D-printed polycaprolactone/nano-hydroxyapatite scaffold. The results demonstrated that the polycaprolactone/nano-hydroxyapatite/collagen scaffold with a radial pattern promoted endogenous bone regeneration and angiogenesis compared to scaffolds with positive and edge patterns.
MATERIALS & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Kenny Man, Ines A. Barroso, Mathieu Y. Brunet, Ben Peacock, Angelica S. Federici, David A. Hoey, Sophie C. Cox
Summary: This study investigated the potential of using a GelMA-LAP hydrogel to improve the retention and delivery of epigenetically enhanced osteoblast-derived extracellular vesicles (EVs). The results showed that LAP can enhance the mechanical properties and shape fidelity of GelMA hydrogels, as well as increase mineralization capacity and release of EVs from the hydrogel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Ounissa Sadoun-Daikha, Maria Luisa Gonzalez Rodriguez, L' Hachemi Azouz, Antonio M. Rabasco, Farouk Rezgui
Summary: This study aimed to develop PCL microspheres for better control of valsartan release, using experimental design to analyze the effects of independent variables on encapsulation efficiency and particle size. The optimized conditions yielded microspheres with high encapsulation efficiency and small particle size, showing improved drug release in simulated gastric fluid and sustained release in phosphate buffered saline. The mathematical modeling studies indicated that the encapsulated drug release was governed by the Fickian diffusion mechanism.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
