期刊
LEUKEMIA & LYMPHOMA
卷 60, 期 14, 页码 3395-3405出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2019.1636983
关键词
Interleukin 17; classical Hodgkin lymphoma; microenvironment; T helper lymphocytes; CD30
资金
- Italian Association for Cancer Research (AIRC, Milan, Italy)/Cariverona Foundation (Verona, Italy)
In classical Hodgkin lymphoma (cHL), the significance of the interplay between Hodgkin and Reed-Sternberg cells (HRS) and reactive T cells remains poorly defined. By immunohistochemistry on bioptic cHL specimens, we found that HRS and surrounding T lymphocytes stained positive for IL-17 in 40% of cases. IL-17 was detectable in a similar proportion of patients' sera and correlated with disease burden. Supernatants of KM-H2 and HDLM-2 cHL cell lines guided preferential chemotaxis of CCR6(+) T lymphocytes. Coculture of cHL cell lines with PBMC promoted the enrichment of Th17 lymphocytes and Foxp3(+)/IL-17(+) cells, whereas T regulatory cells slightly decreased. Soluble CD30 downmodulated membrane CD30 expression on T cells and contributed to their polarization shift by stimulating IL-17 production and reducing IFN-gamma synthesis. Thus, HRS and a number of reactive CD4(+) T cells, attracted by tumor-secreted chemokines, produce an IL-17 tumor-shaped inflammatory milieu in a cHL subset.
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