期刊
APPLIED SURFACE SCIENCE
卷 379, 期 -, 页码 489-496出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2016.04.109
关键词
Nosocomial infections; P. aeruginosa; PTFE; Hybrid nanocomposite thin films; Antimicrobial activity
类别
资金
- FEDER funds
- national funds through the program COMPETE - Programa Operacional Factores de Competitividade
- national funds through FCT - Fundacao para a Ciencia e a Tecnologia [CENTRO-07-0224-FEDER-002001, PTDC/BIA-MIC/114958/2009]
- Fundação para a Ciência e a Tecnologia [PTDC/BIA-MIC/114958/2009] Funding Source: FCT
Nosocomial infections are considered an important problem in healthcare systems and are responsible for a high percentage of morbidity. Among the pathogenic microorganisms responsible for this situation Pseudomonas aeruginosa (P. aeruginosa) is consider one of the most hazardous also due to the fact that antibiotic resistant and multi-resistant organisms begin to emerge as the prevalent strains. In this work the surface of poly(tetrafluoroethylene) (PTFE) was modified by the deposition of PTFE thin films with and without silver. The hydrophobic characteristics of PTFE were attenuated by the co-deposition of PTFE and poly(amide) (PA) with and without silver. The results show that this hospital isolated bacteria is able to degrade PTFE as bulk material as well as some of the developed thin films. However, the combination of both polymer and metal induced the formation of a nanocomposite structure with antimicrobial properties against P. aeruginosa, assessed in three different biotic tests. (C) 2016 Elsevier B.V. All rights reserved.
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