Article
Multidisciplinary Sciences
Bruno Pedraz-Petrozzi, Marta Marszalek-Grabska, Anna Kozub, Klaudia Szalaj, Alicja Trzpil, Anna Stachniuk, Eva Kathrin Lamade, Maria Gilles, Michael Deuschle, Waldemar A. Turski, Emilia Fornal
Summary: Tryptophan breakdown metabolites formed along the kynurenine pathway have a significant impact on pregnancy and fetal development. This study used liquid chromatography-tandem mass spectrometry to measure the levels of tryptophan, kynurenine, and kynurenic acid in various biological samples. The method showed good precision and accuracy, with significant differences in the concentrations of these substances in different maternal-fetal compartments. The findings provide insight into the role of the kynurenine pathway in fetal development and may contribute to further research in this field.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Stefan Moritsch, Bernadette Moedl, Irene Scharf, Lukas Janker, Daniela Zwolanek, Gerald Timelthaler, Emilio Casanova, Maria Sibilia, Thomas Mohr, Lukas Kenner, Dietmar Herndler-Brandstetter, Christopher Gerner, Mathias Mueller, Birgit Strobl, Robert Eferl
Summary: This study investigates the role of Janus kinase Tyk2 in solid tumors and suggests its tumor-suppressive functions in immune cells and epithelial cancer cells. It also reveals the different immune editing patterns and regulation of immune checkpoint genes in Tyk2-deficient tumors, highlighting the importance of Tyk2 in colorectal cancer progression and immune surveillance.
Article
Multidisciplinary Sciences
Gevi Federica, Fanelli Giuseppina, Lelli Veronica, Zarletti Gianpaolo, Tiberi Massimo, De Molfetta Veronica, Scapigliati Giuseppe, Timperio Anna Maria
Summary: Evidence shows that individuals infected by SARS-CoV-2 experience altered metabolism in multiple organs. However, our understanding of the relationship between host metabolism and inflammatory responses is limited. This study focuses on the relationship between post-infection stages of SARS-CoV-2 and distinct metabolic pathways, identifying altered metabolism of tryptophan and urea cycle pathways in peripheral blood mononuclear cells. These findings suggest a reprogramming of leukocyte metabolism related to protective immunity against SARS-CoV-2.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
Natsumi Funeshima, Ryotaro Miura, Taiga Katoh, Hikari Yaginuma, Takeshi Kitou, Itaru Yoshimura, Kunitoshi Konda, Seizo Hamano, Koumei Shirasuna
Summary: Metabolomic analysis identified 17 plasma metabolites that distinguished between repeat breeder and healthy cows, with decreased levels of various bile acids among the repeat breeders. Interestingly, no significant differences in metabolites were found in the uterine luminal fluids between the two groups.
BMC VETERINARY RESEARCH
(2021)
Review
Immunology
Li Wang, YingLan Hou, HongXia Yuan, Hongliang Chen
Summary: Chlamydia trachomatis (C. trachomatis) is a common bacterial sexually transmitted infection and a global public health concern. The mechanisms underlying C. trachomatis infection are not fully understood, but the bacterium is able to adapt to immune responses and persist within host cells. This review discusses the characteristics of chlamydial infections, the biosynthesis and regulation of tryptophan, the relationship between tryptophan and C. trachomatis, and the links between the tryptophan/IFN-gamma axis and C. trachomatis persistence.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Anje Cauwels, Sandra Van Lint, Elke Rogge, Annick Verhee, Bram Van Den Eeckhout, Shengru Pang, Marco Prinz, Niko Kley, Gilles Uze, Jan Tavernier
Summary: Type I interferon has been the first drug approved for treating multiple sclerosis, but it comes with considerable side effects. Targeting IFN activity specifically towards different immune cells can enhance protective effects against experimental autoimmune encephalitis, improving immunosuppressive capacity and cytokine responses.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Li-Yin Hung, Christopher F. Pastore, Bonnie Douglas, De'Broski R. Herbert
Summary: The study demonstrates that myeloid-derived IL-33 plays a key role in restraining colitic disease, while intestinal epithelial cell-derived IL-33 is dispensable for disease severity or tissue recovery.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Immunology
Dadi Xie, Fengfeng Li, Deshui Pang, Shiyuan Zhao, Meihua Zhang, Zhongfa Ren, Chunmei Geng, Changshui Wang, Ning Wei, Pei Jiang
Summary: This study aimed to evaluate the utility metabolomic analysis of target tissues in exploring new biomarkers for early diagnosis and treatment of IBD. The results showed significant changes in amino acid, organic acid, glucide, and purine profiles, impacting pathways ranging from amino acid metabolism to purine metabolism. Using GC-MS-based profiling of metabolite changes may provide a more comprehensive view for understanding IBD pathogenesis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Physical
Madiha Zahra Syeda, Tu Hong, Min Zhang, Yanfei Han, Xiaoling Zhu, Songmin Ying, Longguang Tang
Summary: Cancer immunotherapy has made significant progress, but low patient response rates and immune-related adverse events remain major challenges. In this study, TME responsive nanomedicine was developed to enhance antitumor immune responses and minimize side effects. The synthesized prodrug nanoparticles demonstrated effective tumor targeting, tumor growth inhibition, and activation of antitumor immunity. This study may have implications for future clinical trials.
Article
Pharmacology & Pharmacy
Tian-Yuan Yu, Yi-Ming Feng, Wei-Song Kong, Shan-Ni Li, Xue-Jiao Sun, Gui Zhou, Rui-Fang Xie, Xin Zhou
Summary: This study aimed to evaluate the effect of the natural polyphenol gallic acid (GA) on the NLRP3 inflammasome in DSS-induced colitis in mice. The results showed that GA could attenuate weight loss, relieve symptoms, and improve colonic morphological injury in mice with colitis. GA also reduced the levels of pro-inflammatory cytokines and downregulated the protein and mRNA expressions of the NLRP3 pathway. Furthermore, GA inhibited the expression of inflammatory markers and suppressed NO release in macrophage cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hansol Joo, Mi-Kyung Oh, Ji Yeon Kang, Hyun Sung Park, Dong-Hoon Chae, Jieun Kim, Jong-Hee Lee, Hee Min Yoo, Uimook Choi, Do-Kyun Kim, Hakmo Lee, Sungjoo Kim, Kyung-Rok Yu
Summary: This study demonstrates that EVs secreted from WJ-MSCs primed with ER stress inducer TSG have enhanced immunomodulatory properties, showing potential for treating immune-mediated inflammatory diseases.
Article
Microbiology
Bihui Liu, Lei Yang, Ya Wu, Xin Zhao
Summary: This study investigated the effects of Limosilactobacillus fermentum HFY06 (LF-HFY06) on murine colitis. The results showed that LF-HFY06 increased colon length and ameliorated pathological damage, enhanced antioxidant enzyme activities, reduced inflammatory cytokine levels, and inhibited inflammation through the NF-κB signaling pathway. LF-HFY06 has the potential to prevent and treat colitis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yohei Shirakami, Takayuki Nakanishi, Noritaka Ozawa, Takayasu Ideta, Takahiro Kochi, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Takuji Tanaka, Masahito Shimizu
Summary: The study showed that RQ-15986 inhibited colitis-associated colorectal tumorigenesis by attenuating inflammation, suppressing cell proliferation, and modulating the expression of indoleamine 2,3-dioxygenase. Targeting prostaglandin E2/EP4 signaling might be a useful strategy for chemoprevention of inflammation-related colorectal cancer.
Article
Biochemistry & Molecular Biology
Li-Ping Zhao, Jian Wu, Wei Quan, Yu Zhou, Hui Hong, Gu-Yu Niu, Shu-Bing Ting-Li, Shu-Bing Huang, Chen-Meng Qiao, Wei-Jiang Zhao, Chun Cui, Yan-Qin Shen
Summary: Inflammatory bowel disease can cause pathological changes in organs like the gut and brain. This study investigated the effects of DSS-induced colitis on tryptophan metabolism in serum and brain. It found that acute colitis had more severe symptoms than sub-chronic colitis and that both colitis groups altered the Trp-Kyn-Kyna pathway in serum. Only the 3% DSS group activated the Trp-Kyn pathway in the brain.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Immunology
Li-Ping Zhao, Jian Wu, Wei Quan, Yu Zhou, Hui Hong, Gu-Yu Niu, Ting Li, Shu-Bing Huang, Chen-Meng Qiao, Wei-Jiang Zhao, Chun Cui, Yan-Qin Shen
Summary: Accumulative studies suggest that inflammatory bowel disease (IBD) may cause multiple central nervous system (CNS) pathologies. This study revealed that DSS-induced colitis can lead to dysregulation of the Kyn pathway in both serum and brain, as well as alter the composition and diversity of the gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Duree Shin, Aryung Nam, Kun Ho Song, Kyoung Won Seo
JOURNAL OF FELINE MEDICINE AND SURGERY
(2019)
Article
Veterinary Sciences
Hyebin Wang, Aryung Nam, Kunho Song, Hwa Young Youn, Kyoung Won Seo
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2020)
Article
Veterinary Sciences
Hye Young Kim, Aryung Nam, Kun Ho Song, Hwa Young Youn, Kyoung Won Seo
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2020)
Article
Cell & Tissue Engineering
Hwan Hee Park, Seunghee Lee, Yeonsil Yu, Sae Mi Yoo, Song Yi Baek, Namhee Jung, Kwang-Won Seo, Kyung-Sun Kang
Article
Veterinary Sciences
Duri Song, Ye-In Oh, Jeong-Mi Kim, Doo-Sung Cheon, Dae-Yong Kim, Kyoung-Won Seo
VETERINARY MEDICINE AND SCIENCE
(2020)
Article
Veterinary Sciences
Yi-Kyeong Jeong, Ye-In Oh, Kun-Ho Song, Kyoung Won Seo
BMC VETERINARY RESEARCH
(2020)
Article
Veterinary Sciences
Jae-Geum Cho, Ye-In Oh, Kun-Ho Song, Kyoung-Won Seo
Summary: This study found that in the infection group, median levels of procalcitonin and absolute neutrophil count were significantly higher than in the normal group, while heparin-binding protein levels showed no significant difference. A procalcitonin level >366 pg/ml was a better biomarker of bacterial infection, compared to heparin-binding protein and absolute neutrophil count.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2021)
Article
Veterinary Sciences
Sookin Nam, Tae-won Kim, Kun-ho Song, Edward C. Feldman, Kyoung-won Seo
Summary: This study analyzed the accuracy of trilostane strength in medication packets filled by hand and using a semi-automatic packing device in veterinary clinics in Korea. The results showed that only 40.9% of trilostane-containing packets had acceptable strength, potentially impacting the treatment response for hyperadrenocorticism in dogs.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Da Sol Park, Jongbok Lee, Kun-Ho Song, Kyoung Won Seo
Summary: This is a case report of a cat with acute feline erythroleukaemia and FeLV infection, treated with high-dose cytarabine chemotherapy. While the clinical signs and anaemia improved after treatment, the overall survival time was short, indicating the treatment was not effective. Further studies on erythroleukaemia chemotherapy protocols are necessary.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Veterinary Sciences
Aryung Nam, Woo-Jin Song, Ju-Hyun An, Robert B. Rebhun, Hwa-Young Youn, Kyoung-Won Seo
Summary: This study reveals that the Hh/SMO signaling pathway is activated in canine OSA cell lines and that cyclopamine suppresses the survival of OSA cells by inhibiting SMO. This suggests that the Hh/SMO signaling pathway could be a potential therapeutic target for canine OSA.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Veterinary Sciences
Hyung-Kyu Chae, Ye-In Oh, Sumin Park, Ju-Hyun An, Kyoungwon Seo, Kyuyong Kang, Seung-nam Chu, Hwa-Young Youn
Summary: This study retrospectively evaluated the efficacy and safety of oral paclitaxel in dogs with various cancers. The results showed good response rates in certain cancer types and minimal adverse events. Therefore, oral paclitaxel could be a viable option for managing cancer in dogs.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Veterinary Sciences
Jae-Hyeon Im, Su-Min Park, Ju-Hyun An, Tea-Hee Kim, Hyung-Kyu Chae, Ye-In Oh, Kyoung-Won Seo, Hwa-Young Youn
Summary: This study aimed to assess the correlation between serum IL-2R and B2M concentrations and the diagnosis and prognosis of canine lymphoma. Results showed that IL-2R concentrations were significantly elevated at the time of lymphoma diagnosis, but B2M concentrations were not. In relapsed dogs, both IL-2R and B2M concentrations were significantly higher than in the control and chemotherapy response groups. Monitoring serum B2M concentration seems to be useful for predicting relapse.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Veterinary Sciences
Jongbok Lee, Jung Keun Lee, Jawon Kim, Ul Soo Choi, Kyoung Won Seo
VETERINARY MEDICINE AND SCIENCE
(2020)
Article
Veterinary Sciences
Jun-Seok Park, Jae-Hong Park, Kyoung-Won Seo, Kun-Ho Song
JOURNAL OF VETERINARY SCIENCE
(2019)
Article
Veterinary Sciences
Hwa-Ran Hong, Ye-In Oh, Young Jun Kim, Kyoung-Won Seo
JOURNAL OF VETERINARY SCIENCE
(2019)