Review
Nutrition & Dietetics
Huoyan Liang, Qingqing Mu, Wenju Sun, Liming Liu, Simin Qiu, Zili Xu, Yuqing Cui, Yan Yan, Tongwen Sun
Summary: This systematic review and meta-analysis showed that intravenous vitamin C (IVVC) treatment did not improve the 28-day mortality in septic patients. Subgroup analysis indicated a trend of reducing the 28-day mortality in patients with sepsis but not septic shock. IVVC monotherapy was found to decrease the 28-day mortality in septic patients. The study suggests that the combination therapy of Hydrocortisone, Ascorbic acid, Thiamine (HAT) is not superior to IVVC monotherapy for septic patients. Further research is needed to confirm these findings and explore the mechanisms underlying the enhanced efficacy of IVVC monotherapy in septic patients.
FRONTIERS IN NUTRITION
(2023)
Review
Critical Care Medicine
Andrea Carsetti, Riccardo Antolini, Erika Casarotta, Elisa Damiani, Francesco Gasparri, Benedetto Marini, Erica Adrario, Abele Donati
Summary: This study assessed the accuracy of shock index (SI) in predicting the need for massive transfusion (MT) and mortality in adult trauma patients. The results showed that SI may not be a reliable tool for predicting the need for MT in adult trauma patients, but it can be used to identify patients with a low risk of mortality.
Review
Oncology
Franziska Bottger, Andrea Valles-Marti, Loraine Cahn, Connie R. Jimenez
Summary: Vitamin C has potential as a potent anti-cancer agent when administered intravenously and in high doses. It demonstrates multi-targeting effects as a cancer-specific, pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator, and immune modulator. Despite lacking strong clinical data and phase III studies, there is a need for more awareness and utilization of this promising, non-toxic cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Surgery
Shimena R. Li, Francis Guyette, Joshua Brown, Mazen Zenati, Katherine M. Reitz, Brian Eastridge, Raminder Nirula, Gary A. Vercruysse, Terence O'Keeffe, Bellal Joseph, Matthew D. Neal, Brian S. Zuckerbraun, Jason L. Sperry
Summary: The study analyzed the timing and benefits of prehospital TXA administration in injured patients, finding that giving TXA within 1 hour post-injury is associated with lower 30-day mortality, reduced incidence of multiple organ failure, and decreased transfusion requirements.
Article
Surgery
Geoffrey R. Nunns, Navin Vigneshwar, Marguerite R. Kelher, Gregory R. Stettler, Lajos Gera, Julie A. Reisz, Angelo D'Alessandro, Joshua Ryon, Kirk C. Hansen, Fabia Gamboni, Ernest E. Moore, Erik D. Peltz, Mitchell J. Cohen, Kenneth L. Jones, Angela Sauaia, Xiayuan Liang, Anirban Banerjee, Arsen Ghasabyan, James G. Chandler, Sophia Rodawig, Carter Jones, Andrew Eitel, Patrick Hom, Christopher C. Silliman
Summary: Severely injured patients who developed ARDS showed increased levels of metabolites, including creatine, dehydroascorbate, fumarate, and succinate, in their plasma. Succinate played a role in priming PMNs, leading to their sequestration in the lung and eventually resulting in ARDS. Inhibition of SUCNR1 prevented PMN priming, sequestration, and ARDS. Targeting succinate and SUCNR1 could potentially prevent the development of ARDS globally.
Review
Biochemistry & Molecular Biology
Desire Pantalone, Carlo Bergamini, Jacopo Martellucci, Giovanni Alemanno, Alessandro Bruscino, Gherardo Maltinti, Maximilian Sheiterle, Riccardo Viligiardi, Roberto Panconesi, Tommaso Guagni, Paolo Prosperi
Summary: Severe burns and trauma trigger prolonged immune and inflammatory responses, impacting morbidity and mortality rates. These conditions can lead to multiorgan failure and death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Christopher Cameron McCoy, Megan Brenner, Juan Duchesne, Derek Roberts, Paula Ferrada, Tal Horer, David Kauvar, Mansoor Khan, Andrew Kirkpatrick, Carlos Ordonez, Bruno Perreira, Artai Priouzram, Bryan A. Cotton
Summary: Whole blood transfusion played a significant role in treating casualties in past wars, but civilian centers have transitioned to blood component therapies. Recent studies suggest that whole blood transfusion may be more effective for treating trauma patients.
Article
Biochemistry & Molecular Biology
Ian S. LaCroix, Mitchell Cohen, Ernest E. Moore, Monika Dzieciatkowska, Travis Nemkov, Terry R. Jr Jr Schaid, Margaret Debot, Kenneth Jones, Christopher C. Silliman, Kirk C. Hansen, Angelo D'Alessandro
Summary: This study characterized the effectiveness of red blood cell (RBC) transfusion in trauma patients using plasma metabolomics and proteomics. The results showed that transfusion of one or more RBC units can alter the levels of various compounds in circulation, potentially affecting thromboinflammatory modulation after trauma. This effect was most pronounced in patients with higher injury severity scores and was proportional to the number of units transfused. Additionally, transfusion was associated with changes in the circulating levels of coagulation factors, fibrinogen chains, and RBC proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Patrice Rosengrave, Emma Spencer, Jonathan Williman, Jan Mehrtens, Stacey Morgan, Tara Doyle, Kymbalee van der Heyden, Anna Morris, Geoff Shaw, Anitra C. Carr
Summary: This study investigated the effect of intravenous vitamin C administration on vasopressor requirements and outcomes in patients with septic shock. The results showed that intravenous vitamin C did not significantly decrease vasopressor dosage or duration. There were also no significant differences in SOFA scores, length of stay, and mortality between the intervention and placebo groups. Further research is needed to consider factors such as intervention timing, dosage, duration, and trial location to provide more definitive evidence.
Review
Nutrition & Dietetics
Kuo-Chuan Hung, Min-Hsiang Chuang, Jen-Yin Chen, Chih-Wei Hsu, Chong-Chi Chiu, Ying-Jen Chang, Chia-Wei Lee, I-Wen Chen, Cheuk-Kwan Sun
Summary: This meta-analysis investigated the effects of intravenous vitamin C on mortality rate in critically ill patients. The analysis showed that patients who received vitamin C treatment had a lower risk of mortality compared to those who did not. However, further research is needed to confirm these findings. Subgroup analysis indicated that low dosage of vitamin C was associated with reduced mortality risk, while high dosage did not show significant benefits. The use of vasopressors and mechanical ventilation was shorter in the vitamin C group.
FRONTIERS IN NUTRITION
(2023)
Article
Critical Care Medicine
Mark Barry, Alpa Trivedi, Lindsay R. Vivona, Jenna Chui, Praneeti Pathipati, Byron Miyazawa, Shibani Pati
Summary: This study evaluated the persistent endotheliopathy and organ injury after hemorrhagic shock and trauma (HS/T) in a mouse model. The results showed that endotheliopathy and lung injury were evident at 3 hours but recovered by 24 hours. This suggests that more severe injury coupled with supportive care is necessary to evaluate endotheliopathy and organ injury outside of the acute period.
Article
Biochemistry & Molecular Biology
Zhangsheng Yang, Milomir O. Simovic, Peter R. Edsall, Bin Liu, Tomas S. Cancio, Andriy I. Batchinsky, Leopoldo C. Cancio, Yansong Li
Summary: This study found that levels of HMGB1 were increased early after trauma and were associated with systemic inflammation, injury severity and traumatic brain injury. In animal experiments, CX-01 showed potential in inhibiting HMGB1 activity, reducing inflammation and tissue damage, and increasing survival, suggesting it as a possible adjuvant treatment for traumatic hemorrhage.
Article
Critical Care Medicine
Shannon C. Walker, Robert P. Richter, Lei Zheng, Amit R. Ashtekar, Jan O. Jansen, Jeffrey D. Kerby, Jillian R. Richter
Summary: Acute traumatic coagulopathy (ATC) is an endogenous impairment in hemostasis that often leads to early mortality after trauma. Damage to the endothelial glycocalyx is associated with ATC, but the specific relationship between hyaluronan (HA), a key constituent of the glycocalyx, and ATC has not been evaluated.
Review
Microbiology
Jennifer A. Munley, Stacey L. Kirkpatrick, Gwendolyn S. Gillies, Letitia E. Bible, Philip A. Efron, Ravinder Nagpal, Alicia M. Mohr
Summary: The intestinal microbiome is crucial for immune function and homeostasis in the host. Studies on patients and models of traumatic injuries have shown that trauma leads to dysregulation of immune function, systemic inflammation, and alterations in gut microbiome diversity and composition, possibly transitioning to a pathobiome state. Sex has also been identified as a variable influencing microbiome alterations after trauma. Therapies such as fecal transplantation have been used to mitigate these changes and aid in post-injury recovery.
Article
Nutrition & Dietetics
Huiyan Zhu, Xiaoya Xu, Kai Zhang, Qiaoping Ye
Summary: Intravenous vitamin C reduces short-term mortality and duration of vasopressor in patients with sepsis or septic shock, but has no effect on the length of ICU stay and SOFA score.
FRONTIERS IN NUTRITION
(2022)
Article
Veterinary Sciences
Penny S. Reynolds, Jacquelyn McCarter, Christopher Sweeney, Bassem M. Mohammed, Donald F. Brophy, Bernard Fisher, Erika J. Martin, Ramesh Natarajan
LABORATORY ANIMALS
(2019)
Article
Oncology
Rio S. Boothello, Nirmita J. Patel, Chetna Sharon, Elsamani I. Abdelfadiel, Shravan Morla, Donald F. Brophy, H. Robert Lippman, Umesh R. Desai, Bhaumik B. Patel
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Hematology
Sunita Patel-Hett, Erika J. Martin, Bassem M. Mohammed, Swapnil Rakhe, Pengling Sun, John C. Barrett, Melinda E. Nolte, Janice Kuhn, Debra D. Pittman, John E. Murphy, Donald F. Brophy
Article
Multidisciplinary Sciences
Loren K. Liebrecht, Jason Newton, Erika J. Martin, Niluka Wickramaratne, Sudha Jayaraman, Jinfeng Han, Michel Aboutanos, Donald F. Brophy, Martin J. Mangino
Article
Hematology
Mari Enoksson, Erika J. Martin, Heidi Holmberg, Mette S. Jensen, Mads Kjelgaard-Hansen, Thomas Egebjerg, Jens Buchardt, Thomas N. Krogh, Helle Demuth, Annika Sanfridson, Ida Hilden, Marianne Kjalke, Donald F. Brophy
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Letter
Cardiac & Cardiovascular Systems
Cory R. Trankle, Chau Vo, Erika Martin, Laura Puckett, Mohammad S. Siddiqui, Donald F. Brophy, Todd Stravitz, Luis A. Guzman
JACC-CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Surgery
Jonathan D. Auten, Christian S. McEvoy, Paul J. Roszko, Travis M. Polk, Ryan E. Kachur, Jean D. Kemp, Ramesh Natarajan, Greg J. Zarow
JOURNAL OF SURGICAL RESEARCH
(2020)
Article
Medicine, General & Internal
William Bianchi, Taylor George, Christian McEvoy, Mark Piehl, Ana Manzano, Michael Boboc, Gregory J. Zarow, Ramesh Natarajan, Micah J. Gaspary, Jonathan Auten, Paul J. D. Roszko
Article
Pharmacology & Pharmacy
Grady A. Fortner, John J. Devlin, Andrew J. McGowan, Michael Boboc, Ramesh Natarajan, Gregory J. Zarow
Review
Nutrition & Dietetics
Naren Gajenthra Kumar, Daniel Contaifer, Parthasarathy Madurantakam, Salvatore Carbone, Elvin T. Price, Benjamin Van Tassell, Donald F. Brophy, Dayanjan S. Wijesinghe
Article
Hematology
Erika J. Martin, Melinda E. Nolte, Janice Kuhn, Nicole Schmidt, Nils Pfaff, Donald F. Brophy
Summary: The study showed that befovacimab had dose-dependent pro-coagulant effects in vitro, with concentrations of 5 to 10 nM demonstrating similar effects on coagulation as blood samples supplemented with rFVIII 10 to 40%.
Article
Surgery
Jiepei Zhu, J. Travis Parsons, Yang Yang, Erika Martin, Donald F. Brophy, Bruce D. Spiess
Summary: The study in sheep model demonstrated minimal impact of PFC infusion on inflammatory cell lines, with a slight decrease in platelet count observed after Oxygent infusion while returning to baseline levels. No platelet effect was seen after Perftoran infusion.
JOURNAL OF SURGICAL RESEARCH
(2021)
Letter
Hematology
Kaushik Das, Usha R. Pendurthi, Marylyn Manco-Johnson, Erika J. Martin, Donald F. Brophy, L. Vijaya Mohan Rao
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Meeting Abstract
Hematology
Gary Lee Simmons, Roy Sabo, Erika Martin, Donald Brophy, Maja Radic, Bernard J. Fisher, Ramesh Natarajan, Dayanjan Wijesinghe, Alexandra Gol-Chambers, Charles E. Hall, May Aziz, Kelly G. Hawks, Ali Jafri, Robyn Bernard, Harold M. Chung, William B. Clark, John M. McCarty, Catherine H. Roberts, Alpha A. Fowler, Amir A. Toor
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)