期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 16, 期 155, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2019.0244
关键词
complex systems; self-organization; elastic networks; mechanochemical motions in enzymes; molecular motors; allosteric effects
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, through the World Premier International Research Center (WPI) Initiative
- JSPS KAKENHI [JP19K03765, JP16K05518]
While belonging to the nanoscale, protein machines are so complex that tracing even a small fraction of their cycle requires weeks of calculations on super-computers. Surprisingly, many aspects of their operation can be however already reproduced by using very simple mechanical models of elastic networks. The analysis suggests that, similar to other self-organized complex systems, functional collective dynamics in such proteins is effectively reduced to a low-dimensional attractive manifold.
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