Article
Clinical Neurology
Audrey Maillet, Elise Metereau, Leon Tremblay, Emilie Favre, Helene Klinger, Eugenie Lhommee, Didier Le Bars, Anna Castrioto, Stephane Prange, Veronique Sgambato, Emmanuel Broussolle, Paul Krack, Stephane Thobois
Summary: The severity of dopaminergic and serotonergic dysfunction in Parkinson's disease worsens with disease duration, spreading from midbrain/subcortical to cortical regions. Early onset apathy is associated with more severe dopaminergic and serotonergic disruption, similar to intermediate disease duration patients. The severity of neuropsychiatric symptoms appears primarily related to serotonergic alteration within corticostriatal limbic areas.
MOVEMENT DISORDERS
(2021)
Article
Cell Biology
Candela Barettino, Alvaro Ballesteros-Gonzalez, Andres Aylon, Xavier Soler-Sanchis, Leticia Orti, Selene Diaz, Isabel Reillo, Francisco Garcia-Garcia, Francisco Jose Iborra, Cary Lai, Nathalie Dehorter, Xavier Leinekugel, Nuria Flames, Isabel Del Pino
Summary: This study investigates the role of the tyrosine kinase receptor ErbB4 in the formation and function of serotonergic circuits by disrupting gene expression specific to serotonergic subsets. It shows that ErbB4 expression in a subset of serotonergic neurons is necessary for axonal arborization to the forebrain, but not for innervation of other targets. Additionally, ErbB4 deficiency in serotonergic neurons leads to specific behavioral deficits in memory processing, involving aversive or social components.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Li Cheng, Jiaying Liu, Zhong Chen
Summary: Histamine not only modulates the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition, and arousal, which are severely affected in neuropsychiatric disorders. Recent experimental and clinical findings show the precise role of the histaminergic system in neuropsychiatric disorders, including its cell-type role and circuit bases in narcolepsy, schizophrenia, Alzheimer's disease, Tourette's syndrome, and Parkinson's disease.
Review
Biochemistry & Molecular Biology
Ji Hwan Lee, Woojin Kim
Summary: Oxaliplatin, a commonly used chemotherapeutic agent, can induce peripheral neuropathy, but its mechanism is not yet clearly understood; the serotonergic system may play a role in neuropathic pain, but further research is needed to determine its exact role.
Review
Neurosciences
Yan Cai, Xiaolong Li, Hongli Zhou, Jiyin Zhou
Summary: Both peripheral and central serotonergic systems play a vital role in blood glucose regulation and the development of diabetes and its complications, suggesting their potential clinical significance as therapeutic targets.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Yunqi Chao, Yonghui Jiang, Mianling Zhong, Kaiyan Wei, Chenxi Hu, Yifang Qin, Yiming Zuo, Lili Yang, Zheng Shen, Chaochun Zou
Summary: Alternative splicing plays a crucial role in regulating gene expression patterns post-transcriptionally, particularly in adipogenesis. Aberrant expression and alterations in splicing regulators are linked to mutations in obesity-related genes, indicating their potential role in diet-induced obesity and metabolic dysregulation. Research on the splicing machinery's interaction with obesity and metabolic disorders provides insights for potential therapeutic strategies in clinical settings.
CELL AND BIOSCIENCE
(2021)
Review
Cell Biology
Tien-Wei Hsu, Brendon Stubbs, Chih-Sung Liang, Tien-Yu Chen, Ta-Chuan Yeh, Chih-Chuan Pan, Che-Sheng Chu
Summary: This meta-analysis demonstrates that serotonergic antidepressants effectively alleviate overall neuropsychiatric symptoms, agitation, depressive symptoms, and care burden in patients with dementia, as well as improving cognitive function.
AGEING RESEARCH REVIEWS
(2021)
Article
Behavioral Sciences
Bryony N. Thorne, Bart A. Ellenbroek, Darren J. Day
Summary: Serotonergic signaling is important in neuropsychiatric disorders, with SERT playing a crucial role. Animal models have highlighted sex differences in SERT function and brain development, but there is a bias in representation of sexes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Mariana Lapo Pais, Joao Martins, Miguel Castelo-Branco, Joana Goncalves
Summary: Tryptophan is an essential amino acid that plays a role in neuropsychiatric diseases. Women have a higher susceptibility to serotonin alterations due to changes in tryptophan levels, leading to a female sex bias in neuropsychiatric diseases. Further research is needed on the impact of diet and sex steroids on tryptophan metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Kate Thomson, Cindy Karouta, Daniel Weber, Nichola Hoffmann, Ian Morgan, Tamsin Kelly, Regan Ashby
Summary: Atropine, a commonly used drug for myopia treatment, inhibits the development of myopia by modulating serotonin receptor activity. This finding suggests the potential use of atropine in combination with serotonergic signaling regulation therapy for treating myopia.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Carolina Ramos Mendonca, Raul Manhaes-de-Castro, Barbara Juacy Rodrigues Costa de Santana, Luana Olegario da Silva, Ana Elisa Toscano, Omar Guzman-Quevedo, Ligia Cristina Monteiro Galindo
Summary: This systematic review investigated the effects of flavonols on the serotonergic system. The results showed that flavonols can modify physiological aspects of the system, increasing serotonin levels, decreasing its metabolite levels, and promoting antioxidant effects. Additionally, flavonols were found to modulate the serotonergic system, associated with antidepressant and anxiolytic activities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Behavioral Sciences
Haimei Li, Alonso Fernandez-Guasti, Yi Xu, Dick Swaab
Summary: According to the neuro-hormonal theory, sexual orientation in humans develops under the influence of sex hormones. Evidence from basic research suggests that neurotransmitters may also play a role in influencing sexual orientation, with changes in neurotransmitter systems during development potentially leading to alterations in sexual preference. This mechanism may contribute to the relationship between non-heterosexual orientation and increased prevalence of neuropsychiatric disorders in humans.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Peijun Tian, Renying Zou, Luyao Wang, Ying Chen, Xin Qian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Gang Wang, Wei Chen
Summary: This study investigated the potential psychotropic effects of a combined three-strain probiotic intervention for human MDD patients. The results showed that multi-probiotics significantly reduced depression symptoms and improved gastrointestinal functions, with serotonergic system modification as the key mechanism.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Zoology
Gerald Soslau
Summary: The serotonergic system, composed of serotonin, serotonin transporter, and serotonin receptors, plays a vital role in the cardiovascular system, regulating vascular tone and blood pressure. Understanding the mechanisms of action of serotonin is crucial for developing new drugs and treating various diseases.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2022)
Review
Behavioral Sciences
Emmanuelle Courtiol, Edenia C. Menezes, Catia M. Teixeira
Summary: Serotonin plays a critical role in development and behavior, with its involvement in reward being a topic of debate. Classical studies using electrical stimulation and pharmacological approaches have produced contradictory results on the role of serotonin in reward. More recent optogenetic studies suggest that activation of the serotonergic cells in the Raphe to VTA pathway can mediate reinforcement learning through the excitation of dopaminergic neurons. Understanding the interaction between the serotonergic and dopaminergic systems is crucial for insights into neuropsychiatric disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Jose M. Gonzalez-Dominguez, Alejandro Anson-Casaos, Laura Grasa, Luis Abenia, Alba Salvador, Eduardo Colom, Jose E. Mesonero, J. Enrique Garcia-Bordeje, Ana M. Benito, Wolfgang K. Maser
Article
Psychiatry
I Lasheras, P. Seral, E. Latorre, E. Barroso, P. Gracia-Garcia, J. Santabarbara
ASIAN JOURNAL OF PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Berta Buey, Andrea Belles, Eva Latorre, Ines Abad, Maria Dolores Perez, Laura Grasa, Jose Emilio Mesonero, Lourdes Sanchez
Summary: Lactoferrin, whey, and buttermilk have been shown to modulate intestinal innate immunity and oxidative stress on intestinal epithelial cells, making them potentially interesting ingredients for functional foods. They can reduce lipid peroxidation levels and oxidative stress induced by lipopolysaccharide, as well as alter the expression of TLR receptors. This suggests that they have the potential to mitigate inflammation and oxidative stress in the body.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ilaria Marsilio, Valentina Caputi, Eva Latorre, Silvia Cerantola, Andrea Paquola, Ana I. Alcalde, Jose E. Mesonero, Siobhain M. O'Mahony, Antonella Bertazzo, Cristina Giaroni, Maria Cecilia Giron
Summary: The study found that treatment with OxPAPCs can disrupt the structural and functional integrity of the enteric nervous system (ENS), leading to changes in serotoninergic pathways and 5-HT tissue levels, potentially increasing the risk of developing functional gastrointestinal disorders during adolescence.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Medicine, General & Internal
Monica Gros, Belen Gros, Jose Emilio Mesonero, Eva Latorre
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with unknown etiology, potentially related to neurotransmitter dysfunctions. Research has shown that IBS patients often have abnormal neurotransmitter levels, leading to exploration of novel pharmacological approaches such as 5-HT3 receptor antagonists, 5-HT4 receptor agonists, and GABA-analogous medications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Elena Layunta, Berta Buey, Jose Emilio Mesonero, Eva Latorre
Summary: Disruption of the microbiota-gut-brain axis can lead to various pathologies affecting the brain and intestine. Serotonin is identified as a crucial mediator in the communication between microbiota, gut, and brain, playing a significant role in gastrointestinal and brain physiology. The intestinal microbiota also play a key role in serotonin signaling, highlighting the importance of serotonin as a mediator in microbiota-host interactions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biophysics
J. M. Gonzalez-Dominguez, L. Grasa, J. Frontinan-Rubio, E. Abas, A. Dominguez-Alfaro, J. E. Mesonero, A. Criado, A. Anson-Casaos
Summary: This study found that the functionalized complex of single-walled carbon nanotubes and type-II nanocrystalline cellulose showed higher activity against colon cancer cells in vitro, and this effect was associated with the presence of fluorescein rather than capecitabine.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Editorial Material
Medicine, General & Internal
Eva Latorre, Jose Emilio Mesonero
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Elena Layunta, Eva Latorre, Laura Grasa, Maria Pilar Arruebo, Berta Buey, Ana Alcalde, Jose E. Mesonero
Summary: TLR9 activation inhibits serotonin transporter activity and expression, while serotonin increases TLR9 expression. This interaction may play a crucial role in maintaining intestinal homeostasis.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Ines Abad, Andrea Sanguesa, Maria Ubieto, Juan J. Carraminana, Maria D. Perez, Berta Buey, Jose E. Mesonero, Laura Grasa, Lourdes Sanchez
Summary: Milk is a valuable source of bioactive proteins that have defensive properties for protecting newborns. This study investigated the antibacterial activity of bovine milk lactoferrin (LF) against the emergent pathogen Cronobacter sakazakii and its effects on oxidative stress and Toll-like receptor expression. The results showed that LF exhibited clear antibacterial activity against C. sakazakii and inhibited its adhesion and internalization into Caco-2/TC7 cells. LF also reduced oxidative stress and altered Toll-like receptor expression, particularly the downregulation of TLR4. These findings highlight the potential of LF as an ingredient in functional foods.
INTERNATIONAL DAIRY JOURNAL
(2022)
Review
Food Science & Technology
Berta Buey, Elena Layunta, Eva Latorre, Jose Emilio Mesonero
Summary: Dairy-derived bioactive components, such as proteins and bioactive peptides, have health-promoting effects by modulating serotonin functions. These components regulate neurobiological and intestinal physiology, making them potential therapeutic adjuvants for gut-brain axis disorders.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Biology
Berta Buey, Ana Forcen, Laura Grasa, Elena Layunta, Jose Emilio Mesonero, Eva Latorre
Summary: Serotonin is a key neurotransmitter that plays a role in various behaviors and functions. Recent studies have shown that gut microbiota can modulate serotonergic signaling. This study aims to analyze the effect of short-chain fatty acids on the gastrointestinal serotonin system.