Review
Biochemistry & Molecular Biology
Masaki Kobayashi, Yusuke Deguchi, Yuka Nozaki, Yoshikazu Higami
Summary: PGC-1 alpha plays a crucial role in regulating mitochondrial function and adipocyte-specific functions in white adipose tissue, with its function being affected by metabolic changes such as obesity and caloric restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Hashim Islam, Alessandra Amato, Jacob T. Bonafiglia, Fasih A. Rahman, Nicholas Preobrazenski, Andrew Ma, Craig A. Simpson, Joe Quadrilatero, Brendon J. Gurd
Summary: In human skeletal muscle, signaling pathways, mRNA/protein expression, and substrate storage do not seem to be affected by whole-body energetic stress during the initial hours of fasting.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jihye Yoo, Jiyoung Park, Darong Kim, Yeonjoo Huh, Hea-Young Park Choo, Hyun Ae Woo
Summary: By synthesizing 12 novel compounds and evaluating their biological activities, it was found that 4 compounds exhibited strong inhibitory activities on IL-1 beta and IL-6 mRNA expression. Further in vivo activity evaluation indicated that 2 compounds significantly decreased mRNA levels of IL-1 beta, IL-6, and TNF-alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Christoph Schultheiss, Edith Willscher, Lisa Paschold, Cornelia Gottschick, Bianca Klee, Svenja-Sibylla Henkes, Lidia Bosurgi, Jochen Dutzmann, Daniel Sedding, Thomas Frese, Matthias Girndt, Jessica I. Hoell, Michael Gekle, Rafael Mikolajczyk, Mascha Binder
Summary: Post-acute sequelae of COVID-19 (PASC) is a global problem with unknown molecular drivers. A study found that 67.8% of participants, mostly with mild infections, reported PASC, with symptoms including fatigue, dyspnea, and concentration deficit. These symptoms persisted in 60% of participants over an average 8-month follow-up period. PASC was associated with elevated plasma levels of IL-18, IL-6, and TNF.
CELL REPORTS MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aline Boveto Santamarina, Ruan Carlos Macedo Moraes, Victor Nehmi Filho, Gilson Masahiro Murata, Jessica Alves de Freitas, Danielle Araujo de Miranda, Anderson Romerio Azevedo Cerqueira, Soraia Katia Pereira Costa, Ana Flavia Fernandes Ferreira, Luiz Roberto Britto, Juliana Alves de Camargo, Daniela Rodrigues de Oliveira, Flavia Neto de Jesus, Jose Pinhata Otoch, Ana Flavia Marcal Pessoa
Summary: The study found that the new nutraceutical could improve insulin resistance and hepatic steatosis by regulating gene expression of IL-6, IL-10, and Pgc-1α.
Editorial Material
Immunology
Lukai Zhai, Connie M. Krawczyk
Summary: The reduction of SPARC during caloric restriction (CR) is found to offer beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.
Article
Cell Biology
Laura Pelosi, Maria Grazia Berardinelli, Laura Forcina, Francesca Ascenzi, Emanuele Rizzuto, Marco Sandri, Fabrizio De Benedetti, Bianca Maria Scicchitano, Antonio Musaro
Summary: IL-6 is a pleiotropic cytokine with different and opposite effects under healthy and pathologic conditions. It can stimulate muscle growth in healthy conditions but may lead to muscle wasting in pathological conditions. Increased plasma levels of IL-6 may be associated with stunted growth and muscle wasting.
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Review
Oncology
Erwan Eriau, Juliette Paillet, Guido Kroemer, Jonathan G. Pol
Summary: Reduced food intake and caloric restriction mimetics have been shown to increase healthy lifespan, reduce cancer incidence, and enhance responses to certain cancer treatments. These effects are mediated by cellular mechanisms and vary between cancer cells and healthy cells due to differences in metabolic requirements. Additionally, both reduced food intake and caloric restriction mimetics can induce autophagy, improving the efficacy of certain cancer treatments that induce immunogenic cell death and enhance the therapeutic efficacy of chemo-immunotherapies.
Article
Medicine, General & Internal
Peng Deng, Nana Tang, Lin Li, Guohui Zou, Yang Xu, Zhongyong Liu
Summary: The combined detection of IL-1 beta, IL-6, and TNF-alpha shows better diagnostic value for sepsis-induced cardiomyopathy (SIC) and is closely related to the prognoses of patients.
Article
Oncology
Katherine K. Clifton, Cynthia X. Ma, Luigi Fontana, Lindsay L. Peterson
Summary: Intermittent fasting (IF) has gained popularity as a potential anticarcinogenic strategy, but its effects on cancer patients remain unclear without high-quality randomized clinical trials. More research is needed to determine the risks and benefits of IF for cancer patients before it can be recommended outside of clinical trials.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Endocrinology & Metabolism
Haoling Chen, Wenguo Fan, Hongwen He, Fang Huang
Summary: PPGC-1 (Peroxisome proliferator-activated receptor-gamma coactivator-1) is an inducible co-regulator of nuclear receptors involved in various biological responses. PGC-1 alpha and PGC-1 beta, as master regulators of mitochondrial biogenesis and function, play key roles in bone metabolism by rapidly inducing under increased metabolic activities and regulating osteoblastogenesis and osteoclastogenesis through interactions with key transcription factors.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Medicine, Research & Experimental
Evelyn Lopez Soares, Fabio Andre dos Santos, Tayline Mroczek, Debora Cristina de Lima, Hemily Victoria Bardini Josefino, Bruna Carolina Mehret Scorsin, Dionizia Xavier Scomparin, Gilson Cesar Nobre Franco
Summary: The study suggests that caloric restriction can reduce alveolar bone loss in obese rats with experimental periodontitis, while also benefiting glycemic profile and clinical periodontal measures.
Article
Medicine, Research & Experimental
Evelyn Lopez Soares, Fabio Andre dos Santos, Tayline Mroczek, Debora Cristina de Lima, Hemily Victoria Bardini Josefino, Luise Adrieli Bochenek da Silva, Leomar Emanuel Almeida Mecca, Gilson Cesar Nobre Franco
Summary: The study found that caloric restriction reduced alveolar bone loss, improved the glycemic profile, and alleviated gingival inflammation in rats with experimental periodontitis.
Article
Medicine, Research & Experimental
Gladys Ferrere, Maryam Tidjani Alou, Peng Liu, Anne-Gaelle Goubet, Marine Fidelle, Oliver Kepp, Sylvere Durand, Valerio Iebba, Aurelie Fluckiger, Romain Daillere, Cassandra Thelemaque, Claudia Grajeda-Iglesias, Carolina Alves Costa Silva, Fanny Aprahamian, Deborah Lefevre, Liwei Zhao, Bernhard Ryffel, Emeline Colomba, Monica Arnedos, Damien Drubay, Conrad Rauber, Didier Raoult, Francesco Asnicar, Tim Spector, Nicola Segata, Lisa Derosa, Guido Kroemer, Laurence Zitvogel
Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.
Review
Physiology
Tanja Oosthuyse, Juliette A. Strauss, Anthony C. Hackney
Summary: This review outlines recent advances in understanding the molecular signaling of ovarian hormones and menstrual phase variations in exercise metabolism. The study found that estrogen and progesterone have different effects on exercise performance and metabolism during different phases of the menstrual cycle, which is important for training and performance of female athletes.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Piotr P. P. Gorski, Truls Raastad, Max Ullrich, Daniel C. C. Turner, Jostein Hallen, Sebastian Imre Savari, Tormod S. S. Nilsen, Adam P. P. Sharples
Summary: Cancer survivors have impaired skeletal muscle, but aerobic training can improve this. The DNA methylation in skeletal muscle differs between cancer survivors and healthy individuals, but training can reset it towards a healthier state.
Article
Nutrition & Dietetics
Tommy Slater, William J. A. Mode, Mollie G. Pinkney, John Hough, Ruth M. James, Craig Sale, Lewis J. James, David J. Clayton
Summary: This study assessed the effects of 7-hr fasting before evening exercise on energy intake, metabolism, and performance. The study found that fasted evening exercise reduced net energy intake and increased fat oxidation, but also decreased exercise performance, motivation, and enjoyment.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Endocrinology & Metabolism
Nicole Ball, Susan Duncan, Yueying Zhang, Rocky Payet, Isabelle Piec, Eloise Whittle, Jonathan C. Y. Tang, Inez Schoenmakers, Berenice Lopez, Allison Chipchase, Arun Kumar, Leslie Perry, Heather Maxwell, Yiliang Ding, William D. Fraser, Darrell Green
Summary: Loss-of-function mutations in the CYP24A1 protein-coding region can lead to infantile hypercalcemia type 1 (HCINF1), characterized by nephrocalcinosis, hypercalcemia, hypercalciuria, and renal stone formation. Some patients with apparent CYP24A1 phenotypes do not have pathogenic mutations. This study found that certain variants in the 3' untranslated region of CYP24A1 affected mRNA secondary structure and translation, leading to abnormal 1,25(OH)2D catabolism.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Marilena Christodoulou, Terence J. Aspray, Terence J. Aspray, Isabelle Piec, Christopher Washbourne, Jonathan C. Y. Tang, William D. Fraser, Inez Schoenmakers, Terry J. Aspray, Roger M. Francis, Elaine McColl, Thomas Chadwick, Ann Prentice, Inez Schoenmakers
Summary: Bone and renal metabolism are regulated by common factors, and there is extensive cross-talk between these organs. This study investigated the influence of estimated Glomerular Filtration Rate (eGFR) on vitamin D metabolites, Wnt signaling, and bone metabolism. The findings showed that even a moderate decline in eGFR can affect vitamin D metabolism, Wnt signaling, and bone turnover markers. Vitamin D supplementation has beneficial effects on the markers of the renal-bone axis.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Physiology
Joonsung Lee, Josh E. Bridge, David R. Clark, Claire E. Stewart, Robert M. Erskine
Summary: We examined the impact of collagen hydrolysate supplementation on the properties of the patellar tendon in female soccer players. After 10 weeks of soccer training, the group receiving collagen supplementation showed increased stiffness and Young's modulus of the patellar tendon compared to the placebo group. These findings suggest that collagen supplementation may improve the mechanical and material properties of the patellar tendon in high-level female soccer players.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell Biology
J. H. Lautaoja, D. C. Turner, A. P. Sharples, R. Kivela, S. Pekkala, J. J. Hulmi, L. Yla-Outinen
Summary: The number of studies using skeletal muscle cell culture models to study exercise in vitro is increasing rapidly. Omics approaches, such as transcriptomics, proteomics, and metabolomics, have been used to analyze the molecular responses to exercise mimicking stimuli in cultured myotubes. Electrical pulse stimulation and mechanical stretch are the most commonly used methods to mimic exercise in vitro. This mini-review provides an up-to-date overview of the 2-D and 3-D models and the use of omics approaches to study the molecular response to exercise in vitro.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cell Biology
Arnold Tan, Awais Z. Younis, Alexander Evans, Jade V. Creighton, Clare Coveny, David J. Boocock, Craig Sale, Gareth G. Lavery, Amanda S. Coutts, Craig L. Doig
Summary: The PARP1 enzyme generates and applies ADP-Ribose, a post-translational modification. PARP1 plays important roles in genome maintenance, cellular identity, and energy homeostasis. In skeletal muscle cells, PARP1-mediated PARylation regulates the myogenic program and the muscle response to steroid hormones. PARylation is sensitive to glucose concentrations and glucocorticoids, which are crucial for muscle development and metabolism. PARP1 also influences the transcriptional activation of specific genes critical to skeletal muscle pathology, providing potential targets for selective glucocorticoid modulation.
CELL DEATH DISCOVERY
(2023)
Article
Public, Environmental & Occupational Health
Stephanie J. Hanley, Ian Varley, Craig Sale, Kirsty J. Elliott-Sale
Summary: This retrospective study explored the experiences of women with overweight or obesity regarding physical activity, diet and quality of life leading up to, during, and following pregnancy.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Nutrition & Dietetics
Thomas J. O'Leary, Sarah Jackson, Rachel M. Izard, Neil P. Walsh, Charlotte V. Coombs, Alexander T. Carswell, Samuel J. Oliver, Jonathan C. Y. Tang, William D. Fraser, Julie P. Greeves
Summary: This study examined the sex differences in Fe status and its association with endurance and musculoskeletal outcomes in military training. The results showed that training decreased hemoglobin and ferritin levels in both men and women, but the decrease was more significant in women. Lower ferritin levels were associated with slower endurance performance, lower bone mineral density, and higher bone metabolism markers. Therefore, improving Fe stores before training can protect hemoglobin levels, improve endurance, and prevent injury in women.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Cell & Tissue Engineering
Janelle Tarum, Hans Degens, Mark D. Turner, Claire Stewart, Craig Sale, Livia Santos
Summary: Healthy skeletal muscle has the ability to regenerate after injury, but this ability is impaired in aging muscle due to dysfunctional satellite cells and reduced myogenic capacity. This study developed a high-throughput in vitro model to assess muscle regeneration in young and aged muscle cell cultures. The results suggest that aged muscle cells have reduced regeneration capacity and show significant changes in signalling pathways associated with muscle development and contraction. Understanding these mechanisms can aid in the development of new therapies for impaired muscle regeneration in older age.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Paul A. Swinton, Kirsty J. Elliott-Sale, Craig Sale
Summary: This large cohort study examined the reliability and validity of heel ultrasound for estimating bone mineral density. The reliability between left and right heels was poor, as was the agreement with dual-energy X-ray absorptiometry. Heel ultrasound should be used cautiously for estimating bone mineral density.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Cell Biology
K. Habra, J. R. D. Pearson, P. Le Vu, C. Puig-Saenz, M. J. Cripps, M. A. Khan, M. D. Turner, C. Sale, S. E. B. McArdle
Summary: Carnosine has a significant inhibitory effect on the proliferation of prostate cancer cells and does not have detrimental effects on healthy cells. Further in vivo research is needed to determine the potential use of carnosine as a treatment for prostate cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Sport Sciences
Rita Civil, Eimear Dolan, Paul A. Swinton, Livia Santos, Ian Varley, Philip J. Atherton, Kirsty J. Elliott-Sale, Craig Sale
Summary: This study aimed to investigate the responses and variability of P1NP and beta-CTX-1 after prolonged, continuous running in young healthy adult males. The results showed that the increase in P1NP was likely due to biological artifacts, and the small decrease in beta-CTX-1 was related to the markers' circadian rhythm rather than the running intervention.
SPORTS MEDICINE-OPEN
(2023)
Article
Medicine, General & Internal
Charlotte Coombs, T. J. O'Leary, J. C. Y. Tang, W. D. Fraser, J. P. Greeves
Summary: This study investigated the bone density and biochemical markers of bone metabolism in women taking hormonal contraceptives at the start of basic military training. The results showed that the use of depot-medroxyprogesterone acetate (DMPA) was associated with increased bone turnover and decreased cortical bone integrity of the tibia, while trabecular bone was not affected by contraceptive use.
BMJ MILITARY HEALTH
(2023)