Article
Chemistry, Applied
Thomas Scattolin, Giorgia Valente, Lara Luzietti, Michele Piva, Nicola Demitri, Ilaria Lampronti, Roberto Gambari, Fabiano Visentin
Summary: New Pt(0) derivatives exhibit highly selective cytotoxicity against ovarian cancer cells, associated with the activation of an apoptosis process, suggesting a mechanism of action potentially different from cisplatin.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jose Manuel Veiga del Pino, Franco Scalambra, Cristina Bermejo-Casadesus, Anna Massaguer, Federico Garcia-Maroto, Antonio Romerosa
Summary: A water-soluble ruthenium complex was synthesized and characterized by various techniques. Its optical and biological properties were studied and compared with other ruthenium complexes. The complex showed high anticancer activity under visible light irradiation and exhibited no toxicity against red blood cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ilya G. Shenderovich
Summary: The P-31 chemical shift of 1,3,5-triaza-7-phosphaadamantane (PTA) is solely influenced by non-covalent interactions, with a maximum change of 6 ppm due to hydrogen bonding, but over 100 ppm when the phosphorus atom is coordinated to a metal. This difference can be utilized to validate or refute structural models of organometallic transition metal complexes by comparing experimental and DFT calculated values.
Article
Chemistry, Inorganic & Nuclear
Malgorzata Kwiatkowska, Piotr Kielbasinski
Summary: The enzyme-promoted hydrolysis of racemic ester derivatives of PTA 11 and its P-sulfide 12 resulted in unreacted esters and corresponding acids, with moderate yields depending on the solvent and enzyme used. However, the products obtained were racemic mixtures in all cases.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2022)
Article
Chemistry, Inorganic & Nuclear
Csenge Tamara Szolnoki, Gabor Papp, Henrietta Horvath, Ferenc Joo, Agnes Katho, Antal Udvardy
Summary: In aqueous HBr solution, PTA yielded the triprotonated form and another compound. The solid state structures of some compounds were determined by X-ray diffraction.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2022)
Article
Chemistry, Multidisciplinary
Ivy L. Librando, Abdallah G. Mahmoud, Sonia A. C. Carabineiro, M. Fatima C. Guedes da Silva, Carlos F. G. C. Geraldes, Armando J. L. Pombeiro
Summary: Three hydrophilic PTA ammonium salts were synthesized through N-alkylation and used to prepare a new set of water-soluble copper(I) complexes, which showed high catalytic activity in one-pot azide-alkyne cycloaddition reactions. The most active catalysts were immobilized on activated carbon and carbon nanotubes, displaying efficient catalytic performance and recyclability.
Article
Biochemistry & Molecular Biology
Javier Quero, Francesco Ruighi, Jesus Osada, M. Concepcion Gimeno, Elena Cerrada, Maria Jesus Rodriguez-Yoldi
Summary: Temperature can affect the properties of some anticancer drugs, improving their efficiency and selectivity. Gold(I) complexes derived from phosphanes have been found to exhibit antiproliferative effects on colon cancer cells by influencing the intracellular redox state and cell cycle, leading to apoptosis. Furthermore, this cytotoxic effect is enhanced by hyperthermia and polyfluorinated chains.
Article
Chemistry, Multidisciplinary
Vishakha Kaim, Sandeep Kaur-Ghumaan
Summary: Two new mononuclear Mn(i) carbonyl complexes with phosphaadamantane-substituted ligands were synthesized, showing good solubility in aqueous media and effective catalytic activity for electrochemical proton reduction reactions.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Belen Lopez-Sanchez, Ana Belen Bohome-Espinosa, Franco Scalambra, Antonio Romerosa
Summary: The complex [RuCp(H2O-kappa O)(mPTA)(2)](CF3SO3)(3)center dot MeOH (4 center dot MeOH) was synthesized and its crystal structure determined by X-ray diffraction. The catalytic activity of 4 for the redox isomerization of 2-cyclohexen-1-ol into cyclohexanone was studied in different systems, with the highest conversion rate achieved in biphasic water/cyclohexane. The aqueous phase containing 4 was recycled up to 7 consecutive runs without significant losses of catalyst.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sofie M. P. Vanden Broeck, Catherine S. J. Cazin
Summary: This review focuses on manganese complexes bearing N-heterocyclic carbene (NHC) ligands. The complexes exhibit different properties in various oxidation states and are widely used in catalytic reactions, particularly in CO2 reduction, hydrosilylation and alkylation.
Article
Chemistry, Multidisciplinary
Wioletta Kosnik, Dawid Lichosyt, Marcin Sniezek, Angelika Janaszkiewicz, Krzysztof Wozniak, Maura Malinska, Bartosz Trzaskowski, Anna Kajetanowicz, Karol Grela
Summary: The formation of sterically hindered C-C double bonds through catalytic olefin metathesis is a challenging task for Ru catalysts. To overcome this limitation, a new NHC ligand was designed, which reduced the susceptibility of small-size NHC catalysts to decomposition. The resulting isomeric complexes exhibited similar high thermodynamic stability but different application profiles in catalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Anita Bhatia, Senthilkumar Muthaiah
Summary: Four new water-soluble bidentate ligands containing phosphadamantane have been synthesized and characterized. Compound 1 is the first example of a water-soluble chelating cyclopentadienyl ligand containing 1,3,5-triaza-7-phosphaadamantane.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2023)
Review
Chemistry, Multidisciplinary
Thomas Scattolin, Giovanni Tonon, Eleonora Botter, Sebastien G. Guillet, Nikolaos V. Tzouras, Steven P. Nolan
Summary: The review focuses on the design of gold-based synthons that enable the synthesis of target complexes through simple steps under mild conditions. Mechanistic aspects of their synthesis and reactivity, as well as applications as efficient pre-catalysts, antitumor agents, and photo-emissive materials, are discussed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Antal Udvardy, Csenge Tamara Szolnoki, Eva Kovats, David Nyul, Gyula Tamas Gal, Gabor Papp, Ferenc Joo, Agnes Katho
Summary: A new solvent-free synthesis method has been developed for the clean synthesis of a P-carboxy-ethyl derivative with high yield. The resulting phosphabetaine formed crystalline 1D coordination polymers, whose solid state structures were influenced by the anion of the Ag+-salt used in synthesis. The new Ag-based coordination polymers were characterized using various techniques, revealing their loss of polymeric nature upon dissolution in water.
INORGANICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Stefan Czarnocki, Louis Monsigny, Michal Sienkiewicz, Anna Kajetanowicz, Karol Grela
Summary: A modular and flexible strategy for synthesizing N-heterocyclic carbene (NHC) ligands bearing Bronsted base tags has been proposed and used to prepare two tagged NHC ligands with different acid residues. These tagged NHC ligands serve as an attractive starting point for the synthesis of olefin metathesis ruthenium catalysts with non-dissociating ligands. The impact of the Bronsted base tags on the activity of the obtained olefin metathesis catalysts has been investigated.
Article
Chemistry, Multidisciplinary
Oliwia Matuszewska, Tommaso Battisti, Ruben R. Ferreira, Nicolas Biot, Nicola Demitri, Cecile Meziere, Magali Allain, Marc Salle, Samuel Manas-Valero, Eugenio Coronado, Elisa Fresta, Ruben D. Costa, Davide Bonifazi
Summary: Peri-thiaxanthenothiaxanthene is a sulfur-doped derivative of peri-xanthenoxanthene, which can be used to manipulate the properties of semiconductor materials by adjusting the oxidation state of the sulfur atoms. Chemical and electrochemical oxidation of peri-thiaxanthenothiaxanthene resulted in the formation of sulfoxide, sulfone, and sulfonium derivatives. These derivatives exhibited unique molecular and solid-state arrangements, with face-to-face pi-pi stacking organization. The optical bandgap of the compounds increased as the sulfur atoms were progressively oxidized, with the bis-sulfone derivative displaying the widest bandgap. The MV complexes showed high conductivity at room temperature, making them promising for semiconductor applications. Additionally, the electroluminescence properties of the complexes were tested, and they were found to be the first sulfur-doped mid-emitting PAH-based light-emitting electrochemical cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Riccardo Barbari, Chiara Tupini, Elisa Durini, Eleonora Gallerani, Francesco Nicoli, Ilaria Lampronti, Anna Baldisserotto, Stefano Manfredini
Summary: A current research trend in the health field is to discover multifunctional compounds that can interact with multiple biological targets, simplifying multidrug therapies and improving patient compliance. This study synthesized new chemicals with a benzothiazole structure and tested them for antioxidant, UV-filtering, and antitumor activities. Compound BZTcin4 showed excellent activity and selectivity towards Colo-38, with good antioxidant capacity and broad-spectrum photoprotective profile.
Article
Chemistry, Multidisciplinary
Andrea Pizzi, Andrea Daolio, Roberta Beccaria, Nicola Demitri, Fiorenza Viani, Giuseppe Resnati
Summary: Experimental findings confirm that the sulfur atom in benzisothiazolinones has a remarkable tendency to form short and directional chalcogen bondings, suggesting the crucial role of sulfur's electrophilicity in initiating the biopharmacological activities of these compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Miriam Calabrese, Andrea Pizzi, Andrea Daolio, Maurizio Ursini, Antonio Frontera, Nicola Demitri, Carsten Lenczyk, Jakub Wojciechowski, Giuseppe Resnati
Summary: This study discovers that the C(sp3) atoms on the methylene moiety can act as electrophilic sites in self-assembly processes and form bidentate tetrel bonds with nucleophiles. Experimental (X-ray structural analysis) and theoretical evidence (DFT calculations) have confirmed this finding.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Inorganic & Nuclear
Enrica Bortolamiol, Giacomo Isetta, Isabella Caligiuri, Nicola Demitri, Stefano Paganelli, Flavio Rizzolio, Thomas Scattolin, Fabiano Visentin
Summary: A general method for synthesizing novel cationic Pd(II) indenyl complexes with one alkyl/aryl phosphine and one N-heterocyclic carbene is reported. The complexes showed high stability in both solid and solution states. These organopalladium compounds have shown promising potential as antiproliferative agents against ovarian cancer cells and as catalysts in Suzuki-Miyaura coupling reactions in aqueous media.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Chiara Tupini, Matteo Zurlo, Jessica Gasparello, Irene Lodi, Alessia Finotti, Thomas Scattolin, Fabiano Visentin, Roberto Gambari, Ilaria Lampronti
Summary: This study demonstrates that the combination therapy using PNA targeting miR-221 and a new palladium allyl complex is effective in inducing apoptosis in tumor cells. Therefore, this combination treatment could be a promising approach for cancer control.
Article
Biochemistry & Molecular Biology
Anna Baldisserotto, Riccardo Barbari, Chiara Tupini, Raissa Buzzi, Elisa Durini, Ilaria Lampronti, Stefano Manfredini, Erika Baldini, Silvia Vertuani
Summary: This research explored the use of plant extracts as potential new active ingredients in nutrition, cosmetics, and pharmaceuticals. The study focused on Moringa oleifera, a plant known for its nutritional properties, and evaluated the antioxidant, antifungal, photoprotective, and cytotoxicity effects of different extracts and infusions obtained from leaves harvested in Paraguay. The results suggest that Moringa oleifera could be beneficial in combating skin aging and oxidative stress, and may have potential applications as natural additives in sunscreens.
Article
Chemistry, Multidisciplinary
Giulio Pavan, Luca Morgan, Nicola Demitri, Chiara Alberoni, Thomas Scattolin, Alessandro Aliprandi
Summary: A family of novel thermally activated delayed fluorescence (TADF) emitters was synthesized by a simple and metal-free method, and their structures were characterized. The photophysical and electrochemical properties of different donors were systematically tested and correlated with their performance in electrochemiluminescence using benzoyl peroxide as a co-reactant or in annihilation conditions. Efficiency in electrochemiluminescence was mainly determined by the electrochemical reversibility of the redox processes rather than the photophysical properties, and the annihilation efficiency strongly depended on the pulse sequence. The alkylated imidazole moiety allowed for the insertion of functional groups, enabling practical applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Francesca Arcudi, Andrea Sartorel, Anna Fortunato, Tomas Marangoni, Nicola Demitri, Michele Maggini, Luka Dordevic
Summary: A new triflatophenylporphyrin building block for Pd-catalyzed cross-coupling reactions is proposed. Compared to halophenylporphyrins, its purification is much easier. The triflatophenylporphyrin is also suitable in microwave-assisted Sonogashira cross-coupling and has been used to prepare a donor-acceptor array.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Ilenia D'Abbrunzo, Emma Bianco, Lara Gigli, Nicola Demitri, Rebecca Birolo, Michele R. Chierotti, Irena Skoric, Jennifer Keiser, Cecile Haberli, Dario Voinovich, Dritan Hasa, Beatrice Perissutti
Summary: This paper presents a successful case of combining drugs through cocrystallization, resulting in a novel solid with favorable properties. The cocrystal exhibits higher anthelmintic activity and prevents the transformation of one drug into an insoluble form.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Biomaterials
Kanwal Asif, Muhammad Adeel, Md. Mahbubur Rahman, Isabella Caligiuri, Tiziana Perin, Maja Cemazar, Vincenzo Canzonieri, Flavio Rizzolio
Summary: ChemoDynamic Therapy (CDT) utilizes Fenton/Fenton-like reactions to generate oxidative stress for cancer treatment. However, the limited catalyst ions and ROS scavenging activity of GPX4 restrict its application. Therefore, an efficient strategy to regulate the Fenton reaction (using dual metal cations) and inhibit GPX4 activity is highly desired.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Giuseppe Gentile, Beatrice Bartolomei, Jacopo Dosso, Nicola Demitri, Giacomo Filippini, Maurizio Prato
Summary: This paper reports the synthesis and characterization of a novel pi-extended tetra-phenol dihydrophenazine, which exhibits high reducing properties in the excited state and shows excellent catalytic activity in dehalogenation and C-C bond formation reactions. This functionalized pi-extended dihydrophenazine demonstrates great potential as an organo-photocatalyst.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Luca Morgan, Giulio Pavan, Nicola Demitri, Chiara Alberoni, Thomas Scattolin, Marco Roverso, Sara Bogialli, Alessandro Aliprandi
Summary: A unified metal-free procedure was used to synthesize and characterize a selection of Thermally Activated Delayed Fluorescence (TADF) emitters. A promising compound with terephthalonitrile as the acceptor and diphenylamines as donors showed significantly higher electrochemiluminescence efficiency than the standard [Ru(bpy)3](PF6)2. A novel water-soluble TADF emitter (Na4[4DPASO3TPN]) was also synthesized and characterized for electrochemiluminescence in an aqueous medium.
Article
Chemistry, Multidisciplinary
Yijue Xu, Miriam Calabrese, Nicola Demitri, Andrea Pizzi, Tamali Nag, Ivan Hung, Zhehong Gan, Giuseppe Resnati, David L. Bryce
Summary: The bonding between rhenium and organic perrhenates is investigated using Re-185/187 solid-state NMR and Re-185/187 NQR techniques. The quadrupolar couplings of Re-185/187 can distinguish MaB samples from control samples, and their precise values are affected by the shear strain of ReO4- anions.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yijue Xu, Miriam Calabrese, Nicola Demitri, Andrea Pizzi, Tamali Nag, Ivan Hung, Zhehong Gan, Giuseppe Resnati, David L. Bryce
Summary: In this study, the bonding between rhenium and the matrix in a set of organic perrhenates was investigated using Re-185/187 solid-state NMR and Re-185/187 NQR techniques. The quadrupolar couplings of Re-185/187 were able to distinguish between MaB samples and control samples, and their precise values were determined by the shear strain of the ReO4- anions.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Guojun Hu, Ziyue Deng, Yanwei Wang, Dan Yuan, Yong Zhang, Yingming Yao
Summary: A series of rare-earth metal complexes were synthesized and used as efficient initiators for the polymerization of trimethylene carbonate (TMC) and (L)-lactide ((L)-LA).
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Van Ha Nguyen, John H. K. Yip
Summary: In this study, eight PtII-azulene complexes were synthesized to investigate the effect of metalation on the electronic structures, spectroscopy, and luminescence of organic chromophores. The results showed that the attachment of Pt substituents to azulene affected the HOMOs, LUMOs, and luminescence properties. The study provides insights into the role of metalation in modifying the properties of organic chromophores.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Moon Kedia, Virender Singh, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: This study synthesized two types of neutral binuclear metallocycles using a one-pot solvothermal method and characterized their structures. The analysis revealed that these complexes adopt a binuclear heteroleptic cyclic architecture and belong to phosphine oxide donor (P=O)-based supramolecular coordination cyclic complexes.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Radhey S. Srivastava
Summary: This study demonstrates the effectiveness of zero-valent elements as reductants for the deoxydehydration reaction of polyols catalyzed by ONO-pincer ligated molybdenum dioxo. The insolubility and easy separability of the reductants and their oxidized products during the reaction are emphasized. Additionally, the choice of ligand has an impact on the catalytic performance of the reaction.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Hao Zhou, Yajun Sun, Li Deng, Weiran Yang, Yuehui Li
Summary: Efficient Ru-catalyzed hydrogenation of aldehydes was achieved using carbazole-derived phosphine ligands, with the crucial role of N-H moiety in promoting the catalytic reaction. The method was successfully applied in the Co/Ru-catalyzed hydroformylation process, resulting in the production of long-chain alcohols with excellent yields.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Theodor Danescu, Alexandru Lupan, Radu Silaghi-Dumitrescu, R. Bruce King
Summary: The structures and energies of complexes containing (Me2C2N2P)2Ru2(CO)n and (Me2C2N2P)2Fe2(CO)n have been studied. Low-energy structures are characterized by the presence of bridging diazaphospholyl rings, while higher-energy structures involve different ligand structures.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Savannah C. Kapper, Aamani Ponnekanti, Jonas Schaab, Tian-yi Li, Christine L. Chung, Gael Ung, Peter I. Djurovich, Mark E. Thompson
Summary: Organometallic iridium complexes with two cyclometalated ligands and one bis-oxazoline derived ancillary ligand were studied. These complexes have emission spanning across the visible and near-ultraviolet region, with moderate to high photoluminescence quantum yields. The (ppy)2Ir(BOX-CN) complexes were resolved into Delta- and Lambda-diastereomers based on solubility differences.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Zahra Karimi Sangari, Hossein Naeimi
Summary: In this research, a nanostructured CoCuFe2O4 catalyst was prepared using a brief and useful synthetic strategy. This catalyst was used for synthesizing 1,2,4,5-tetrasubstituted imidazole derivatives under ultrasonic irradiation. The approach offers advantages such as high efficiency, short reaction times, simplicity of the reaction medium, accelerated reaction rates, and easier separation and purification of products.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Rukhsana Gul, Wajid Munir, Ebraheem Abdu Musad Saleh, Shaukat Shujah, Muhammad Sirajuddin, Saira Tabassum, Khalil Ur Rehman, Dilfaraz Khan, Sameerah I. Al-Saeedi, Ehab A. Abdelrahman
Summary: Two new Schiff base ligands were synthesized and used to form copper, nickel, and cobalt complexes. The synthesized compounds were characterized and screened for various biological activities. The metal complexes showed better activities in antibacterial, antifungal, antidiabetic, and antioxidant assays.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Review
Chemistry, Inorganic & Nuclear
Ahsan Nazir, Pengwei Huo, Ameena Tur Rasool
Summary: This review explores the potential of g-C3N4-based S-scheme heterojunctions in addressing environmental issues. It summarizes the mechanism and preparation techniques of S-scheme heterojunctions based on g-C3N4, and presents recent studies on their applications in pollutant removal, CO2 reduction, hydrogen production, and bacterial disinfection. The review concludes with an outlook on future challenges for g-C3N4-based S-scheme heterojunctions.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Francois Mazars, Koffi Senam Etse, Guillermo Zaragoza, Lionel Delaude
Summary: The activity of three Pd-PEPPSI catalyst precursors with N-heterocyclic carbene (NHC) ligands derived from caffeine and theophylline in Mizoroki-Heck reactions was tested. The results showed that the catalysts achieved high conversions and yields, especially in the presence of electron-withdrawing substituents.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Bo-Han Wu, Xue Zhou, Lin Liu, Zheng-Bo Han
Summary: Researching carbon dioxide removal from flue gas and natural gas is crucial. Metal-organic frameworks (MOFs) are commonly used in adsorption due to their high surface area, porosity, and chemical properties. An ultra-microporous MOF CPM-20(Co) with mixed ligand was synthesized using inexpensive ligands. The material exhibited high selectivities and low regenerative energy, making it a promising option for CO2 separation in industries.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)