Article
Food Science & Technology
Saranya Suwanangul, Pannapapol Jaichakan, Nukrob Narkprasom, Supaluck Kraithong, Kanjana Narkprasom, Papungkorn Sangsawad
Summary: This study investigated the use of different encapsulating agents to protect Bacillus coagulans spores and maintain their bioactivity. The results showed that SMC5 was the optimal condition for microencapsulation and gastrointestinal digestion, offering both protection and bioactivity preservation for the spores.
Article
Food Science & Technology
Chia-Wei Liao, Man-Chia Hung, Chung-Yi Wang, Bang-Yuan Chen
Summary: This study evaluated the survival of Bacillus coagulans spores (BCS) in pineapple juice, cold brew tea, and cold brew coffee pasteurized using high-pressure processing (HPP) or thermal processing (TP). The results showed that HPP or TP alone reduced the microbial count to below the detection limit in all samples, but had little effect on BCS. No significant differences were observed in the pH value and total soluble solids for the entire storage period. However, TP did change the color of the beverages. In addition, the BCS had a high survival rate in gastrointestinal tract simulation tests and the sensory qualities of the beverages were retained regardless of the pasteurization treatment used.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Eunbyul Cho, Ju Young Kim, Belong Cho, Joong Su Lee, Yeo Cho Yoon, Yong Chul Shin, Hyerim Kim, Siye Gil, Sohye Kim
Summary: This study evaluated the efficacy of Curezyme-LAC, a mixture of six fermented grains by B. coagulans, in reducing fat mass in adults with obesity. After 12 weeks of treatment, the Curezyme-LAC group showed significant reductions in visceral adipose tissue, total fat mass, body weight, BMI, and waist circumference compared to the placebo group.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Muhammed Majeed, Shaheen Majeed, Sivakumar Arumugam, Furqan Ali, Kirankumar Beede
Summary: The study showed that Bacillus coagulans MTCC 5856 demonstrated excellent resistance to high temperatures (90 degrees C) and gastric acid, making it suitable for a wide range of functional foods such as milk, fruit juices, chapati, and wheat noodles.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Biaosheng Lin, Dingyan He, Wenying Wen, Bin Lin, Yan Li, Xiaohong Chen
Summary: Bacillus coagulans LYBC06 strain with lactate-producing capacity was isolated from a fattening pig's digestive tract. Resequencing revealed a less variable genome with a heterozygous ratio of 0.042%, SNP variants of 0.4273% and InDel mutations of 0.0182%. Mutated genes were involved in strain growth, energy metabolism regulation, and production of proteases and lactate. The LYBC06 strain had similar characteristics to other Bacillus coagulans strains and the production of lactate was associated with the LdhL1 gene.
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
(2023)
Article
Chemistry, Multidisciplinary
Huai-Song Wang, Xing-Yu Wang, Hao-Tian Ding, Xin-Yuan Hu, Jie Li, Chen Cheng, Feng Zheng
Summary: In this study, a whole-cell biosensor was designed to monitor the in situ generated nitrosamines by detecting nitrosamine-induced DNA damage. To protect the biosensor in the gastric acid environment, a metal-organic gel was used for encapsulation. This approach successfully detected the genotoxicity of nitrosamines converted from nitrite in the gastrointestinal tract of mice.
Review
Biochemistry & Molecular Biology
Guangming Zhong
Summary: Research findings suggest that Chlamydia trachomatis plays a significant role in genital tract pathogenicity but can also colonize the gastrointestinal tract for extended periods. Plasmid and chromosome-encoded factors have varying importance in colonization of different parts of the GI tract, playing crucial roles in the spread and colonization of Chlamydia.
TRENDS IN MICROBIOLOGY
(2021)
Article
Oncology
Shan-Shan Li, Xiao-Hui Zhai, Hai-Ling Liu, Ting-Zhi Liu, Tai-Yuan Cao, Dong-Mei Chen, Le-Xin Xiao, Xiao-Qin Gan, Ke Cheng, Wan-Jia Hong, Yan Huang, Yi-Fan Lian, Jian Xiao
Summary: Our study provides a comprehensive view of the exonic mutation profile of the largest pGI-DLBCL cohort to date. The results could facilitate the clinical development of novel therapeutic and prognostic biomarkers for pGI-DLBCL.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Microbiology
Yuqi Li, Jian Gao, Yihan Xue, Ruolin Sun, Xiaoni Sun, Zhanying Sun, Suozhu Liu, Zhankun Tan, Weiyun Zhu, Yanfen Cheng
Summary: This study investigated the bacterial composition and metabolic pathways in the gastrointestinal tracts (GITs) of Hu sheep fed with wheat straw (WS) instead of alfalfa (AL) in isocaloric and isonitrogenous diets. The results showed that the replacement of AL with WS significantly affected the rumen microbiota, hindgut microbiota, and metabolism networks. Feeding WS had an impact on the structure and function of the bacterial network in the GITs of Hu sheep.
Article
Biotechnology & Applied Microbiology
Yuhong Lai, Xiuyun Wu, Xianliang Zheng, Weiguang Li, Lushan Wang
Summary: This study investigated the characteristics of feather degradation by Bacillus sp. CN2 using functional-degradomics technology. It was found that CN2 had strong feather keratin degradation activity and produced efficient keratinases that could degrade feathers into small peptides and release soluble proteins. This study provides insights into the degradation mechanisms of keratinous substrates and may inspire the design of optimal enzyme cocktails for industrial applications.
BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS
(2023)
Article
Gastroenterology & Hepatology
Keisaku Yamada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Eri Ishikawa, Takuya Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Eizaburo Ohno, Hiroki Kawashima, Takashi Honda, Masatoshi Ishigami, Mitsuhiro Fujishiro
Summary: PCCE-2 shows a high diagnostic yield for lesions in the whole GI tract of patients with CD, recommending its use as a pan-enteric tool in clinical settings.
BMC GASTROENTEROLOGY
(2021)
Article
Oncology
Alessandra Macciotta, Alberto Catalano, Maria Teresa Giraudo, Elisabete Weiderpass, Pietro Ferrari, Heinz Freisling, Sandra M. Colorado-Yohar, Carmen Santiuste, Pilar Amiano, Alicia K. Heath, Heather A. Ward, Sofia Christakoudi, Paolo Vineis, Deependra Singh, Salvatore Vaccarella, Matthias B. Schulze, Anouk E. Hiensch, Evelyn M. Monninkhof, Verena Katzke, Rudolf Kaaks, Rosario Tumino, Fulvio Lazzarato, Lorenzo Milani, Antonio Agudo, Christina C. Dahm, Laura Baglietto, Vittorio Perduca, Gianluca Severi, Sara Grioni, Salvatore Panico, Eva Ardanaz, Kristin B. Borch, Faith O. Benebo, Tonje Braaten, Maria-Jose Sanchez, Claudia Giachino, Carlotta Sacerdote, Fulvio Ricceri
Summary: This study examines the association between educational level and cancer incidence and finds that individuals with lower education have a higher risk of developing stomach, lung, kidney (in women), and bladder (in men) cancers, while having a lower risk of melanoma and breast cancer (in post-menopausal women). The study also suggests that specific lifestyle behaviors may explain part of this association.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Economics
Zuzana Spacirova, Stephen Kaptoge, Leticia Garcia-Mochon, Miguel Rodriguez Barranco, Maria Jose Sanchez Perez, Nicola P. Bondonno, Anne Tjonneland, Elisabete Weiderpass, Sara Grioni, Jaime Espin, Carlotta Sacerdote, Catarina Schiborn, Giovanna Masala, Sandra M. Colorado-Yohar, Lois Kim, Karel G. M. Moons, Gunnar Engstrom, Matthias B. Schulze, Lea Bresson, Concepcion Moreno-Iribas, David Epstein
Summary: The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). The study found that one-off screening using a uniform risk threshold is cost-effective compared to no systematic screening, but the results are sensitive to assumptions about CVD incidence rates.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Oncology
Sofia Christakoudi, Konstantinos K. Tsilidis, Laure Dossus, Sabina Rinaldi, Elisabete Weiderpass, Christian S. Antoniussen, Christina C. Dahm, Anne Tjonneland, Lene Mellemkjaer, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Anne M. May, Evelyn M. Monninkhof, J. Ramon Quiros, Catalina Bonet, Maria-Jose Sanchez, Pilar Amiano, Maria-Dolores Chirlaque, Marcela Guevara, Ann H. Rosendahl, Tanja Stocks, Aurora Perez-Cornago, Sandar Tin Tin, Alicia K. Heath, Elom K. Aglago, Laia Peruchet-Noray, Heinz Freisling, Elio Riboli
Summary: Associations between body shape and breast cancer risk remain unclear. Although waist and hip circumferences are strongly positively correlated with body mass index (BMI), waist-to-hip ratio is still associated with breast cancer risk, especially in post-menopausal women, those aged >= 55 years, and ER- and PR- subtypes.
Article
Food Science & Technology
Silvia Tagliamonte, Raffaele Romano, Manuela Flavia Chiacchio, Alessandra Aiello, Lucia De Luca, Vincenzo Salzano, Paola Vitaglione
Summary: This study aimed to reutilize tomato pomace, a by-product of the tomato-processing industry, in the development of tomato sauce and assess its nutritional content and bioaccessibility. The innovative tomato sauce products showed higher levels of carotenoids, α-tocopherol, and total antioxidant capacity (TAC) compared to traditional sauce. Bioaccessibility of carotenoids and α-tocopherol varied among the different tomato sauce formulations, while total polyphenols content was higher in the sauce with 100% tomato pomace.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Donato Angelino, Monica Dinu, Barbara Gandossi, Nicoletta Pellegrini, Daniela Martini
Summary: This study compared the level of processing and the nutritional quality of breakfast cereals on the Italian market. The findings show that NOVA 4 products had higher energy, fat, and sugar content, while NOVA 1 products had higher fiber and protein content. The results suggest a connection between the lower nutritional quality of NOVA 4 foods and the risk of chronic diseases.
Article
Gastroenterology & Hepatology
Antonio Francavilla, Giulio Ferrero, Barbara Pardini, Sonia Tarallo, Laura Zanatto, Gian Paolo Caviglia, Sabina Sieri, Sara Grioni, Giulia Francescato, Francesco Stalla, Cristina Guiotto, Lucia Crocella, Marco Astegiano, Mauro Bruno, Pier Luigi Calvo, Paolo Vineis, Davide Giuseppe Ribaldone, Alessio Naccarati
Summary: Current treatment for celiac disease is adhering to a gluten-free diet, but its long-term molecular effects are still unknown. This study explored fecal small non-coding RNAs and gut microbiome profiles in celiac disease subjects and found altered miRNA and microbial profiles in treated celiac disease subjects.
Article
Horticulture
Valeria Menga, Clara Fares, Ana Campa, Juan Jose Ferreira, Elena Bitocchi, Roberto Papa, Romina Beleggia
Summary: A study characterized 54 snap bean lines grown under organic farming for various traits and grouped them based on pod cross-section shape and color. Significant differences were observed among lines and groups for all the investigated traits. The phenolic composition and antioxidant activity of selected lines with contrasting firmness and belonging to different color groups were investigated, revealing a general decrease in some compounds after cooking. The study provides useful information for designing specific varieties for different markets and purposes.
Article
Oncology
Hasmik Grigoryan, Partow Imani, Carlotta Sacerdote, Giovanna Masala, Sara Grioni, Rosario Tumino, Paolo Chiodini, Sandrine Dudoit, Paolo Vineis, Stephen M. Rappaport
Summary: Using untargeted adductomics, researchers identified features associated with non-Hodgkin lymphoma (NHL) by studying stable reactive oxygen species (ROS) adducts in human serum albumin. The results suggest that altered ROS homeostasis may contribute to NHL incidence, with differences observed between males and females.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Food Science & Technology
Silvia Tagliamonte, Roberta Barone Lumaga, Francesca De Filippis, Vincenzo Valentino, Rosalia Ferracane, Mathilde Guerville, Ivana Gandolfi, Giovanni Barbara, Danilo Ercolini, Paola Vitaglione
Summary: Despite not being lactose intolerant, many healthy individuals experience gastrointestinal discomfort after consuming milk. This study aimed to explore the digestion of milk protein and related physiological responses in individuals reporting gastrointestinal discomfort. The findings revealed that these individuals had slower milk protein digestion, lower hormone responses, and higher serum DPPIV activity compared to individuals without gastrointestinal discomfort.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Romina Beleggia, Valeria Menga, Flavia Fulvio, Clara Fares, Daniela Trono
Summary: This study evaluated the phytochemical content and antioxidant activity in the inflorescences of six industrial hemp genotypes. The results showed that genotype, cropping year, and their interaction significantly affected the measured traits, with cropping year being the main source of variation. The dioecious genotypes demonstrated more consistent performance over the three years, with Fibrante showing the highest and most stable phytochemical content. Conversely, Santhica 27 had the lowest accumulation of phytochemicals, except for cannabigerol, which was found at its highest level in this genotype. These findings can guide breeders in selecting new hemp genotypes with improved phytochemical levels in their inflorescences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Veronica Oliviero, Silvia Tagliamonte, Rosalia Ferracane, Paola Vitaglione
Summary: This study aimed to evaluate the effects of incorporating protein hydrolysates in a conventional muffin on glycemic index (GI) and release of bioactive peptides (BAPs) during digestion. Results showed that muffins with hydrolyzed pea and rice proteins significantly reduced GI and released BAPs, while high concentration of casein hydrolysate increased GI and delivered opioid and DPPIV-inhibitor BAPs.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Agriculture, Dairy & Animal Science
Dieu Donne Kiatti, Alessandro Vastolo, Bossima Ivan Koura, Paola Vitaglione, Monica Isabella Cutrignelli, Serena Calabro
Summary: The chemical composition and in vitro fermentation of pineapple by-products from two West African pineapple varieties were evaluated. Significant differences were observed between the varieties and by-products. Pineapple by-products have the potential to be used in ruminants' diets, but further research is needed to assess their storability and impact on animals.
Review
Nutrition & Dietetics
Carmen Monge-Montero, Liandre F. van der Merwe, Silvia Tagliamonte, Carlo Agostoni, Paola Vitaglione
Summary: This study aims to gain a deeper understanding of the reasons why mothers choose mixed milk feeding (MMF). The study identified and categorized 13 different drivers/reasons for MMF, including perceived choice, necessity, and pressure. Factors such as perceived breast milk insufficiency, breastfeeding difficulties, and returning to work were commonly reported reasons for MMF.
Article
Biochemistry & Molecular Biology
Jananee Muralidharan, Cindy Romain, Letizia Bresciani, Pedro Mena, Donato Angelino, Daniele Del Rio, Linda H. Chung, Pedro E. Alcaraz, Julien Cases
Summary: This study evaluated the nutrikinetics and bioavailability of a flavanone-rich product, Sinetrol (R) Xpur, in overweight and obese individuals. The results showed that while urinary excretion of metabolites decreased significantly over 16 weeks, there was no significant decrease in circulating metabolites. This suggests that chronic intake may not offer the same bioavailability as acute intake.
Article
Biochemistry & Molecular Biology
Aytul Hamzalioglu, Silvia Tagliamonte, Vural Gokmen, Paola Vitaglione
Summary: This study explored the interactions between casein and different phenol compounds during digestion, and monitored their effects on the bioaccessibility of phenol compounds and bioactive peptides. The results showed that co-digestion of casein with phenol compounds increased the bioaccessible total antioxidant capacity and promoted the release of antioxidant peptides. Furthermore, the type and concentration of phenols affected the release of bioactive peptides.