Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mehdi Mouheb, Morgane Pierre-Jean, Christophe Ferme, Anne Devillers, Thierry Lamy, Florence Le Jeune, Roch Houot, Xavier Palard-Novello
Summary: This study successfully extracted the dissemination patterns of HL using [F-18]-FDG PET/CT and a probability network model.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haojun Yu, Yushen Gu, Wei Fan, Yongju Gao, Meiyun Wang, Xiaohua Zhu, Zhifang Wu, Jianjun Liu, Biao Li, Hubing Wu, Zhaoping Cheng, Shuxia Wang, Yiqiu Zhang, Baixuan Xu, Sijin Li, Hongcheng Shi
Summary: This consensus provides protocols for using FDG imaging on total-body PET/CT scanners for cancer diagnosis and treatment planning. The consensus emphasizes reducing imaging time and injected FDG activity to improve clinical imaging outcomes.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Dan Cohen, Chava Perry, Shir Hazut-Krauthammer, Mikhail Kesler, Yair Herishanu, Efrat Luttwak, Einat Even-Sapir, Irit Avivi
Summary: This paper summarizes the experience in assessing the extent and metabolic characteristics of MALT lymphomas using [F-18]FDG PET-CT. It reveals that PET-CT has a high detection rate for extranodal lesions located in tissues with low/homogeneous physiologic [F-18]FDG uptake, and increased [F-18]FDG uptake in extranodal lesions predicts worse disease progression.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Medicine, General & Internal
Na Dai, Rongcui Cai, Shengming Deng, Shibiao Sang
Summary: This study aimed to differentiate false-positive from true-positive positron emission tomography (PET) results after hematopoietic stem cell transplantation (SCT) for lymphoma involvement by analyzing clinical variables and specific imaging features. The associations and significance of PET positivity and clinical information were assessed, and survival probabilities were compared. False-positive PET results were common, and several variables could help differentiate false-positive from true-positive post-SCT PET results.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Qixin Wang, Wenxin Tang, Songsong Yang, Yue Chen
Summary: Solitary non-Hodgkin lymphoma of the trachea is extremely rare, presenting symptoms such as cough and dyspnea. Diagnosis typically requires histology and immunohistochemistry confirmation.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yue Zhang, Liqian Yu, Rang Wang, Minggang Su
Summary: A 69-year-old man with a history of extranodal NK/T-Cell lymphoma, nasal type (ENKTL-NT), underwent an interim F-18-FDG PET/CT scan for response evaluation. The scan revealed intense focal uptake at the penile glans, initially suspected as urinary contamination. However, the patient reported redness and swelling of the penis, leading to a highly suspected diagnosis of ENKTL-NT recurrence at the penile glans. This diagnosis was confirmed by percutaneous biopsy.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuetao Chen, Shuailiang Wang, Yumei Lai, Guochang Wang, Maomao Wei, Xiao Jin, Jin Ding, Yan Zhang, Yunfei Shi, Feng Wang, Hua Zhu, Zhi Yang, Xuejuan Wang
Summary: The study aimed to compare the diagnostic performance of Ga-68-labeled fibroblast activation protein (FAP) inhibitor (FAPI) and F-18-labeled FDG PET/CT in diagnosing lymphomas and investigate the influence of FAP and glycolytic markers on tracer uptake. The results showed that F-18-FDG PET/CT had a higher staging accuracy and detected more lymph node and extranodal lesions than 68Ga-FAPI PET/CT. Ga-68-FAPI PET/CT was inferior in diagnosing lymphomas with low FAP expression, but it could help reveal the molecular profile of lymphomas.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Zhenying Chen, Qianqian Xue, Chao Huang, Shaobo Yao, Weibing Miao
Summary: This study highlights the potential role of Ga-68-Pentixafor PET/CT in diagnosing and treating Burkitt lymphoma, and suggests further research directions.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Haifa Bahri, Catherine Chassagne-Clement, Anne-Sophie Michallet, Thomas Mognetti, Emmanuelle Nicolas-Virelizier
Summary: Cholesterol granuloma (CG) is a type of foreign body-type granuloma that forms in response to cholesterol crystals, which can mimic tumor involvement due to its avid uptake of F-18-FDG, similar to sarcoid granulomas or fibrous dysplasia.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Akram Al-Ibraheem, Farah Anwer, Malik E. Juweid, Qaid Ahmed Shagera, Aysar N. Khalaf, Shahed Obeidat, Areen Mansour, Mohammad Ma'koseh, Khalid Halahleh, Imad Jaradat, Nidal Almasri, Asem Mansour
Summary: The study assessed the predictive value of interim FDG-PET/CT in HL patients treated with ABVD chemotherapy. The results showed that iPET was strongly associated with treatment response and prognosis, and could help tailor therapy to individual patients.
SCIENTIFIC REPORTS
(2022)
Article
Hematology
Cedric Rossi, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, Don-Marc Franchini, Nadia Amara, Charlotte Syrykh, Pierre Bories, Lucie Oberic, Loic Ysebaert, Laurent Martin, Selim Ramla, Philippine Robert, Claire Tabouret-Viaud, Rene-Olivier Casasnovas, Jean-Jacques Fournie, Christine Bezombes, Camille Laurent
Summary: This study identified that baseline whole-body maximum standardized uptake (SUVmax) greater than 14.5 is associated with poorer progression-free survival (PFS) in follicular lymphoma (FL) patients. Immune T-cell infiltration and immune checkpoint expression were not associated with baseline PET metrics. However, FL samples with Ki-67 staining greater than or equal to 10% showed enrichment of cell cycle/DNA genes and significantly higher SUVmax values. High baseline SUVmax reflects FL tumor proliferation and can be used, along with Ki-67 proliferative index, to identify patients at risk of early relapse with rituximab chemotherapy.
Article
Oncology
Rene-Olivier Casasnovas, George Follows, Josee M. Zijlstra, Joost S. P. Vermaat, Nagesh Kalakonda, Sylvain Choquet, Eric Van den Neste, Brian Hill, Catherine Thieblemont, Federica Cavallo, Fatima De la Cruz, John Kuruvilla, Nada Hamad, Ulrich Jaeger, Paolo F. Caimi, Ronit Gurion, Krzysztof Warzocha, Sameer Bakhshi, Juan-Manuel Sancho, Michael Schuster, Miklos Egyed, Fritz Offner, Theodoros P. Vassilakopoulos, Priyanka Samal, Matthew Ku, Xiwen Ma, Kamal Chamoun, Jatin Shah, Miguel Canales, Marie Maerevoet, Sharon Shacham, Michael G. Kauffman, Andre Goy
Summary: The SADAL study evaluated the use of selinexor in patients with relapsed/refractory DLBCL. DLBCL subtype, C-MYC and BCL-2 expression levels, and baseline hemoglobin levels influenced the treatment efficacy. Single agent selinexor showed positive responses in DLBCL patients in the clinical setting.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Hematology
Simon Rule, Wolney Gois Barreto, Javier Briones, Angelo M. Carella, Olivier Casasnovas, Chris Pocock, Clemens-Martin Wendtner, Francesco Zaja, Susan Robson, Lachlan MacGregor, Roger R. Tschopp, Sonja Nick, Martin Dreyling
Summary: Rituximab plus chemotherapy induction followed by up to 2 years of maintenance therapy has long-term benefits in terms of progression-free survival for patients with indolent non-Hodgkin lymphoma. It is uncertain whether further prolonged maintenance with rituximab provides additional benefits.
Article
Oncology
Emmanuel Bachy, Vincent Camus, Catherine Thieblemont, David Sibon, Rene-Olivier Casasnovas, Loic Ysebaert, Gandhi Damaj, Stephanie Guidez, Gian Matteo Pica, Won Seog Kim, Soon Thye Lim, Marc Andre, Alejandro Martin Garcia-Sancho, Maria Jesus Penarrubia, Philipp B. Staber, Judith Trotman, Andreas Huettmann, Vittorio Stefoni, Alessandro Re, Philippe Gaulard, Marie-Helene Delfau-Larue, Laurence de Leval, Michel Meignan, Ju Li, Franck Morschhauser, Richard Delarue
Summary: This study is a randomized phase III study comparing Ro-CHOP with CHOP in previously untreated adult PTCL patients. The study results showed that the addition of romidepsin to CHOP did not improve PFS, response rates, nor overall survival and increased the frequency of grade >= 3 treatment-emergent adverse events.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Josee M. Zijlstra, George Follows, Rene-Olivier Casasnovas, Joost S. P. Vermaat, Nagesh Kalakonda, Sylvain Choquet, Brian Hill, Catherine Thieblemont, Federica Cavallo, Fatima De la Cruz, John Kuruvilla, Nada Hamad, Ulrich Jaeger, Paolo Caimi, Ronit Gurion, Krzysztof Warzocha, Sameer Bakhshi, Juan-Manuel Sancho, Michael Schuster, Miklos Egyed, Fritz Offner, Theodoros P. Vassilakopoulos, Priyanka Samal, Matthew Ku, Jenny Xu, Kelly Corona, Kamal Chamoun, Jatin Shah, Miguel Canales, Marie Maerevoet
Summary: Selinexor, an oral selective inhibitor of nuclear export, has shown similar activity and tolerability across most clinical characteristics in patients with relapsed or refractory DLBCL. This novel medication may address an important unmet clinical need in DLBCL treatment, with its oral administration and consistency in responses in heavily pretreated patients.
Article
Medicine, General & Internal
Wendy Revailler, Anne Segolene Cottereau, Cedric Rossi, Rudy Noyelle, Thomas Trouillard, Franck Morschhauser, Olivier Casasnovas, Catherine Thieblemont, Steven Le Gouill, Marc Andre, Herve Ghesquieres, Romain Ricci, Michel Meignan, Salim Kanoun
Summary: The total metabolic tumor volume (TMTV) in lymphomas is a new prognostic factor that can be automated using deep learning CNNs. By training with manual TMTV segmentations, a model has been developed to generate accurate segmentations with high dice scores, reducing computation time significantly.
Editorial Material
Oncology
Cedric Rossi, Rene-Olivier Casasnovas
Summary: Novel targeted approaches have significantly improved the prognosis of patients with relapsed/refractory Hodgkin lymphoma, especially with the use of inhibitors like Nivolumab and pembrolizumab.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thibault Escobar, Sebastien Vauclin, Fanny Orlhac, Christophe Nioche, Pascal Pineau, Laurence Champion, Herve Brisse, Irene Buvat
Summary: This study proposes a method for designing radiomic models that combines handcrafted radiomics with sub-regional analysis. By analyzing data from 51 patients with soft tissue sarcoma, the method is shown to produce quantitative maps that highlight the signal contributing to the decision, identifying biological patterns consistent with disease grading systems and knowledge.
Article
Engineering, Biomedical
Laura Dal Toso, Zacharias Chalampalakis, Irene Buvat, Claude Comtat, Gary Cook, Vicky Goh, Julia A. Schnabel, Paul K. Marsden
Summary: This study presents a deep learning approach to improve the quantification of lung tumour radiotracer uptake and tumour shape definition in PET imaging. The network trained with simulated tumour data shows better estimates in reconstructed PET images.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Christophe Bonnet, Jehan Dupuis, Herve Tilly, Thierry Lamy, Christophe Fruchart, Steven le Gouill, Catherine Thieblemont, Franck Morschhauser, Olivier Casasnovas, Krimo Bouabdallah, Herve Ghesquieres, Eric Van den Neste, Marc Andre, Guillaume Cartron, Gilles Salles
Summary: This study evaluated the safety of combining ibrutinib with rituximab, dexamethasone, and cytarabine in patients with relapsed/refractory B-cell lymphoma. The combination with R-DHAP resulted in dose-limiting toxicities, while the combination with R-DHAOx allowed for higher ibrutinib dosage but with relevant toxicities.
Article
Oncology
Madeline Devaux, Mathieu Boulin, Morgane Mounier, Denis Caillot, Nuri Ahwij, Adelie Herbin, Jean Noel Bastie, Camille Favennec, Philippine Robert, Pauline Pistre, Stephanie Bost, Pauline Amiot, Laurence Jacquesson, Olivier Casasnovas, Cedric Rossi, Pauline Gueneau
Summary: This study demonstrates that a collaboration between nurses, pharmacists, and hematologists can reduce adverse events in patients with Hodgkin and non-Hodgkin lymphoma receiving highly haematotoxic chemotherapy regimens. The earlier detection of symptoms and better management of supportive care at home resulted in reduced re-hospitalizations and improved patient satisfaction and quality of life.
Article
Oncology
Franck Morschhauser, Loretta Nastoupil, Pierre Feugier, Jean-Marc Schiano de Colella, Herve Tilly, Maria Lia Palomba, Emmanuel Bachy, Christophe Fruchart, Edward N. Libby, Rene-Olivier Casasnovas, Ian W. Flinn, Corinne Haioun, Herve Maisonneuve, Loic Ysebaert, Nancy L. Bartlett, Kamal Bouabdallah, Pauline Brice, Vincent Ribrag, Steven Le Gouill, Nicolas Daguindau, Stephanie Guidez, Gian Matteo Pica, Alejandro Martin Garcia-Sancho, Armondo Lopez-Guillermo, Jean-Francois Larouche, Kiyoshi Ando, Maria Gomes da Silva, Marc Andre, Wu Kalung, Laurie H. Sehn, Koji Izutsu, Guillaume Cartron, Argyrios Gkasiamis, Russell Crowe, Luc Xerri, Nathan H. Fowler, Gilles Salles
Summary: The second interim analysis of the RELEVANCE trial after 6 years of follow-up showed that lenalidomide plus rituximab provided similar efficacy to rituximab plus chemotherapy in patients with advanced-stage follicular lymphoma. It demonstrated comparable, durable efficacy and safety, offering a chemo-free alternative for previously untreated patients with FL.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Luc-Matthieu Fornecker, Julien Lazarovici, Igor Aurer, Rene-Olivier Casasnovas, Anne-Claire Gac, Christophe Bonnet, Krimo Bouabdallah, Pierre Feugier, Lena Specht, Lysiane Molina, Mohamed Touati, Cecile Borel, Aspasia Stamatoullas, Emmanuelle Nicolas-Virelizier, Laurent Pascal, Pieternella Lugtenburg, Nicola Di Renzo, Thierry Vander Borght, Alexandra Traverse-Glehen, Peggy Dartigues, Martin Hutchings, Annibale Versari, Michel Meignan, Massimo Federico, Marc Andre
Summary: This study evaluated the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in early-stage unfavorable Hodgkin lymphoma. The results showed that BV-AVD had a higher PET-negative rate compared to ABVD after two cycles. High total metabolic tumor volume was associated with shorter progression-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kibrom B. Girum, Louis Rebaud, Anne-Segolene Cottereau, Michel Meignan, Jerome Clerc, Laetitia Vercellino, Olivier Casasnovas, Franck Morschhauser, Catherine Thieblemont, Irenene Buvat
Summary: This study found that surrogate TMTV and Dmax features, calculated automatically using an artificial intelligence algorithm from only 2 PET MIP images, can serve as prognostic biomarkers in DLBCL patients.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Letter
Hematology
Roch Houot, Viola Poeschel, Bettina Altmann, Stephanie Angel, Lorenz Thurner, Thomas Illmer, Marc Andre, Martin Dreyling, Herve Maisonneuve, Herve Tilly, Stephanie Mayer, Olivier Casasnovas, Steven Le Gouill, Fritz Offner, Guillaume Cartron, Andrea Kerkhoff, Thomas Weber, Joerg Hoffmann, Marita Ziepert, Wolfram Klapper, Emmanuel Itti, Dirk Hellwig, Giorgi Natchkebia, Laurence de Leval, Andreas Rosenwald, Corinne Haioun, Laurent Dercle, Philippe Gaulard, Gerhard Held