Article
Radiology, Nuclear Medicine & Medical Imaging
Clemens Mingels, Karl Peter Bohn, Axel Rominger, Ali Afshar-Oromieh, Ian Alberts
Summary: This study investigated the diagnostic accuracy of [F-18]PSMA-1007 PET/CT in biochemically recurrent prostate cancer. The results showed good performance in terms of regional sensitivity and negative predictive value, but limited positive predictive value, especially for bone lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Xing Zhou, Xiao Jiang, Luzhou Liu, Xiaoxiong Wang, Chuan Li, Yutang Yao, Ying Kou, Jiaqi Shen, Taipeng Shen, Zeng Li, Shengke Yang, Shukui Zhou, Hong Liao, Zhifu Luo, Xiaoai Wu, Shirong Chen, Zhuzhong Cheng
Summary: 18F-PSMA-1007 PET/CT demonstrates a high detection rate for patients with a raised PSA level after radical prostatectomy, which is essential for further clinical management.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian Rosar, Fadi Khreish, Robert J. Marlowe, Andrea Schaefer-Schuler, Caroline Burgard, Stephan Maus, Sven Petto, Mark Bartholomae, Samer Ezziddin
Summary: Preliminary data suggest that using Zr-89-labeled PSMA ligand radiotracers may be more effective than using tracers with short-lived radionuclides in detecting suspicious lesions in patients with biochemical recurrence of prostate cancer. In this study, 78% of patients had suspicious lesions detected on 24-h and 48-h scans, with higher detection rates on the 48-h scans. This suggests that imaging at a later time may be preferable.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Mads T. Christensen, Mads R. Jochumsen, Soren Klingenberg, Karina D. Sorensen, Michael Borre, Kirsten Bouchelouche
Summary: This study aimed to investigate new predictors of Ga-68-Prostate-Specific Membrane Antigen (PSMA) PET/CT detection rate and determine the detection rate dependent on PSA levels. The results showed that the detection rate of PCa recurrence was strongly correlated with pre-PET PSA levels, while other clinical variables had no significant impact on the detection rate.
Article
Oncology
D. J. H. Baas, M. Schilham, R. Hermsen, J. M. S. de Baaij, H. J. E. J. Vrijhof, R. J. Hoekstra, J. P. M. Sedelaar, H. V. N. Kusters-Vandevelde, M. Gotthardt, C. H. W. Wijers, J. P. van Basten, D. M. Somford
Summary: This study indicates that preoperative PSMA-PET/CT may be a valuable tool for patient counseling for RARP and ePLND, as it can predict the risk of postoperative BCP and early BCR.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isabel Rauscher, Amir Karimzadeh, Kilian Schiller, Thomas Horn, Calogero D'Alessandria, Charlott Franz, Hannah Worther, Noemi Nguyen, Stephanie E. Combs, Wolfgang Andreas Weber, Matthias Eiber
Summary: The study investigated a new class of PSMA-targeting agents, F-18-rhPSMA-7.3, in patients with biochemical recurrence after radical prostatectomy. The data showed high detection efficacy and potential impact on clinical management, with potential changes in treatment plans for nearly two-thirds of patients.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Oncology
Xuefeng Qiu, Mengxia Chen, Haoli Yin, Qing Zhang, Haoyang Li, Suhan Guo, Yao Fu, Shiming Zang, Shuyue Ai, Feng Wang, Hongqian Guo
Summary: The study found that SUVmax, maximum diameter of the index tumor, and T stage on preoperative PSMA-ligand PET/CT were significantly associated with BCR. The PSMA-ligand PET/CT-based risk model showed good efficacy in predicting 2-year BCR after RP.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Uprimny, Steffen Bayerschmidt, Alexander Stephan Kroiss, Josef Fritz, Bernhard Nilica, Hanna Svirydenka, Clemens Decristoforo, Elisabeth von Guggenberg, Wolfgang Horninger, Irene Johanna Virgolini
Summary: This study aimed to assess the impact of forced diuresis with early furosemide injection on the detection rate of local recurrence in prostate cancer patients with biochemical recurrence referred for Ga-68-PSMA-11 PET/CT, as well as determine whether the injection of furosemide shortly after tracer injection increases renal washout of Ga-68-PSMA-11.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Endocrinology & Metabolism
Jie Jiang, Xiaoxia Tang, Yongzhu Pu, Yong Yang, Conghui Yang, Fake Yang, Yadong Tian, Jindan Li, Hua Sun, Sheng Zhao, Long Chen
Summary: This article reviews the progress of PET/CT research in biochemical recurrence of prostate cancer, aiming to introduce new technologies and provide more direction for future research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Farshad Moradi, Heying Duan, Hong Song, Guido A. Davidzon, Benjamin I. Chung, Alan E. C. Thong, Andreas M. Loening, Pejman Ghanouni, Geoffrey Sonn, Andrei Iagaru
Summary: Prostate-specific membrane antigen (PSMA) PET has high accuracy in initial staging of prostate cancer and can predict patient prognosis. This study found that 68Ga-PSMA-11 uptake is correlated with clinical and pathological findings and can stratify the risk of prostate cancer patients before treatment.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Yining Wang, Yiping Shi, Yinjie Zhu, Lian Xu, Gang Huang, Jianjun Liu
Summary: Ga-68-PSMA PET/CT has a high detection rate in prostate cancer patients with biochemical recurrence, but few studies have explored other imaging methods for patients with negative Ga-68-PSMA findings. This study found that PSA level and Gleason score are independent predictors of F-18-FDG-positive findings, with patients with high PSA and Gleason score most likely to benefit from F-18-FDG PET/CT.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Sara Harsini, Don Wilson, Francois Benard
Summary: Based on in vitro studies, it is known that androgen deprivation therapy (ADT) increases prostate-specific membrane antigen (PSMA) expression on prostate cancer (PCa) cells. This study aimed to analyze the influence of ongoing ADT on [F-18]DCFPyL positron emission tomography/computed tomography (PET/CT) performance in patients with biochemical recurrent PCa. The results showed that patients under ADT at the time of imaging had a higher detection rate and radiotracer uptake compared to patients not under ADT.
Article
Multidisciplinary Sciences
Mohamad Haidar, Alain S. Abi-Ghanem, Hicham Moukaddam, Malak El Jebai, Safaa Al Zakleet, Samir Al Rayess, Abdul Rahman Akkawi, Mutaz Kassas, Hani Tamim, Albert El Hajj, Enrique Estrada-Lobato, Medhat M. Osman, Ali Shamseddine
Summary: The aim of this study was to analyze the efficacy of (68) Ga-PSMA PET/CT in detecting disease presence in patients with biochemical recurrence (BCR) of prostate cancer (PCa). Among the 52 patients recruited for the study, 65.4% had positive PSMA-PET/CT scans. The positivity was significantly associated with PSA level, PSA doubling time, Gleason score, and TNM staging. This study confirms the effectiveness of PSMA-PET/CT in patients with BCR.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Harun Ilhan, Markus Kroenke, Alexander Wurzer, Marcus Unterrainer, Matthias Heck, Claus Belka, Karina Knorr, Thomas Langbein, Isabel Rauscher, Nina -Sophie Schmidt-Hegemann, Kilian Schiller, Peter Bartenstein, Hans-Jurgen Wester, Matthias Eiber
Summary: This study investigated the efficacy of F-18-rhPSMA-7 PET/CT in patients with biochemical recurrence of prostate cancer after radiotherapy. The results showed that F-18-rhPSMA-7 PET/CT had high detection rates and comparable diagnostic efficacy to other PSMA ligands.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Luca Filippi, Oreste Bagni, Carmelo Crisafulli, Ivan Cerio, Gabriele Brunotti, Agostino Chiaravalloti, Orazio Schillaci, Franca Dore
Summary: The aim of this study was to evaluate the detection rate (DR) of F-18-FACBC PET/CT and its impact on the management of patients with biochemical recurrence from prostate cancer. The results showed that F-18-FACBC PET/CT had a DR of 76.9% in the entire cohort, with no significant difference among different PSA levels, and had a significant impact on clinical management.
Article
Urology & Nephrology
Shaan A. Setia, John Smith, Demetri Cendo, Johnathan Yoder, Michael A. Gorin, Matthew J. Allaway, Srinivas Vourganti
Summary: A retrospective study on patients undergoing freehand transperineal prostate biopsy over the past decade suggests that antimicrobial prophylaxis may be safely omitted in selected patients when using the freehand TP approach.
Article
Radiology, Nuclear Medicine & Medical Imaging
Liang Dong, Yun Su, Yinjie Zhu, Mark C. Markowski, Mei Xin, Michael A. Gorin, Baijun Dong, Jiahua Pan, Martin G. Pomper, Jianjun Liu, Kenneth J. Pienta, Wei Xue, Steven P. Rowe
Summary: This study evaluated the association between a new biochemical recurrence risk stratification system and PSMA-targeted PET/CT findings. High-risk BCR patients had a higher positive rate on PSMA PET/CT scans, and they were independent predictors of positive scan results. The combination of BCR risk group and prostate-specific antigen showed a higher area under the curve compared to using prostate-specific antigen alone.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Urology & Nephrology
Eduard Roussel, Umberto Capitanio, Alexander Kutikov, Egbert Oosterwijk, Ivan Pedrosa, Steven P. Rowe, Michael A. Gorin
Summary: The incidental detection of renal masses has been increasing, but many of these tumors are benign and do not require treatment. However, most patients with incidentally detected renal tumors undergo treatment for presumed cancer, leading to unnecessary surgical interventions and complications. Therefore, there is a need for improved tools to aid in the pre-treatment characterization of renal tumors to guide patient management.
Article
Urology & Nephrology
Akshay Sood, Wooju Jeong, Isaac Palma-Zamora, Firas Abdollah, Mohit Butaney, Nicholas Corsi, Hallie Wurst, Sohrab Arora, Naveen Kachroo, Oudai Hassan, Nilesh Gupta, Michael A. Gorin, Mani Menon
Summary: Precision prostatectomy is a novel focal therapy technique that offers excellent functional recovery and tumor control for patients with intermediate- or high-volume low-risk prostate cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Esther Mena, Steven P. Rowe, Joanna H. Shih, Liza Lindenberg, Baris Turkbey, Aloyse Fourquet, Frank I. Lin, Stephen Adler, Philip Eclarinal, Yolanda L. McKinney, Deborah E. Citrin, William Dahut, Bradford J. Wood, Richard Chang, Elliot Levy, Maria Merino, Michael A. Gorin, Martin G. Pomper, Peter A. Pinto, Janet F. Eary, Peter L. Choyke, Kenneth J. Pienta
Summary: This study investigated the factors predicting scan positivity and disease location in patients with biochemical recurrence of prostate cancer after primary local therapy. PSA and PSAdt were found to be independent predictors of scan positivity and disease location.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Steven P. Rowe, Andreas Buck, Ralph A. Bundschuh, Constantin Lapa, Sebastian E. Serfling, Thorsten Derlin, Takahiro Higuchi, Michael A. Gorin, Martin G. Pomper, Rudolf A. Werner
Summary: Prostate-specific membrane antigen (PSMA)-directed positron emission tomography (PET) has gained increasing interest for imaging of men affected by prostate cancer (PC). [ (18) F]DCFPyL has been widely utilized for staging, restaging, and change in management, and has shown promise for response assessment in patients under specific treatments.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2022)
Article
Oncology
Shaan Setia, Jamaal Jackson, Demetri Cendo, Michael A. Gorin, Matthew Allaway, Srinivas Vourganti
Summary: The study evaluated the diagnostic performance of systematic freehand transperineal biopsy (fTPb), finding that combining it with the Prostate Biopsy Collaborative Group (PBCG) nomogram can effectively predict clinically significant cancers. Patients with prostate cancer who underwent pre-biopsy multiparametric magnetic resonance imaging had an increased number of biopsy cores and a significantly higher detection rate of clinically significant cancer.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Biochemical Research Methods
Rudolf A. Werner, Bilel Habacha, Susanne Luetje, Lena Bundschuh, Takahiro Higuchi, Philipp Hartrampf, Sebastian E. Serfling, Thorsten Derlin, Constantin Lapa, Andreas K. Buck, Markus Essler, Kenneth J. Pienta, Mario A. Eisenberger, Mark C. Markowski, Laura Shinehouse, Rehab AbdAllah, Ali Salavati, Martin A. Lodge, Martin G. Pomper, Michael A. Gorin, Ralph A. Bundschuh, Steven P. Rowe
Summary: This study evaluated the test-retest repeatability of lesion uptake in patients imaged with F-18-DCFPyL PET/CT. The results showed that SUV parameters demonstrated high repeatability, especially in lymph nodes, while volumetric parameters showed low repeatability.
Article
Oncology
Andrew F. Voter, Rudolf A. Werner, Kenneth J. Pienta, Michael A. Gorin, Martin G. Pomper, Lilja B. Solnes, Steven P. Rowe
Summary: This article provides an overview of PSMA, F-18-DCFPyL, and compares their performance to conventional prostate imaging modalities. The clinical trials OSPREY and CONDOR have shown the superiority of F-18-DCFPyL in staging and restaging prostate cancer. The remarkable diagnostic accuracy of PSMA-PET is reshaping prostate cancer imaging.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Review
Endocrinology & Metabolism
Mohammad S. Sadaghiani, Sara Sheikhbahaei, Rudolf A. Werner, Kenneth J. Pienta, Martin G. Pomper, Michael A. Gorin, Lilja B. Solnes, Steven P. Rowe
Summary: PSMA-targeted endoradiotherapy/radioligand therapy (PRLT) is effective in castration resistant prostate cancer (CRPC). The evaluation of PRLT mainly focuses on prostate-specific antigen (PSA) decline and overall survival (OS). The study found that PRLT can lead to a higher proportion of patients with PSA decline and prolong overall survival in CRPC patients.
Correction
Oncology
Neal A. Patel, Art Sedrakyan, Fernando Bianco, Ruth Etzioni, Michael A. Gorin, Wei-Chun Hsu, Jialin Mao, Paul L. Nguyen, Edward Schaeffer, Jonathan Shoag, Andrew Vickers, Jim C. Hu
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Urology & Nephrology
Sneha Parekh, Parita Ratnani, Ugo Falagario, Dara Lundon, Deepshikha Kewlani, Jordan Nasri, Zach Dovey, Dimitrios Stroumbakis, Daniel Ranti, Ralph Grauer, Stanislaw Sobotka, Adriana Pedraza, Vinayak Wagaskar, Lajja Mistry, Ivan Jambor, Anna Lantz, Otto Ettala, Armando Stabile, Pekka Taimen, Hannu J. Aronen, Juha Knaapila, Ileana Montoya Perez, Giorgio Gandaglia, Alberto Martini, Wolfgang Picker, Erik Haug, Luigi Cormio, Tobias Nordstrom, Alberto Briganti, Peter J. Bostrom, Giuseppe Carrieri, Kenneth Haines, Michael A. Gorin, Peter Wiklund, Mani Menon, Ash Tewari
Summary: A comprehensive online web-based tool was developed to predict the risk of prostate cancer (PCa) using magnetic resonance imaging (MRI) and clinical data, applicable to different types of patients. The tool combines multiparametric MRI with clinical variables and demonstrates its efficiency and applicability through accurate validation in a large European cohort. This tool is available as a free web-based tool, aiding clinicians in better patients counseling and treatment decision-making.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Article
Surgery
Nelson N. Stone, Michael P. Wilson, Steven H. Grif, Jos Immerzeel, Frans Debruyne, Michael A. Gorin, Wayne Brisbane, Peter F. Orio, Laura S. Kim, Jonathan J. Stone
Summary: This study investigated the feasibility of using an augmented reality headset for remote training of clinicians on medical devices. The results showed that the remote training platform provided realistic training on anatomical models, and it had the potential to reduce infectious exposures, lower training costs, and increase proctor availability.
SURGERY OPEN SCIENCE
(2022)
Review
Urology & Nephrology
Spyridon P. Basourakos, Mark N. Alshak, Patrick J. Lewicki, Emily Cheng, Michael Tzeng, Antonio P. DeRosa, Mathew J. Allaway, Ashley E. Ross, Edward M. Schaeffer, Hiten D. Patel, Jim C. Hu, Michael A. Gorin
Summary: A systematic review and meta-analysis were conducted to evaluate infectious complications after transperineal prostate biopsy with or without the administration of prophylactic antibiotics. The study found that prophylactic antibiotics do not decrease the rate of postbiopsy sepsis but may have a small benefit in terms of preventing less serious infections.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Article
Oncology
Michael A. Gorin, Hiten D. Patel, Steven P. Rowe, Noah M. Hahn, Hans J. Hammers, Alice Pons, Bruce J. Trock, Phillip M. Pierorazio, Thomas R. Nirschl, Daniela C. Salles, Julie E. Stein, Tamara L. Lotan, Janis M. Taube, Charles G. Drake, Mohamad E. Allaf
Summary: In this study, the safety and tolerability of preoperative administration of three doses of the immune checkpoint inhibitor nivolumab in patients with clinically localized high-risk renal cell carcinoma were evaluated. The study demonstrated the safety of this approach and found that a subset of patients may have features of an immune-related pathologic response.
EUROPEAN UROLOGY ONCOLOGY
(2022)