Review
Neurosciences
Andrea Moreno
Summary: The field of learning and memory traditionally viewed forgetting as an error, but recent studies suggest it may be a purposeful mechanism. Molecular pathways like postsynaptic glutamate receptors and neuromodulators are believed to be related to forgetting, providing new directions for research.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Ping Liao, Qing-Yun Wu, Sen Li, Kai-Bin Hu, Hui-Lin Liu, Hai-Yan Wang, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wang
Summary: Abscisic acid (ABA) is a hormone found in plants and animals that regulates blood glucose and inflammation. It has therapeutic effects on obesity, diabetes, atherosclerosis, and inflammatory diseases. Studies have shown that ABA can cross the blood-brain barrier and improve learning, memory, and cognitive ability in the central nervous system. Additionally, it plays a crucial role in improving Alzheimer's disease, depression, and anxiety.
Review
Biochemistry & Molecular Biology
Mahshid Ebrahimnejad, Paniz Azizi, Vahide Alipour, Mohammad-Reza Zarrindast, Salar Vaseghi
Summary: This article reviews the conflicting effects of exercise on memory in rodents and discusses the underlying mechanisms. The role of neurotransmitter systems and their interaction with brain-derived neurotrophic factor (BDNF) in modulating exercise effects on memory is highlighted. The article suggests further investigation into the specific effects of different types of exercise on neurotransmitter systems and emphasizes their importance in memory modulation.
NEUROCHEMICAL RESEARCH
(2022)
Review
Neurosciences
Irene Reyes-Resina, Sebastian Samer, Michael R. Kreutz, Anja M. Oelschlegel
Summary: Sleep plays a central role in memory consolidation and brain function; however, the specific molecular mechanisms underlying these processes are still not fully understood, with many unknown factors hindering a deeper appreciation of their impact on synaptic function and memory formation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Environmental Sciences
Yifeng Rang, Huan Liu, Chunhong Liu
Summary: This review summarizes the mechanisms underlying Nonylphenol (NP)-induced learning and memory impairment and proposes possible therapeutic methods. Through behavior tests and other studies, oxidative stress, neurotransmitter disorder, synaptic plasticity impairment, and neuron injury are identified as key factors contributing to learning and memory deficits. In addition, chronic inflammation and increased gut permeability are also suggested to be associated with NP-induced learning and memory impairment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Neurosciences
Marco Capogna, Pablo E. Castillo, Arianna Maffei
Summary: GABAergic interneurons are highly diverse and play a crucial role in regulating neural circuits for learning and memory. Inhibitory synaptic plasticity in the hippocampus and neocortex is essential for circuit dynamics, with different interneuron types supporting unique roles.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Bryony Laura Winters, Christopher Walter Vaughan
Summary: This article discusses how the endogenous cannabinoid transmitter system regulates synaptic transmission throughout the nervous system by inducing the synthesis of endocannabinoids in the postsynaptic neuron to modulate presynaptic inputs, leading to short-term and long-term plasticity changes. While this regulation is nearly ubiquitous, there are major regional and synapse-specific variations in different regions of the brain due to the myriad pre- and postsynaptic mechanisms involved in eCB signaling.
Article
Physics, Fluids & Plasmas
Wenxuan Zou, Chan Li, Haiping Huang
Summary: In this study, the authors propose a spike and slab distribution to model the individual connections in recurrent neural networks for temporal credit assignment. They derive a mean-field algorithm to train the network and apply the method to classification and multisensory integration tasks. The study uncovers important connections in the network and reveals different types of neural selectivity.
Article
Neurosciences
Xingzhi He, Jiarui Li, Guangjun Zhou, Jing Yang, Sam McKenzie, Yanjun Li, Wenwen Li, Jun Yu, Yang Wang, Jing Qu, Zhiying Wu, Hailan Hu, Shumin Duan, Huan Ma
Summary: This study shows a positive correlation between hippocampal oscillatory strength and excitatory monosynaptic drive onto inhibitory neurons in freely behaving mice. By manipulating experience-dependent E -> I synaptic input/plasticity, the researchers were able to demonstrate its role in memory function. Deleting a specific protein affected long-term memory and brain wave rhythms.
Article
Biochemical Research Methods
Daniele Linaro, Matthew J. Levy, David L. Hunt
Summary: The transformation of synaptic input into action potential output is a fundamental process in cellular computation, which is determined by cellular morphology and the expression profile of ion channels. This study uses high-resolution morphological reconstructions and patch-clamp electrophysiology data to build biophysically detailed models of hippocampal neurons, and successfully matches the firing phenotypes of different cell types by adjusting the expression pattern of ion channel genes.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Haiyang Yu, Huanhuan Wei, Jiangdong Gong, Hong Han, Mingxue Ma, Yongfei Wang, Wentao Xu
Summary: Artificial synapses (ASs) are electronic devices that mimic important functions of biological synapses in artificial neuromorphic networks for brain-inspired computing. They need to simulate a range of biological synaptic functions and minimize feature size and energy consumption for high-density energy-efficient integration.
Review
Pharmacology & Pharmacy
Hang Wang, Xianghuan Dong, Maher Un Nisa Awan, Jie Bai
Summary: This review briefly summarizes the studies on epigenetics involved in METH addiction, elucidating the molecular mechanism of METH addiction and the effects of METH on neurotransmitter release and brain area activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Wanqiu Niu, Yanhong Duan, Yu Kang, Xiaohua Cao, Qingsheng Xue
Summary: This study investigated the effect of propofol on fear memory extinction and synaptic plasticity in a PTSD mice model. The results showed that propofol can accelerate fear memory extinction and restore impaired synaptic plasticity in the hippocampus of PTSD mice.
Article
Multidisciplinary Sciences
Zhongrong Wang, Wei Wang, Pan Liu, Gongjie Liu, Jiahang Li, Jianhui Zhao, Zhenyu Zhou, Jingjuan Wang, Yifei Pei, Zhen Zhao, Jiaxin Li, Lei Wang, Zixuan Jian, Yichao Wang, Jianxin Guo, Xiaobing Yan
Summary: A high-performance, superlow power consumption memristor device based on WSe2 quantum dots is demonstrated, showing excellent resistive switching memory behavior and good stability. The device is able to simulate different functions of artificial synapses and has high accuracy in digit recognition, paving the way for future low power neuromorphic computing.
Article
Biochemistry & Molecular Biology
Adam R. Gold, David L. Glanzman
Summary: The neurobiological nature of memory trace is still controversial, with the synaptic plasticity hypothesis being the most widely accepted hypothesis. However, there are mnemonic phenomena that it cannot account for. Recent research suggests that epigenetic and genomic mechanisms also play important roles in memory.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Jan Karbowski
PLOS COMPUTATIONAL BIOLOGY
(2015)
Article
Biochemical Research Methods
Franciszek Rakowski, Jan Karbowski
PLOS COMPUTATIONAL BIOLOGY
(2017)
Article
Evolutionary Biology
Yuguo Yu, Jan Karbowski, Robert N. S. Sachdev, Jianfeng Feng
BMC EVOLUTIONARY BIOLOGY
(2014)
Article
Mathematical & Computational Biology
Jan Karbowski
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2009)
Article
Multidisciplinary Sciences
Jan Karbowski
Article
Multidisciplinary Sciences
Jan Karbowski
Review
Neurosciences
Jan Karbowski
FRONTIERS IN NEURAL CIRCUITS
(2014)
Article
Mathematical & Computational Biology
Franciszek Rakowski, Jagan Srinivasan, Paul W. Sternberg, Jan Karbowski
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2013)
Article
Mathematical & Computational Biology
Jan Karbowski
Summary: This study explores the energy requirement of information storage in plastic synapses, revealing bistability in synaptic weights and the energy primarily used for battling fluctuations in synapses. Additionally, Fischer information and memory lifetime sharply increase at the onset of synaptic bistability, while plasticity energy rate changes only mildly.
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Mathematical & Computational Biology
Jan Karbowski, Gary Schindelman, Christopher J. Cronin, Adeline Seah, Paul W. Sternberg
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2008)
Article
Biology
Jan Karbowski
Article
Biology
Jan Karbowski, Christopher J. Cronin, Adeline Seah, Jane E. Mendel, Daniel Cleary, Paul W. Sternberg
JOURNAL OF THEORETICAL BIOLOGY
(2006)
Article
Mathematical & Computational Biology
J Karbowski, GB Ermentrout
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2004)
Article
Mathematical & Computational Biology
J Karbowski
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2003)