Aldose reductase regulates hyperglycemia-induced HUVEC death via SIRT1/AMPK-α1/mTOR pathway

Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death

(2018) Kirtikar Shukla et al.   BIOCHEMICAL PHARMACOLOGY

Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction

(2018) Himangshu Sonowal et al.   BIOCHEMICAL PHARMACOLOGY

Aldose Reductase Mediates NLRP3 Inflammasome–Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice

(2017) Pabitra B Pal et al.   ENDOCRINOLOGY

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

(2017) Himangshu Sonowal et al.   Scientific Reports

Reversibility of endothelial dysfunction in diabetes: role of polyphenols

(2016) N. Suganya et al.   BRITISH JOURNAL OF NUTRITION

Antidiabetic Agents and Endothelial Dysfunction - Beyond Glucose Control

(2015) Linnéa Eriksson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights

(2015) Ahmet Can Timucin et al.   CELLULAR SIGNALLING

Role of polyphenols in improving endothelial dysfunction in diabetes

(2014) Valérie Schini-Kerth   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial dysfunction — A major mediator of diabetic vascular disease

(2013) Cristina M. Sena et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

(2013) S. Vedantham et al.   DIABETES

Oxidative Stress in Diabetes: Implications for Vascular and Other Complications

(2013) Dario Pitocco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

(2013) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

(2012) Zhao Chong et al.   Cardiovascular Diabetology

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Targeting Aldose Reductase for the Treatment of Cancer

(2012) R. Tammali et al.   CURRENT CANCER DRUG TARGETS

Roles of SIRT1 in High Glucose-induced Endothelial Impairment: Association with Diabetic Atherosclerosis

(2011) Juhong Yang et al.   ARCHIVES OF MEDICAL RESEARCH

Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways

(2011) Soojeong Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation

(2010) Jinling Hou et al.   CURRENT NEUROVASCULAR RESEARCH

Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

(2010) Corey E. Tabit et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Protective Role of SIRT1 in Diabetic Vascular Dysfunction

(2009) Masayuki Orimo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AMP-ACTIVATED PROTEIN KINASE ACTIVATION AS A STRATEGY FOR PROTECTING VASCULAR ENDOTHELIAL FUNCTION

(2008) Ming-Hui Zou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Transcriptional targets of sirtuins in the coordination of mammalian physiology

(2008) Jerome N Feige et al.   CURRENT OPINION IN CELL BIOLOGY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors

(2008) J. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA