Article
Pharmacology & Pharmacy
Meijun Liu, Binghong Xu, Yuying Ma, Luqing Shang, Sheng Ye, Yaxin Wang
Summary: This study demonstrated the effective antiviral activity of cyanoacrylate and Boc-protected cyanoarylamide derivatives as inhibitors against EV71, showing broad antiviral effects across various cell lines and viral strains. The binding pockets between these inhibitors and 3C(pro) were elucidated through docking studies, providing valuable insights for the development of clinically effective medicines to treat EV71 infections.
ANTIVIRAL RESEARCH
(2021)
Article
Virology
Zhuoran Li, Ya'ni Wu, Hui Li, Wenqian Li, Juan Tan, Wentao Qiao
Summary: EV71 3C protein cleaves PMLIV at specific sites, reducing its antiviral function and disrupting the formation of PML-NBs, promoting virus replication.
Article
Microbiology
Hui Li, Yunfang Yao, Yu Chen, Shuangling Zhang, Zhi Deng, Wentao Qiao, Juan Tan
Summary: In this study, the interaction between immune-associated protein TRAF3 interacting protein 3 (TRAF3IP3) and EV71 3C(pro) was investigated. It was found that TRAF3IP3 can inhibit EV71 replication, while 3C(pro) can resist this inhibition through proteolytic cleavage of TRAF3IP3. The nuclear export signal (NES) of TRAF3IP3 plays a role in altering the localization of 3C(pro) and inhibiting EV71 replication.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Organic
Tugce G. Erbay, Daniel P. Dempe, Bhaskar Godugu, Peng Liu, Kay M. Brummond
Summary: This study demonstrates that alpha-methylene-gamma-lactams can serve as tunable surrogates for highly reactive alpha-methylene-gamma-lactones, with the reactivity of the alpha-methylene modulated by the N substituent. Density functional theory calculations using the M06-2X functional with the SMD solvation model and methyl thiolate as a model nucleophile reliably predict the relative reactivities of the alpha-methylene-gamma-lactams. Quasiharmonic approximations further improve the agreement between experimental results and computational predictions.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Virology
Shanshan Fan, Zihang Xu, Pengfei Liu, Yali Qin, Mingzhou Chen
Summary: Several viruses inhibit the formation of RNA processing bodies, including enterovirus 71, which relies on its 2A protease to block P-body formation and promote viral replication. The interaction between DDX6 and viral RNA also facilitates viral replication.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Daniel D. T. Andrews, Marli Vlok, Dorssa Akbari Bani, Brenna N. Hay, Yasir Mohamud, Leonard J. Foster, Honglin Luo, Christopher M. Overall, Eric Jan
Summary: Host antiviral factors use the retinoic acid-inducible gene I (RIG-I)-like receptor pathway to sense virus infection and trigger the production of interferons, which establish an antiviral state. The chaperone protein 14-3-3 & epsilon; plays a key role in this pathway by facilitating the delivery of the viral sensor protein RIG-I to the mitochondria. However, the enteroviral 3C protease cleaves 14-3-3 & epsilon; during infection, disrupting its function and promoting virus infection. This study reveals a novel viral strategy that evades the host antiviral response.
JOURNAL OF VIROLOGY
(2023)
Article
Virology
Xiaoman Wo, Yuan Yuan, Yong Xu, Yang Chen, Yao Wang, Shuoxuan Zhao, Lexun Lin, Xiaoyan Zhong, Yan Wang, Zhaohua Zhong, Wenran Zhao
Summary: This study revealed that during EV-A71 infection, TDP-43 undergoes cleavage and translocation to the cytoplasm, mediated by viral proteases. This suggests a potential role of TDP-43 in the pathogenesis of EV-A71 infection.
Article
Chemistry, Multidisciplinary
Christian Taplan, Marc Guerre, Filip E. Du Prez
Summary: This study investigates the use of beta-amino esters as building blocks for dynamic covalent networks, showing that dynamic covalent exchange occurs through dynamic aza-Michael reaction and catalyst-free transesterification. The versatility and robustness of this chemistry are demonstrated by creating covalent adaptable networks using readily available multifunctional acrylates and amines. Reprocessable, densely cross-linked materials with a wide range of glass transition temperatures and high creep resistance at elevated temperatures are achieved.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Bo Qin, Gregory B. Craven, Pengjiao Hou, Julian Chesti, Xinran Lu, Emma S. Child, Rhodri M. L. Morgan, Wenchao Niu, Lina Zhao, Alan Armstrong, David J. Mann, Sheng Cui
Summary: This study successfully applied quantitative irreversible tethering (qIT) to identify fragments that can inhibit the proteases of Enterovirus 71 and SARS-CoV-2, and found that the inhibition could disrupt the active dimeric unit.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Polymer Science
Xiaoyi Xu, Yue Yue, Guoqing Xin, Ning Huang
Summary: A new kind of perylene-based 2D COF was designed and synthesized based on the C-2 + C-2 topological diagram, and its electrical performance was enhanced through donor-acceptor interaction.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Chenxiang Lin, Xiaolin Liu, Baoqiu Yu, Chaozheng Han, Lei Gong, Chiming Wang, Ying Gao, Yongzhong Bian, Jianzhuang Jiang
Summary: A chemical modification strategy was developed to enhance the photocatalytic activity of COFs, resulting in the fabrication of HBT-COF which showed significantly improved hydrogen production rate compared to BT-COF. This enhancement was attributed to finely tuned energy levels, improved wettability, broadened visible light absorption, efficient charge separation and transfer, and enhanced interactions between the COF catalyst and reaction substrates.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Microbiology
Tran Thao Vy Le, Phuc-Chau Do
Summary: Hand, foot, and mouth disease is a common infection with no available vaccination or therapy. Current research focuses on the differences between strains of Enterovirus-A71, requiring testing of antiviral agents on multiple strains or mutations. This study evaluated previously reported inhibitors and investigated potential candidates using molecular docking, discovering that Hesperidin might be the most promising candidate for inhibiting various strains of EV-A71.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Guang-Bo Wang, Fu-Cheng Zhu, Qian-Qian Lin, Jing-Lan Kan, Ke-Hui Xie, Sha Li, Yan Geng, Yu-Bin Dong
Summary: A benzodifuran-based donor-acceptor covalent organic framework was synthesized and utilized for efficient simulated sunlight-driven photocatalytic hydrogen evolution from water, achieving a superior and steady hydrogen evolution rate of 1390 μmol g-1 h-1 and an outstanding apparent quantum yield (AQY) of 7.8% at 420 nm.
CHEMICAL COMMUNICATIONS
(2021)
Article
Virology
Zinuo Chen, Ruikun Du, Laura Cooper, Jazmin G. Achi, Meiyue Dong, Yan Ran, Jiwei Zhang, Peng Zhan, Lijun Rong, Qinghua Cui
Summary: Sulforaphane (SFN) has been identified as an effective inhibitor of SARS-CoV-2 by targeting the viral 3-chymotrypsin-like protease (3CL(pro)). It acts as a slow-binding inhibitor, forming a covalent complex with the catalytic cysteine of 3CL(pro). This study has identified a potential lead compound for the development of therapeutic agents against SARS-CoV-2 infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Medicinal
Vinicius Bonatto, Anwar Shamim, Fernanda Dos R. Rocho, Andrei Leitao, F. Javier Luque, Jeronimo Lameira, Carlos A. Montanari
Summary: Covalent inhibitors play a central role in drug discovery projects, especially in the current pandemic situation, with a focus on inhibiting viral proteases or human proteases. This study evaluated the suitability of free energy perturbation (FEP) calculations as a tool for predicting the binding affinity of reversible covalent inhibitors of hCatL, demonstrating FEP as a powerful predictor tool in developing and understanding the activity of reversible covalent inhibitors.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Biochemistry & Molecular Biology
Linfeng Li, Chandrakala Basavannacharya, Kitti Wing Ki Chan, Luqing Shang, Subhash G. Vasudevan, Zheng Yin
CHEMICAL BIOLOGY & DRUG DESIGN
(2015)
Article
Chemistry, Medicinal
Yangyang Zhai, Xiangshuai Zhao, Zhengjie Cui, Man Wang, Yaxin Wang, Linfeng Li, Qi Sun, Xi Yang, Debin Zeng, Ying Liu, Yuna Sun, Zhiyong Lou, Luqing Shang, Zheng Yin
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Microbiology
Luqing Shang, Shumei Zhang, Xi Yang, Jixue Sun, Linfeng Li, Zhengjie Cui, Qiuhong He, Yu Guo, Yuna Sun, Zheng Yin
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Chemistry, Medicinal
Wenjun Wang, Lei Li, Chen Jin, Yujie Niu, Sen Li, Ji Ma, Linfeng Li, Yu Liu, Li Cai, Wei Zhao, Peng George Wang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Chemistry, Medicinal
Peng Wang, Lin-Feng Li, Qing-Yin Wang, Lu-Qing Shang, Pei-Yong Shi, Zheng Yin
Article
Multidisciplinary Sciences
Ming-zhu Ding, Hui-fang Yan, Lin-feng Li, Fang Zhai, Lu-qing Shang, Zheng Yin, Ying-jin Yuan
Article
Chemistry, Medicinal
Yuying Ma, Chengyou Shang, Peng Yang, Linfeng Li, Yangyang Zhai, Zheng Yin, Binghe Wang, Luqing Shang
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Bala C. Chenna, Linfeng Li, Drake M. Mellott, Xiang Zhai, Jair L. Siqueira-Neto, Claudia Calvet Alvarez, Jean A. Bernatchez, Emily Desormeaux, Elizabeth Alvarez Hernandez, Jana Gomez, James H. McKerrow, Jorge Cruz-Reyes, Thomas D. Meek
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Drake M. Mellott, Chien-Te Tseng, Aleksandra Drelich, Pavla Fajtova, Bala C. Chenna, Demetrios H. Kostomiris, Jason Hsu, Jiyun Zhu, Zane W. Taylor, Klaudia Kocurek, Vivian Tat, Ardala Katzfuss, Linfeng Li, Miriam A. Giardini, Danielle Skinner, Ken Hirata, Michael C. Yoon, Sungjun Beck, Aaron F. Carlin, Alex E. Clark, Laura Beretta, Daniel Maneval, Vivian Hook, Felix Frueh, Brett L. Hurst, Hong Wang, Frank M. Raushel, Anthony J. O'Donoghue, Jair Lage de Siqueira-Neto, Thomas D. Meek, James H. McKerrow
Summary: K777, an irreversible inactivator of cysteine proteases, has shown reduction in the infectivity of SARS-CoV-2 in various host cells. By inhibiting the activity of host cathepsin L, this drug prevents the processing of viral spike protein, thereby reducing viral infectivity.
ACS CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Linfeng Li, Bala C. Chenna, Kai S. Yang, Taylor R. Cole, Zachary T. Goodall, Miriam Giardini, Zahra Moghadamchargari, Elizabeth A. Hernandez, Jana Gomez, Claudia M. Calvet, Jean A. Bernatchez, Drake M. Mellott, Jiyun Zhu, Andrew Rademacher, Diane Thomas, Lauren R. Blankenship, Aleksandra Drelich, Arthur Laganowsky, Chien-Te K. Tseng, Wenshe R. Liu, A. Joshua Wand, Jorge Cruz-Reyes, Jair L. Siqueira-Neto, Thomas D. Meek
Summary: A novel class of self-masked aldehyde inhibitors has been developed for the major cysteine protease of Chagas disease, showing potent and reversible inhibition while potentially improving pharmacokinetic properties. The study also elucidated the kinetic and chemical mechanism of these inhibitors and applied the strategy to design anti-SARS-CoV-2 drugs.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Anneliese S. Ashhurst, Arthur H. Tang, Pavla Fajtova, Michael C. Yoon, Anupriya Aggarwal, Max J. Bedding, Alexander Stoye, Laura Beretta, Dustin Pwee, Aleksandra Drelich, Danielle Skinner, Linfeng Li, Thomas D. Meek, James H. McKerrow, Vivian Hook, Chien-Te Tseng, Mark Larance, Stuart Turville, William H. Gerwick, Anthony J. O'Donoghue, Richard J. Payne
Summary: The study identifies cathepsin L as a key protease used by coronaviruses for cell entry and a potential drug target for antiviral treatment against SARS-CoV-2. The researchers discovered that gallinamide A and synthetic analogues are potent inhibitors of cathepsin L, showing promising antiviral activity against SARS-CoV-2. The combination with a TMPRSS2 inhibitor further enhances the antiviral effect.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Jia Zheng, Wei Zhang, Linfeng Li, Yi He, Yue Wei, Yongjun Dang, Shenyou Nie, Zufeng Guo
Summary: Targeted therapy is a groundbreaking innovation in cancer treatment, with FGFRs being recognized as promising therapeutic targets. Several generations of FGFR kinase inhibitors have been developed over the past two decades.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C. Chenna, Drake M. Mellott, Zane W. Taylor, Vivian Tat, Christopher Z. Garcia, Ardala Katzfuss, Chien-Te K. Tseng, Thomas D. Meek
Summary: This study developed a novel class of compounds called self-masked aldehyde inhibitors (SMAIs) that have potential as drug targets for infectious diseases such as Chagas disease and COVID-19. The SMAIs demonstrated strong anti-SARS-CoV-2 activity in infected human cells, showing their effectiveness as potential therapeutics.
FRONTIERS IN CHEMISTRY
(2022)