期刊
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
卷 55, 期 3, 页码 251-265出版社
SPRINGER
DOI: 10.1007/s10840-019-00574-3
关键词
Cardiac ablation; Irreversible electroporation; Pulsed electric field; Atrial fibrillation; Arrhythmias; Catheter ablation; Translational studies
资金
- Slovenian Research Agency (ARRS) through ARRS research programme-Electroporation-based technologies and treatments [P2-0249]
Introduction Irreversible electroporation (IRE) utilizing high voltage pulses is an emerging strategy for catheter-based cardiac ablation with considerable growth in the preclinical arena. Methods A systematic search for articles was performed from three sources (PubMed, EMBASE, and Google Scholar). The primary outcome was the efficacy of tissue ablation with characteristics of lesion formation evaluated by histologic analysis. The secondary outcome was focused on safety and damage to collateral structures. Results Sixteen studies met inclusion criteria. IRE was most commonly applied to the ventricular myocardium (n = 7/16, 44%) by a LifePak 9 Defibrillator (n = 9/16, 56%), NanoKnife Generator (n = 2/16, 13%), or other custom generators (n = 5/16, 31%). There was significant heterogeneity regarding electroporation protocols. On histological analysis, IRE was successful in creating ablation lesions with variable transmurality depending on the electric pulse parameters and catheter used. Conclusion Preclinical studies suggest that cardiac tissue ablation using IRE shows promise in delivering efficacious, safe lesions.
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