Article
Chemistry, Multidisciplinary
Daniel P. Harrison, Varshini J. Kumar, Johanna N. Noppers, Josef B. G. Gluyas, Alexandre N. Sobolev, Stephen A. Moggach, Paul J. Low
Summary: This article describes a convenient modification to established synthetic routes for the preparation of complexes, as well as the differences in oxidation processes between iron and ruthenium analogues. The study also reveals limited differences in the gross electronic structures of Cp vs. Cp* derivatives in both iron and ruthenium series through redox properties and spectroelectrochemical investigations.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Janos P. Meszaros, Gabor Nemeti, Jelena M. Poljarevic, Tamas Holczbauer, Nora V. May, Eva A. Enyedy
Summary: The solution speciation and reactivity of Rh(η5-C5Me5), Ru(η6-p-cymene), and Ru(η6-toluene) complexes with 2,4-pyridinedicarboxylic acid and 2-picolinic acid were studied and compared. X-ray diffraction analysis revealed structures of the complexes, showing different geometries and stability preferences. Complexes with 2,4-pyridinedicarboxylic acid were found to form more stable complexes compared to those with 2-picolinic acid, especially with Ru(η6-arene) complexes.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Orsolya Domotor, Ricardo G. Teixeira, Gabriella Spengler, Fernando Avecilla, Fernanda Marques, Oscar A. Lenis-Rojas, Cristina P. Matos, Rodrigo F. M. de Almeida, Eva A. Enyedy, Ana Isabel Tomaz
Summary: In this study, two Ru(II)-polypyridyl compounds were prepared and characterized. The solid-state structure was confirmed by X-ray diffraction analysis. The solubility, stability, and lipophilicity of the complexes were investigated under physiological mimetic conditions, as well as their potential uptake by passive diffusion. The complexes exhibited cytotoxicity on ovarian and colon cancer cells and induced late apoptosis and necrosis. They showed weak binding to human serum albumin but significant binding to calf thymus DNA.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Ivan Nemec, Jana Kasparkova, Viktor Brabec, Pavel Starha
Summary: In this study, model compounds such as Ru-dca and Ir-dca were used to investigate the behavior of complexes containing bioactive substituents like dichloroacetate (dca) in solution, with characterization done using techniques such as single-crystal X-ray analysis. However, these complexes did not demonstrate antiproliferative activity in four human cancer cell lines.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Betty Y. T. Lee, Matthew P. Sullivan, Ena Yano, Kelvin K. H. Tong, Muhammad Hanif, Tomoyo Kawakubo-Yasukochi, Stephen M. F. Jamieson, Tilo Soehnel, David C. Goldstone, Christian G. Hartinger
Summary: N-Heterocyclic carbene (NHC) ligands have been widely studied in medicinal inorganic chemistry. In this study, a series of half-sandwich [M(L)(NHC)Cl-2] complexes with N-flanking anthracenyl moiety were prepared and their anticancer activities were investigated, showing cytotoxicity in low micromolar range. The Ru derivative 1a exhibited stability and specific interactions with biomolecules.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Carsten Mueller, Justin Schu, Bernd Morgenstern, Michael Zimmer, Marc Schmidtmann, Andre Schaefer
Summary: Phosphanyl-substituted tin(ii) half sandwich complexes, which form head-to-tail dimers due to the Lewis acidic tin center and Lewis basic phosphorous atom, were reported. Their properties and reactivities were investigated both experimentally and theoretically. Furthermore, related transition metal complexes of these species are presented.
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
William Meza-Morales, Yair Alvarez-Ricardo, Leidys L. Perez-Gonzalez, Rosario Tavera-Hernandez, Maria Teresa Ramirez-Apan, Ruben A. Toscano, Ruben Sanchez-Obregon, Marco A. Obregon-Mendoza, Raul G. Enriquez
Summary: This study reports the crystal structures of two homoleptic metal complexes of Dimethoxycurcumin with gallium and indium. The ligands in each complex exhibit different conformations, with the (DiMeOC)2-Ga complex showing two different conformers and the (DiMeOC)3-In complex exhibiting three different conformations. The (DiMeOC)2-Ga complex demonstrates higher cytotoxic activity against the K562 cell line compared to cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Patrycja Rogala, Agnieszka Jablonska-Wawrzycka, Grzegorz Czerwonka, Katarzyna Kazimierczuk, Katarzyna Galczynska, Slawomir Michalkiewicz, Justyna Kalinowska-Tluscik, Marta Karpiel, Karel D. Klika
Summary: This study reports the synthesis and characterization of arene ruthenium complexes containing benzimidazole moiety, which have promising antimicrobial and anticancer activity. The compounds were characterized by various analytical techniques and their molecular structures were determined. Biological studies showed that the complexes exhibit bacteriostatic activity against Pseudomonas aeruginosa PAO1 strain and are non-toxic to normal cells.
Article
Chemistry, Inorganic & Nuclear
Yuliang Yang, Xiaofeng Zou, Yanyan Sun, Feihong Chen, Jian Zhao, Shaohua Gou
Summary: This article presents a rational design of half-sandwich Ru(II) complexes for mitochondria-targeted anticancer and antimetastatic agents by introducing the NDI unit into the N,N-chelating ligand of these complexes, which exhibit excellent emission performance. These complexes have potential applications in the design of multifunctional theranostic agents and fluorescent biomarkers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yeye She, Yanhua Lu, Chaohong Jia, Yahong Li, Yi-Quan Zhang, Jin-lei Yao
Summary: The utilization of di-pyrrolyl Schiff base ligand H2L in organolanthanide chemistry is presented, and complexes with lanthanide ions (Dy, Ho, Er, and Gd) were synthesized. The magnetic properties of these complexes were investigated and explained by DFT calculations.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sudhir Lima, Atanu Banerjee, Gurunath Sahu, Sushree Aradhana Patra, Kausik Sahu, Takahiro Sasamori, Giuseppe Sciortino, Eugenio Garribba, Rupam Dinda
Summary: In this study, five new mononuclear mixed ligand oxidovanadium(IV) complexes were synthesized and characterized. These complexes contain tridentate O,N,O-donor aroylhydrazones as the main ligand and N,N-chelating 2,2'-bipyridine and 1,10-phenanthroline as the co-ligand. The interaction of these complexes with two proteins was studied, and their cytotoxicity against human cervical cancer and colon cancer cell lines was evaluated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Xueyan Hu, Lihua Guo, Mengqi Liu, Qiuya Zhang, Yuwen Gong, Mengru Sun, Shenghan Feng, Youzhi Xu, Yiming Liu, Zhe Liu
Summary: In this study, a series of zwitterionic half-sandwich P,N-chelating organometallic complexes were synthesized, characterized, and evaluated for their biological activity. These complexes exhibited enhanced anticancer activity, potentially attributed to their increased lipophilic property and intracellular uptake levels. Additionally, they showed biomolecular interactions with bovine serum albumin (BSA), induced cell apoptosis, targeted lysosomes, and inhibited cell migration.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Roman I. Nekrasov, Tat'yana A. Peganova, Ivan V. Fedyanin, Evgenii I. Gutsul, Oleg A. Filippov, Natalia V. Belkova, Alexander M. Kalsin
Summary: A series of pentamethylcyclopentadienyl rhodium complexes were synthesized and characterized, and some complexes were found to have low stability and high nucleophilicity and reactivity.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Alexander N. Selikhov, Ivan Lapshin, Anton Cherkasov, Georgy K. Fukin, Alexander A. Trifonov
Summary: Various half-sandwich complexes were synthesized under different reaction conditions, indicating the versatility of the reactions towards ligand substitution and complex formation.
Article
Biochemistry & Molecular Biology
Orsolya Domotor, Ricardo G. Teixeira, Gabriella Spengler, Fernando Avecilla, Fernanda Marques, Oscar A. Lenis-Rojas, Cristina P. Matos, Rodrigo F. M. de Almeida, Eva A. Enyedy, Ana Isabel Tomaz
Summary: In this study, two Ru(II)-polypyridyl compounds were prepared and characterized. The solid-state structure was confirmed by X-ray diffraction analysis. The solubility, stability, and lipophilicity of the complexes were investigated under physiological mimetic conditions, as well as their potential uptake by passive diffusion. The complexes exhibited cytotoxicity on ovarian and colon cancer cells and induced late apoptosis and necrosis. They showed weak binding to human serum albumin but significant binding to calf thymus DNA.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tamas Pivarcsik, Vivien Posa, Hilda Kovacs, Nora May, Gabriella Spengler, Szonja P. Posa, Szilard Toth, Zeinab Nezafat Yazdi, Csilla Ozvegy-Laczka, Imre Ugrai, Istvan Szatmari, Gergely Szakacs, Eva A. Enyedy
Summary: This article investigates a novel 5-nitro-8-hydroxyquinoline-proline hybrid and its Rh(eta(5)-C5Me5) and Ru(eta(6)-p-cymene) complexes, which have excellent solubility in water and show inhibitory effects on sensitive and multidrug-resistant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Orsolya Domotor, Eva A. Enyedy
Summary: Uncertainties exist in plasma protein binding and blood distribution of the COVID-19 therapeutics favipiravir (FAVI), molnupiravir (MOLNU), and imatinib (IMA). This study investigated the proton dissociation processes, solubility, lipophilicity, and serum protein binding of these drugs. The results showed different degrees of lipophilicity at different pH values. MOLNU was hydrolyzed by blood serum proteins, while FAVI had weak binding to blood proteins and IMA showed high affinity binding to AGP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shirley A. R. Sancha, Nikoletta Szemeredi, Gabriella Spengler, Maria-Jose U. Ferreira
Summary: In order to overcome multidrug resistance in cancer chemotherapy, lycorine, a major Amaryllidaceae alkaloid isolated from Pancratium maritimum, was derivatized to obtain 31 new compounds. These compounds showed significant activity in the study of anticancer drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tatsiana Petrasheuskaya, Ferenc Kovacs, Nora Igaz, Andrea Ronavari, Balint Hajdu, Laura Bereczki, Nora May, Gabriella Spengler, Bela Gyurcsik, Monika Kiricsi, Eva Frank, Eva A. Enyedy
Summary: A series of novel estradiol-based salicylaldehyde (thio)semicarbazones and their Cu(II) complexes were synthesized and characterized. The Cu(II)-estradiol-semicarbazone complex structure was determined by X-ray crystallography. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative showed high cytotoxicity against cancer cells and significant activity against Staphylococcus aureus bacteria strain. Estradiol-TSCs exhibited efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not significantly affect the physicochemical and biological properties.
Article
Pharmacology & Pharmacy
Janos P. Meszaros, Wolfgang Kandioller, Gabriella Spengler, Alexander Prado-Roller, Bernhard K. Keppler, Eva A. Enyedy
Summary: This study introduces half-sandwich Rh complexes that can be activated in the acidic, extracellular pH of tumor tissue, reducing the side effects and improving the efficacy of chemotherapy.
Article
Biochemistry & Molecular Biology
Elek Ferencz, Gabriella Spengler, Istvan Zupko, Martin Vollar, Zoltan Peter Zomborszki, Norbert Kusz, Judit Hohmann, Balazs Kovacs, Dezso Csupor, Eszter Laczko-Zold, Boglarka Csupor-Loffler
Summary: Common ragweed (Ambrosia artemisiifolia L.) is an invasive plant in Europe used in folk medicine. The chemical composition of its above-ground parts is well-studied, but less is known about the metabolites of the roots. In this study, several compounds were isolated from the root extracts, including a new compound called thiophene E (6). Thiophene E exhibited cytotoxic and antiproliferative effects on A-431 epidermoid skin cancer cells. Another compound, taraxerol-3-O-acetate, showed slight antiproliferative effect on gynecological cancer cell lines. These findings highlight the need for further studies on the safety of ragweed root.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Nadia Ribeiro, Ipek Bulut, Baris Sergi, Vivien Posa, Gabriella Spengler, Giuseppe Sciortino, Vania Andre, Liliana P. Ferreira, Tarita Biver, Valeria Ugone, Eugenio Garribba, Joao Costa-Pessoa, Eva A. Enyedy, Ceyda Acilan, Isabel Correia
Summary: This study reports the synthesis and characterization of a group of benzoylhydrazones and their Cu(II) complexes. The complexes exhibited moderate-to-strong interaction with bovine serum albumin and showed higher antiproliferative activity compared to the corresponding free ligand and cisplatin. Compound 8 demonstrated the most promising properties with low IC50 values, high induction of oxidative stress and DNA damage, resulting in high rates of apoptosis.
FRONTIERS IN CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Balint Racz, Annamaria Kincses, Krisztian Laczi, Gabor Rakhely, Enrique Dominguez-alvarez, Gabriella Spengler
Summary: Recently, the anticancer activity of symmetrical selenoesters was investigated in sensitive and resistant human colon adenocarcinoma cells. The compounds showed synergistic interaction with doxorubicin and exhibited ABCB1 inhibitory and apoptosis-inducing effects. Transcriptome analysis revealed that symmetrical selenoesters may influence the redox state of cells and interfere with metastasis formation.
Article
Chemistry, Medicinal
Ricardo G. Teixeira, Janos P. Meszaros, Beatriz Matos, Leonor Corte-Real, Cristina P. R. Xavier, Xavier Fontrodona, M. Helena Garcia, Isabel Romero, Gabriella Spengler, M. Helena Vasconcelos, Ana Isabel Tomaz, Eva A. Enyedy, Andreia Valente
Summary: This article presents the synthesis and properties of a series of novel ruthenium(II)-cyclopentadienyl organometallic compounds. These compounds exhibit high activity in anti-cancer and antibacterial applications. Compounds 6 and 7 show remarkable inhibitory effects on colorectal cancer and non-small cell lung cancer. Additionally, these compounds demonstrate potent antibacterial activity against methicillin-resistant Staphylococcus aureus strains. The study also reveals interactions between these complexes and human serum albumin and calf thymus DNA.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Bara Krizkovska, Lan Hoang, Daniela Brdova, Kristyna Klementova, Nikoletta Szemeredi, Anna Louckova, Olga Kronusova, Gabriella Spengler, Petr Kastanek, Jana Hajslova, Jitka Viktorova, Jan Lipov
Summary: Salvia officinalis L., Sambucus nigra L., Matricaria chamomilla L., Agrimonia eupatoria L., Fragaria vesca L., and Malva sylvestris L. are plants that have been used in European folk medicine for treating skin wounds and infections. This study investigated their potential as adjuvants for the treatment of antibiotic-resistant bacteria. The results showed that Malva sylvestris had the highest antimicrobial activity, while Fragaria vesca and Sambucus nigra demonstrated potential as efflux pump inhibitors. Overall, these plants have potential for improving antibiotic treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Janos P. Meszaros, Hilda Kovacs, Gabriella Spengler, Ferenc Kovacs, Eva Frank, Eva A. Enyedy
Summary: A salicylhydroxamic acid-estradiol hybrid molecule (E2HA) was synthesized, which forms high-stability complexes with essential metal ions (iron, copper) and exhibits moderate anticancer activity in human cancer cell lines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Christopher Wittmann, Orsolya Domotor, Irina Kuznetcova, Gabriella Spengler, Johannes Reynisson, Lauren Holder, Gavin J. J. Miller, Eva A. A. Enyedy, Ruoli Bai, Ernest Hamel, Vladimir B. B. Arion
Summary: A series of benzazocines and benzazonines, along with their copper(II) complexes, were synthesized and characterized. The compounds showed strong antiproliferative activity and selectivity towards malignant cell lines.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
