Article
Immunology
Arpit Amin, Alfonso Molina, Lisa Quach, Takahiro Ito, Robert McMillan, Joseph DiNorcia, Vatche G. Agopian, Fady M. Kaldas, Douglas G. Farmer, Ronald W. Busuttil, Drew J. Winston
Summary: A retrospective study of liver transplant recipients with pretransplant Aspergillus colonization at Ronald Reagan UCLA Medical Center showed that these patients can still undergo successful liver transplantation with appropriate antifungal prophylaxis, and posttransplant outcome is mainly determined by noninfectious complications rather than fungal infection. Pretransplant Aspergillus colonization alone should not necessarily preclude or delay liver transplantation.
Article
Medicine, General & Internal
Anna Engell Holm, Hans Henrik Lawaetz Schultz, Helle Krogh Johansen, Tania Pressler, Thomas Kromann Lund, Martin Iversen, Michael Perch
Summary: This study monitored the time of bacterial re-colonization in lung transplant patients with cystic fibrosis and found that 70% of patients were re-colonized by bacteria after 2 years, with no observed impact on survival rates from re-colonization or different bacterial species.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
William Danjou, Paul Chabert, Thomas Perpoint, Pierre Pradat, Patrick Miailhes, Andre Boibieux, Agathe Becker, Carine Fuchsmann, Frederic Laurent, Stephane Tringali, Sandrine Roux, Claire Triffault-Fillit, Florent Valour, Tristan Ferry
Summary: Necrotizing external otitis is a severe bone infection that mainly occurs in elderly and diabetic patients, often caused by Pseudomonas aeruginosa. Fungal infections significantly impact the outcome of the infection.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Yoshiki Katada, Shunsaku Nakagawa, Miki Nagao, Yuko Yoshida, Yuya Matsuda, Yuki Yamamoto, Kotaro Itohara, Satoshi Imai, Atsushi Yonezawa, Takayuki Nakagawa, Kazuo Matsubara, Satona Tanaka, Daisuke Nakajima, Hiroshi Date, Tomohiro Terada
Summary: This study identified important risk factors for developing Invasive Aspergillus infection (IA) under itraconazole prophylaxis, including older age, history of interstitial pneumonia, and CMV infection. In addition, early cessation of valganciclovir prophylaxis may increase the risk of CMV infection. These findings can help clinicians optimize prophylactic strategies for IA in lung transplant recipients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Rachel Rosen, Margot Lurie, Madeline Kane, Courtney DiFilippo, Alexandra Cohen, Dawn Freiberger, Debra Boyer, Gary Visner, Monica Narvaez-Rivas, Enju Liu, Kenneth Setchell
Summary: This study found that lung bile is almost universally present in symptomatic patients, and higher concentrations are associated with poorer respiratory outcomes.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Biology
Karsten M. Heil, Matthias Helmschrott, Fabrice F. Darche, Tom Bruckner, Philipp Ehlermann, Michael M. Kreusser, Andreas O. Doesch, Wiebke Sommer, Gregor Warnecke, Norbert Frey, Rasmus Rivinius
Summary: This study examined the risk factors, treatment, and prognosis of post-transplant lung cancer in patients who received heart transplantation. Recipient age, COPD, and history of smoking were identified as risk factors for post-transplant lung cancer. Patients diagnosed in early stages had significantly better survival rates, emphasizing the importance of routine reassessment of smoking status and intensified lung cancer screening for high-risk heart transplant recipients.
Review
Cardiac & Cardiovascular Systems
Pakpoom Phoompoung, Armelle Perez Cortes Villalobos, Shilpa Jain, Farid Foroutan, Ani Orchanian-Cheff, Shahid Husain
Summary: This study systematically evaluated the risk factors of invasive fungal infection (IFI) in lung transplant recipients. The results showed that independent risk factors for invasive aspergillosis (IA) after lung transplantation include previous fungal colonization, cytomegalovirus infection, and single lung transplantation. Pre-emptive antifungal therapy is a protective factor against IA in the lung transplant population.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Dermatology
Marco Vecchiato, Stefano Piaserico, Giulia Biolo, Anna Chiara Frigo, Monica Loy, Federico Rea, Irene Russo, Mauro Alaibac
Summary: This study aimed to determine the incidence and risk factors of skin cancers in lung transplant recipients, finding that age, gender, phototype, and voriconazole use were significant predictors for squamous cell carcinoma development. Male gender and phototype were identified as independent risk factors for basal cell carcinoma.
DERMATOLOGIC THERAPY
(2021)
Editorial Material
Microbiology
Shivani Singh, Leopoldo N. Segal
Summary: Li et al. demonstrate the pathogenic role of Neisseria spp., previously thought to be commensal, in bronchiectasis. This article discusses the evolution of our thinking from the classical Koch's postulates to a complex network of microbial-host interactions and their role in disease pathogenesis.
CELL HOST & MICROBE
(2022)
Article
Gastroenterology & Hepatology
John W. Blackett, Luke Benvenuto, Miguel M. Leiva-Juarez, Frank D'Ovidio, Selim Arcasoy, Daniela Jodorkovsky
Summary: Gastroparesis is common after lung transplantation and is associated with worse outcomes, particularly the development of CLAD. Black patients are more likely to be diagnosed with gastroparesis post-transplant. While gastroparesis is linked to CLAD, it does not impact overall mortality.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Immunology
Signe Marie Wulff, Michael Perch, Jannik Helweg-Larsen, Pia Bredahl, Maiken Cavling Arendrup, Jens Lundgren, Marie Helleberg, Cornelia Geisler Crone
Summary: Early diagnosis and treatment of cytomegalovirus (CMV) and invasive aspergillosis (IA) can improve outcomes for lung transplant recipients (LTXr). This study examined the rates of CMV after IA and vice versa, and found that the risk of CMV was high in the first 3 months after IA, while the risk of IA was significantly increased in the first 3 months after CMV. Systematic screening for CMV following the diagnosis of IA, and vice versa, may improve timeliness of diagnosis and outcomes for LTXr.
Article
Infectious Diseases
Elizabeth R. Wan, Sophie A. Elands, Stephen B. Walsh
Summary: A 68-year-old renal transplant recipient experienced multiple complications after a deceased donor transplant, including graft failure, hematoma, recurrent bleeding, and skin infection caused by Aspergillus flavus. Systemic aspergillosis is rare but recognized in immunocompromised patients, and diagnosis requires histology or culture confirmation. Treatment involves systemic antifungals and involvement of microbiology services, but the prognosis is poor.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Isabelle Moneke, Ecem Deniz Ogutur, Johannes Kalbhenn, Ina Hettich, Bernward Passlick, Wolfgang Jungraithmayr, Omer Senbaklavaci
Summary: This study retrospectively analyzed the medical records of 221 lung transplant recipients and found a high incidence of thromboembolism (TE) after lung transplantation (LTX). Independent predictors for TE included a BMI > 25 and age > 55, as well as cardiovascular risk factors closely associated with the metabolic syndrome. These findings highlight the need for intensified research to assess the risks and benefits of regular screening or prolonged TE prophylaxis in these patients.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Multidisciplinary Sciences
Martin Agud, Ines de Medrano, Ana Mendez-Echevarria, Talia Sainz, Federico Roman, Guillermo Ruiz Carrascoso, Luis Escosa-Garcia, Clara Molina Amores, Francisco Jose Climent, Aroa Rodriguez, Marta Garcia-Fernandez de Villalta, Cristina Calvo
Summary: This study aimed to assess the rates of drug-resistant bacterial colonization and associated risk factors in children with complex chronic conditions admitted to a national reference unit in Spain. The results showed a low rate of nasal colonization of S. aureus and MRSA in these children, while the rate of MR-GNB colonization was high. Immunossupressive therapy, antibiotic prophylaxis, history of infections, previous surgeries, and length of hospital admission in the previous year were identified as important risk factors for MR-GNB colonization.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Elizabeth N. Pavlisko, Megan L. Neely, Heather Kopetskie, David M. Hwang, Carol F. Farver, W. Dean Wallace, Andrea Arrossi, Peter Illei, Michelle L. Sever, Jerry Kirchner, Courtney W. Frankel, Laurie D. Snyder, Tereza Martinu, Michael Y. Shino, Lorenzo Zaffiri, Nikki Williams, Mark A. Robien, Lianne G. Singer, Marie Budev, Wayne Tsuang, Pali D. Shah, John M. Reynolds, S. Sam Weigt, John A. Belperio, Scott M. Palmer, Jamie L. Todd
Summary: This study determined the prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP) on lung recipient outcomes in relation to the timing of transplantation. Late ALI/OP was found to increase the risk of chronic lung allograft dysfunction or death/retransplantation by two to three times, while early ALI/OP did not show any association with these outcomes. Risk factors for late ALI/OP included grade 3 primary graft dysfunction, higher degree of donor/recipient human leukocyte antigen mismatch, bacterial or viral respiratory infection, and an early ALI/OP event.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Elizabeth Roosma, Johanna P. Van Gemert, Auke E. S. De Zwart, Coretta C. Van Leer-Buter, Merel E. Hellemons, Elize M. Berg, Bart Luijk, Rogier A. S. Hoek, Diana A. Van Kessel, Onno W. Akkerman, Huib A. M. Kerstjens, Erik A. M. Verschuuren, C. Tji Gan
Summary: This study retrospectively analyzed the impact of COVID-19 on transplant function in LTx patients, showing high mortality in hospitalized patients, decline in lung function 3 months post infection, gradual improvement at 6 months but still lower than pre-infection levels.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Cynthia L. Green, Brian C. Gulack, Shaf Keshavjee, Lianne G. Singer, Kenneth McCurry, Marie M. Budev, Tammy L. Reece, Anne O. Lidor, Scott M. Palmer, R. Duane Davis
Summary: A multicenter retrospective study found limited benefits of fundoplication for preventing bronchiolitis obliterans syndrome and improving survival compared to reflux disease without surgery after lung transplantation. However, the study had limitations in terms of sample size, follow-up duration, and potential selection bias, highlighting the need for a randomized, prospective study.
ANNALS OF THORACIC SURGERY
(2023)
Article
Urology & Nephrology
Tim J. Knobbe, Daan Kremer, Rianne M. Douwes, Michele F. Eisenga, Antonio W. Gomes-Neto, Coby Annema, J. Casper Swarte, Frank Klont, Gerjan Navis, Stefan P. Berger, Stephan J. L. Bakker
Summary: Prior studies have shown that the use of proton pump inhibitors (PPIs) can negatively impact gut microbiota and the absorption of micronutrients, such as iron and magnesium. This study aims to investigate the association between PPI use and fatigue and health-related quality of life (HRQoL) in kidney transplant recipients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Pharmacology & Pharmacy
Jeroen J. Koomen, Tim R. Knobbe, Tanja Zijp, Daan Kremer, C. Tji Gan, Erik A. M. Verschuuren, Stephan J. L. J. Bakker, Daan J. Touw, Pieter Colin, TransplantLines Investigators
Summary: This study aimed to establish plasma concentration ranges reflecting the currently used target ranges of whole blood tacrolimus concentrations. By developing a pharmacokinetic model and performing simulations, it was found that the whole blood target ranges for kidney and lung transplant recipients corresponded to plasma concentration ranges of 0.06-0.26 ng/mL and 0.10-0.93 ng/mL, respectively.
CLINICAL PHARMACOKINETICS
(2023)
Review
Immunology
Clea Melenotte, Vishukumar Aimanianda, Monica Slavin, Jose Maria Aguado, Darius Armstrong-James, Yee-Chun Chen, Shahid Husain, Christian Van Delden, Faouzi Saliba, Agnes Lefort, Francoise Botterel, Olivier Lortholary
Summary: Invasive aspergillosis is a rare but serious infection in liver transplant recipients, with a high mortality rate. Risk factors before, during, and after transplantation have been identified, and accurate diagnosis requires collaboration between radiology and clinical biology. It is recommended to reduce the dose of tacrolimus and closely monitor blood levels when using certain drugs, and surgery should be considered on a case-by-case basis. Antifungal prophylaxis and environmental measures should be implemented to prevent outbreaks.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Multidisciplinary Sciences
Kamal Hamed, Marc Engelhardt, Laura L. Kovanda, Jin Ju Huang, Jean Yan, Jalal A. Aram
Summary: Isavuconazole was found to have a higher rate of adverse events and lower efficacy in patients aged 65 and above with invasive fungal diseases.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Johanna van Gemert, Fleur Steenberg, Coretta van Leer-Buter, Huib Kerstjens, Willie Steenhuis, Onno Akkerman, Erik Verschuuren, Tji Gan
Summary: COVID-19 causes high mortality in LTx patients, so vaccination in this population is crucial. However, the antibody response is impaired after multiple vaccinations. This study aims to investigate the possibility of increasing this response and identify risk factors for non-response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Davide Lo Porto, Andrea Cona, Francesca Todaro, Elena De Carolis, Francesca Cardinale, Neha Hafeez, Giuseppina Di Martino, Pier Giulio Conaldi, Maurizio Sanguinetti, Paolo Antonio Grossi, Alessandra Mularoni
Summary: Phaeohyphomycosis is a diverse infection caused by pigmented fungi, and solid organ transplant recipients are at increased risk due to immunosuppression. In this study, three successful cases of phaeohyphomycosis in transplant recipients were treated with surgery and antifungal therapy. A literature review revealed a wide range of fungal species, with Alternaria being the most common. Early diagnosis and treatment are crucial in preventing disease dissemination.
Review
Microbiology
Muneyoshi Kimura, Sagar Kothari, Wajiha Gohir, Jose F. Camargo, Shahid Husain
Summary: MicroRNAs (miRNAs) play a crucial role in post-transcriptional gene expression regulation, disease pathogenesis, and immune response. They are explored as diagnostic biomarkers and therapeutic targets in clinical settings.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Dmitry Rozenberg, Lianne G. Singer
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Letter
Oncology
Nick Veltmaat, Yujie Zhong, Filipe Montes de Jesus, Geok Wee Tan, Johanna A. A. Bult, Martijn M. Terpstra, Pim G. N. J. Mutsaers, Wendy B. C. Stevens, Rogier Mous, Joost S. P. Vermaat, Martine E. D. Chamuleau, Walter Noordzij, Erik A. M. Verschuuren, Klaas Kok, Joost L. Kluiver, Arjan Diepstra, Wouter J. Plattel, Anke Van den Berg, Marcel Nijland
Summary: The study investigates the use of cfDNA for genomic profiling of PTLD, and explores its potential as a screening tool. Analysis showed that 41% of patients had EBV-positive tumors and 76% had stage IV disease. The study provides important insights into the genetic variations and EBV infection in PTLD.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Silvia Martini, Margherita Saracco, Donatella Cocchis, Fabrizia Pittaluga, Bruna Lavezzo, Francesca Barisone, Luigi Chiusa, Antonio Amoroso, Massimo Cardillo, Paolo A. Grossi, Renato Romagnoli
Summary: This study evaluated the medium-term outcomes of liver transplant recipients from COVID-19 donors and found favorable results in terms of patient survival. However, there was a higher risk of hepatic artery thrombosis compared to recipients from COVID-19-negative donors.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Review
Immunology
Dafna Yahav, Melissa R. Gitman, Ili Margalit, Tomer Avni, Mariska M. G. Leeflang, Shahid Husain
Summary: This meta-analysis examined the predictive value of TST and IGRA for active TB in solid organ transplantation patients. The results showed that both tests have a high negative predictive value but a low positive predictive value.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
J. Casper Swarte, Tim J. Knobbe, Johannes R. Bjork, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Summary: This study investigates the association between the gut microbiome and Health-Related Quality of Life (HRQoL) in kidney transplant recipients. The results show that multiple bacterial species are associated with lower HRQoL in this population, and physical and mental HRQoL explain a significant part of the variance in the gut microbiome. Additionally, metabolic and neuroactive pathways are also associated with lower HRQoL, suggesting potential modifiable factors to improve HRQoL.
NATURE COMMUNICATIONS
(2023)
Article
Surgery
R. van Pel, C. T. Gan, W. van der Bij, E. A. M. Verschuuren, J. P. A. van Gemert, C. van de Wauwer, M. E. Erasmus, D. J. Slebos
Summary: Post lung transplantation airway complications, especially stenosis, significantly affect survival. Risk factors for the development of airway complications are unclear.
TRANSPLANT INTERNATIONAL
(2023)
