Article
Medical Laboratory Technology
Hui Ma, Chun-Hua Chen, Yan-Mei Li, Jing-Jing Wang, Zhi-De Hu
Summary: Plasma D-dimer is a marker for screening thrombosis and hemostasis disorders. Heterophilic antibodies can cause falsely elevated D-dimer, so identifying falsely elevated D-dimer in laboratory practice is of great value.
CLINICA CHIMICA ACTA
(2022)
Article
Emergency Medicine
Mohsin Khan, Scott M. Alter, Lisa M. Clayton, Patrick G. Hughes, Richard D. Shih, Joshua J. Solano
Summary: The study aimed to compare the test characteristics of AADD measured in DDU with different cutoff values in geriatric patients suspected of PE, showing that AADD maintained sensitivity with improved specificity compared to standard cutoff. In this population, AADD could safely reduce imaging by 19% without missing any PEs, highlighting its value as a valid tool for ruling out PE in geriatric patients.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Clinical Neurology
Yanjun Guo, Pamela M. Rist, Maria Sabater-Lleal, Paul de Vries, Nicholas Smith, Paul M. Ridker, Tobias Kurth, Daniel Chasman
Summary: The study found that increased levels of coagulation factors VIII and von Willebrand factor, as well as phosphorylated fibrinopeptide A, were associated with migraine susceptibility, especially in migraine with aura. This suggests a potential causal relationship between hemostatic measures and migraine, particularly in certain subtypes.
Article
Cardiac & Cardiovascular Systems
Huoying Cai, Baihong Pan, Jie Xu, Shuai Liu, Lei Wang, Kemin Wu, Pu Yang, Jianhua Huang, Wei Wang
Summary: There are significant differences in clinical and serum profiles between peripheral artery disease (PAD) and abdominal aortic aneurysm (AAA). D-dimer (>0.675 mg/L) is a reliable biomarker for predicting AAA in PAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Orthopedics
Xi Chen, Wenwei Qian, Xisheng Weng, Jin Lin, Jin Jin, Yiou Wang, Shibai Zhu
Summary: Plasma Fbg showed similar diagnostic performance as CRP and ESR in predicting culture-positive PJI. Plasma D-dimer had high specificity but low sensitivity. Further studies are needed to investigate the difference between serum D-dimer and plasma D-dimer in the arthroplasty population.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Hong Xu, Jing Zhou, Qiang Huang, Zeyu Huang, Jinwei Xie, Zongke Zhou
Summary: The ability of D-dimer to diagnose periprosthetic joint infection (PJI) before revision hip or knee arthroplasty is still controversial, and the differences in diagnostic ability between serum- or plasma-based assays of D-dimer and fibrin (fibrinogen) degradation product (FDP) are uncertain.
ORTHOPAEDIC SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Maxime Taquet, Zuzanna Skorniewska, Adam Hampshire, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Olivia C. Leavy, Matthew Richardson, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Ruth M. Saunders, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Parisa Mansoori, Ewen M. Harrison, Annemarie B. Docherty, Nazir I. Lone, Jennifer Quint, Naveed Sattar, Christopher E. Brightling, Louise V. Wain, Rachael E. Evans, John R. Geddes, Paul J. Harrison
Summary: Post-COVID cognitive deficits are complex and have both objective and subjective components. A study on COVID-19 hospitalized patients identified two distinct blood biomarker profiles that predict cognitive outcomes 6 and 12 months later. These findings provide insights into the biology of post-COVID cognitive deficits.
Article
Food Science & Technology
Yiping Tang, Yuanyuan Yang, Xuan Lu, Qiuchen Liu, Qiaohong Li, Xia Song, Man Wang, Hankun Hu, Li Zhou, Yefu Wang
Summary: Thrombosis is a major cause of death worldwide and the currently available drugs for treatment have limitations. Subtilisin QK, as a potential oral thrombolytic agent, has a high fibrinolytic activity and can be absorbed and exert thrombolytic effects in the body.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Pharmacology & Pharmacy
Kadri Kangro, Alisa S. S. Wolberg, Matthew J. Flick
Summary: SARS-CoV-2 infection can lead to severe pathological changes including significant activation of the clotting system and thrombus formation, resulting in abnormal fibrinogen and fibrin degradation. Fibrinogen and the fibrin degradation product D-dimer may serve as biomarkers for poor prognosis in COVID-19. Emerging studies suggest that fibrinogen plays an active role in the pathogenesis of COVID-19.
CURRENT DRUG TARGETS
(2022)
Review
Biochemistry & Molecular Biology
Nurul H. Sulimai, Jason Brown, David Lominadze
Summary: This review discusses the role of fibrinogen and its derivatives in inflammatory diseases and their effects on immunomodulation.
Article
Cardiac & Cardiovascular Systems
Lijun Chen, Wang Xu, Juanxia Chen, Huifang Zhang, Xiaobo Huang, Liting Ma, Genggeng Yu, Yanjun Zhou, Bin Ma, Chao Chen, Yanhong Liu, Xiaoyong Ma
Summary: This study aimed to evaluate the differences in coagulation indicators between the stable phase and acute exacerbation of COPD. The results showed that during acute exacerbation, the levels of white blood cell count, neutrophil count, fibrinogen, and D-dimer were significantly increased, while mean platelet volume, activated partial thromboplastin time, and prothrombin time were significantly decreased. Furthermore, mean platelet volume was negatively correlated with white blood cell count and neutrophil count, and forced expiratory volume in one second was negatively correlated with D-dimer and fibrinogen.
Review
Neurosciences
Tingting Wen, Zhaohui Zhang
Summary: Neurodegenerative diseases are incurable conditions that progressively impair cognitive and behavioral functions of the nervous system. Fibrinogen, a glycoprotein, plays a crucial role in inflammation and tissue repair and interacts with nervous system cells. Accumulating evidence suggests that fibrinogen deposits in the brains of patients with neurodegenerative diseases. By regulating pathophysiological mechanisms, fibrinogen can exacerbate neurodegenerative diseases, while depletion of fibrinogen contributes to improved cognitive function. This review comprehensively summarizes the mechanisms and functions of fibrinogen in neurodegenerative diseases and discusses potential treatments.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Hematology
Albe Carina Swanepoel, Zelda De Lange-Loots, Marike Cockeran, Marlien Pieters
Summary: In this population study, factors such as female gender, obesity, poor glycemic control, increased low-density lipoprotein cholesterol, and decreased high-density lipoprotein cholesterol were associated with progression to prothrombotic clot properties with age. In contrast, alcohol consumption had a protective effect.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Sally Bevan, Colin Longstaff
Summary: The study found that the instability of frozen-dried D-dimer plasma may result in 10%-18% loss of reactivity per year when stored at -20 degrees Celcius. Freeze-dried fibrin degradation products added to plasma were also unstable, although the sugar trehalose was found to improve stability. However, this preparation was not suitable as a standard for widely used assay platforms.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Orthopedics
Giovanni Balato, Tiziana Ascione, Enrico Festa, Elena De Vecchi, Pasquale Pagliano, Antonio Pellegrini, Giuseppe Pandolfo, Roberta Siciliano, Nicola Logoluso
Summary: This retrospective study aimed to determine the optimal thresholds for serum d-dimer and fibrinogen to differentiate aseptic failure from periprosthetic joint infection (PJI), and evaluate the predictive value of our thresholds compared to previous ones. The study found that an increased d-dimer level beyond 1063 ng/ml showed a better predictive value than the previously proposed threshold. The combined determination of d-dimer and fibrinogen displayed high specificity and should be considered an excellent tool to rule out an infection. The accuracy of the proposed cutoffs is more effective than previously reported.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Bogdan Dumitru Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Luis Ibanez, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nouria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Helene Larrue, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Remy Schwarzer, Christian Jansen, Marie-Angele Robic, Irene Conejo, Javier Martinez Gonzalez, Maria Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Georgina Casanovas, Jaume Bosch, Juan-Carlos Garcia-Pagan, Dominique Thabut
Summary: pTIPS is more effective in improving survival compared to endoscopic treatment for high-risk patients with cirrhosis and variceal bleeding. HE at admission does not affect the efficacy of pTIPS.
Article
Gastroenterology & Hepatology
Agustin Albillos, Aleksander Krag
Summary: Non-selective beta-blockers (NSBBs) have been the standard treatment for bleeding from oesophageal varices, but the best clinical use of NSBBs remains uncertain. This article aims to define the therapeutic window of NSBBs in cirrhosis from an individualized perspective. The use of NSBBs in patients without varices lacks robust evidence, while carvedilol appears superior to propranolol. The clinical risk-to-benefit ratio worsens in advanced decompensated stages, with high risk in patients with refractory ascites, low blood pressure, and renal impairment.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jacob Broder Brodersen, Jens Kjeldsen, Torben Knudsen, Michael Dam Jensen
Summary: This study aims to compare the agreement between pan-enteric capsule endoscopy (CE) and ileocolonoscopy (IC) for determining the severity and classification of lesions in ileocolonic Crohn's disease (CD). The results show a strong correlation between IC and CE in assessing the severity of ileocolonic CD, but fair to moderate agreement in sub-scores.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Endocrinology & Metabolism
Stinus Gadegaard Hansen, Charlotte Wilhelmina Wernberg, Lea Ladegaard Gronkjaer, Birgitte Gade Jacobsen, Tina Di Caterino, Aleksander Krag, Claus Bogh Juhl, Mette Munk Lauridsen, Vikram V. Shanbhogue
Summary: This study aimed to assess bone mineral density (BMD) in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD) and examine if the severity of NAFLD affects BMD. The results showed that neither steatosis nor nonalcoholic steatohepatitis (NASH) exerted a detrimental effect on BMD in these relatively young patients.
Article
Gastroenterology & Hepatology
Yun Huang, Sara E. Stinson, Helene Baek Juel, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Trine Nielsen, Niels Grarup, Oluf Pedersen, Michael Christiansen, Elizaveta Chabanova, Henrik S. Thomsen, Aleksander Krag, Stefan Stender, Jens-Christian Holm, Torben Hansen
Summary: This study investigated the effects of eight previously reported genome-wide significant steatogenic variants on liver and cardiometabolic traits in children and adolescents. The results showed that these variants were associated with higher liver fat and distinct patterns of plasma lipids. The genetic risk score (GRS) based on these variants was also associated with higher prevalence of hepatic steatosis and had potential clinical utility for risk stratification.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Stine Johansen, Mads F. Israelsen, Ida Villesen, Nikolaj J. Torp, Mette Nielsen, Maria P. Kjaergaard, Katrine D. Lindvig, Camilla Hansen, Peter N. Andersen, Ditlev Rasmussen, Sonke J. Detlefsen, Diana Leeming, Maja Thiele, Morten Karsdal, Aleksander Krag, Ema Anastasiadou, Manimozhian Arumugam, Peer Bork, Torben Hansen, Roland Henrar, Hans Israelsen, Morten Karsdal, Cristina Legido-Quigley, Hans Olav Melberg, Maja Thiele, Jonel Trebicka, Aleksander Krag, Mathias Mann, Jelle Matthijnssens
Summary: This study aimed to assess the PRO-C3 model in predicting liver-related events in patients with alcohol-related liver disease. The results showed that the PRO-C3 model had high prognostic accuracy in predicting these events.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Zhaohui Bai, Nahum Mendez-Sanchez, Fernando Gomes Romeiro, Andrea Mancuso, Cyriac Abby Philips, Frank Tacke, Metin Basaranoglu, Massimo Primignani, Mostafa Ibrahim, Yu Jun Wong, Filipe Gaio Nery, Rolf Teschke, Carlos Noronha Ferreira, Alberto E. Munoz, Kanokwan Pinyopornpanish, Thierry Thevenot, Shivaram Prasad Singh, Arpan Mohanty, Sanjaya K. Satapathy, Lorenzo Ridola, Hitoshi Maruyama, Evangelos Cholongitas, Giovanni Battista Levi Sandri, Li Yang, Yongping Yang, Erica Villa, Aleksander Krag, Florence Wong, Rajiv Jalan, Alastair O'Brien, Mauro Bernardi, Xingshun Qi
Summary: A international consensus statement on the use of human albumin (HA) for the treatment of liver cirrhosis-related complications has been developed. It proposes 12 clinically significant position statements, recommending short-term HA infusion for the management of hepatorenal syndrome, large volume paracentesis, and spontaneous bacterial peritonitis. Long-term HA administration can be considered in specific settings, but pulmonary edema should be closely monitored.
Article
Cardiac & Cardiovascular Systems
Eva M. Gram-Kampmann, Thomas B. Olesen, Camilla D. Hansen, Mie B. Hugger, Jane M. Jensen, Aase Handberg, Henning Beck-Nielsen, Aleksander Krag, Michael H. Olsen, Kurt Hojlund
Summary: This study examined the effect of a high-fat low-carbohydrate diet (LCD) on endothelial function and markers of low-grade inflammation in patients with type 2 diabetes (T2D). The results showed that a 6-month high-fat LCD did not adversely affect endothelial function or low-grade inflammation markers, suggesting that this diet does not increase the risk of cardiovascular disease.
CARDIOVASCULAR DIABETOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Aleksander Krag, Mary E. Rinella
Summary: Despite the urgent need, biomarkers for NASH that are approved and clinically usable are still hard to find, but a new study brings us closer to this goal.
Article
Gastroenterology & Hepatology
Anders Mark-Christensen, Line Riis Jolving, Pavithra Laxsen Anru, Joseph A. Murray, Rasmus Gaardskaer Nielsen, Niels Qvist, Soren Laurberg, Henriette Engberg, Jens Kjeldsen, Bente Mertz Norgard
Summary: In this nationwide Danish cohort study, it was found that patients with ulcerative colitis who underwent total colectomy had a higher risk of being diagnosed with inflammatory and autoimmune disease (IAD) compared to those who did not.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Sofia Hjerrild Thomsen, Pantea Zinolabedinbik, Jacob Broder Brodersen, Torben Knudsen, Jens Kjeldsen, Michael Dam Jensen
Summary: This study examined the additional information obtained with mucosal biopsies and the feasibility of CE as a single diagnostic procedure. The results showed that the additional information obtained from biopsies is limited in patients with a reliable CE result, and biopsies are still warranted for patients with an atypical endoscopic appearance or suspected malignancy.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Letter
Gastroenterology & Hepatology
Mads Israelsen, Nikolaj Torp, Stine Johansen, Maja Thiele, Aleksander Krag
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Malin Fromme, Carolin V. Schneider, Nurdan Gueldiken, Samira Amzou, Yizhao Luo, Monica Pons, Joan Genesca, Marc Miravitlles, Katrine Thorhauge, Johan Waern, Jan Sperl, Sona Frankova, Marc Bartel, Holger Zimmer, Markus Zorn, Aleksander Krag, Alice Turner, Christian Trautwein, Pavel Strnad
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Ida Ziegler Spedtsberg, Ida Villesen, Stine Johansen, Johanne Kragh Hansen, Katrine Prier Lindvig, Peter Andersen, Nikolaj Torp, Mads Israelsen, Camilla Dalby Hansen, Katrine Thorhauge, Katrine Bech, Emil Deleuran Hansen, Sonke Detlefsen, Diana Leeming, Morten Karsdal, Aleksander Krag, Maja Thiele
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Katrine Thorhauge, Georg Semmler, Stine Johansen, Katrine Prier Lindvig, Maria Kjaergaard, Nikolaj Torp, Johanne Kragh Hansen, Camilla Dalby Hansen, Peter Andersen, Mads Israelsen, Jonel Trebicka, Thomas Reiberger, Maja Thiele, Aleksander Krag
JOURNAL OF HEPATOLOGY
(2023)