Lysolipid receptor cross-talk regulates lymphatic endothelial junctions in lymph nodes

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells

(2018) Naoki Kobayashi et al.   Scientific Reports

Sphingosine -1 Phosphate Receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury

(2018) Nathalie Burg et al.   Arthritis & Rheumatology

Lacteal junction zippering protects against diet-induced obesity

(2018) Feng Zhang et al.   SCIENCE

A dark side to omega-3 fatty acids

(2017) Keisuke Yanagida et al.   NATURE

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets

(2017) Thiet M. Vu et al.   NATURE

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

(2017) Julia Joung et al.   Nature Protocols

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An engineered S1P chaperone attenuates hypertension and ischemic injury

(2017) Steven L. Swendeman et al.   Science Signaling

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

Novel Structural Insights into GPCR–β-Arrestin Interaction and Signaling

(2017) Ravi Ranjan et al.   TRENDS IN CELL BIOLOGY

Bioluminescence imaging of G protein-coupled receptor activation in living mice

(2017) Mari Kono et al.   Nature Communications

An engineered S1P chaperone attenuates hypertension and ischemic injury

(2017) Steven L. Swendeman et al.   Science Signaling

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

High-throughput functional genomics using CRISPR–Cas9

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Lysophosphatidic acid as a lipid mediator with multiple biological actions

(2014) S. Aikawa et al.   JOURNAL OF BIOCHEMISTRY

Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo

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Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo

(2014) Mari Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamin 2–dependent endocytosis is required for sustained S1PR1 signaling

(2014) Tim Willinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurements

(2014) Judith A. Stolwijk et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis

(2013) Z. Bai et al.   JOURNAL OF IMMUNOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development

(2013) Y. Hisano et al.   Biology Open

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Rho family GTPases

(2012) Alan Hall   BIOCHEMICAL SOCIETY TRANSACTIONS

SnapShot: Bioactive Lysophospholipids

(2012) Wouter H. Moolenaar et al.   CELL

Autotaxin through Lysophosphatidic Acid Stimulates Polarization, Motility, and Transendothelial Migration of Naive T Cells

(2012) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

(2012) Alejandra Mendoza et al.   Cell Reports

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

(2011) Brady K Atwood et al.   BMC GENOMICS

Insights into the pharmacological relevance of lysophospholipid receptors

(2011) Tetsuji Mutoh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of Mammalian Physiology, Development, and Disease by the Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors

(2011) Victoria A. Blaho et al.   CHEMICAL REVIEWS

Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

(2011) Myat Lin Oo et al.   JOURNAL OF CLINICAL INVESTIGATION

GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood

(2011) T. I. Arnon et al.   SCIENCE

LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis

(2010) H. Sumida et al.   BLOOD

CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P1) Function through Interaction with Membrane Helix 4

(2010) Alexander J. Bankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720

(2010) Yu Hisano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist

(2010) J. S. Swaney et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

(2010) J. Chun et al.   PHARMACOLOGICAL REVIEWS

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions

(2008) Tae Nakasaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

(2008) Takao Shimizu   Annual Review of Pharmacology and Toxicology

Lysophospholipid receptors in vertebrate development, physiology, and pathology

(2008) Athanasia Skoura et al.   JOURNAL OF LIPID RESEARCH

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells

(2008) Irina L Grigorova et al.   NATURE IMMUNOLOGY

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE