Article
Microbiology
Tomoki Inagaki, Kang-Hsin Wang, Ashish Kumar, Chie Izumiya, Hiroki Miura, Somayeh Komaki, Ryan R. Davis, Clifford G. Tepper, Harutaka Katano, Michiko Shimoda, Yoshihiro Izumiya
Summary: KICS is a chronic inflammatory disease caused by KSHV infection, characterized by high KSHV viral load and sustained elevation of IL-6 levels. Prolonged exposure to vIL-6 leads to changes in chromatin landscape, resulting in increased cytokine production and higher risk of inflammatory response.
Review
Immunology
Yin-Huai Chen, Sarah Spencer, Arian Laurence, James E. D. Thaventhiran, Holm H. Uhlig
Summary: The IL-6 family of cytokines plays crucial roles in immune protection, organ development, tissue regeneration, and metabolism. Genetic errors in cytokines or cytokine receptor units can lead to complex phenotypes and impact diseases like hyper-IgE syndrome. Understanding the GP130-STAT3 signaling pathway can inform therapeutic approaches for immune-mediated disorders, but may also result in infection susceptibility.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peng-Yuan Chang, Hung-Kang Wu, Yu-Hsu Chen, Yu-Pao Hsu, Ming-Te Cheng, Ching-Hsiao Yu, Shau-Kwaun Chen
Summary: This study investigated the effects of IL-6 co-stimulation on RANKL-stimulated RAW cells, revealing its role in cell proliferation, apoptosis, differentiation, and pro-inflammatory responses. The results showed that IL-6 induced transient proliferation and disturbed osteoclastogenesis, while promoting pro-inflammatory responses in monocytic cells.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Jazib Uddin, Sunil Tomar, Ankit Sharma, Lisa Waggoner, Varsha Ganesan, Sahiti Marella, Yanfen Yang, Taeko Noah, Simone Vanoni, Andrew Patterson, Chang Zeng, Paul S. Foster, Rodney Newberry, Shrinivas Bishu, John Y. Kao, Michael J. Rosen, Lee Denson, Philip D. King, Kasper Hoebe, Senad Divanovic, Ariel Munitz, Simon P. Hogan
Summary: The inhibitory receptor PIR-B plays a role in regulating CD4(+) IL17a(+) T-cell pathogenic memory responses, modulating chronic intestinal inflammatory responses and the development of colitis. The downstream axis involving PIR-B, Src-homology region 2 domain-containing phosphatase-1/2, and mammalian target of rapamycin complex 1 signaling is important for CD4(+) IL17a(+) cell survival. Furthermore, transcriptional signatures associated with Th17 cells and tissue resident memory networks were enriched in PIR-B+ murine CD4(+) T cells and human CD4(+) T cells expressing LILRB3, demonstrating the potential significance of PIR-B and its human homologue in inflammatory diseases.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Hagar Taman, Christopher G. Fenton, Endre Anderssen, Jon Florholmen, Ruth H. Paulssen
Summary: This study investigated the relationship between transcriptomic and genome-wide DNA methylation profiles in treatment-naive severe UC patients. The findings suggest that DNA hypo-methylation is correlated with approximately 80% of differentially expressed genes in severe UC compared to mild UC, with enriched pathways related to immune regulation and inflammation. Specifically, hypo-methylation of anti-inflammatory genes in severe UC may play a role in mitigating inflammation in the gut and could serve as potential biomarkers for disease severity and targeted treatment strategies.
Article
Clinical Neurology
Yoonhyuk Jang, Woo-Jin Lee, Han Sang Lee, Kon Chu, Sang Kun Lee, Soon-Tae Lee
Summary: Anakinra may be a therapeutic option for refractory cerebral autoinflammatory diseases, but it may be ineffective for some patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido
Summary: This study investigated the involvement of IL-6 trans-signaling in DVT and found a strong correlation between the Asp358Ala variant and sIL6-R levels. The high frequency of the Asp358Ala mutation and elevated IL-6 levels in DVT patients may explain the association between IL-6 overactivation and DVT outcome. These findings provide a proof of concept for targeting IL-6 trans-signaling as a new strategy for DVT adjuvant therapy.
Article
Immunology
Nabila Seddiki, Martyn French
Summary: Both COVID-19 and mycobacterial IRIS are characterized by immunopathology and pro-inflammatory responses, with monocyte/macrophage activation resulting from inadequate adaptive immune responses, leading to exacerbated inflammation. Targeting both the immunomodulatory and pro-inflammatory effects of the 'cytokine storm' may improve therapy for these conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juliane Lokau, Christoph Garbers
Summary: IL-6 and IL-11 are important pleiotropic cytokines that signal through specific receptors, with unique structures. Research has shown that chimeric receptors containing the stalk region of IL-11R can be blocked by a protease inhibitor other than ADAM10 during cleavage.
Review
Oncology
Cosmin-Victor Ene, Ilinca Nicolae, Bogdan Geavlete, Petrisor Geavlete, Corina Daniela Ene
Summary: Inflammatory processes play a crucial role in the development of prostate tumors. Modulating the expression and activity of the cytokine Interleukin-6 may provide a means of preventing or improving these pathologies.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Critical Care Medicine
Sarah Rehou, Abdikarim Abdullahi, Marc G. Jeschke
Summary: This study aimed to investigate the role of sIL-6R in burn injury. The results showed that patients with a higher IL-6/sIL-6R ratio had significantly higher mortality. This suggests that IL-6 signaling via its membrane-bound receptor with an anti-inflammatory function is important.
Article
Medicine, General & Internal
Anthony C. Gordon, Farah Al-Beidh, Kathryn M. Rowan, Alistair D. Nichol, Yaseen M. Arabi, Djillali Annane, Ahi Beane, Wilma Van Bentum-Puijk, Lindsay R. Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Adrian Buzgau, Allen C. Cheng, Michelle A. Detry, Eamon J. Duffy, Lise J. Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M. Higgins, Thomas E. Hills, Christopher M. Horvat, Francois Lamontagne, Patrick R. Lawler, Helen L. Leavis, Kelsey M. Linstrum, Edward Litton, Elizabeth Lorenzi, John C. Marshall, Florian B. Mayr, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Susan C. Morpeth, Srinivas Murthy, Katrina Orr, Rachael L. Parke, Jane C. Parker, Asad E. Patanwala, Ville Pettill, Emma Rademaker, Marlene S. Santos, Christina T. Saunders, Christopher W. Seymour, Manu Shankar-Hari, Wendy L. Sligl, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Steve A. Webb, Lennie P. G. Derde
Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Physiology
Paulina Villar-Fincheira, Aaron J. Paredes, Tomas Hernandez-Diaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceno, Jorge Mandiola, Nicole Bruneau, Lorena Garcia, Maria Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Summary: The study aims to evaluate the effects of exercise on plasma IL-6 and sIL-6R levels, and their relationship with vascular remodeling. Results show that post-marathon HT athletes had higher post-race plasma sIL-6R levels than LT athletes, suggesting a possible role of IL-6 in vascular remodeling, with a proposed association between IL-6 and aortic dilation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Yue Qi, Wei Xiong, Shukui Yu, Zhengde Du, Tengfei Qu, Lu He, Wei Wei, Lingjun Zhang, Ke Liu, Yi Li, David Z. He, Shusheng Gong
Summary: C1ql1-null mice showed progressive hearing loss with reduced nerve fibers innervating inner and outer hair cells, while spiral ganglion neurons appeared normal. C1ql1 is essential for hair cell innervation and outer hair cell survival, but not necessary for maturation of presynaptic machinery in inner hair cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Bo Meng, Adam Abdullahi, Isabella A. T. M. Ferreira, Niluka Goonawardane, Akatsuki Saito, Izumi Kimura, Daichi Yamasoba, Pehuen Pereyra Gerber, Saman Fatihi, Surabhi Rathore, Samantha K. Zepeda, Guido Papa, Steven A. Kemp, Terumasa Ikeda, Mako Toyoda, Toong Seng Tan, Jin Kuramochi, Shigeki Mitsunaga, Takamasa Ueno, Kotaro Shirakawa, Akifumi Takaori-Kondo, Teresa Brevini, Donna L. Mallery, Oscar J. Charles, John E. Bowen, Anshu Joshi, Alexandra C. Walls, Laurelle Jackson, Darren Martin, Kenneth G. C. Smith, John Bradley, John A. G. Briggs, Jinwook Choi, Elo Madissoon, Kerstin B. Meyer, Petra Mlcochova, Lourdes Ceron-Gutierrez, Rainer Doffinger, Sarah A. Teichmann, Andrew J. Fisher, Matteo S. Pizzuto, Anna de Marco, Davide Corti, Myra Hosmillo, Joo Hyeon Lee, Leo C. James, Lipi Thukral, David Veesler, Alex Sigal, Fotios Sampaziotis, Ian G. Goodfellow, Nicholas J. Matheson, Kei Sato, Ravindra K. Gupta
Summary: The Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 and can evade neutralizing antibodies more effectively compared to the Delta variant. A third dose of mRNA vaccine can provide enhanced protection. Omicron has lower replication in lung and gut cells and less efficiently cleaves its spike protein compared to Delta.
Article
Critical Care Medicine
Shuang A. Guo, Georgina S. Bowyer, John R. Ferdinand, Mailis Maes, Zewen K. Tuong, Eleanor Gillman, Mingfeng Liao, Rik G. H. Lindeboom, Masahiro Yoshida, Kaylee Worlock, Hudaa Gopee, Emily Stephenson, Catherine A. Gao, Paul A. Lyons, Kenneth G. C. Smith, Muzlifah Haniffa, Kerstin B. Meyer, Marko Z. Nikolic, Zheng Zhang, Richard G. Wunderink, Alexander Misharin, Gordon Dougan, Vilas Navapurkar, Sarah A. Teichmann, Andrew Conway Morris, Menna R. Clatworthy
Summary: Obesity has a negative impact on respiratory tract immunity in both adult and pediatric COVID-19 patients, leading to suppressed immune cell responses. Obese individuals show decreased expression of interferon and tumor necrosis factor in lung epithelial and immune cells. These findings have important implications for treatment strategies and recommend the specific application of recombinant interferons in obese patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Helene Ruffieux, Aimee L. Hanson, Samantha Lodge, Nathan G. Lawler, Luke Whiley, Nicola Gray, Tui H. Nolan, Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aloka de Sa, Victoria S. Pelly, Prasanti Kotagiri, Nathalie R. Kingston, John Bradley, Elaine Holmes, Julien K. Wist, Jeremy A. Nicholson, Paul Lyons, Kenneth G. C. Smith, Sylvia Richardson, Glenn Bantug, Christoph Hess
Summary: We analyzed detailed longitudinal phenotyping data from 215 individuals with varying disease severities to understand the biology behind individual patient responses to SARS-CoV-2 infection. Our findings revealed distinct profiles of 'systemic recovery', including the progression and resolution of inflammatory, immune cell, metabolic, and clinical responses. We identified strong correlations between innate immune cell numbers, kynurenine metabolites, and lipid metabolites, which have implications for homeostasis restoration, risk of death, and long COVID.
Article
Multidisciplinary Sciences
Amelie Bonaud, Laetitia Gargowitsch, Simon M. Gilbert, Elanchezhian Rajan, Pablo Canales-Herrerias, Daniel Stockholm, Nabila F. Rahman, Mark O. Collins, Hakan Taskiran, Danika L. Hill, Andres Alloatti, Nagham Alouche, Stephanie Balor, Vanessa Soldan, Daniel Gillet, Julien Barbier, Francoise Bachelerie, Kenneth G. C. Smith, Julia Jellusova, Pierre Bruhns, Sebastian Amigorena, Karl Balabanian, Michelle A. Linterman, Andrew A. Peden, Marion Espeli
Summary: We identified SNARE Sec22b as a critical regulator of plasma cell maintenance and function. In the absence of Sec22b, plasma cells were hardly detectable and serum antibody titers were dramatically reduced, leading to a failure in mounting a protective immune response. Mechanistically, Sec22b contributes to efficient antibody secretion and is involved in regulating plasma cell transcriptional identity, as well as the morphology of the endoplasmic reticulum and mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Engineering, Civil
Yang Yang, Yi Pik Cheng, Weiming Gong, Hong Fan, Guoliang Dai
Summary: This paper presents a series of scaled 1-g shaking table tests to study the seismic response of scaled nuclear power stations with DPRF in clay under earthquake excitations. Three different cushion types were adopted to investigate their effects on the structure and foundation. The results indicate that cushions A and B outperform cushion C in terms of the fundamental frequency, horizontal displacement, and acceleration response. Although the cushion type has negligible impact on the bending moments of the disconnected piles, the maximum bending moments are found to be proportional to the near-pile acceleration. Additionally, the rocking behavior of a structure with DPRF should be given more attention under earthquake loads.
Article
Hematology
Sevgi Kostel Bal, Sarah Giuliani, Jana Block, Peter Repiscak, Christoph Hafemeister, Tala Shahin, Nurhan Kasap, Bernhard Ransmayr, Yirun Miao, Cheryl van de Wetering, Alexandra Frohne, Raul Jimenez Heredia, Michael Schuster, Samaneh Zoghi, Vanessa Hertlein, Marini Thian, Aleksandr Bykov, Royala Babayeva, Sevgi Bilgic Eltan, Elif Karakoc-Aydiner, Lisa E. Shaw, Iftekhar Chowdhury, Markku Varjosalo, Rafael J. Arguello, Matthias Farlik, Ahmet Ozen, Edgar Serfling, Loic Dupre, Christoph Bock, Florian Halbritter, J. Thomas Hannich, Irinka Castanon, Michael J. Kraakman, Safa Baris, Kaan Boztug
Summary: In this study, the researchers investigated the role of NFATC1 mutations in human immunity and found evidence of metabolic plasticity in patient T cells. The study also demonstrated that metformin and rosiglitazone can improve the effector functions of patient T cells.
Article
Oncology
Harshath Gupta, Hitoshi Inoue, Yasutomo Nakai, Masashi Nakayama, Tracy Jones, Jessica L. Hicks, Balasubramanian Kumar, Meltem Gurel, William G. Nelson, Angelo M. De Marzo, Srinivasan Yegnasubramanian
Summary: GSTP1 is lowly expressed in normal prostate luminal cells but induced in most proliferative inflammatory atrophy (PIA) lesions. It is silenced in prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma (CaP) through CpG island promoter hypermethylation. Methylation density progressively increases in precursor lesions, with PIN lesions showing more partial methylation compared to CaP lesions.
CANCER PREVENTION RESEARCH
(2023)
Article
Allergy
Dylan Lawless, Hana Lango Allen, James E. D. Thaventhiran, Sarah Goddard, Oliver S. Burren, Evie Robson, N. I. H. R. BioResource Rare Dis Consortium NIHR BioResource Rare Dis Consortium, Daniel Peckham, Kenneth G. C. Smith, Sinisa Savic
Summary: This study analyzed the manifestation of cystic fibrosis (CF), a common genetic disorder, in patients with primary immunodeficiency (PID). The research found that patients carrying specific CFTR gene variants had worse outcome in terms of structural lung disease. Genome sequencing also identified cases of CFTR dysfunction in PID, suggesting the potential of precision medicine in treating traditional Mendelian disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Agatha C. van der Klaauw, Emily Horner, Pehuen Pereyra-Gerber, Utkarsh S. Agrawal, William Foster, Sarah Spencer, Bensi Vergese, Miriam Smith, Elana D. Henning, Isobel A. Ramsay, Jack M. Smith, Stephane J. Guillaume, Hayley M. Sharpe, Iain Hay, Sam Thompson, Silvia H. Innocentin, Lucy Booth, Chris Robertson, Colin McCowan, Steven Kerr, Thomas J. Mulroney, Martin P. O'Reilly, Thevinya P. Gurugama, Lihinya A. Gurugama, Maria Rust, Alex Ferreira, Soraya Ebrahimi, Lourdes Ceron-Gutierrez, Jacopo Scotucci, Barbara J. Kronsteiner, Susanna Dunachie, Paul J. Klenerman, Adrian A. Park, Francesco Rubino, Abigail Lamikanra, Hannah Stark, Nathalie Kingston, Lise Estcourt, Heli Harvala, David A. Roberts, Rainer J. Doffinger, Michelle Linterman, Nicholas Matheson, Aziz Sheikh, I. Sadaf Farooqi, James E. D. Thaventhiran
Summary: Obesity is associated with an increased risk of severe COVID-19 infection and mortality. COVID-19 vaccines may be less effective in individuals with obesity. A study in Scotland found that vaccinated individuals with severe obesity were more likely to experience hospitalization or death from COVID-19. Another study found that individuals with severe obesity had lower levels of neutralizing antibodies after vaccination compared to individuals with a normal BMI, and the decline in antibody levels was faster in people with severe obesity.
Article
Medicine, General & Internal
Jana Block, Christina Rashkova, Irinka Castanon, Samaneh Zoghi, Jessica Platon, Rico C. Ardy, Mitsuhiro Fujiwara, Beatriz Chaves, Rouven Schoppmeyer, Caspar I. van der Made, Raul Jimenez Heredia, Frederike L. Harms, Samin Alavi, Laia Alsina, Paula Sanchez Moreno, Rainiero Avila Polo, Rocio Cabrera-Perez, Sevgi Kostel Bal, Laurene Pfajfer, Bernhard Ransmayr, Anna-Katharina Mautner, Ryohei Kondo, Anna Tinnacher, Michael Caldera, Michael Schuster, Cecilia Dominguez Conde, Rene Platzer, Elisabeth Salzer, Thomas Boyer, Han G. Brunner, Judith E. Nooitgedagt-Frons, Estibaliz Iglesias, Angela Deya-Martinez, Marisol Camacho-Lovillo, Joerg Menche, Christoph Bock, Johannes B. Huppa, Winfried F. Pickl, Martin Distel, Jeffrey A. Yoder, David Traver, Karin R. Engelhardt, Tobias Linden, Leo Kager, J. Thomas Hannich, Alexander Hoischen, Sophie Hambleton, Sabine Illsinger, Lydie Da Costa, Kerstin Kutsche, Zahra Chavoshzadeh, Jaap D. van Buul, Jordi Anton, Joan Calzada-Hernandez, Olaf Neth, Julien Viaud, Akihiko Nishikimi, Loic Dupre, Kaan Boztug
Summary: This study reveals that DOCK11 regulates T-cell shape and migration as well as erythroid development. Inherited loss-of-function variants in DOCK11 resulted in early-onset severe immune dysregulation and normocytic anemia.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Juan Carlos Yam-Puc, Zhaleh C. Hosseini, Emily Horner, Pehuen Pereyra Gerber, Nonantzin Beristain-Covarrubias, Robert Hughes, Aleksei Lulla, Maria Rust, Rebecca Boston, Magda Ali, Katrin Fischer, Edward Simmons-Rosello, Martin O'Reilly, Harry H. Robson, Lucy Booth, Lakmini Kahanawita, Andrea Correa-Noguera, David Favara, Lourdes Ceron-Gutierrez, Baerbel Keller, Andrew Craxton, Georgina S. F. Anderson, Xiao-Ming Sun, Anne Elmer, Caroline Saunders, Areti Bermperi, Sherly Jose, Nathalie E. Kingston, Thomas Mulroney, Lucia P. G. A. Pinon, Michael Chapman, Sofia E. Grigoriadou, Marion R. MacFarlane, Anne Willis, Kiran Patil, Sarah Spencer, Emily S. Staples, Klaus Warnatz, Matthew Buckland, Florian Hollfelder, Marko Hyvonen, Rainer Doffinger, Christine J. Parkinson, Sara Lear, Nicholas Matheson, James E. D. Thaventhiran
Summary: The research shows that age-associated B cells (ABC) remain transcriptionally similar in individuals with reduced immune cell function. Higher pre-vaccine levels of ABC are associated with poor vaccine response. ABCs from different conditions have common transcriptional profiles and can be categorized based on their expression of immune genes.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Julia Guthrie, Sevgi Koestel Bal, Salvo Danilo Lombardo, Felix Mueller, Celine Sin, Christiane V. R. Huetter, Joerg Menche, Kaan Boztug
Summary: This study utilizes a network-based approach to integrate 186 genetic immune diseases into a comprehensive map of human immune dysregulation called AutoCore. AutoCore is divided into 19 endotypes corresponding to cohesive disease subgroups, providing a molecular mechanism-based disease classification and therapeutic targeting.
Article
Pediatrics
Akif Kavgaci, Deniz Bayrakoglu, Sevgi Kostel Bal, Sule Haskologlu, Nisa Eda Cullas Ilarslan, Seda Topcu, Emel Okulu, Candan Islamoglu, Meltem Arikan, Figen Dogu, Kamile Aydan Ikinciogullari
Summary: This study aimed to examine the thymopoiesis in healthy children by measuring recent thymic emigrants (RTE) and establish the RTE reference values in Turkish children. The results showed that the absolute count and relative ratios of RTE cells were highest during the first year of life, decreasing significantly with age. These findings may contribute to early diagnosis and monitoring of immune reconstitution.
TURKISH JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin J. Dunmore, Paul D. Upton, Kate Auckland, Romit J. Samanta, Paul A. Lyons, Kenneth G. C. Smith, Stefan W. Graf, Charlotte Summers, Nicholas Morrell
Summary: Similar to other causes of acute respiratory distress syndrome, COVID-19 is characterized by abnormal expression of vascular injury biomarkers. This study presents the first report that circulating plasma bone morphogenetic proteins (BMPs), BMP9 and pBMP10, involved in vascular protection, are reduced in hospitalized patients with COVID-19.
PULMONARY CIRCULATION
(2023)
