Article
Immunology
Kia C. Ferrell, Erica L. Stewart, Claudio Counoupas, Thomas M. Ashhurst, Warwick J. Britton, Nikolai Petrovsky, James A. Triccas
Summary: The study provides a comprehensive understanding of the immune response to intrapulmonary adjuvant administration, revealing transient and non-polarized innate cell recruitment to lungs and local lymph nodes induced by vaccination. Fluorescently labeled adjuvant particles showed widespread tissue dissemination and uptake by innate immune cells, leading to changes in innate and adaptive cell subsets. The preclinical evidence supports delta-inulin as a suitable adjuvant for pulmonary vaccines.
MUCOSAL IMMUNOLOGY
(2021)
Article
Immunology
Junfei Wei, Venkatesh L. Hegde, Ananta V. Yanamandra, Madison P. O'Hara, Brian Keegan, Kathryn M. Jones, Ulrich Strych, Maria Elena Bottazzi, Bin Zhan, K. Jagannadha Sastry, Peter J. Hotez
Summary: Trichuriasis is a neglected tropical disease affecting the poorest populations. Researchers are developing a vaccine composed of Tm-WAP49 protein to be delivered through intranasal immunization. Preliminary results in a mouse model showed high levels of antibody response and significant reduction in worm burden. The addition of adjuvants further improved the vaccine efficacy, inducing robust cellular responses and long-term T cell memory.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Adam M. Weiss, Jainu Ajit, Tyler J. Albin, Neeraj Kapoor, Shilpa Maroju, Aym Berges, Lucy Pill, Jeff Fairman, Aaron P. Esser-Kahn
Summary: This study demonstrated the successful use of CFPS technology to produce large quantities of site-specific antigen-adjuvant conjugates for enhanced antigen presentation and T-cell production. Site-specific conjugation using copper-free click chemistry significantly improved the efficacy of the OVA-CpG conjugates both in vitro and in vivo, reducing the required CpG dose for T-cell production tenfold.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Takashi Kimoto
Summary: The development of a safe and effective mucosal adjuvant is crucial for influenza vaccine administration. This study focused on the use of bovine pulmonary surfactant (PS) as a basis for the adjuvant, which when administered intranasally with the influenza vaccine, induced specific immune responses in the respiratory tract mucosa. The researchers investigated the metabolism and rapid turnover of PS and successfully developed a PS-based mucosal adjuvant.
Article
Microbiology
Jingen Zhu, Swati Jain, Jian Sha, Himanshu Batra, Neeti Ananthaswamy, Paul B. Kilgore, Emily K. Hendrix, Yashoda M. Hosakote, Xiaorong Wu, Juan P. Olano, Adeyemi Kayode, Cristi L. Galindo, Simran Banga, Aleksandra Drelich, Vivian Tat, Chien-Te K. Tseng, Ashok K. Chopra, Venigalla B. Rao
Summary: This study reports the development of a needle-free, bacteriophage T4-based mucosal vaccine that induces strong mucosal immunity, robust humoral and cellular immune responses, and provides complete protection against various SARS-CoV-2 variants.
Review
Immunology
Victor Vaernewyck, Boaz Arzi, Niek N. Sanders, Eric Cox, Bert Devriendt
Summary: Periodontal disease affects a large portion of adults and can lead to systemic disorders. Control options primarily focus on removing plaque and calculus, but altering host inflammatory response and reducing bacterial triggers are also important. Vaccines may provide a potent adjunct to mechanical debridement for prevention and treatment, but the complexity of periodontal disease complicates vaccine development. Recent advances in mucosal vaccination may help bridge this gap.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Daniel Mott, Jason Yang, Christina Baer, Kadamba Papavinasasundaram, Christopher M. Sassetti, Samuel M. Behar
Summary: We used a mouse model to investigate how Mycobacterium tuberculosis survives in macrophages despite immune pressure. CD4 T cells can recognize infected macrophages, while CD8 T cells show limited recognition and cannot inhibit M. tuberculosis growth. High numbers of M. tuberculosis inside macrophages lead to cell death and presentation of TB10.4 antigen to CD8 T cells by other macrophages. This mode of antigen presentation may have both beneficial and harmful effects on the host.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Anirban Sengupta, Mohammad Azharuddin, Maria E. Cardona, Claudia Devito, Eleanore von Castelmur, Anna Wehlin, Zuzanna Pietras, Maria Sunnerhagen, Robert Selegard, Daniel Aili, Ali Alamer, Jorma Hinkula, Noha Al-Otaibi
Summary: This study investigated the effectiveness of using a combination of specific antigens and adjuvants through intranasal administration in inducing immune responses. The results showed that this strategy was able to induce both mucosal and systemic immune responses. Additionally, lipid adjuvants were found to enhance the vaccine effect.
Article
Oncology
Max O. Meneveau, Pankaj Kumar, Kevin T. Lynch, Sapna P. Patel, Craig L. Slingluff
Summary: This study found that adding peptide antigens to incomplete Freund's adjuvant (IFA) enhanced antigen presentation pathways and tertiary lymphoid structure gene signatures in the vaccine-site microenvironment (VSME). Adding the Toll-like receptor 3 (TLR3) agonist polyICLC (pICLC) induced an immunologically favorable VSME one week after injection, but had little impact after multiple injections. Repeated injections at the same site enhanced immune pathway stimulation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Raj S. Patel, Babita Agrawal
Summary: Investigating a highly cross-protective vaccine against SARS-CoV-2 variants is crucial. The study found that immunization with lipopeptides derived from conserved epitopes of SARS-CoV-2 led to enhanced immune responses and neutralizing antibodies against multiple variants. These findings support the development of a cross-protective SARS-CoV-2 vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Donato Amodio, Alessandra Ruggiero, Mayla Sgrulletti, Chiara Pighi, Nicola Cotugno, Chiara Medri, Elena Morrocchi, Luna Colagrossi, Cristina Russo, Salvatore Zaffina, Gigliola Di Matteo, Cristina Cifaldi, Silvia Di Cesare, Beatrice Rivalta, Lucia Pacillo, Veronica Santilli, Carmela Giancotta, Emma Concetta Manno, Marta Ciofi Degli Atti, Massimiliano Raponi, Paolo Rossi, Andrea Finocchi, Caterina Cancrini, Carlo Federico Perno, Viviana Moschese, Paolo Palma
Summary: The study analyzed the immune response following the BNT162b2 mRNA COVID-19 vaccine in immunocompromised patients compared to healthy controls. It found that some immunocompromised patients did not develop specific CD4+CD40L+ T cell responses, indicating the importance of evaluating T cell immune responses in this subpopulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Richard I. Walker, A. Louis Bourgeois
Summary: Oral immunization is an effective strategy against mucosal enteric pathogens. Inactivated whole bacterial cells can also induce protective immunity. Developing a safe and simple delivery format with controlled immunogenic amounts of complex antigens is essential. Enhancing the efficacy of whole cell vaccines can be achieved through genetic engineering and the use of mucosal adjuvants. The development of ETVAX, a vaccine candidate against enterotoxigenic Escherichia coli (ETEC), has shown promising results.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Natalia Syrimi, Flora Sourri, Maria-Christina Giannakopoulou, Dimitrios Karamanis, Asterios Pantousas, Persefoni Georgota, Eleni Rokka, Zoe Vladeni, Euaggelia Tsiantoula, Evangelia Soukara, Nikoletta Lavda, Dimitrios Gkaragkanis, Aikaterini Zisaki, Panagiotis Vakalidis, Vasiliki Goula, Evdokia Loupou, Leonidas Palaiodimos, Dimitrios Hatzigeorgiou
Summary: In this study, the trajectory of humoral and cellular immunity after nine months of primary vaccination with the BNT162b2 mRNA vaccine among 189 healthcare workers was investigated. Correlations between immunity parameters and common variables and comorbidities were also examined. The study found a significant drop in antibodies over time, with age and smoking status affecting the rise of antibodies. T-cell activation was not demonstrated in more than half of the participants at nine months. Female gender and antibody levels at four months predicted the detection of cellular immunity at nine months post-vaccination. This study contributes to our understanding of the immune response to the BNT162b2 mRNA vaccine and its associated factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Cristina Venegas-Vargas, Lucas P. Taylor, Dennis L. Foss, Traci K. Godbee, Ryan Philip, Meggan Bandrick
Summary: This study evaluated immune responses to different PCV2 vaccines in pigs and found that the trivalent chimeric vaccine induced robust cell-mediated immunity and protective efficacy following either a single dose or splitting the dose into two administrations.
Review
Immunology
Rosendo Luria-Perez, Luis A. Sanchez-Vargas, Paola Munoz-Lopez, Gabriela Mellado-Sanchez
Summary: The Flaviviridae family consists of RNA enveloped viruses that cause diseases in humans, with mucosal vaccines showing promise as an alternative route for immunization due to their ability to induce long-term immunity, needle-free administration, and diverse antigen delivery systems.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ting Wang, Yuanyuan Zhen, Xiaoyu Ma, Biao Wei, Ning Wang
ACS APPLIED MATERIALS & INTERFACES
(2015)
Article
Biophysics
Ting Wang, Yuanyuan Zhen, Xiaoyu Ma, Biao Wei, Shuqin Li, Ning Wang
COLLOIDS AND SURFACES B-BIOINTERFACES
(2015)
Article
Pharmacology & Pharmacy
Ting Wang, Ning Wang
CURRENT PHARMACEUTICAL DESIGN
(2015)
Review
Pharmacology & Pharmacy
Ning Li, Ning Wang, Xueting Wang, Yuanyuan Zhen, Ting Wang
Meeting Abstract
Nanoscience & Nanotechnology
Ting Wang, Yuanyuan Zhen, Ning Li, Zhixuan Wang, Ning Wang
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2016)
Article
Biotechnology & Applied Microbiology
Xueting Wang, Ning Wang, Ning Li, Yuanyuan Zhen, Ting Wang
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2016)
Meeting Abstract
Chemistry, Multidisciplinary
Ning Wang, Yuanyuan Zhen, Ning Li, Xueting Wang, Ting Wang
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Chemistry, Multidisciplinary
Ning Wang, Yuanyuan Zhen, Yiguang Jin, Xueting Wang, Ning Li, Shaohong Jiang, Ting Wang
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Chemistry, Medicinal
Ning Li, Ning Wang, Tingni Wu, Changlu Qiu, Xueting Wang, Shaohong Jiang, Zina Zhang, Ting Liu, Chunliu Wei, Ting Wang
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2018)
Article
Immunology
Ning Wang, Changlu Qiu, Minnan Chen, Ting Liu, Ting Wang
Article
Polymer Science
Ning Wang, Chunliu Wei, Zina Zhang, Ting Liu, Ting Wang
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2020)
Article
Materials Science, Biomaterials
Yuanyuan Qi, Can Wang, Rui Qian, Minnan Chen, Pingping Jiang, Ting Wang, Ning Wang
Summary: The novel TUDC procedure allows for efficient loading of poorly water-soluble drugs into liposome interiors, with improved drug encapsulation efficiency. When combined with mathematical equations and thermodynamic process, it can accurately predict loading results, reducing experimental workload and enhancing liposome development efficiency.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Polymer Science
Jiale Li, Conghui Li, Hui Zhang, Xiang Gao, Ting Wang, Zengming Wang, Aiping Zheng
Summary: In this study, hot-melt extrusion was used to prepare azithromycin amorphous solid dispersion, solving the issues of bitter taste and low solubility. The selection of a suitable polymer was based on solubility parameter calculations, and the formulation and process were optimized using design of experiments.
Review
Pharmacology & Pharmacy
Ning Wang, Rui Qian, Ting Liu, Tingni Wu, Ting Wang
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
(2019)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)