期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 547, 期 -, 页码 309-317出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2019.04.017
关键词
Magnesium alloy; Layer-by-layer; Heat treatment; Corrosion resistance; Antibacterial property; Sustained release
资金
- National Natural Science Foundation of China [51571134]
- Shandong University of Science and Technology (SDUST) Research Fund [2014TDJH104]
- Shandong Provincial Natural Science Foundation [ZR2017BEM002]
Magnesium (Mg) alloys have received considerable attentions as the emerging biodegradable implant materials in orthopedic surgery applications. However, the rapid corrosion rate and the susceptibility to bacterial infection have prevented their wide spread applications to date. In this work, the gentamicin-loaded multilayers have been constructed on Mg alloys through spin-assisted layer-by-layer (SLbL) assembly. Heat treatment is applied for improving the corrosion resistance and prolonging the drug release profile. In addition, the treated multilayer can promote the formation of hydroxyapatite (HA) during the long-time immersion in Hank's balanced salt solution (HBSS). (C) 2019 Elsevier Inc. All rights reserved.
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