Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells

The hematopoietic stem cell niche: What's so special about bone?

(2018) Benjamin J. Frisch   BONE

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell

(2018) Jonathan Hoggatt et al.   CELL

The hematopoietic stem cell niche: from embryo to adult

(2018) Xin Gao et al.   DEVELOPMENT

Niches for Hematopoietic Stem Cells and Their Progeny

(2018) Qiaozhi Wei et al.   IMMUNITY

The Emerging Link Between the Complement Cascade and Purinergic Signaling in Stress Hematopoiesis

(2018) Mariusz Z. Ratajczak et al.   Frontiers in Immunology

Pharmacological characterisation of a tool αvβ1 integrin small molecule RGD-mimetic inhibitor

(2018) Alex L. Wilkinson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment

(2017) Bradley W. Blaser et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial

(2017) Darja Karpova et al.   Journal of Translational Medicine

Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow

(2017) Emily Bowers et al.   NATURE MEDICINE

LFA-1 integrin antibodies inhibit leukocyte  4 1-mediated adhesion by intracellular signaling

(2016) M. Gronholm et al.   BLOOD

Enhanced in utero allogeneic engraftment in mice after mobilizing fetal HSCs by  4 1/7 inhibition

(2016) A. G. Kim et al.   BLOOD

Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak

(2016) Ingrid G. Winkler et al.   EXPERIMENTAL HEMATOLOGY

New agents in HSC mobilization

(2016) Mélanie J. Domingues et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Targeting of Mesenchymal Stromal Cells byCre-Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells

(2016) Jingzhu Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CXCR2 modulates bone marrow vascular repair and haematopoietic recovery post-transplant

(2015) Sarah J. M. Hale et al.   BRITISH JOURNAL OF HAEMATOLOGY

Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking

(2015) M Z Ratajczak et al.   LEUKEMIA

Concise Review: CXCR4/CXCL12 Signaling in Immature Hematopoiesis-Lessons From Pharmacological and Genetic Models

(2015) Darja Karpova et al.   STEM CELLS

Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)

(2014) S Borkowska et al.   LEUKEMIA

The Orphan Nuclear Receptor NR4A1 Specifies a Distinct Subpopulation of Quiescent Myeloid-Biased Long-Term HSCs

(2014) Ruben H. Land et al.   STEM CELLS

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor

(2013) D Karpova et al.   LEUKEMIA

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Different microvascular permeability responses elicited by the CXC chemokines MIP-2 and KC during leukocyte recruitment: Role of LSP1

(2012) Xi Lei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Granulocyte colony stimulating factor expands hematopoietic stem cells within the central but not endosteal bone marrow region

(2012) Jochen Grassinger et al.   CYTOKINE

Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial

(2012) David H Miller et al.   LANCET NEUROLOGY

Hematopoietic stem cell mobilization: updated conceptual renditions

(2012) H Bonig et al.   LEUKEMIA

Glioblastoma Cell-Secreted Interleukin-8 Induces Brain Endothelial Cell Permeability via CXCR2

(2012) Julie Dwyer et al.   PLoS One

Neutrophil arrest by LFA-1 activation

(2012) Craig T. Lefort et al.   Frontiers in Immunology

Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4

(2011) M P Rettig et al.   LEUKEMIA

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Diabetic Stem-Cell “Mobilopathy”

(2011) John F. DiPersio   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function

(2011) F. Ferraro et al.   Science Translational Medicine

The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization

(2010) J-P Lévesque et al.   LEUKEMIA

BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells

(2009) P. Ramirez et al.   BLOOD

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

(2009) M. J. Christopher et al.   BLOOD

Insights into the biology of mobilized hematopoietic stem/progenitor cells through innovative treatment schedules of the CXCR4 antagonist AMD3100

(2009) Halvard Bonig et al.   EXPERIMENTAL HEMATOLOGY

A Role for a CXCR2/Phosphatidylinositol 3-Kinase   Signaling Axis in Acute and Chronic Vascular Permeability

(2009) J. Gavard et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab

(2008) H. Bonig et al.   BLOOD